{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:24:35Z","timestamp":1792898675315,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.envint.2023.108235","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T21:11:25Z","timestamp":1695762685000},"page":"108235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Associations between perfluoroalkyl substances and the severity of non-alcoholic fatty liver disease"],"prefix":"10.1016","volume":"180","author":[{"given":"Norma","family":"David","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9512-9314","authenticated-orcid":false,"given":"Jean-Philippe","family":"Antignac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Marchand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Michalak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9deric","family":"Oberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Fouchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Lannes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Blanchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-4772","authenticated-orcid":false,"given":"Etienne B.","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Boursier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1699-0278","authenticated-orcid":false,"given":"Cl\u00e9mence M.","family":"Canivet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2023.108235_b0005","doi-asserted-by":"crossref","first-page":"101602","DOI":"10.1016\/j.molmet.2022.101602","article-title":"Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice","volume":"66","author":"Attema","year":"2022","journal-title":"Mol Metab"},{"key":"10.1016\/j.envint.2023.108235_b0010","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.envint.2018.02.031","article-title":"Perfluoroalkyl substances in adolescents in northern Norway: Lifestyle and dietary predictors. The Troms\u00f8 study, Fit Futures 1","volume":"114","author":"Averina","year":"2018","journal-title":"Environ Int"},{"key":"10.1016\/j.envint.2023.108235_b0015","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.envpol.2019.01.064","article-title":"Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines","volume":"247","author":"Bassler","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2023.108235_b0020","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jhep.2019.04.020","article-title":"New sequential combinations of non-invasive fibrosis tests provide an accurate diagnosis of advanced fibrosis in NAFLD","volume":"71","author":"Boursier","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.envint.2023.108235_b0025","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.envint.2023.108235_b0030","unstructured":"Canada, S., 2010. Biosurveillance humaine des substances chimiques de l\u2019environnement. Available: https:\/\/www.canada.ca\/fr\/sante-canada\/services\/sante-environnement-milieu-travail\/contaminants-environnementaux\/biosurveillance-humaine-substances-chimiques-environnement.html."},{"key":"10.1016\/j.envint.2023.108235_b0035","doi-asserted-by":"crossref","first-page":"124963","DOI":"10.1016\/j.jhazmat.2020.124963","article-title":"Chronic exposure to PFO4DA and PFO5DoDA, two perfluoroalkyl ether carboxylic acids (PFECAs), suppresses hepatic stress signals and disturbs glucose and lipid metabolism in male mice","volume":"411","author":"Chen","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2023.108235_b0040","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.chemosphere.2018.05.191","article-title":"Polybrominated diphenyl ethers and perfluorinated alkyl substances in blood serum of New Zealand adults, 2011\u20132013","volume":"208","author":"Coakley","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.108235_b0045","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1080\/15287390802361763","article-title":"Altered fatty acid homeostasis and related toxicologic sequelae in rats exposed to dietary potassium perfluorooctanesulfonate (PFOS)","volume":"71","author":"Curran","year":"2008","journal-title":"J. Toxic. Environ. Health A"},{"key":"10.1016\/j.envint.2023.108235_b0050","doi-asserted-by":"crossref","first-page":"147476","DOI":"10.1016\/j.scitotenv.2021.147476","article-title":"Serum concentrations of per-\/polyfluoroalkyl substances and risk of type 2 diabetes: A case-control study","volume":"787","author":"Duan","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2023.108235_b0055","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jhep.2015.11.004","article-title":"EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease","volume":"64","author":"European Association for the Study of the Liver (EASL)","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.envint.2023.108235_b0060","unstructured":"Evaluation of per- and poly- fluoroalkyl substances (PFASs) in Airservices Australia\u2019s Aviation Rescue Fire Fighting Service (ARFFS) Staff \u2013 2018\/2019."},{"key":"10.1016\/j.envint.2023.108235_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106340","article-title":"Exposure of the French population to bisphenols, phthalates, parabens, glycol ethers, brominated flame retardants, and perfluorinated compounds in 2014\u20132016: Results from the Esteban study","author":"Fillol","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.108235_b0070","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.envint.2023.108235_b0075","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ijheh.2016.12.014","article-title":"ADONA and perfluoroalkylated substances in plasma samples of German blood donors living in South Germany","volume":"220","author":"Fromme","year":"2017","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.envint.2023.108235_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108743","article-title":"A mortality study on male subjects exposed to polyfluoroalkyl acids with high internal dose of perfluorooctanoic acid","volume":"179","author":"Girardi","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2023.108235_b0085","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/1047322X.1990.10389587","article-title":"Estimation of Average Concentration in the Presence of Nondetectable Values","volume":"5","author":"Hornung","year":"1990","journal-title":"Appl. Occup. Environ. Hyg."},{"key":"10.1016\/j.envint.2023.108235_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105220","article-title":"Perfluoroalkyl Substances and Severity of Nonalcoholic Fatty Liver in Children: An Untargeted Metabolomics Approach","volume":"134","author":"Jin","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.108235_b0095","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.envint.2023.108235_b0100","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.toxlet.2018.09.001","article-title":"Serum concentrations of perfluorinated compounds among children living in Sicily (Italy)","volume":"298","author":"Ledda","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envint.2023.108235_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2020.113596","article-title":"Association between exposure to per- and polyfluoroalkyl substances and blood glucose in pregnant women","volume":"230","author":"Li","year":"2020","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.envint.2023.108235_b0110","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1038\/ajg.2009.707","article-title":"Investigation of the Associations Between Low-Dose Serum Perfluorinated Chemicals and Liver Enzymes in US Adults","volume":"105","author":"Lin","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.envint.2023.108235_b0115","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.envres.2015.06.033","article-title":"Levels of perfluoroalkyl substances and risk of coronary heart disease: Findings from a population-based longitudinal study","volume":"142","author":"Mattsson","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2023.108235_b0120","unstructured":"National Report on Human Exposure to Environmental Chemicals. 2022; 10.15620\/cdc:105345. https:\/\/www.cdc.gov\/exposurereport\/index.html."},{"key":"10.1016\/j.envint.2023.108235_b0125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.envres.2019.02.013","article-title":"Liver function biomarkers disorder is associated with exposure to perfluoroalkyl acids in adults: Isomers of C8 Health Project in China","volume":"172","author":"Nian","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2023.108235_b0130","doi-asserted-by":"crossref","first-page":"157481","DOI":"10.1016\/j.scitotenv.2022.157481","article-title":"Interlaboratory Comparison Investigations (ICIs) and External Quality Assurance Schemes (EQUASs) for human biomonitoring of perfluoroalkyl substances (PFASs) in serum as part of the quality assurance programme under HBM4EU","volume":"847","author":"N\u00fcbler","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2023.108235_b0135","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.envint.2013.06.004","article-title":"Accumulation of perfluoroalkyl substances in human tissues","volume":"59","author":"P\u00e9rez","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.108235_b0140","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.envint.2019.01.027","article-title":"Persistent organic pollutants and gestational diabetes: A multi-center prospective cohort study of healthy US women","volume":"124","author":"Rahman","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.108235_b0145","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12940-015-0066-z","article-title":"Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study","volume":"14","author":"Rantakokko","year":"2015","journal-title":"Environ. Health"},{"key":"10.1016\/j.envint.2023.108235_b0150","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.envint.2018.04.052","article-title":"Changes in markers of liver function in relation to changes in perfluoroalkyl substances - A longitudinal study","volume":"117","author":"Salihovic","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.108235_b0155","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1056\/NEJMoa2029349","article-title":"Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease","volume":"385","author":"Sanyal","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envint.2023.108235_b0160","article-title":"Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease","volume":"S0168827821021048","author":"Sen","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.envint.2023.108235_b0165","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00204-007-0246-x","article-title":"Perfluorooctanoic acid-induced hepatic toxicity following 21-day oral exposure in mice","volume":"82","author":"Son","year":"2008","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2023.108235_b0170","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/hep.31483","article-title":"Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children","volume":"72","author":"Stratakis","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.envint.2023.108235_b0175","doi-asserted-by":"crossref","first-page":"e87137","DOI":"10.1371\/journal.pone.0087137","article-title":"Perinatal exposure to perfluorooctane sulfonate affects glucose metabolism in adult offspring","volume":"9","author":"Wan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envint.2023.108235_b0180","doi-asserted-by":"crossref","first-page":"113515","DOI":"10.1016\/j.fct.2022.113515","article-title":"Systemic toxicity induced by topical application of perfluoroheptanoic acid (PFHpA), perfluorohexanoic acid (PFHxA), and perfluoropentanoic acid (PFPeA) in a murine model","volume":"171","author":"Weatherly","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envint.2023.108235_b0185","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.freeradbiomed.2015.06.043","article-title":"Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate","volume":"87","author":"Yan","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envint.2023.108235_b0190","doi-asserted-by":"crossref","first-page":"108138","DOI":"10.1016\/j.envint.2023.108138","article-title":"PPAR\u03b1\/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per- and polyfluoroalkyl substances: An integrated approach","volume":"178","author":"Yang","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.108235_b0195","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/TP.0000000000002484","article-title":"Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: Implications for Liver Transplantation","volume":"103","author":"Younossi","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.envint.2023.108235_b0200","doi-asserted-by":"crossref","first-page":"106621","DOI":"10.1016\/j.envint.2021.106621","article-title":"Environmental exposure to perfluoroalkyl substances in early pregnancy, maternal glucose homeostasis and the risk of gestational diabetes: A prospective cohort study","volume":"156","author":"Yu","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.108235_b0205","doi-asserted-by":"crossref","first-page":"23963","DOI":"10.1038\/srep23963","article-title":"Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a High-throughput Targeted Metabolomics Approach","volume":"6","author":"Yu","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412023005081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412023005081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T12:34:49Z","timestamp":1758976489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412023005081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":41,"alternative-id":["S0160412023005081"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2023.108235","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations between perfluoroalkyl substances and the severity of non-alcoholic fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2023.108235","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108235"}}