{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:44:18Z","timestamp":1786988658790,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3603000"],"award-info":[{"award-number":["2022YFC3603000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M742913"],"award-info":[{"award-number":["2023M742913"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008865","name":"Xiamen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.envint.2024.108616","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T12:29:09Z","timestamp":1711715349000},"page":"108616","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Associations of polycyclic aromatic hydrocarbons mixtures with cardiovascular diseases mortality and all-cause mortality and the mediation role of phenotypic ageing: A time-to-event analysis"],"prefix":"10.1016","volume":"186","author":[{"given":"Siyu","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9895-3234","authenticated-orcid":false,"given":"Ya","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2024.108616_b0005","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.envint.2016.02.006","article-title":"The association of urinary polycyclic aromatic hydrocarbon biomarkers and cardiovascular disease in the US population","volume":"89\u201390","author":"Alshaarawy","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2024.108616_b0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.envres.2014.02.012","article-title":"Atherosclerotic process in taxi drivers occupationally exposed to air pollution and co-morbidities","volume":"131","author":"Brucker","year":"2014","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2024.108616_b0015","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/jech-2022-219142","article-title":"Biological ageing and the risks of all-cause and cause-specific mortality among people with diabetes: a prospective cohort study","volume":"76","author":"Chen","year":"2022","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.envint.2024.108616_b0020","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/S0140-6736(17)30505-6","article-title":"Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015","volume":"389","author":"Cohen","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.envint.2024.108616_b0025","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0009-2797(02)00067-4","article-title":"Induction of cellular oxidative stress by aryl hydrocarbon receptor activation","volume":"141","author":"Dalton","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envint.2024.108616_b0030","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1161\/HYPERTENSIONAHA.121.18809","article-title":"Per- and polyfluoroalkyl substances and incident hypertension in multi-racial\/ethnic women: the study of women\u2019s health across the nation","volume":"79","author":"Ding","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.envint.2024.108616_b0035","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1093\/ije\/dyz061","article-title":"The association of urine metals and metal mixtures with cardiovascular incidence in an adult population from Spain: the Hortega Follow-Up Study","volume":"48","author":"Domingo-Relloso","year":"2019","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.envint.2024.108616_b0040","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.envres.2009.09.010","article-title":"Association of urinary polycyclic aromatic hydrocarbons and serum C-reactive protein","volume":"110","author":"Everett","year":"2010","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2024.108616_b0045","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1021\/acs.est.2c07611","article-title":"Association of endocrine-disrupting chemicals with all-cause and cause-specific mortality in the U.S.: a prospective cohort study","volume":"57","author":"Fan","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2024.108616_b0050","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.envpol.2017.10.042","article-title":"Association of polycyclic aromatic hydrocarbons exposure with atherosclerotic cardiovascular disease risk: A role of mean platelet volume or club cell secretory protein","volume":"233","author":"Hu","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2024.108616_b0055","doi-asserted-by":"crossref","DOI":"10.1289\/EHP5838","article-title":"A Quantile-based g-computation approach to addressing the effects of exposure mixtures","volume":"128","author":"Keil","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2024.108616_b0060","doi-asserted-by":"crossref","first-page":"7446","DOI":"10.1021\/es401639x","article-title":"Dose-response relationships of polycyclic aromatic hydrocarbons exposure and oxidative damage to DNA and lipid in coke oven workers","volume":"47","author":"Kuang","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2024.108616_b0065","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13376","article-title":"Genetic associations for two biological age measures point to distinct aging phenotypes","volume":"20","author":"Kuo","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.envint.2024.108616_b0070","article-title":"Association between urinary polycyclic aromatic hydrocarbons and hypertension in the Korean population: data from the Second Korean National Environmental Health Survey (2012\u20132014)","volume":"10","author":"Lee","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envint.2024.108616_b0075","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.envint.2024.108616_b0080","doi-asserted-by":"crossref","DOI":"10.1289\/EHP2773","article-title":"Exposure to polycyclic aromatic hydrocarbons and accelerated DNA methylation aging","volume":"126","author":"Li","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2024.108616_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145841","article-title":"Subgroup analysis of the relationship between polycyclic aromatic hydrocarbons and rheumatoid arthritis: Data from the National Health and Nutrition Examination Survey, 2003\u20132014","volume":"775","author":"Li","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2024.108616_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002718","article-title":"A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study","volume":"15","author":"Liu","year":"2018","journal-title":"PLoS Med."},{"key":"10.1016\/j.envint.2024.108616_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114907","article-title":"Association between polycyclic aromatic hydrocarbon exposure and hypertension among the U.S. adults in the NHANES 2003\u20132016: A cross-sectional study","volume":"217","author":"Lu","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2024.108616_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.112775","article-title":"Association of urinary polycyclic aromatic hydrocarbon metabolites and cardiovascular disease among US population: A cross-sectional study","volume":"209","author":"Mallah","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2024.108616_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156626","article-title":"Association between polycyclic aromatic hydrocarbons (PAH) dietary exposure and mortality risk in the E3N cohort","volume":"840","author":"Marques","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2024.108616_b0110","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1161\/01.CIR.0000026393.47805.21","article-title":"Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques","volume":"106","author":"Martinet","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.envint.2024.108616_b0115","doi-asserted-by":"crossref","DOI":"10.1515\/ijb-2017-0006","article-title":"Estimation and Inference for the Mediation Proportion","volume":"13","author":"Nevo","year":"2017","journal-title":"Int. J. Biostat."},{"key":"10.1016\/j.envint.2024.108616_b0120","first-page":"1381","article-title":"Hydroxyl polycyclic aromatic hydrocarbons in human urine as biomarkers of exposure to PAHs","volume":"18","author":"Niu","year":"2006","journal-title":"Prog. Chem."},{"key":"10.1016\/j.envint.2024.108616_b0125","doi-asserted-by":"crossref","unstructured":"Roth, G.A., Mensah, G.A., Johnson, C.O., Addolorato, G., Ammirati, E., Baddour, L.M., Barengo, N.C., Beaton, A.Z., Benjamin, E.J., Benziger, C.P., Bonny, A., Brauer, M., Brodmann, M., Cahill, T.J., Carapetis, J., Catapano, A.L., Chugh, S.S., Cooper, L.T., Coresh, J., Criqui, M., DeCleene, N., Eagle, K.A., Emmons-Bell, S., Feigin, V.L., Fern\u00e1ndez-Sol\u00e0, J., Fowkes, G., Gakidou, E., Grundy, S.M., He, F.J., Howard, G., Hu, F., Inker, L., Karthikeyan, G., Kassebaum, N., Koroshetz, W., Lavie, C., Lloyd-Jones, D., Lu, H.S., Mirijello, A., Temesgen, A.M., Mokdad, A., Moran, A.E., Muntner, P., Narula, J., Neal, B., Ntsekhe, M., Moraes de Oliveira, G., Otto, C., Owolabi, M., Pratt, M., Rajagopalan, S., Reitsma, M., Ribeiro, A.L.P., Rigotti, N., Rodgers, A., Sable, C., Shakil, S., Sliwa-Hahnle, K., Stark, B., Sundstr\u00f6m, J., Timpel, P., Tleyjeh, I.M., Valgimigli, M., Vos, T., Whelton, P.K., Yacoub, M., Zuhlke, L., Murray, C., Fuster, V., GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group, 2020. Global burden of cardiovascular diseases and risk factors, 1990-2019: Update from the GBD 2019 study. J. Am. Coll. Cardiol. 76, 2982\u20133021. 10.1016\/j.jacc.2020.11.010.","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"10.1016\/j.envint.2024.108616_b0130","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1021\/acs.est.5b04110","article-title":"Oral bioavailability, bioaccessibility, and dermal absorption of PAHs from soil\u2014State of the Science","volume":"50","author":"Ruby","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2024.108616_b0135","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0167-7799(02)01943-1","article-title":"Polycyclic aromatic hydrocarbons: environmental pollution and bioremediation","volume":"20","author":"Samanta","year":"2002","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.envint.2024.108616_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107614","article-title":"Personal airborne chemical exposure and epigenetic ageing biomarkers in healthy Chinese elderly individuals: Evidence from mixture approaches","volume":"170","author":"Shi","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2024.108616_b0145","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcancer.2021.07.001","article-title":"Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer","volume":"76","author":"Stading","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.envint.2024.108616_b0150","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.envres.2018.06.041","article-title":"Exploring the association between polycyclic aromatic hydrocarbons and diabetes among adults in the United States","volume":"166","author":"Stallings-Smith","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2024.108616_b0155","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00216-016-9933-x","article-title":"Quantification of urinary mono-hydroxylated metabolites of polycyclic aromatic hydrocarbons by on-line solid phase extraction-high performance liquid chromatography-tandem mass spectrometry","volume":"409","author":"Wang","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.envint.2024.108616_b0160","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1016\/j.scitotenv.2010.07.034","article-title":"Studying associations between urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) and cardiovascular diseases in the United States","volume":"408","author":"Xu","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2024.108616_b0165","doi-asserted-by":"crossref","first-page":"71131","DOI":"10.1007\/s11356-023-27428-w","article-title":"Association between mixed exposure of polycyclic aromatic hydrocarbons and telomere length in general population: NHANES 2001\u20132002","volume":"30","author":"Yang","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envint.2024.108616_b0170","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.envres.2019.03.053","article-title":"The impact on T-regulatory cell related immune responses in rural women exposed to polycyclic aromatic hydrocarbons (PAHs) in household air pollution in Gansu, China: A pilot investigation","volume":"173","author":"Yao","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2024.108616_b0175","doi-asserted-by":"crossref","unstructured":"Zhang, Y.-B., Chen, C., Pan, X.-F., Guo, J., Li, Y., Franco, O.H., Liu, G., Pan, A., 2021. Associations of healthy lifestyle and socioeconomic status with mortality and incident cardiovascular disease: Two prospective cohort studies. BMJ, n604. Doi: 10.1136\/bmj.n604.","DOI":"10.1136\/bmj.n604"}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412024002022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412024002022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T13:00:37Z","timestamp":1717678837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412024002022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":35,"alternative-id":["S0160412024002022"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2024.108616","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations of polycyclic aromatic hydrocarbons mixtures with cardiovascular diseases mortality and all-cause mortality and the mediation role of phenotypic ageing: A time-to-event analysis","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2024.108616","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108616"}}