{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:12:52Z","timestamp":1791519172821,"version":"4.3.4"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["311765-E-DOHaD"],"award-info":[{"award-number":["311765-E-DOHaD"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007772","name":"Agir pour les Maladies Chroniques","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012952","name":"Universit\u00e9 Grenoble Alpes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["825712"],"award-info":[{"award-number":["825712"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["874583"],"award-info":[{"award-number":["874583"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030971","name":"Centre Hospitalier, Universit\u00e9 Grenoble Alpes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018457","name":"International Association of Bryologists","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["308333-892 HELIX"],"award-info":[{"award-number":["308333-892 HELIX"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022077","name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-17-CE34-0013"],"award-info":[{"award-number":["ANR-17-CE34-0013"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE36-0005"],"award-info":[{"award-number":["ANR-18-CE36-0005"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-12-PDOC-0029-01"],"award-info":[{"award-number":["ANR-12-PDOC-0029-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["EST-2019\/1\/039"],"award-info":[{"award-number":["EST-2019\/1\/039"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-IDEX5"],"award-info":[{"award-number":["ANR-15-IDEX5"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["EST-2018-1-264"],"award-info":[{"award-number":["EST-2018-1-264"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-22-CE36-0018"],"award-info":[{"award-number":["ANR-22-CE36-0018"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-IDEX-02"],"award-info":[{"award-number":["ANR-15-IDEX-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-14-CE21-0007"],"award-info":[{"award-number":["ANR-14-CE21-0007"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["EST-2016-121"],"award-info":[{"award-number":["EST-2016-121"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["EST-2022-169"],"award-info":[{"award-number":["EST-2022-169"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-19-CE36-0003-01"],"award-info":[{"award-number":["ANR-19-CE36-0003-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.envint.2025.109308","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T16:39:43Z","timestamp":1738255183000},"page":"109308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["PFAS exposure during pregnancy: Implications for placental health and functioning"],"prefix":"10.1016","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5560-6996","authenticated-orcid":false,"given":"Sadia","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Ouidir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1768-9679","authenticated-orcid":false,"given":"Nicolas","family":"Lemaitre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Jovanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Bayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lyon-Caen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2492-8003","authenticated-orcid":false,"given":"Morgane","family":"Desseux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-7868","authenticated-orcid":false,"given":"Cathrine","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Couturier-Tarrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Sm\u00e5stuen Haug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Valmary-Degano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Siroux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Slama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Alfaidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4959-6648","authenticated-orcid":false,"given":"Claire","family":"Philippat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2025.109308_b0005","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1017\/S2040174410000280","article-title":"Beyond birthweight: the maternal and placental origins of chronic disease","volume":"1","author":"Barker","year":"2010","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.envint.2025.109308_b0010","doi-asserted-by":"crossref","DOI":"10.1289\/EHP6233","article-title":"Evaluation of maternal, embryo, and placental effects in CD-1 mice following gestational exposure to Perfluorooctanoic Acid (PFOA) or hexafluoropropylene oxide dimer acid (HFPO-DA or GenX)","volume":"128","author":"Blake","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2025.109308_b0015","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/biostatistics\/kxu058","article-title":"Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures","volume":"16","author":"Bobb","year":"2015","journal-title":"Biostat. Oxf. Engl."},{"key":"10.1016\/j.envint.2025.109308_b0020","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12302-023-00721-8","article-title":"PFAS: forever chemicals\u2014persistent, bioaccumulative and mobile. reviewing the status and the need for their phase out and remediation of contaminated sites","volume":"35","author":"Brunn","year":"2023","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.envint.2025.109308_b0025","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0066","article-title":"The placenta: a multifaceted, transient organ","volume":"370","author":"Burton","year":"2015","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.envint.2025.109308_b0030","doi-asserted-by":"crossref","first-page":"S745","DOI":"10.1016\/j.ajog.2017.11.577","article-title":"Pathophysiology of placental-derived fetal growth restriction","volume":"218","author":"Burton","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.envint.2025.109308_b0035","article-title":"Pre-eclampsia: pathophysiology and clinical implications","volume":"366","author":"Burton","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.envint.2025.109308_b0040","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.placenta.2022.01.009","article-title":"Morphological and functional changes in placentas from prolonged pregnancies","volume":"125","author":"Carroll","year":"2022","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109308_b0045","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.placenta.2024.03.002","article-title":"PFAS alters placental arterial vasculature in term human placentae: a prospective pregnancy cohort study","volume":"149","author":"Chowdhury","year":"2024","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109308_b0050","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/toxsci\/kfac126","article-title":"Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits","volume":"191","author":"Crute","year":"2023","journal-title":"Toxicol. Sci. off. J. Soc. Toxicol."},{"key":"10.1016\/j.envint.2025.109308_b0055","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/pd.5013","article-title":"Perinatal outcome of placental massive perivillous fibrin deposition: a case\u2013control study","volume":"37","author":"Devisme","year":"2017","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.envint.2025.109308_b0060","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/aje\/kwn095","article-title":"Fetal growth indicators and perfluorinated chemicals: a study in the Danish national birth cohort","volume":"168","author":"Fei","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envint.2025.109308_b0065","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1080\/0266476042000214501","article-title":"Beta regression for modelling rates and proportions","volume":"31","author":"Ferrari","year":"2004","journal-title":"J. Appl. Stat."},{"key":"10.1016\/j.envint.2025.109308_b0070","doi-asserted-by":"crossref","first-page":"6117","DOI":"10.1021\/acs.est.3c09611","article-title":"Impact of gestational exposure to individual and combined per- and polyfluoroalkyl substances on a placental structure and efficiency: findings from the ma\u2019anshan birth cohort","volume":"58","author":"Gan","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2025.109308_b0075","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.taap.2014.03.012","article-title":"Perfluorinated chemicals: differential toxicity, inhibition of aromatase activity and alteration of cellular lipids in human placental cells","volume":"277","author":"Gorrochategui","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2025.109308_b0080","doi-asserted-by":"crossref","unstructured":"Gude, N.M., Roberts, C.T., Kalionis, B., King, R.G., 2004. Growth and function of the normal human placenta. Thromb. Res., Special issue - State-of-the-Art 11th International Congress on Antiphospholipid Antibodies 114, 397\u2013407. Doi: 10.1016\/j.thromres.2004.06.038.","DOI":"10.1016\/j.thromres.2004.06.038"},{"key":"10.1016\/j.envint.2025.109308_b0085","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.chroma.2008.10.113","article-title":"A sensitive method for determination of a broad range of perfluorinated compounds in serum suitable for large-scale human biomonitoring","volume":"1216","author":"Haug","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.envint.2025.109308_b0090","unstructured":"Heerema-McKenney, A., Popek, E.J., De Paepe, M., 2019. Diagnostic Pathology: Placenta, ELSEVIER HEALTH SCIENCES. ed, Diagnostic Pathology."},{"key":"10.1016\/j.envint.2025.109308_b0095","doi-asserted-by":"crossref","unstructured":"Helsel, D.R., 2012. Statistics for censored environmental data using Minitab and R, Second edition. ed, Statistics in practice. Wiley, Hoboken, NJ.","DOI":"10.1002\/9781118162729"},{"key":"10.1016\/j.envint.2025.109308_b0100","unstructured":"Hern\u00e1n, M.A., Robins, J.M., 2020. Causal Inference\u00a0: What if, Chapman&Hall\/CRC. ed."},{"key":"10.1016\/j.envint.2025.109308_b0105","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1136\/jcp.2008.055277","article-title":"The anatomy of the normal placenta","volume":"61","author":"Huppertz","year":"2008","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.envint.2025.109308_b0110","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.envres.2017.10.012","article-title":"Prenatal exposure to perfluoralkyl substances (PFASs) associated with respiratory tract infections but not allergy- and asthma-related health outcomes in childhood","volume":"160","author":"Impinen","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2025.109308_b0115","doi-asserted-by":"crossref","unstructured":"Jovanovic, N., Mustieles, V., Althuser, M., Lyon-Caen, S., Alfaidy, N., Thomsen, C., Sakhi, A.K., Sabaredzovic, A., Bayat, S., Couturier-Tarrade, A., Slama, R., Philippat, C., 2024. Associations between synthetic phenols, phthalates, and placental growth\/function: a longitudinal cohort with exposure assessment in early pregnancy. Hum. Reprod. Open 2024, hoae018. Doi: 10.1093\/hropen\/hoae018.","DOI":"10.1093\/hropen\/hoae018"},{"key":"10.1016\/j.envint.2025.109308_b0120","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1053\/plac.2002.0946","article-title":"Pre-eclampsia and maternal anaemia display reduced apoptosis and opposite invasive phenotypes of extravillous trophoblast","volume":"24","author":"Kadyrov","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109308_b0125","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ajog.2005.07.035","article-title":"Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies complicated by maternal anemia and early-onset preeclampsia\/intrauterine growth restriction","volume":"194","author":"Kadyrov","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.envint.2025.109308_b0130","doi-asserted-by":"crossref","first-page":"698","DOI":"10.5858\/arpa.2015-0225-CC","article-title":"Sampling and definitions of placental lesions: amsterdam placental workshop group consensus statement","volume":"140","author":"Khong","year":"2016","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.envint.2025.109308_b0135","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.placenta.2019.07.006","article-title":"Clinicopathological characteristics of miscarriages featuring placental massive perivillous fibrin deposition","volume":"86","author":"Kim","year":"2019","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109308_b0140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0301-2115(00)00423-1","article-title":"Development of the placental villous tree and its consequences for fetal growth","volume":"92","author":"Kingdom","year":"2000","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.envint.2025.109308_b0145","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.placenta.2021.12.013","article-title":"Massive perivillous fibrin deposition of the placenta and pregnancy outcome: a retrospective observational study","volume":"117","author":"Lampi","year":"2022","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109308_b0150","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.mce.2014.10.026","article-title":"Effects of perfluorooctane sulfuric acid on placental PRL-family hormone production and fetal growth retardation in mice","volume":"401","author":"Lee","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envint.2025.109308_b0155","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.placenta.2016.01.010","article-title":"In utero perfluorooctane sulfonate exposure causes low body weights of fetal rats: a mechanism study","volume":"39","author":"Li","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109308_b0160","doi-asserted-by":"crossref","unstructured":"Lyon-Caen, S., Siroux, V., Lepeule, J., Lorimier, P., Hainaut, P., Mossuz, P., Quentin, J., Supernant, K., Meary, D., Chaperot, L., Bayat, S., Cassee, F., Valentino, S., Couturier-Tarrade, A., Rousseau-Ralliard, D., Chavatte-Palmer, P., Philippat, C., Pin, I., Slama, R., Study Group, T.S., 2019. Deciphering the Impact of Early-Life Exposures to Highly Variable Environmental Factors on Foetal and Child Health: Design of SEPAGES Couple-Child Cohort. Int. J. Environ. Res. Public. Health 16, 3888. Doi: 10.3390\/ijerph16203888.","DOI":"10.3390\/ijerph16203888"},{"key":"10.1016\/j.envint.2025.109308_b0165","unstructured":"Marbac, M., Sedki, M., 2017. Variable selection for mixed data clustering: a model-based approach. Doi: 10.48550\/arXiv.1703.02293."},{"key":"10.1016\/j.envint.2025.109308_b0170","first-page":"14182","article-title":"Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes. FASEB","volume":"34","author":"Marinello","year":"2020","journal-title":"J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.envint.2025.109308_b0175","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1039\/C9EM00502A","article-title":"Temporal trends of suspect- and target-per\/polyfluoroalkyl substances (PFAS), extractable organic fluorine (EOF) and total fluorine (TF) in pooled serum from first-time mothers in Uppsala, Sweden, 1996-2017","volume":"22","author":"Miaz","year":"2020","journal-title":"Environ. Sci. Process. Impacts"},{"key":"10.1016\/j.envint.2025.109308_b0180","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.placenta.2009.09.008","article-title":"Non-linear and gender-specific relationships among placental growth measures and the fetoplacental weight ratio\u2606","volume":"30","author":"Misra","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109308_b0185","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.3390\/ijms20225639","article-title":"Maternal platelets\u2014friend or foe of the human placenta?","volume":"20","author":"Moser","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2025.109308_b0190","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1113\/jphysiol.2006.104968","article-title":"Placental adaptive responses and fetal programming","volume":"572","author":"Myatt","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.envint.2025.109308_b0195","doi-asserted-by":"crossref","unstructured":"Nascente, L.M. de P., Grandi, C., Aragon, D.C., Cardoso, V.C., 2020. Placental measurements and their association with birth weight in a Brazilian cohort. Rev. Bras. Epidemiol. Braz. J. Epidemiol. 23, e200004. Doi: 10.1590\/1980-549720200004.","DOI":"10.1590\/1980-549720200004"},{"key":"10.1016\/j.envint.2025.109308_b0200","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.envint.2014.01.007","article-title":"Prenatal exposure to perfluoroalkyl acids and allergic diseases in early childhood","volume":"65","author":"Okada","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109308_b0205","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.reprotox.2020.10.013","article-title":"Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast","volume":"98","author":"Pham","year":"2020","journal-title":"Reprod. Toxicol. Elmsford N"},{"key":"10.1016\/j.envint.2025.109308_b0210","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1289\/ehp.1103634","article-title":"Exposure to phthalates and phenols during pregnancy and offspring size at birth","volume":"120","author":"Philippat","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2025.109308_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.116544","article-title":"In utero exposure to poly- and perfluoroalkyl substances and children respiratory health in the three first years of life","volume":"234","author":"Philippat","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2025.109308_b0220","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1053\/plac.2001.0688","article-title":"Placental calcification: a metastatic process?","volume":"22","author":"Poggi","year":"2001","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109308_b0225","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.aca.2016.12.043","volume":"957","author":"Poothong","year":"2017","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.envint.2025.109308_b0230","first-page":"e080206","article-title":"Placental Calcification Score: a new semiquantitative method to assess pattern and grading of placental calcifications","volume":"8","author":"Rossi","year":"2019","journal-title":"J. Pediatr. Neonatal Individ. Med. JPNIM"},{"key":"10.1016\/j.envint.2025.109308_b0235","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/aje\/kwx332","article-title":"Early-pregnancy plasma concentrations of perfluoroalkyl substances and birth outcomes in project viva: confounded by pregnancy hemodynamics?","volume":"187","author":"Sagiv","year":"2018","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envint.2025.109308_b0240","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.3389\/fphys.2018.01884","article-title":"The possible role of placental morphometry in the detection of fetal growth restriction","volume":"9","author":"Salavati","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.envint.2025.109308_b0245","doi-asserted-by":"crossref","DOI":"10.1177\/03000605231172895","article-title":"Placental weight and its relationship with the birth weight of term infants and body mass index of the mothers","volume":"51","author":"Sathasivam","year":"2023","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.envint.2025.109308_b0250","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/bdr2.1135","article-title":"Hypoxia and placental development","volume":"109","author":"Soares","year":"2017","journal-title":"Birth Defects Res."},{"key":"10.1016\/j.envint.2025.109308_b0255","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.placenta.2019.09.007","article-title":"The impact of placental massive perivillous fibrin deposition on neonatal outcome in pregnancies complicated by fetal growth restriction","volume":"87","author":"Spinillo","year":"2019","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109308_b0265","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mce.2011.01.009","article-title":"Perfluorooctanoic acid-induced inhibition of placental prolactin-family hormone and fetal growth retardation in mice","volume":"337","author":"Suh","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envint.2025.109308_b0270","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.ajog.2015.08.030","article-title":"The placenta is the center of the chronic disease universe","volume":"213","author":"Thornburg","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.envint.2025.109308_b0275","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12884-021-03576-0","article-title":"Association of placental chorangiosis with pregnancy complication and prenatal outcome: a case-control study","volume":"21","author":"Vafaei","year":"2021","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.envint.2025.109308_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108014","article-title":"Developmental toxicity of perfluorohexane sulfonate at human relevant dose during pregnancy via disruption in placental lipid homeostasis","volume":"177","author":"Yao","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109308_b0285","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1021\/es303716k","article-title":"Part I. a temporal study of PFCAs and their precursors in human plasma from two German cities 1982-2009","volume":"47","author":"Yeung","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2025.109308_b0290","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/FM9.0000000000000134","article-title":"Placental development and pregnancy-associated diseases","volume":"4","author":"Yu","year":"2022","journal-title":"Matern.-Fetal Med."},{"key":"10.1016\/j.envint.2025.109308_b0295","doi-asserted-by":"crossref","DOI":"10.1289\/EHP13217","article-title":"Evaluating the effect of gestational exposure to perfluorohexane sulfonate on placental development in mice combining alternative splicing and gene expression analyses","volume":"131","author":"Zhang","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2025.109308_b0260","unstructured":"Stevens, R., Odell, N., Wadee, R., 2023. The clinical significance of placental histopathological evaluation in the management of high-risk obstetric patients: A cross-sectional retrospective study. South Afr. J. Obstet. Gynaecol."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412025000595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412025000595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:28:10Z","timestamp":1777642090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412025000595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":59,"alternative-id":["S0160412025000595"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2025.109308","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PFAS exposure during pregnancy: Implications for placental health and functioning","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2025.109308","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109308"}}