{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:56:40Z","timestamp":1791950200920,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730089"],"award-info":[{"award-number":["81730089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273660"],"award-info":[{"award-number":["82273660"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["2023"],"award-info":[{"award-number":["2023"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.envint.2023.108381","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T10:58:32Z","timestamp":1702378712000},"page":"108381","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Construction of an adverse outcome pathway framework based on integrated data to evaluate arsenic-induced non-alcoholic fatty liver disease"],"prefix":"10.1016","volume":"183","author":[{"given":"Bowen","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binafsha","family":"Manzoor Syed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6107-9232","authenticated-orcid":false,"given":"Qizhan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2023.108381_b0005","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/etc.34","article-title":"Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment","volume":"29","author":"Ankley","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envint.2023.108381_b0010","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrgastro.2013.41","article-title":"Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis","volume":"10","author":"Anstee","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.envint.2023.108381_b0015","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/toxsci\/kfw017","article-title":"Integrating Publicly Available Data to Generate Computationally Predicted Adverse Outcome Pathways for Fatty Liver","volume":"150","author":"Bell","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2023.108381_b0020","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s00420-013-0914-5","article-title":"Assessment of liver function in two groups of outdoor workers exposed to arsenic","volume":"87","author":"Casale","year":"2014","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.envint.2023.108381_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115370","article-title":"Generating adverse outcome pathway (AOP) of inorganic arsenic-induced adult male reproductive impairment via integration of phenotypic analysis in comparative toxicogenomics database (CTD) and AOP wiki","volume":"411","author":"Chai","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2023.108381_b0030","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1021\/acs.est.6b06230","article-title":"Quantitative Adverse Outcome Pathways and Their Application to Predictive Toxicology","volume":"51","author":"Conolly","year":"2017","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.108381_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116320","article-title":"Particulate arsenic trioxide induces higher DNA damage and reactive oxygen species than soluble arsenite in lung epithelial cells","volume":"457","author":"Cooper","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2023.108381_b0040","doi-asserted-by":"crossref","first-page":"D948","DOI":"10.1093\/nar\/gky868","article-title":"The Comparative Toxicogenomics Database: update 2019","volume":"47","author":"Davis","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envint.2023.108381_b0045","doi-asserted-by":"crossref","first-page":"D1257","DOI":"10.1093\/nar\/gkac833","article-title":"Comparative Toxicogenomics Database (CTD): update 2023","volume":"51","author":"Davis","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envint.2023.108381_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.880298","article-title":"Association of Inflammatory Cytokines With Non-Alcoholic Fatty Liver Disease","volume":"13","author":"Duan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envint.2023.108381_b0055","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the, L.; European Association for the Study of, D.; European Association for the Study of, O. EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol 2016;64:1388-1402.","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"10.1016\/j.envint.2023.108381_b0060","doi-asserted-by":"crossref","DOI":"10.1289\/EHP2566","article-title":"Association of Low-Moderate Arsenic Exposure and Arsenic Metabolism with Incident Diabetes and Insulin Resistance in the Strong Heart Family Study","volume":"125","author":"Grau-Perez","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2023.108381_b0065","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/S0002-9440(10)63056-8","article-title":"Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications","volume":"159","author":"Guicciardi","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.envint.2023.108381_b0070","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1172\/JCI68101","article-title":"Positive feedback between NF-kappaB and TNF-alpha promotes leukemia-initiating cell capacity","volume":"124","author":"Kagoya","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envint.2023.108381_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.107029","article-title":"The association of arsenic exposure and arsenic metabolism with all-cause, cardiovascular and cancer mortality in the Strong Heart Study","volume":"159","author":"Kuo","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.108381_b0080","doi-asserted-by":"crossref","first-page":"48260","DOI":"10.1007\/s11356-023-25540-5","article-title":"Associations of arsenic exposure with liver injury in US adults: NHANES 2003\u20132018","volume":"30","author":"Li","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envint.2023.108381_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164746","article-title":"As3MT via consuming SAM is involved in arsenic-induced nonalcoholic fatty liver disease by blocking m(6)A-mediated miR-142-5p maturation","volume":"892","author":"Li","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2023.108381_b0090","doi-asserted-by":"crossref","first-page":"e014215","DOI":"10.1136\/bmjopen-2016-014215","article-title":"Association between soil heavy metals and fatty liver disease in men in Taiwan: a cross sectional study","volume":"7","author":"Lin","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.envint.2023.108381_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103330","article-title":"hOGG1 promoter methylation, hOGG1 genetic variants and their interactions for risk of coal-borne arsenicosis: A case-control study","volume":"75","author":"Ma","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"559\u2013571","key":"10.1016\/j.envint.2023.108381_b0100","first-page":"e555","article-title":"An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans","volume":"27","author":"Mardinoglu","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.envint.2023.108381_b0105","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1289\/ehp.1205875","article-title":"The broad scope of health effects from chronic arsenic exposure: update on a worldwide public health problem","volume":"121","author":"Naujokas","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2023.108381_b0110","unstructured":"OECD Users' Handbook supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways 2018."},{"key":"10.1016\/j.envint.2023.108381_b0115","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1126\/science.1081903","article-title":"The ecology of arsenic","volume":"300","author":"Oremland","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.envint.2023.108381_b0120","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1080\/10937400903358934","article-title":"Biomonitoring for environmental exposures to arsenic","volume":"12","author":"Orloff","year":"2009","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.envint.2023.108381_b0125","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1126\/science.aba1510","article-title":"Global threat of arsenic in groundwater","volume":"368","author":"Podgorski","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.envint.2023.108381_b0130","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.envint.2023.108381_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117940","article-title":"Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management","volume":"289","author":"Rahaman","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2023.108381_b0140","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jhep.2017.05.016","article-title":"Treatment of NAFLD with diet, physical activity and exercise","volume":"67","author":"Romero-Gomez","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.envint.2023.108381_b0145","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1289\/ehp.1104867","article-title":"Mortality in young adults following in utero and childhood exposure to arsenic in drinking water","volume":"120","author":"Smith","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2023.108381_b0150","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tox.2013.08.011","article-title":"The adverse outcome pathway concept: a pragmatic tool in toxicology","volume":"312","author":"Vinken","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2023.108381_b0155","doi-asserted-by":"crossref","first-page":"e0182830","DOI":"10.1371\/journal.pone.0182830","article-title":"Metabolomics reveals that vine tea (Ampelopsis grossedentata) prevents high-fat-diet-induced metabolism disorder by improving glucose homeostasis in rats","volume":"12","author":"Wan","year":"2017","journal-title":"PLoS One"},{"issue":"58\u201377","key":"10.1016\/j.envint.2023.108381_b0160","first-page":"e11","article-title":"Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development","volume":"56","author":"Wang","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.envint.2023.108381_b0165","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1111\/bph.14938","article-title":"Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3\/NF-kappaB pathway in mice","volume":"177","author":"Wang","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.envint.2023.108381_b0170","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1042\/BCJ20190799","article-title":"C-Jun\/C7ORF41\/NF-kappaB axis mediates hepatic inflammation and lipid accumulation in NAFLD","volume":"477","author":"Yan","year":"2020","journal-title":"Biochem. J"},{"key":"10.1016\/j.envint.2023.108381_b0175","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S2213-8587(14)70032-4","article-title":"Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome","volume":"2","author":"Yki-J\u00e4rvinen","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.envint.2023.108381_b0180","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.envint.2023.108381_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.153932","article-title":"Associating diethylhexyl phthalate to gestational diabetes mellitus via adverse outcome pathways using a network-based approach","volume":"824","author":"Zhang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2023.108381_b0190","doi-asserted-by":"crossref","first-page":"17858","DOI":"10.1021\/acs.est.2c05357","article-title":"Chlorinated Organophosphate Flame Retardants Impair the Lung Function via the IL-6\/JAK\/STAT Signaling Pathway","volume":"56","author":"Zhu","year":"2022","journal-title":"Environ. Sci. Tech."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412023006542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412023006542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T04:18:18Z","timestamp":1732162698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412023006542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":38,"alternative-id":["S0160412023006542"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2023.108381","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Construction of an adverse outcome pathway framework based on integrated data to evaluate arsenic-induced non-alcoholic fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2023.108381","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108381"}}