{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:13:59Z","timestamp":1792174439017,"version":"4.4.0"},"reference-count":218,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["1275527"],"award-info":[{"award-number":["1275527"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["35753"],"award-info":[{"award-number":["35753"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["375202"],"award-info":[{"award-number":["375202"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["403948"],"award-info":[{"award-number":["403948"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["422778"],"award-info":[{"award-number":["422778"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004961","name":"Instituto Tecnol\u00f3gico y de Estudios Superiores de Monterrey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004961","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.envint.2024.108462","type":"journal-article","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:15:49Z","timestamp":1706400949000},"page":"108462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Urine biomarkers for Alzheimer's disease: A new opportunity for wastewater-based epidemiology?"],"prefix":"10.1016","volume":"184","author":[{"given":"Arnoldo","family":"Armenta-Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica T.","family":"N\u00fa\u00f1ez-Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassandra O.","family":"Rodriguez-Aguill\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Aguayo-Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariel Araceli","family":"Oyervides-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane A.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dami\u00e0","family":"Barcel\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayaprakash","family":"Saththasivam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Lawler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Eduardo","family":"Sosa-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Parra-Sald\u00edvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2024.108462_b0005","article-title":"Tumor-derived urinary exosomal long non-coding RNAs as diagnostic biomarkers for bladder cancer","volume":"19","author":"Abbastabar","year":"2020","journal-title":"EXCLI Journal"},{"key":"10.1016\/j.envint.2024.108462_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107217","article-title":"Opportunities and limits of wastewater-based epidemiology for tracking global health and attainment of UN sustainable development goals","volume":"163","author":"Adhikari","year":"2022","journal-title":"Environ. Int."},{"issue":"9","key":"10.1016\/j.envint.2024.108462_b0015","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.3390\/v15091941","article-title":"Passive sampler technology for viral detection in wastewater-based surveillance: current state and nanomaterial opportunities","volume":"15","author":"Aguayo-Acosta","year":"2023","journal-title":"Viruses"},{"issue":"2","key":"10.1016\/j.envint.2024.108462_b0020","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1177\/0004563218812986","article-title":"A rapid and sensitive fluorescence method for detecting urine formaldehyde in patients with Alzheimer\u2019s disease","volume":"56","author":"Ai","year":"2019","journal-title":"Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0025","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13041-020-00658-6","article-title":"Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia","volume":"13","author":"Aldana","year":"2020","journal-title":"Mol. Brain"},{"issue":"4","key":"10.1016\/j.envint.2024.108462_b0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/colloids6040061","article-title":"A Colorimetric Detection of Noradrenaline in Wastewater Using Citrate-Capped Colloidal Gold Nanoparticles Probe","volume":"6","author":"Ally","year":"2022","journal-title":"Colloids and Interfaces"},{"key":"10.1016\/j.envint.2024.108462_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2020.116125","article-title":"Analytical methodologies for the detection of SARS-CoV-2 in wastewater: Protocols and future perspectives","volume":"134","author":"Alygizakis","year":"2021","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.envint.2024.108462_b0040","unstructured":"Alzheimer\u2019s Disease International. (2019). Dementia statistics | Alzheimer\u2019s Disease International (ADI). Home | Alzheimer\u2019s Disease International (ADI). (8). Alzheimer\u2019s Disease International. Retrieved November 10, 2022 from https:\/\/www.alzint.org\/about\/dementia-facts-figures\/dementia-statistics\/."},{"key":"10.1016\/j.envint.2024.108462_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160103","article-title":"Systematic scoping review evaluating the potential of wastewater-based epidemiology for monitoring cardiovascular disease and cancer","volume":"858","author":"Amin","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2024.108462_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.bionps.2021.100041","article-title":"Diagnostic biomarkers in Alzheimer\u2019s disease","volume":"5","author":"Andersen","year":"2021","journal-title":"Biomarkers in Neuropsychiatry"},{"issue":"7","key":"10.1016\/j.envint.2024.108462_b0055","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.3390\/ijms23073785","article-title":"Brain Metabolic Alterations in Alzheimer\u2019s Disease","volume":"23","author":"Ardanaz","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2024.108462_b0060","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fnagi.2018.00021","article-title":"Use of Peptides for the Management of Alzheimer\u2019s Disease: Diagnosis and Inhibition","volume":"10","author":"Baig","year":"2018","journal-title":"Front. Aging Neurosci."},{"issue":"10","key":"10.1016\/j.envint.2024.108462_b0065","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3390\/biomedicines8100421","article-title":"Body Fluid Biomarkers for Alzheimer\u2019s Disease\u2014An Up-To-Date Overview","volume":"8","author":"B\u0103la\u0219a","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.envint.2024.108462_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.cscee.2020.100042","article-title":"Wastewater-Based Epidemiology to monitor COVID-19 outbreak: Present and future diagnostic methods to be in your radar","volume":"2","author":"Barcel\u00f3","year":"2020","journal-title":"Case Studies in Chemical and Environmental Engineering"},{"issue":"4","key":"10.1016\/j.envint.2024.108462_b0075","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0035-9203(54)90108-X","article-title":"Schistosome infection of snails in a dam traced to pollution with sewage","volume":"48","author":"Bayer","year":"1954","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"46","key":"10.1016\/j.envint.2024.108462_b0080","doi-asserted-by":"crossref","first-page":"18008","DOI":"10.1523\/JNEUROSCI.1402-13.2013","article-title":"Changes in Brain Function Occur Years before the Onset of Cognitive Impairment","volume":"33","author":"Beason-Held","year":"2013","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0085","doi-asserted-by":"crossref","first-page":"e0147236","DOI":"10.1371\/journal.pone.0147236","article-title":"Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes","volume":"11","author":"Berrondo","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.envint.2024.108462_b0090","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12560-020-09424-2","article-title":"Detection and Characterization of Hepatitis E Virus Genotype 3 in Wastewater and Urban Surface Waters in Germany","volume":"12","author":"Beyer","year":"2020","journal-title":"Food and Environmental Virology"},{"issue":"13","key":"10.1016\/j.envint.2024.108462_b0095","doi-asserted-by":"crossref","first-page":"7754","DOI":"10.1021\/acs.est.0c02388","article-title":"Wastewater-Based Epidemiology: Global Collaborative to Maximize Contributions in the Fight Against COVID-19","volume":"54","author":"Bivins","year":"2020","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2024.108462_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117516","article-title":"Variability in RT-qPCR assay parameters indicates unreliable SARS-CoV-2 RNA quantification for wastewater surveillance","volume":"203","author":"Bivins","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.envint.2024.108462_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.129489","article-title":"Isoprostanes in wastewater as biomarkers of oxidative stress during COVID-19 pandemic","volume":"271","author":"Bowers","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2024.108462_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.166230","article-title":"Enhanced detection of mpox virus in wastewater using a pre-amplification approach: A pilot study informing population-level monitoring of low-titer pathogens","volume":"903","author":"Bowes","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.envint.2024.108462_b0115","doi-asserted-by":"crossref","first-page":"e202009045","DOI":"10.1083\/jcb.202009045","article-title":"LNCcation: lncRNA localization and function","volume":"220","author":"Bridges","year":"2021","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.envint.2024.108462_b0120","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/path.4846","article-title":"The many faces of SRPK1","volume":"241","author":"Bullock","year":"2017","journal-title":"J. Pathol."},{"key":"10.1016\/j.envint.2024.108462_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159401","article-title":"Persistence of endogenous RNA biomarkers of SARS-CoV-2 and PMMoV in raw wastewater: Impact of temperature and implications for wastewater-based epidemiology","volume":"857","author":"Burnet","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2024.108462_b0130","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neurobiolaging.2019.05.023","article-title":"Identification of age- and gender-associated long noncoding RNAs in the human brain with Alzheimer\u2019s disease","volume":"81","author":"Cao","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.envint.2024.108462_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141145","article-title":"Discovery of large molecules as new biomarkers in wastewater using environmental proteomics and suitable polymer probes","volume":"747","author":"Carrascal","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"30","key":"10.1016\/j.envint.2024.108462_b0140","doi-asserted-by":"crossref","first-page":"10929","DOI":"10.1021\/acs.est.3c00535","article-title":"Sewage Protein Information Mining: Discovery of Large Biomolecules as Biomarkers of Population and Industrial Activities","volume":"57","author":"Carrascal","year":"2023","journal-title":"Environ. Sci. Tech."},{"issue":"9","key":"10.1016\/j.envint.2024.108462_b0145","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.disamonth.2010.06.001","article-title":"Alzheimer Disease","volume":"56","author":"Castellani","year":"2010","journal-title":"Dis. Mon."},{"issue":"4","key":"10.1016\/j.envint.2024.108462_b0150","doi-asserted-by":"crossref","first-page":"e0231765","DOI":"10.1371\/journal.pone.0231765","article-title":"Urine dicarboxylic acids change in pre-symptomatic Alzheimer\u2019s disease and reflect loss of energy capacity and hippocampal volume","volume":"15","author":"Castor","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.envint.2024.108462_b0155","first-page":"63","volume":"Vol. 97","author":"Chahal","year":"2016","journal-title":"Pathogen and Particle Associations in Wastewater"},{"issue":"5","key":"10.1016\/j.envint.2024.108462_b0160","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1039\/C6SC05615F","article-title":"Ultra-sensitive detection of protein biomarkers for diagnosis of Alzheimer\u2019s disease","volume":"8","author":"Chan","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.envint.2024.108462_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120652","article-title":"Long non-coding RNA MALAT1 protects against A\u03b21\u201342 induced toxicity by regulating the expression of receptor tyrosine kinase EPHA2 via quenching miR-200a\/26a\/26b in Alzheimer\u2019s disease","volume":"302","author":"Chanda","year":"2022","journal-title":"Life Sci."},{"issue":"D1","key":"10.1016\/j.envint.2024.108462_b0170","doi-asserted-by":"crossref","first-page":"D1397","DOI":"10.1093\/nar\/gkac814","article-title":"RNADisease v4.0: An updated resource of RNA-associated diseases, providing RNA-disease analysis, enrichment and prediction","volume":"51","author":"Chen","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envint.2024.108462_b0175","first-page":"1","article-title":"Urinary Exosomal Long Noncoding RNA TERC as a Noninvasive Diagnostic and Prognostic Biomarker for Bladder Urothelial Carcinoma","volume":"2022","author":"Chen","year":"2022","journal-title":"J. Immunol. Res."},{"issue":"9","key":"10.1016\/j.envint.2024.108462_b0180","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/aps.2017.28","article-title":"Amyloid beta: Structure, biology and structure-based therapeutic development","volume":"38","author":"Chen","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.envint.2024.108462_b0185","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.trac.2018.06.004","article-title":"Wastewater-based epidemiology biomarkers: Past, present and future","volume":"105","author":"Choi","year":"2018","journal-title":"TrAC Trends Anal. Chem."},{"issue":"43","key":"10.1016\/j.envint.2024.108462_b0190","doi-asserted-by":"crossref","first-page":"21864","DOI":"10.1073\/pnas.1910242116","article-title":"Social, demographic, and economic correlates of food and chemical consumption measured by wastewater-based epidemiology","volume":"116","author":"Choi","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envint.2024.108462_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139654","article-title":"Do food and stress biomarkers work for wastewater-based epidemiology? A critical evaluation","volume":"736","author":"Choi","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.envint.2024.108462_b0200","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s10571-017-0574-1","article-title":"Tau Proteins and Tauopathies in Alzheimer\u2019s Disease","volume":"38","author":"Chong","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"issue":"10","key":"10.1016\/j.envint.2024.108462_b0205","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1097\/NEN.0000000000000116","article-title":"Lysophosphatidylcholine and Amide as Metabolites for Detecting Alzheimer Disease Using Ultrahigh-Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry-Based Metabonomics","volume":"73","author":"Cui","year":"2014","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.envint.2024.108462_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101480","article-title":"Roles and functions of antisense lncRNA in vascular aging","volume":"72","author":"Cui","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.envint.2024.108462_b0215","article-title":"Pharmaceuticals and Care Products in the Environment: Scientific and Regulatory Issues (26","volume":"Vol. 791","author":"Daughton","year":"2001","journal-title":"American Chemical Society"},{"issue":"3","key":"10.1016\/j.envint.2024.108462_b0220","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3233\/JAD-2001-3310","article-title":"The AD7c-NTP neuronal thread protein biomarker for detecting Alzheimer\u2019s disease*","volume":"3","author":"De La Monte","year":"2001","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"6","key":"10.1016\/j.envint.2024.108462_b0225","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte Chemoattractant Protein-1 (MCP-1): An Overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.envint.2024.108462_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2021.104614","article-title":"LncRNA BDNF-AS as ceRNA regulates the miR-9-5p\/BACE1 pathway affecting neurotoxicity in Alzheimer\u2019s disease","volume":"99","author":"Ding","year":"2022","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.envint.2024.108462_b0235","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.canlet.2021.12.010","article-title":"EBF3 reactivation by inhibiting the EGR1\/EZH2\/HDAC9 complex promotes metastasis via transcriptionally enhancing vimentin in nasopharyngeal carcinoma","volume":"527","author":"Ding","year":"2022","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0240","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12943-022-01526-8","article-title":"Proteomics technologies for cancer liquid biopsies","volume":"21","author":"Ding","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0245","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ana.410290105","article-title":"Developmental regulation of human truncated nerve growth factor receptor","volume":"29","author":"DiStefano","year":"1991","journal-title":"Ann. Neurol."},{"issue":"5","key":"10.1016\/j.envint.2024.108462_b0250","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1111\/jcmm.13578","article-title":"Cell-free lncRNA expression signatures in urine serve as novel non-invasive biomarkers for diagnosis and recurrence prediction of bladder cancer","volume":"22","author":"Du","year":"2018","journal-title":"J. Cell Mol. Med."},{"issue":"18","key":"10.1016\/j.envint.2024.108462_b0255","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.3390\/molecules26185431","article-title":"Quantitative Determination and Environmental Risk Assessment of 102 Chemicals of Emerging Concern in Wastewater-Impacted Rivers Using Rapid Direct-Injection Liquid Chromatography\u2014Tandem Mass Spectrometry","volume":"26","author":"Egli","year":"2021","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.envint.2024.108462_b0260","doi-asserted-by":"crossref","first-page":"292.e19","DOI":"10.1016\/j.urolonc.2018.12.024","article-title":"Measurement of Urinary Level of a Specific Competing endogenous RNA network (FOS and RCAN mRNA\/ miR-324-5p, miR-4738-3p, \/lncRNA miR-497-HG) Enables Diagnosis of Bladder Cancer","volume":"37","author":"Eissa","year":"2019","journal-title":"Urologic Oncology: Seminars and Original Investigations"},{"issue":"4","key":"10.1016\/j.envint.2024.108462_b0265","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2217\/clp.10.37","article-title":"Apolipoproteins in the brain: Implications for neurological and psychiatric disorders","volume":"5","author":"Elliott","year":"2010","journal-title":"Clinical Lipidology"},{"issue":"4","key":"10.1016\/j.envint.2024.108462_b0270","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1212\/WNL.0000000000003537","article-title":"Long-term cortisol measures predict Alzheimer disease risk","volume":"88","author":"Ennis","year":"2017","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.envint.2024.108462_b0275","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.envint.2024.108462_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101492","article-title":"Current research status of blood biomarkers in Alzheimer\u2019s disease: Diagnosis and prognosis","volume":"72","author":"Feng","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.envint.2024.108462_b0285","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00726-006-0409-8","article-title":"Free amino acid and dipeptide changes in the body fluids from Alzheimer\u2019s disease subjects","volume":"32","author":"Fonteh","year":"2007","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0290","first-page":"483","article-title":"Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer\u2019s disease","volume":"11","author":"Fossati","year":"2019","journal-title":"Alzheimer\u2019s & Dementia: Diagnosis, Assessment & Disease Monitoring"},{"issue":"S18","key":"10.1016\/j.envint.2024.108462_b0295","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1017\/S1092852900014164","article-title":"The Interplay of Neurotransmitters in Alzheimer\u2019s Disease","volume":"10","author":"Francis","year":"2005","journal-title":"CNS Spectr."},{"key":"10.1016\/j.envint.2024.108462_b0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163079","article-title":"Assessment of the excretion of oxidative stress biomarkers and anabolic steroids based on sewage: A case study of college students and the general population","volume":"878","author":"Gao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2024.108462_b0305","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.talanta.2018.03.002","article-title":"Reliable determination of new lipid peroxidation compounds as potential early Alzheimer Disease biomarkers","volume":"184","author":"Garc\u00eda-Blanco","year":"2018","journal-title":"Talanta"},{"key":"10.1016\/j.envint.2024.108462_b0310","series-title":"World Alzheimer Report 2021: Journey through the diagnosis of dementia","author":"Gauthier","year":"2021"},{"issue":"5","key":"10.1016\/j.envint.2024.108462_b0315","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/(SICI)1098-2825(1998)12:5<285::AID-JCLA6>3.0.CO;2-5","article-title":"Biochemical assay for AD7C-NTP in urine as an Alzheimer\u2019s disease marker","volume":"12","author":"Ghanbari","year":"1998","journal-title":"J. Clin. Lab. Anal."},{"issue":"8","key":"10.1016\/j.envint.2024.108462_b0320","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0028-3908(01)00019-3","article-title":"Oxidative stress induced-neurodegenerative diseases: The need for antioxidants that penetrate the blood brain barrier","volume":"40","author":"Gilgun-Sherki","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.envint.2024.108462_b0325","doi-asserted-by":"crossref","first-page":"6","DOI":"10.20517\/wecn.2023.19","article-title":"Environmental proteomics: A potential tool in wastewater-based epidemiology","volume":"2","author":"Ginebreda","year":"2023","journal-title":"Water Emerging Contaminants & Nanoplastics"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0330","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jamda.2006.07.002","article-title":"A Multi-Center Blinded Prospective Study of Urine Neural Thread Protein Measurements in Patients With Suspected Alzheimer\u2019s Disease","volume":"8","author":"Goodman","year":"2007","journal-title":"Journal of the American Medical Directors Association"},{"issue":"3","key":"10.1016\/j.envint.2024.108462_b0335","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1089\/dna.2017.4012","article-title":"Long Noncoding RNA EBF3-AS Promotes Neuron Apoptosis in Alzheimer\u2019s Disease","volume":"37","author":"Gu","year":"2018","journal-title":"DNA Cell Biol."},{"issue":"9","key":"10.1016\/j.envint.2024.108462_b0340","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/01616412.2018.1480921","article-title":"Silencing of LncRNA BDNF-AS attenuates A\u03b2 25\u201335 -induced neurotoxicity in PC12 cells by suppressing cell apoptosis and oxidative stress","volume":"40","author":"Guo","year":"2018","journal-title":"Neurol. Res."},{"key":"10.1016\/j.envint.2024.108462_b0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118610","article-title":"Back-estimation of norovirus infections through wastewater-based epidemiology: A systematic review and parameter sensitivity","volume":"219","author":"Guo","year":"2022","journal-title":"Water Res."},{"issue":"7","key":"10.1016\/j.envint.2024.108462_b0350","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/brain\/awy132","article-title":"The cholinergic system in the pathophysiology and treatment of Alzheimer\u2019s disease","volume":"141","author":"Hampel","year":"2018","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.envint.2024.108462_b0355","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biopsych.2020.02.001","article-title":"The \u03b2-Secretase BACE1 in Alzheimer\u2019s Disease","volume":"89","author":"Hampel","year":"2021","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0360","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ajhg.2016.11.012","article-title":"Mutations in EBF3 Disturb Transcriptional Profiles and Cause Intellectual Disability, Ataxia, and Facial Dysmorphism","volume":"100","author":"Harms","year":"2017","journal-title":"Am. J. Hum. Genet."},{"issue":"6","key":"10.1016\/j.envint.2024.108462_b0365","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2217\/bmm-2017-0388","article-title":"A review of biomarkers of Alzheimer\u2019s disease in noninvasive samples","volume":"12","author":"Hartmann","year":"2018","journal-title":"Biomark. Med."},{"key":"10.1016\/j.envint.2024.108462_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143578","article-title":"Detection of SARS-CoV-2 in wastewater in Japan during a COVID-19 outbreak","volume":"758","author":"Hata","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"13\u201314","key":"10.1016\/j.envint.2024.108462_b0375","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.clinbiochem.2006.11.021","article-title":"Increased urinary level of oxidized nucleosides in patients with mild-to-moderate Alzheimer\u2019s disease","volume":"40","author":"Hee Lee","year":"2007","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.envint.2024.108462_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.118032","article-title":"Sensitivity of wastewater-based epidemiology for detection of SARS-CoV-2 RNA in a low prevalence setting","volume":"211","author":"Hewitt","year":"2022","journal-title":"Water Res."},{"issue":"9","key":"10.1016\/j.envint.2024.108462_b0385","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1111\/jgs.17835","article-title":"Medicare spending associated with a dementia diagnosis among older adults","volume":"70","author":"Hoffman","year":"2022","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.envint.2024.108462_b0390","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.omtn.2020.02.008","article-title":"Aberrant Expression Profiles of lncRNAs and Their Associated Nearby Coding Genes in the Hippocampus of the SAMP8 Mouse Model with AD","volume":"20","author":"Hong","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.envint.2024.108462_b0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130147","article-title":"Estimating the prevalence of hypertension in 164 cities in China by wastewater-based epidemiology","volume":"443","author":"Hou","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2024.108462_b0400","article-title":"Combination of Urine Exosomal mRNAs and lncRNAs as Novel Diagnostic Biomarkers for Bladder Cancer","volume":"11","author":"Huang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.envint.2024.108462_b0405","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.598606","article-title":"A Signature of Five Long Non-Coding RNAs for Predicting the Prognosis of Alzheimer\u2019s Disease Based on Competing Endogenous RNA Networks","volume":"12","author":"Huaying","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.envint.2024.108462_b0410","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.676588","article-title":"Long Non-coding RNA RMRP in the Pathogenesis of Human Disorders","volume":"9","author":"Hussen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.envint.2024.108462_b0415","article-title":"Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease","volume":"6","author":"I\u00c5\u0178\u00c4\u00b1n, M., Uysaler, E., \u00c3\u2013zg\u00c3\u00bcr, E., K\u00c3\u00b6seo\u00c4\u0178lu, H., \u00c5\u017eanl\u00c4\u00b1, \u00c3., Y\u00c3\u00bccel, \u00c3. B., Gezer, U\u00e4\u00ff., & Dalay, N.","year":"2015","journal-title":"Front. Genet."},{"issue":"5","key":"10.1016\/j.envint.2024.108462_b0420","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jalz.2010.04.006","article-title":"Alzheimer\u2019s disease, a multifactorial disorder seeking multitherapies","volume":"6","author":"Iqbal","year":"2010","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"10.1016\/j.envint.2024.108462_b0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159350","article-title":"A 30-day follow-up study on the prevalence of SARS-COV-2 genetic markers in wastewater from the residence of COVID-19 patient and comparison with clinical positivity","volume":"858","author":"Islam","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2024.108462_b0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.coesh.2022.100396","article-title":"An opinion on Wastewater-Based Epidemiological Monitoring (WBEM) with Clinical Diagnostic Test (CDT) for detecting high-prevalence areas of community COVID-19 infections","volume":"31","author":"Islam","year":"2023","journal-title":"Current Opinion in Environmental Science & Health"},{"key":"10.1016\/j.envint.2024.108462_b0435","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neuroimage.2017.02.058","article-title":"Multifactorial causal model of brain (dis)organization and therapeutic intervention: Application to Alzheimer\u2019s disease","volume":"152","author":"Iturria-Medina","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.envint.2024.108462_b0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119679","article-title":"Wastewater-based epidemiological surveillance to monitor the prevalence of SARS-CoV-2 in developing countries with onsite sanitation facilities","volume":"311","author":"Jakariya","year":"2022","journal-title":"Environ. Pollut."},{"issue":"18","key":"10.1016\/j.envint.2024.108462_b0445","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.3390\/ijerph17186483","article-title":"Detection of Enteric Viruses and Bacterial Indicators in a Sewage Treatment Center and Shallow Water Bay","volume":"17","author":"Janahi","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.envint.2024.108462_b0450","first-page":"425","volume":"F1000Research, 10","author":"Javaid","year":"2021","journal-title":"Epidemiology of Alzheimer\u2019s Disease and Other Dementias: Rising Global Burden and Forecasted Trends."},{"key":"10.1016\/j.envint.2024.108462_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116585","article-title":"Biosensors for the detection of disease outbreaks through wastewater-based epidemiology","volume":"155","author":"Jim\u00e9nez-Rodr\u00edguez","year":"2022","journal-title":"TrAC Trends Anal. Chem."},{"issue":"3","key":"10.1016\/j.envint.2024.108462_b0460","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3233\/JAD-201273","article-title":"Alzheimer-Associated Neuronal Thread Protein: Research Course and Prospects for the Future","volume":"80","author":"Jin","year":"2021","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"10.1016\/j.envint.2024.108462_b0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111812","article-title":"Roles of lncRNA MAGI2-AS3 in human cancers","volume":"141","author":"Kai-xin","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0470","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1474-4422(21)00412-9","article-title":"2021 marks a new era for Alzheimer\u2019s therapeutics","volume":"21","author":"Kantarci","year":"2022","journal-title":"Lancet Neurol."},{"issue":"5","key":"10.1016\/j.envint.2024.108462_b0475","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S1474-4422(20)30071-5","article-title":"Blood phosphorylated tau 181 as a biomarker for Alzheimer\u2019s disease: A diagnostic performance and prediction modelling study using data from four prospective cohorts","volume":"19","author":"Karikari","year":"2020","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.envint.2024.108462_b0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107143","article-title":"Wastewater-based epidemiology in hazard forecasting and early-warning systems for global health risks","volume":"161","author":"Kasprzyk-Hordern","year":"2022","journal-title":"Environ. Int."},{"issue":"7","key":"10.1016\/j.envint.2024.108462_b0485","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1161\/CIRCULATIONAHA.106.622514","article-title":"Apolipoprotein CIII Induces Expression of Vascular Cell Adhesion Molecule-1 in Vascular Endothelial Cells and Increases Adhesion of Monocytic Cells","volume":"114","author":"Kawakami","year":"2006","journal-title":"Circulation"},{"issue":"36","key":"10.1016\/j.envint.2024.108462_b0490","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.15585\/mmwr.mm7036a2","article-title":"Using Wastewater Surveillance Data to Support the COVID-19 Response\u2014United States, 2020\u20132021","volume":"70","author":"Kirby","year":"2021","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"key":"10.1016\/j.envint.2024.108462_b0495","doi-asserted-by":"crossref","unstructured":"Ku, B. D., Kim, H., Kim, Y. K., & Ryu, H. U. (2020). Comparison of Urinary Alzheimer-Associated Neural Thread Protein (AD7c-NTP) Levels Between Patients With Amnestic and Nonamnestic Mild Cognitive Impairment. American Journal of Alzheimer\u2019s Disease & Other Dementias\u00ae, 35, 153331751988036. https:\/\/doi.org\/10.1177\/1533317519880369.","DOI":"10.1177\/1533317519880369"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0500","doi-asserted-by":"crossref","first-page":"21745","DOI":"10.1038\/s41598-020-78031-9","article-title":"Urinary metabolic phenotyping for Alzheimer\u2019s disease","volume":"10","author":"Kurbatova","year":"2020","journal-title":"Sci. Rep."},{"issue":"16","key":"10.1016\/j.envint.2024.108462_b0505","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.3390\/cancers13164075","article-title":"A Novel Urine Exosomal lncRNA Assay to Improve the Detection of Prostate Cancer at Initial Biopsy: A Retrospective Multicenter Diagnostic Feasibility Study","volume":"13","author":"Li","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.envint.2024.108462_b0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104545","article-title":"Neuro-protective roles of long non-coding RNA MALAT1 in Alzheimer\u2019s disease with the involvement of the microRNA-30b\/CNR1 network and the following PI3K\/AKT activation","volume":"117","author":"Li","year":"2020","journal-title":"Exp. Mol. Pathol."},{"issue":"10","key":"10.1016\/j.envint.2024.108462_b0515","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1001\/archneur.1993.00540100049013","article-title":"Increased Levels of Truncated Nerve Growth Factor Receptor in Urine of Mildly Demented Patients With Alzheimer\u2019s Disease","volume":"50","author":"Lindner","year":"1993","journal-title":"Arch. Neurol."},{"issue":"10","key":"10.1016\/j.envint.2024.108462_b0520","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/jssc.201000799","article-title":"Simultaneous determination of catecholamines and their metabolites related to Alzheimer\u2019s disease in human urine","volume":"34","author":"Liu","year":"2011","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.envint.2024.108462_b0525","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neuroscience.2018.10.001","article-title":"Study on Urine Metabolic Profile of A\u03b225\u201335-Induced Alzheimer\u2019s Disease Using UHPLC-Q-TOF-MS","volume":"394","author":"Liu","year":"2018","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0530","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1186\/s12935-021-02168-4","article-title":"The regulatory role of antisense lncRNAs in cancer","volume":"21","author":"Liu","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"10","key":"10.1016\/j.envint.2024.108462_b0535","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.21037\/tau-21-820","article-title":"Development of a highly sensitive digital PCR assay to quantify long non-coding RNA MYU in urine samples which exhibited great potential as an alternative diagnostic biomarker for prostate cancer","volume":"10","author":"Liu","year":"2021","journal-title":"Transl. Androl. Urol."},{"key":"10.1016\/j.envint.2024.108462_b0540","unstructured":"Liu, K. (2023). Statistics. RNADisease. (101). Retrieved March 2, 2023 from http:\/\/www.rnadisease.org\/statistics."},{"issue":"12","key":"10.1016\/j.envint.2024.108462_b0545","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1073\/pnas.1706100115","article-title":"Susceptibility of brain atrophy to TRIB3 in Alzheimer\u2019s disease, evidence from functional prioritization in imaging genetics","volume":"115","author":"Lorenzi","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envint.2024.108462_b0550","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.coesh.2019.05.007","article-title":"Wastewater-based epidemiology: Current status and future prospects","volume":"9","author":"Lorenzo","year":"2019","journal-title":"Current Opinion in Environmental Science & Health"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0555","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s12944-016-0352-y","article-title":"The emerging role of apolipoprotein C-III: Beyond effects on triglyceride metabolism","volume":"15","author":"Luo","year":"2016","journal-title":"Lipids Health Dis."},{"issue":"2","key":"10.1016\/j.envint.2024.108462_b0560","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/jms.3536","article-title":"Determination of catecholamines and their metabolites in rat urine by ultra-performance liquid chromatography-tandem mass spectrometry for the study of identifying potential markers for Alzheimer\u2019s disease: The UPLC-MS\/MS methods for quantification of CAs","volume":"50","author":"Lv","year":"2015","journal-title":"J. Mass Spectrom."},{"issue":"12","key":"10.1016\/j.envint.2024.108462_b0565","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/j.jocn.2014.04.028","article-title":"Alzheimer-associated urine neuronal thread protein level increases with age in a healthy Chinese population","volume":"21","author":"Ma","year":"2014","journal-title":"J. Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0570","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12014-020-09283-w","article-title":"Recent advances in mass spectrometry based clinical proteomics: Applications to cancer research","volume":"17","author":"Macklin","year":"2020","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.envint.2024.108462_b0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116635","article-title":"Toward smart diagnosis of pandemic infectious diseases using wastewater-based epidemiology","volume":"153","author":"Mahmoudi","year":"2022","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.envint.2024.108462_b0580","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119985","article-title":"Mitochondrial defects: An emerging theranostic avenue towards Alzheimer\u2019s associated dysregulations","volume":"285","author":"Mani","year":"2021","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0585","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13195-017-0290-6","article-title":"Cost of diagnosing dementia in a German memory clinic","volume":"9","author":"Michalowsky","year":"2017","journal-title":"Alzheimer\u2019s Res. Therapy"},{"key":"10.1016\/j.envint.2024.108462_b0595","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/572491","article-title":"Isoprostanes and Neuroprostanes as Biomarkers of Oxidative Stress in Neurodegenerative Diseases","volume":"2014","author":"Miller","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.envint.2024.108462_b0600","article-title":"Mitochondrial Dysfunction and Oxidative Stress in Alzheimer\u2019s Disease","volume":"165","author":"Misrani","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.envint.2024.108462_b0605","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125453","article-title":"Seasonal variation in fluorescence characteristics of dissolved organic matter in wastewater and identification of proteins through HRLC-MS\/MS","volume":"413","author":"Mohapatra","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"23","key":"10.1016\/j.envint.2024.108462_b0610","doi-asserted-by":"crossref","first-page":"9383","DOI":"10.1073\/pnas.87.23.9383","article-title":"A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism","volume":"87","author":"Morrow","year":"1990","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.envint.2024.108462_b0615","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrn.2017.29","article-title":"Not just amyloid: Physiological functions of the amyloid precursor protein family","volume":"18","author":"M\u00fcller","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"issue":"10","key":"10.1016\/j.envint.2024.108462_b0620","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1002\/ajmg.a.62369","article-title":"Clinical spectrum of individuals with de novo EBF3 variants or deletions","volume":"185","author":"Nishi","year":"2021","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.envint.2024.108462_b0625","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117433","article-title":"Making waves: Defining the lead time of wastewater-based epidemiology for COVID-19","volume":"202","author":"Olesen","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.envint.2024.108462_b0630","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2019.460623","article-title":"A sensitive analytical method for the measurement of neurotransmitter metabolites as potential population biomarkers in wastewater","volume":"1612","author":"Pandopulos","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.envint.2024.108462_b0635","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116890","article-title":"Degradation of viral RNA in wastewater complex matrix models and other standards for wastewater-based epidemiology: A review","volume":"158","author":"Parra-Arroyo","year":"2023","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.envint.2024.108462_b0640","unstructured":"Paterson, C. (2018). World Alzheimer Report 2018 The state of the art of dementia research: New frontiers (7). Alzheimer\u2019s Disease International. Retrieved November 10, 2022 from https:\/\/www.alzint.org\/resource\/world-alzheimer-report-2018\/."},{"issue":"2","key":"10.1016\/j.envint.2024.108462_b0645","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/jnc.12304","article-title":"Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer\u2019s disease","volume":"126","author":"Paula-Lima","year":"2013","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.envint.2024.108462_b0650","doi-asserted-by":"crossref","first-page":"1","DOI":"10.35995\/tmj20200206","article-title":"Long Non-Coding RNAs in Plasma and Urine as Potential Biomarkers in Prostate Cancer","volume":"2020","author":"P\u0103unescu","year":"2021","journal-title":"Timisoara Med. J."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0655","first-page":"53","article-title":"Development and validation of a salivary tau biomarker in Alzheimer\u2019s disease","volume":"10","author":"Pekeles","year":"2018","journal-title":"Alzheimer\u2019s & Dementia: Diag. Assess. Disease Monitor."},{"key":"10.1016\/j.envint.2024.108462_b0660","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.clinbiochem.2019.07.008","article-title":"Assessment of lipid peroxidation and artificial neural network models in early Alzheimer Disease diagnosis","volume":"72","author":"Pe\u00f1a-Bautista","year":"2019","journal-title":"Clin. Biochem."},{"issue":"24","key":"10.1016\/j.envint.2024.108462_b0665","doi-asserted-by":"crossref","first-page":"6136","DOI":"10.3390\/ijms20246136","article-title":"Oxidative Damage of DNA as Early Marker of Alzheimer\u2019s Disease","volume":"20","author":"Pe\u00f1a-Bautista","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2024.108462_b0670","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.exger.2019.05.007","article-title":"Neuropsychological assessment and cortisol levels in biofluids from early Alzheimer\u2019s disease patients","volume":"123","author":"Pe\u00f1a-Bautista","year":"2019","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.envint.2024.108462_b0675","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.envres.2017.05.011","article-title":"Cadmium and Alzheimer\u2019s disease mortality in U.S. adults: Updated evidence with a urinary biomarker and extended follow-up time","volume":"157","author":"Peng","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2024.108462_b0680","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116605","article-title":"Emerging ELISA derived technologies for in vitro diagnostics","volume":"152","author":"Peng","year":"2022","journal-title":"TrAC Trends Anal. Chem."},{"issue":"4","key":"10.1016\/j.envint.2024.108462_b0685","doi-asserted-by":"crossref","DOI":"10.1016\/j.jece.2021.105752","article-title":"Non-target protein analysis of samples from wastewater treatment plants using the regions of interest-multivariate curve resolution (ROIMCR) chemometrics method","volume":"9","author":"Perez-Lopez","year":"2021","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.envint.2024.108462_b0690","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2021.116465","article-title":"Identification of biomarkers in wastewater-based epidemiology: Main approaches and analytical methods","volume":"145","author":"Pic\u00f3","year":"2021","journal-title":"TrAC Trends Anal. Chem."},{"issue":"8873","key":"10.1016\/j.envint.2024.108462_b0695","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0140-6736(93)91705-Q","article-title":"Apolipoprotein E polymorphism and Alzheimer\u2019s disease","volume":"342","author":"Poirier","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.envint.2024.108462_b0700","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.116404","article-title":"Making waves: Wastewater-based epidemiology for COVID-19 \u2013 approaches and challenges for surveillance and prediction","volume":"186","author":"Polo","year":"2020","journal-title":"Water Res."},{"issue":"13","key":"10.1016\/j.envint.2024.108462_b0705","doi-asserted-by":"crossref","first-page":"979","DOI":"10.4155\/bio-2018-0056","article-title":"Enrichment of protein therapeutics and biomarkers for LC\u2013MS quantification","volume":"10","author":"Pu","year":"2018","journal-title":"Bioanalysis"},{"issue":"4","key":"10.1016\/j.envint.2024.108462_b0710","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3233\/JAD-170256","article-title":"A Critical Assessment of Research on Neurotransmitters in Alzheimer\u2019s Disease","volume":"57","author":"Reddy","year":"2017","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"10.1016\/j.envint.2024.108462_b0715","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2019.115621","article-title":"A new paradigm in public health assessment: Water fingerprinting for protein markers of public health using mass spectrometry","volume":"119","author":"Rice","year":"2019","journal-title":"TrAC Trends Anal. Chem."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0720","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13148-019-0710-5","article-title":"Characterisation of DNA methylation changes in EBF3 and TBC1D16 associated with tumour progression and metastasis in multiple cancer types","volume":"11","author":"Rodger","year":"2019","journal-title":"Clin. Epigenetics"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0725","doi-asserted-by":"crossref","first-page":"39055","DOI":"10.1038\/srep39055","article-title":"Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F2\u03b1 in wastewater associated with tobacco use","volume":"6","author":"Ryu","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0730","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1124\/jpet.116.237503","article-title":"Oxidative Stress and the Central Nervous System","volume":"360","author":"Salim","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.envint.2024.108462_b0735","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2021.113563","article-title":"A review on detection of SARS-CoV-2 RNA in wastewater in light of the current knowledge of treatment process for removal of viral fragments","volume":"299","author":"Sangkham","year":"2021","journal-title":"J. Environ. Manage."},{"issue":"2","key":"10.1016\/j.envint.2024.108462_b0740","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng1096-199","article-title":"Two stage genome\u2013wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12","volume":"14","author":"Satsangi","year":"1996","journal-title":"Nat. Genet."},{"issue":"25","key":"10.1016\/j.envint.2024.108462_b0745","doi-asserted-by":"crossref","first-page":"6698","DOI":"10.1016\/j.biomaterials.2014.05.008","article-title":"The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation","volume":"35","author":"Sawyer","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.envint.2024.108462_b0750","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.clinbiochem.2020.03.004","article-title":"After another decade: LC\u2013MS\/MS became routine in clinical diagnostics","volume":"82","author":"Seger","year":"2020","journal-title":"Clin. Biochem."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0755","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/neup.12626","article-title":"Aging and Alzheimer\u2019s disease pathology","volume":"40","author":"Sengoku","year":"2020","journal-title":"Neuropathology"},{"issue":"5","key":"10.1016\/j.envint.2024.108462_b0760","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5607\/en20042","article-title":"Urinary Biomarkers for Neurodegenerative Diseases","volume":"29","author":"Seol","year":"2020","journal-title":"Experiment. Neurobiol."},{"key":"10.1016\/j.envint.2024.108462_b0765","doi-asserted-by":"crossref","first-page":"8441","DOI":"10.2147\/OTT.S265853","article-title":"Identification of Long Non-Coding RNA SNHG Family as Promising Prognostic Biomarkers in Acute Myeloid Leukemia","volume":"13","author":"Shi","year":"2020","journal-title":"OncoTargets and Therapy"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0770","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative Stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.envint.2024.108462_b0775","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105689","article-title":"Future perspectives of wastewater-based epidemiology: Monitoring infectious disease spread and resistance to the community level","volume":"139","author":"Sims","year":"2020","journal-title":"Environ. Int."},{"issue":"1\u20133","key":"10.1016\/j.envint.2024.108462_b0785","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1385\/MN:24:1-3:183","article-title":"Nerve Growth Factor","volume":"24","author":"Skaper","year":"2001","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.envint.2024.108462_b0790","doi-asserted-by":"crossref","first-page":"e5465","DOI":"10.1371\/journal.pone.0005465","article-title":"Apolipoprotein C3 Polymorphisms, Cognitive Function and Diabetes in Caribbean Origin Hispanics","volume":"4","author":"Smith","year":"2009","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0795","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1155\/1996\/193092","article-title":"Acid-Stable Serine Proteinase Inhibitors in the Urine of Alzheimer Disease Subjects","volume":"13","author":"Sparro","year":"1996","journal-title":"Dis. Markers"},{"key":"10.1016\/j.envint.2024.108462_b0800","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jtemb.2017.11.005","article-title":"Copper dyshomeostasis in Wilson disease and Alzheimer\u2019s disease as shown by serum and urine copper indicators","volume":"45","author":"Squitti","year":"2018","journal-title":"J. Trace Elem. Med Biol."},{"key":"10.1016\/j.envint.2024.108462_b0805","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101497","article-title":"Identification of altered exosomal microRNAs and mRNAs in Alzheimer\u2019s disease","volume":"73","author":"Su","year":"2022","journal-title":"Ageing Res. Rev."},{"issue":"5\u20136","key":"10.1016\/j.envint.2024.108462_b0810","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000505851","article-title":"A Pilot Study of Urinary Exosomes in Alzheimer\u2019s Disease","volume":"19","author":"Sun","year":"2019","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.envint.2024.108462_b0815","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113294","article-title":"Towards point-of-care diagnosis of Alzheimer\u2019s disease: Multi-analyte based portable chemiresistive platform for simultaneous detection of \u03b2-amyloid (1\u201340) and (1\u201342) in plasma","volume":"186","author":"Supraja","year":"2021","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"10.1016\/j.envint.2024.108462_b0820","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.molcel.2012.08.003","article-title":"Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition","volume":"48","author":"Suraweera","year":"2012","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.envint.2024.108462_b0825","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neulet.2008.02.019","article-title":"Detection of amyloid \u03b2 protein in the urine of Alzheimer\u2019s disease patients and healthy individuals","volume":"435","author":"Takata","year":"2008","journal-title":"Neurosci. Lett."},{"issue":"7","key":"10.1016\/j.envint.2024.108462_b0830","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1007\/s12035-015-9390-0","article-title":"Dissecting Complex and Multifactorial Nature of Alzheimer\u2019s Disease Pathogenesis: A Clinical, Genomic, and Systems Biology Perspective","volume":"53","author":"Talwar","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.envint.2024.108462_b0835","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.147884","article-title":"LncRNA RMRP accelerates autophagy-mediated neurons apoptosis through miR-3142\/TRIB3 signaling axis in alzheimer\u2019s disease","volume":"1785","author":"Tang","year":"2022","journal-title":"Brain Res."},{"key":"10.1016\/j.envint.2024.108462_b0840","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2021.106735","article-title":"A mechanistic survey of Alzheimer\u2019s disease","volume":"281","author":"Tang","year":"2022","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.envint.2024.108462_b0845","article-title":"Aduhelm: Approval of Alzheimer\u2019s drug was highly unorthodox, finds report","volume":"p6","author":"Tanne","year":"2023","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.envint.2024.108462_b0850","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S1474-4422(21)00214-3","article-title":"Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer\u2019s disease and frontotemporal lobar degeneration: A retrospective diagnostic performance study","volume":"20","author":"Thijssen","year":"2021","journal-title":"The Lancet Neurology"},{"issue":"10","key":"10.1016\/j.envint.2024.108462_b0855","doi-asserted-by":"crossref","first-page":"6074","DOI":"10.1038\/s41380-021-01073-6","article-title":"Physiological clearance of amyloid-beta by the kidney and its therapeutic potential for Alzheimer\u2019s disease","volume":"26","author":"Tian","year":"2021","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0860","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neurobiolaging.2009.07.013","article-title":"Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia","volume":"32","author":"Tong","year":"2011","journal-title":"Neurobiol. Aging"},{"issue":"9\u201310","key":"10.1016\/j.envint.2024.108462_b0865","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0531-5565(00)00153-4","article-title":"The metabolism of plasma glucose and catecholamines in Alzheimer\u2019s disease","volume":"35","author":"Umegaki","year":"2000","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.envint.2024.108462_b0870","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.3390\/ijms16023251","article-title":"Neighboring Gene Regulation by Antisense Long Non-Coding RNAs","volume":"16","author":"Villegas","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.envint.2024.108462_b0875","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.bbrc.2016.11.143","article-title":"Dissection of functional lncRNAs in Alzheimer\u2019s disease by construction and analysis of lncRNA\u2013mRNA networks based on competitive endogenous RNAs","volume":"485","author":"Wang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0880","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3109\/1354750X.2014.994036","article-title":"Combining serum and urine biomarkers in the early diagnosis of mild cognitive impairment that evolves into Alzheimer\u2019s disease in patients with the apolipoprotein E \u03b54 genotype","volume":"20","author":"Wang","year":"2015","journal-title":"Biomarkers"},{"issue":"4","key":"10.1016\/j.envint.2024.108462_b0885","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00401-018-1891-2","article-title":"Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies","volume":"136","author":"Wang","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.envint.2024.108462_b0890","article-title":"Correlation Between Urine Formaldehyde and Cognitive Abilities in the Clinical Spectrum of Alzheimer\u2019s Disease","volume":"14","author":"Wang","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0895","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13024-020-00376-6","article-title":"Mitochondria dysfunction in the pathogenesis of Alzheimer\u2019s disease: Recent advances","volume":"15","author":"Wang","year":"2020","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0900","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000496100","article-title":"Molecular Network Analysis of the Urinary Proteome of Alzheimer\u2019s Disease Patients","volume":"9","author":"Watanabe","year":"2019","journal-title":"Dementia and Geriatric Cognitive Disorders Extra"},{"issue":"3","key":"10.1016\/j.envint.2024.108462_b0905","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000509561","article-title":"Urinary Apolipoprotein C3 Is a Potential Biomarker for Alzheimer\u2019s Disease","volume":"10","author":"Watanabe","year":"2020","journal-title":"Dementia and Geriatric Cognitive Disorders Extra"},{"key":"10.1016\/j.envint.2024.108462_b0910","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.719159","article-title":"Alterations in Glycerolipid and Fatty Acid Metabolic Pathways in Alzheimer\u2019s Disease Identified by Urinary Metabolic Profiling: A Pilot Study","volume":"12","author":"Watanabe","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.envint.2024.108462_b0915","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.conb.2021.03.003","article-title":"A current view on Tau protein phosphorylation in Alzheimer\u2019s disease","volume":"69","author":"Wegmann","year":"2021","journal-title":"Curr. Opin. Neurobiol."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0920","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13195-020-00741-z","article-title":"Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer\u2019s disease","volume":"13","author":"Whiley","year":"2021","journal-title":"Alzheimer\u2019s Research & Therapy"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0925","doi-asserted-by":"crossref","first-page":"101","DOI":"10.31887\/DCNS.2019.21.1\/pwhitehouse","article-title":"Ethical issues in early diagnosis and prevention of Alzheimer disease","volume":"21","author":"Whitehouse","year":"2019","journal-title":"Dialogues Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.envint.2024.108462_b0930","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3233\/JAD-220264","article-title":"Making the Case for the Accelerated Withdrawal of Aducanumab","volume":"87","author":"Whitehouse","year":"2022","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"10","key":"10.1016\/j.envint.2024.108462_b0935","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/gps.3925","article-title":"Costs of diagnosing dementia: Results from SveDem, the Swedish Dementia Registry: Dementia diagnostic costs in Sweden","volume":"28","author":"Wimo","year":"2013","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.envint.2024.108462_b0940","unstructured":"World Health Organization. (2017). Global action plan on the public health response to dementia 2017\u20132025 (12). World Health Organization. Retrieved November 10, 2022 from https:\/\/apps.who.int\/iris\/handle\/10665\/259615."},{"key":"10.1016\/j.envint.2024.108462_b0945","unstructured":"World Health Organization. (2022). Noncommunicable diseases (37). World Health Organization. Retrieved March 2, 2023 from https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/noncommunicable-diseases."},{"issue":"8","key":"10.1016\/j.envint.2024.108462_b0950","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1073\/pnas.97.8.4233","article-title":"Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2","volume":"97","author":"Wu","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0955","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.111937","article-title":"Long non-coding RNA MALAT1 promotes the proliferation and migration of Schwann cells by elevating BDNF through sponging miR-129-5p","volume":"390","author":"Wu","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.envint.2024.108462_b0960","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.brainresbull.2013.06.001","article-title":"Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases","volume":"97","author":"Wu","year":"2013","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.envint.2024.108462_b0965","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2021.116508","article-title":"Diffusional microfluidics for protein analysis","volume":"146","author":"Xie","year":"2022","journal-title":"TrAC Trends Anal. Chem."},{"issue":"8","key":"10.1016\/j.envint.2024.108462_b0970","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1111\/ene.14254","article-title":"Diagnostic potential of urinary monocyte chemoattractant protein-1 for Alzheimer\u2019s disease and amnestic mild cognitive impairment","volume":"27","author":"Xu","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.envint.2024.108462_b0975","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.530219","article-title":"Metabolic Dysregulation Contributes to the Progression of Alzheimer\u2019s Disease","volume":"14","author":"Yan","year":"2020","journal-title":"Front. Neurosci."},{"issue":"11","key":"10.1016\/j.envint.2024.108462_b0980","first-page":"1097","article-title":"LncRNA: A link between RNA and cancer. Biochimica et Biophysica Acta (BBA)","volume":"1839","author":"Yang","year":"2014","journal-title":"- Gene Regulatory Mechanisms"},{"issue":"sup1","key":"10.1016\/j.envint.2024.108462_b0985","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/15476286.2021.1950465","article-title":"Non-coding RNAs: The extensive and interactive regulators of the blood-brain barrier permeability","volume":"18","author":"Yang","year":"2021","journal-title":"RNA Biol."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b0990","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0006-8993(83)91179-4","article-title":"Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and down\u2019s syndrome","volume":"280","author":"Yates","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/j.envint.2024.108462_b0995","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.2147\/CMAR.S186108","article-title":"Urinary exosomal expression of long non-coding RNAs as diagnostic marker in bladder cancer","volume":"10","author":"Yazarlou","year":"2018","journal-title":"Cancer Manag. Res."},{"issue":"9","key":"10.1016\/j.envint.2024.108462_b1000","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3390\/metabo10090357","article-title":"Targeted Metabolic Profiling of Urine Highlights a Potential Biomarker Panel for the Diagnosis of Alzheimer\u2019s Disease and Mild Cognitive Impairment: A Pilot Study","volume":"10","author":"Yilmaz","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.envint.2024.108462_b1005","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cca.2014.12.023","article-title":"Distinguishing mild cognitive impairment from Alzheimer\u2019s disease with acrolein metabolites and creatinine in urine","volume":"441","author":"Yoshida","year":"2015","journal-title":"Clin. Chim. Acta"},{"issue":"4","key":"10.1016\/j.envint.2024.108462_b1010","doi-asserted-by":"crossref","first-page":"781","DOI":"10.7150\/jca.37006","article-title":"A Panel of Urinary Long Non-coding RNAs Differentiate Bladder Cancer from Urocystitis","volume":"11","author":"Yu","year":"2020","journal-title":"J. Cancer"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b1015","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/npp.2015.235","article-title":"Gene\u2013Stress\u2013Epigenetic Regulation of FKBP5: Clinical and Translational Implications","volume":"41","author":"Zannas","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.envint.2024.108462_b1020","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jchemneu.2019.04.001","article-title":"BACE1-AS prevents BACE1 mRNA degradation through the sequestration of BACE1-targeting miRNAs","volume":"98","author":"Zeng","year":"2019","journal-title":"J. Chem. Neuroanat."},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b1025","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12943-018-0893-y","article-title":"Expression signatures of exosomal long non-coding RNAs in urine serve as novel non-invasive biomarkers for diagnosis and recurrence prediction of bladder cancer","volume":"17","author":"Zhan","year":"2018","journal-title":"Mol. Cancer"},{"issue":"4","key":"10.1016\/j.envint.2024.108462_b1030","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3171\/2014.11.JNS14770","article-title":"Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury","volume":"122","author":"Zhang","year":"2015","journal-title":"J. Neurosurg."},{"issue":"15","key":"10.1016\/j.envint.2024.108462_b1035","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1002\/elps.201300036","article-title":"Detection and quantification of 8-hydroxy-2\u2032-deoxyguanosine in Alzheimer\u2019s transgenic mouse urine using capillary electrophoresis: CE and CEC","volume":"34","author":"Zhang","year":"2013","journal-title":"Electrophoresis"},{"issue":"3","key":"10.1016\/j.envint.2024.108462_b1040","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4103\/0972-2327.116902","article-title":"A literature review of AD7c-ntp as a biomarker for Alzheimer\u2032s disease","volume":"16","author":"Zhang","year":"2013","journal-title":"Ann. Indian Acad. Neurol."},{"key":"10.1016\/j.envint.2024.108462_b1045","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fnagi.2019.00090","article-title":"Dysregulated Urinary Arginine Metabolism in Older Adults With Amnestic Mild Cognitive Impairment","volume":"11","author":"Zhang","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.envint.2024.108462_b1050","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.111180","article-title":"Deregulated lncRNA MAGI2-AS3 in Alzheimer\u2019s disease attenuates amyloid-\u03b2 induced neurotoxicity and neuroinflammation by sponging miR-374b-5p","volume":"144","author":"Zhang","year":"2021","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.envint.2024.108462_b1055","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3892\/ol.2016.4770","volume":"12","author":"Zhang","year":"2016","journal-title":"LncRNAs and Cancer. Oncology Letters"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b1060","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3233\/JAD-170383","article-title":"Urine AD7c-NTP Predicts Amyloid Deposition and Symptom of Agitation in Patients with Alzheimer\u2019s Disease and Mild Cognitive Impairment","volume":"60","author":"Zhang","year":"2017","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"10.1016\/j.envint.2024.108462_b1065","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jenvman.2018.12.028","article-title":"Identification and function of extracellular protein in wastewater treatment using proteomic approaches: A minireview","volume":"233","author":"Zhang","year":"2019","journal-title":"J. Environ. Manage."},{"key":"10.1016\/j.envint.2024.108462_b1070","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jpba.2016.11.056","article-title":"Analysis of amino acid and monoamine neurotransmitters and their metabolites in rat urine of Alzheimer\u2019s disease using in situ ultrasound-assisted derivatization dispersive liquid-liquid microextraction with UHPLC\u2013MS\/MS","volume":"135","author":"Zhao","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.envint.2024.108462_b1075","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbrc.2022.03.048","article-title":"Urinary and faecal metabolic characteristics in APP\/PS1 transgenic mouse model of Alzheimer\u2019s disease with and without cognitive decline","volume":"604","author":"Zheng","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.envint.2024.108462_b1080","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.bbrc.2012.06.017","article-title":"Plasma amyloid-\u03b2 oligomers level is a biomarker for Alzheimer\u2019s disease diagnosis","volume":"423","author":"Zhou","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envint.2024.108462_b1085","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neuroscience.2020.10.028","article-title":"LncRNA BACE1-AS Promotes Autophagy-Mediated Neuronal Damage Through The miR-214-3p\/ATG5 Signalling Axis In Alzheimer\u2019s Disease","volume":"455","author":"Zhou","year":"2021","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.envint.2024.108462_b1090","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1016\/j.neurobiolaging.2015.07.015","article-title":"Identification of Alzheimer\u2019s disease\u2013associated long noncoding RNAs","volume":"36","author":"Zhou","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.envint.2024.108462_b1095","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1186\/s12877-022-03288-w","article-title":"Urine D-ribose levels correlate with cognitive function in community-dwelling older adults","volume":"22","author":"Zhu","year":"2022","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.envint.2024.108462_b1100","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.115645","article-title":"Profiling of amino acids and their interactions with proteinaceous compounds for sewage sludge dewatering by Fenton oxidation treatment","volume":"175","author":"Zhu","year":"2020","journal-title":"Water Res."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412024000485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412024000485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T12:39:03Z","timestamp":1758976743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412024000485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":218,"alternative-id":["S0160412024000485"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2024.108462","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urine biomarkers for Alzheimer's disease: A new opportunity for wastewater-based epidemiology?","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2024.108462","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108462"}}