{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:22:33Z","timestamp":1789662153862,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.envint.2023.108007","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T01:56:19Z","timestamp":1685757379000},"page":"108007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Nonlinear low dose hematotoxicity of benzene; a pooled analyses of two studies among Chinese exposed workers"],"prefix":"10.1016","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-8163","authenticated-orcid":false,"given":"Roel","family":"Vermeulen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-9698","authenticated-orcid":false,"given":"Qingshan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1687-5587","authenticated-orcid":false,"given":"Martha S.","family":"Linet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7866-8391","authenticated-orcid":false,"given":"Luoping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutzen","family":"Portengen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9096-692X","authenticated-orcid":false,"given":"Jelle","family":"Vlaanderen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Sungkyoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songnian","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn T.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Rappaport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2023.108007_b0005","first-page":"296","article-title":"Haematological effects of chronic benzene poisoning in 217 workers","volume":"28","author":"Aksoy","year":"1971","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.envint.2023.108007_b0010","first-page":"56","article-title":"Details of blood changes in 32 patients with pancytopenia associated with long-term exposure to benzene","volume":"29","author":"Aksoy","year":"1972","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.envint.2023.108007_b0015","first-page":"785","article-title":"Exposure to benzene in Turkey between 1983 and 1985: a haematological study on 231 workers","volume":"44","author":"Aksoy","year":"1987","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.envint.2023.108007_b0020","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S1470-2045(09)70358-4","article-title":"A review of human carcinogens\u2013Part F: chemical agents and related occupations","volume":"10","author":"Baan","year":"2009","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.envint.2023.108007_b0025","first-page":"929","article-title":"Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1","volume":"63","author":"Bauer","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.envint.2023.108007_b0035","first-page":"619","article-title":"A study of the hematologic effects of chronic low-level exposure to benzene","volume":"33","author":"Collins","year":"1991","journal-title":"J. Occup. Med"},{"key":"10.1016\/j.envint.2023.108007_b0040","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00043764-199703000-00013","article-title":"Evaluation of lymphopenia among workers with low-level benzene exposure and the utility of routine data collection","volume":"39","author":"Collins","year":"1997","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.envint.2023.108007_b0045","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/0960327119895570","article-title":"Genetic, epigenetic, and lineage-directed mechanisms in benzene-induced malignancies and hematotoxicity targeting hematopoietic stem cells niche","volume":"39","author":"Dewi","year":"2020","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.envint.2023.108007_b0050","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1158\/1055-9965.EPI-06-0262","article-title":"Modeling human metabolism of benzene following occupational and environmental exposures","volume":"15","author":"Kim","year":"2006","journal-title":"Cancer Epidemiol. Biomarkers Prevent."},{"key":"10.1016\/j.envint.2023.108007_b0055","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/carcin\/bgi297","article-title":"Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism","volume":"27","author":"Kim","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.envint.2023.108007_b0060","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.1102443","article-title":"Hematotoxicity in workers exposed to low levels of benzene","volume":"306","author":"Lan","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.envint.2023.108007_b0065","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1289\/ehp.8948","article-title":"Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers","volume":"115","author":"Lin","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2023.108007_b0070","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/S1470-2045(17)30832-X","article-title":"Carcinogenicity of benzene","volume":"18","author":"Loomis","year":"2017","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.envint.2023.108007_b0075","doi-asserted-by":"crossref","unstructured":"McHale, C., Zhang, L., Lan, Q., et al., 2008. Low-Dose, Occupational Exposure to the Leukemogen Benzene Induces Robust Changes in the Blood Transcriptome Associated with Altered Immune System Biology. Blood 112, 440\u2013440.","DOI":"10.1182\/blood.V112.11.1207.1207"},{"key":"10.1016\/j.envint.2023.108007_b0080","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/carcin\/bgr297","article-title":"Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment","volume":"33","author":"McHale","year":"2012","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.envint.2023.108007_b0085","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cbi.2005.03.025","article-title":"Benzene and the hemopoietic stem cell","volume":"153\u2013154","author":"Morgan","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envint.2023.108007_b0090","first-page":"83","article-title":"Early effects of low benzene exposure on blood cell counts in Bulgarian petrochemical workers","volume":"100","author":"Pesatori","year":"2009","journal-title":"Med. Lav."},{"key":"10.1016\/j.envint.2023.108007_b0095","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/ajim.10121","article-title":"Hematological changes among Chinese workers with a broad range of benzene exposures","volume":"42","author":"Qu","year":"2002","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.envint.2023.108007_b0100","doi-asserted-by":"crossref","first-page":"e33733","DOI":"10.1371\/journal.pone.0033733","article-title":"Panax ginseng modulates cytokines in bone marrow toxicity and myelopoiesis: ginsenoside Rg1 partially supports myelopoiesis","volume":"7","author":"Raghavendran","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.envint.2023.108007_b0105","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cbi.2009.12.017","article-title":"Human benzene metabolism following occupational and environmental exposures","volume":"184","author":"Rappaport","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envint.2023.108007_b0110","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/ajim.10138","article-title":"Benzene exposure and hematopoietic mortality: A long-term epidemiologic risk assessment","volume":"42","author":"Rinsky","year":"2002","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.envint.2023.108007_b0115","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/(SICI)1097-0274(199603)29:3<236::AID-AJIM3>3.0.CO;2-O","article-title":"Hematotoxicity among Chinese workers heavily exposed to benzene","volume":"29","author":"Rothman","year":"1996","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.envint.2023.108007_b0120","first-page":"2839","article-title":"Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C\u2013>T mutation and rapid fractional excretion of chlorzoxazone","volume":"57","author":"Rothman","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.envint.2023.108007_b0125","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0344-0338(11)80705-3","article-title":"Bone marrow morphology in patients with neutropenia due to chronic exposure to organic solvents (benzene): early lesions","volume":"190","author":"Ruiz","year":"1994","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.envint.2023.108007_b0130","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.toxlet.2020.05.036","article-title":"Derivation of an occupational exposure limit for benzene using epidemiological study quality assessment tools","volume":"334","author":"Schnatter","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envint.2023.108007_b0135","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1667\/RR13256.1","article-title":"Analysis of the lymphocytopoiesis dynamics in nonirradiated and irradiated humans: a modeling approach","volume":"181","author":"Smirnova","year":"2014","journal-title":"Radiat. Res."},{"key":"10.1016\/j.envint.2023.108007_b0140","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/bjh.14510","article-title":"Recent advances in understanding clonal haematopoiesis in aplastic anaemia","volume":"177","author":"Stanley","year":"2017","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.envint.2023.108007_b0145","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cbi.2010.01.007","article-title":"Low level occupational benzene exposure and hematological parameters","volume":"184","author":"Swaen","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envint.2023.108007_b0150","doi-asserted-by":"crossref","first-page":"e91828","DOI":"10.1371\/journal.pone.0091828","article-title":"Characterization of changes in gene expression and biochemical pathways at low levels of benzene exposure","volume":"9","author":"Thomas","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envint.2023.108007_b0155","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.yrtph.2004.05.010","article-title":"A hematology surveillance study of petrochemical workers exposed to benzene","volume":"40","author":"Tsai","year":"2004","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envint.2023.108007_b0160","first-page":"105","article-title":"Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in China","volume":"48","author":"Vermeulen","year":"2004","journal-title":"Ann. Occup. Hygiene"},{"key":"10.1016\/j.envint.2023.108007_b0165","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1289\/ehp.0901127","article-title":"Flexible meta-regression to assess the shape of the benzene-leukemia exposure-response curve","volume":"118","author":"Vlaanderen","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2023.108007_b0170","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/aje\/kwr118","article-title":"The impact of saturable metabolism on exposure-response relations in 2 studies of benzene-induced leukemia","volume":"174","author":"Vlaanderen","year":"2011","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envint.2023.108007_b0175","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/stem.5530150736","article-title":"Acute radiation disease and biological dosimetry in 1993","volume":"15","author":"Vorobiev","year":"1997","journal-title":"Stem Cells"},{"key":"10.1016\/j.envint.2023.108007_b0185","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/(SICI)1097-0274(199603)29:3<247::AID-AJIM4>3.0.CO;2-N","article-title":"Risk of low red or white blood cell count related to estimated benzene exposure in a rubberworker cohort (1940\u20131975)","volume":"29","author":"Ward","year":"1996","journal-title":"Am. J. Ind. Med."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412023002805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412023002805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T12:29:21Z","timestamp":1758976161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412023002805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":35,"alternative-id":["S0160412023002805"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2023.108007","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonlinear low dose hematotoxicity of benzene; a pooled analyses of two studies among Chinese exposed workers","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2023.108007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108007"}}