{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:14:14Z","timestamp":1791173654944,"version":"4.1.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T00:00:00Z","timestamp":1744502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["101034307"],"award-info":[{"award-number":["101034307"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"Paivikki and Sakari Sohlberg Fundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","award":["MBE2968"],"award-info":[{"award-number":["MBE2968"]}],"id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","award":["MBE2960"],"award-info":[{"award-number":["MBE2960"]}],"id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["814978"],"award-info":[{"award-number":["814978"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministry of Education Youth and Sports of the Czech Republic","doi-asserted-by":"publisher","award":["LM2023066"],"award-info":[{"award-number":["LM2023066"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["334800"],"award-info":[{"award-number":["334800"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013840","name":"Biocenter Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013840","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007753","name":"It\u00e4-Suomen Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007753","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030846","name":"Biokeskus Kuopio, It\u00e4-Suomen yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.envint.2025.109467","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T11:12:01Z","timestamp":1746443521000},"page":"109467","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia"],"prefix":"10.1016","volume":"199","author":[{"given":"Sohvi","family":"Ohtonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henna","family":"J\u00e4ntti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Giudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Shakirzyanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e1\u0148a","family":"Z\u00e1vodn\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Belevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica Mar\u00eda","family":"Sabogal-Gu\u00e1queta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liudmila","family":"Saveleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari-Anna","family":"V\u00e4\u00e4n\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Rillo-Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Perciballi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna-Mari","family":"Tervo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"G\u00f3mez-Budia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zden\u011bk","family":"Krej\u010d\u00edk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Aakko-Saksa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Koistinaho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0160\u00e1rka","family":"Lehtonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja M.","family":"Kanninen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Topinka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eija","family":"Jokitalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia M.","family":"Dolga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasi I.","family":"Jalava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Korhonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Malm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2025.109467_b0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031495","article-title":"Comparative analysis identifies similarities between the human and murine microglial sensomes","volume":"22","author":"Abels","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2025.109467_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122286","article-title":"Synergistic, antagonistic, and additive effects of naphthalene, phenanthrene, fluoranthene and benzo(k)fluoranthene on Artemia franciscana nauplii and adult","volume":"335","author":"Albarano","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2025.109467_b0015","doi-asserted-by":"crossref","first-page":"42390","DOI":"10.1007\/s11356-020-10574-w","article-title":"Inflammatory effects of particulate matter air pollution","author":"Arias-P\u00e9rez","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envint.2025.109467_b0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002340","article-title":"Microscopy image browser: a platform for segmentation and analysis of multidimensional datasets","volume":"14","author":"Belevich","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.envint.2025.109467_b0025","article-title":"Preparation of cultured cells for serial block face scanning electron microscopy (SBEM)","author":"Boassa","year":"2022","journal-title":"protocols.io."},{"key":"10.1016\/j.envint.2025.109467_b0030","doi-asserted-by":"crossref","first-page":"e804","DOI":"10.1016\/S2542-5196(22)00200-5","article-title":"Maternal exposure to ambient black carbon particles and their presence in maternal and fetal circulation and organs: an analysis of two independent population-based observational studies","volume":"6","author":"Bongaerts","year":"2022","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.envint.2025.109467_b0035","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11654-3","article-title":"Ambient black carbon particles reach the fetal side of human placenta","volume":"10","author":"Bov\u00e9","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envint.2025.109467_b0040","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/0192623307313011","article-title":"Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid \u03b2-42 and \u03b1-synuclein in children and young adults","volume":"36","author":"Calder\u00f3n-Garcidue\u00f1as","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.envint.2025.109467_b0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbi.2023.02.023","article-title":"Real-time mechanisms of exacerbated synaptic remodeling by microglia in acute models of systemic inflammation and tauopathy","volume":"110","author":"Cangalaya","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.envint.2025.109467_b0050","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.etap.2015.06.012","article-title":"Automobile diesel exhaust particles induce lipid droplet formation in macrophages in vitro","volume":"40","author":"Cao","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envint.2025.109467_b0055","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/nprot.2017.036","article-title":"Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes","volume":"12","author":"Chen","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.envint.2025.109467_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113378","article-title":"Effects of air pollution on human health \u2013 Mechanistic evidence suggested by in vitro and in vivo modelling","volume":"212","author":"Chen","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2025.109467_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2016.11.010","article-title":"Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain","volume":"374","author":"Cole","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2025.109467_b0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41577-023-00837-1","article-title":"The biology of TREM receptors","author":"Colonna","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.envint.2025.109467_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112581","article-title":"Possible association between PM2.5 and neurodegenerative diseases: a systematic review","volume":"208","author":"Cristaldi","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2025.109467_b0080","article-title":"Exposure to diesel exhaust induces changes in EEG in human volunteers","volume":"5","author":"Cr\u00fcts","year":"2008","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envint.2025.109467_b0085","doi-asserted-by":"crossref","DOI":"10.1007\/s10534-025-00665-x","article-title":"Heavy metal-induced disruption of the autophagy-lysosomal pathway: implications for aging and neurodegenerative disorders","author":"Das","year":"2025","journal-title":"Biometals"},{"key":"10.1016\/j.envint.2025.109467_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrrev.2022.108441","article-title":"Systematic review on primary and secondary genotoxicity of carbon black nanoparticles in mammalian cells and animals","author":"Di Ianni","year":"2022","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"10.1016\/j.envint.2025.109467_b0095","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/s41590-023-01558-2","article-title":"Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro","volume":"24","author":"Dolan","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.envint.2025.109467_b0100","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1002\/glia.22419","article-title":"Activation of KCNN3\/SK3\/KCa2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia","volume":"60","author":"Dolga","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.envint.2025.109467_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.104989","article-title":"Hippocampal inflammation and oxidative stress following exposure to diesel exhaust nanoparticles in male and female mice","volume":"145","author":"Ehsanifar","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.envint.2025.109467_b0110","doi-asserted-by":"crossref","first-page":"23527","DOI":"10.1007\/s11356-022-23882-0","article-title":"Cognitive impairment, depressive-like behaviors and hippocampal microglia activation following exposure to air pollution nanoparticles","volume":"30","author":"Ehsanifar","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envint.2025.109467_b0115","doi-asserted-by":"crossref","first-page":"50856","DOI":"10.1007\/s11356-022-19367-9","article-title":"Exposure to urban air pollution particulate matter: neurobehavioral alteration and hippocampal inflammation","volume":"29","author":"Ehsanifar","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envint.2025.109467_b0120","unstructured":"European Environment Agency, 2023. Harm to human health from air pollution in Europe: burden of disease 2023 [WWW Document]. DOi: 10.2800\/721439."},{"key":"10.1016\/j.envint.2025.109467_b0125","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3390\/cells11010124","article-title":"Microglia-like cells promote neuronal functions in cerebral organoids","volume":"11","author":"Fagerlund","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.envint.2025.109467_b0130","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00329","article-title":"Role of microglia TLRs in neurodegeneration","volume":"12","author":"Fiebich","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.envint.2025.109467_b0135","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baz046","article-title":"PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data","author":"Franz\u00e9n","year":"2019","journal-title":"Database"},{"key":"10.1016\/j.envint.2025.109467_b0140","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nn.4597","article-title":"Transcriptomic analysis of purified human cortical microglia reveals age-associated changes","volume":"20","author":"Galatro","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.envint.2025.109467_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167200","article-title":"Lysosomal dysfunction in carbon black-induced lung disorders","volume":"905","author":"Gao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2025.109467_b0150","article-title":"Brief diesel exhaust exposure acutely impairs functional brain connectivity in humans: a randomized controlled crossover study","volume":"22","author":"Gawryluk","year":"2023","journal-title":"Environ. Health"},{"key":"10.1016\/j.envint.2025.109467_b0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1012022","article-title":"StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling","volume":"20","author":"Giudice","year":"2024","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.envint.2025.109467_b0160","article-title":"Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia","author":"Giudice","year":"2025","journal-title":"Zenodo"},{"key":"10.1016\/j.envint.2025.109467_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104715","article-title":"Glial smog: Interplay between air pollution and astrocyte-microglia interactions","volume":"136","author":"G\u00f3mez-Budia","year":"2020","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.envint.2025.109467_b0170","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-020-02017-7","article-title":"Diesel exhaust impairs TREM2 to dysregulate neuroinflammation","volume":"17","author":"Greve","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.envint.2025.109467_b0175","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaa1146","article-title":"cola: an R\/Bioconductor package for consensus partitioning through a general framework","volume":"49","author":"Gu","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envint.2025.109467_b0180","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/glia.24532","article-title":"Low-grade systemic inflammation stimulates microglial turnover and accelerates the onset of Alzheimer\u2019s-like pathology","volume":"72","author":"Guerrero-Carrasco","year":"2024","journal-title":"Glia"},{"key":"10.1016\/j.envint.2025.109467_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164215","article-title":"Toxicity of exhaust emissions from high aromatic and non-aromatic diesel fuels using in vitro ALI exposure system","volume":"890","author":"Hakkarainen","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2025.109467_b0190","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1096\/fj.08-106997","article-title":"Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P\u2010glycoprotein up\u2010regulation at the blood\u2010brain barrier","volume":"22","author":"Hartz","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.envint.2025.109467_b0195","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13812-z","article-title":"Dual microglia effects on blood brain barrier permeability induced by systemic inflammation","volume":"10","author":"Haruwaka","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envint.2025.109467_b0200","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.614972","article-title":"Honing the double-edged sword: improving human iPSC-microglia models","author":"Hedegaard","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envint.2025.109467_b0205","doi-asserted-by":"crossref","first-page":"16009","DOI":"10.1038\/npjparkd.2016.9","article-title":"Creation of a library of induced pluripotent stem cells from Parkinsonian patients","volume":"2","author":"Holmqvist","year":"2016","journal-title":"NPJ Parkinsons Dis"},{"key":"10.1016\/j.envint.2025.109467_b0210","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.cell.2022.05.021","article-title":"Parkinson\u2019s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes","volume":"185","author":"Hu","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.envint.2025.109467_b0215","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2019.00113","article-title":"The lysosome signaling platform: adapting with the Times","volume":"7","author":"Inpanathan","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.envint.2025.109467_b0220","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12989-024-00564-y","article-title":"Particulate matter from car exhaust alters function of human iPSC-derived microglia","volume":"21","author":"J\u00e4ntti","year":"2024","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envint.2025.109467_b0225","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-022-02486-y","article-title":"Microglial amyloid beta clearance is driven by PIEZO1 channels","volume":"19","author":"J\u00e4ntti","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.envint.2025.109467_b0230","article-title":"An air particulate pollutant induces neuroinflammation and neurodegeneration in human brain models","volume":"8","author":"Kang","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.envint.2025.109467_b0235","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.stemcr.2019.08.004","article-title":"PSEN1DeltaE9, APPswe, and APOE4 confer disparate phenotypes in human iPSC-derived microglia","volume":"13","author":"Konttinen","year":"2019","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.envint.2025.109467_b0240","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kr\u00e4mer","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envint.2025.109467_b0245","doi-asserted-by":"crossref","DOI":"10.1038\/s12276-020-0405-1","article-title":"Ultrafine particles: unique physicochemical properties relevant to health and disease","author":"Kwon","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.envint.2025.109467_b0250","doi-asserted-by":"crossref","unstructured":"Law, C.W., Alhamdoosh, M., Su, S., Dong, X., Tian, L., Smyth, G.K., Ritchie, M.E., 2018. RNA-seq analysis is easy as 1-2-3 with limma, Glimma and edgeR [version 3; peer review: 3 approved]. F1000Res 5. DOi: 10.12688\/f1000research.9005.3.","DOI":"10.12688\/f1000research.9005.3"},{"key":"10.1016\/j.envint.2025.109467_b0255","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/glia.22805","article-title":"Aryl hydrocarbon receptor mediates both proinflammatory and anti-inflammatory effects in lipopolysaccharide-activated microglia","volume":"63","author":"Lee","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.envint.2025.109467_b0260","article-title":"Pattern recognition receptors in health and diseases","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.envint.2025.109467_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105487","article-title":"Activation of NLRP3 in microglia exacerbates diesel exhaust particles-induced impairment in learning and memory in mice","volume":"136","author":"Li","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109467_b0270","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.envpol.2018.04.081","article-title":"Ultrafine particle emissions from modern Gasoline and Diesel vehicles: an electron microscopic perspective","volume":"239","author":"Liati","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2025.109467_b0275","article-title":"Neurotoxicity of the air-borne particles: from molecular events to human diseases","author":"Liu","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2025.109467_b0280","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.envint.2025.109467_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114908","article-title":"Deep proteomic analysis of microglia reveals fundamental biological differences between model systems","volume":"43","author":"Lloyd","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.envint.2025.109467_b0290","article-title":"Chemical multi-fingerprinting of exogenous ultrafine particles in human serum and pleural effusion","volume":"11","author":"Lu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envint.2025.109467_b0295","doi-asserted-by":"crossref","first-page":"10797","DOI":"10.1073\/pnas.1605941113","article-title":"Magnetite pollution nanoparticles in the human brain","volume":"113","author":"Maher","year":"2016","journal-title":"PNAS"},{"key":"10.1016\/j.envint.2025.109467_b0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2023.102751","article-title":"Calcium signaling in lysosome-dependent cell death","volume":"113","author":"Milani","year":"2023","journal-title":"Cell Calcium"},{"key":"10.1016\/j.envint.2025.109467_b0305","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev-physiol-012110-142317","article-title":"Lysosomal acidification mechanisms","volume":"74","author":"Mindell","year":"2012","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.envint.2025.109467_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2018.01.019","article-title":"Emergent synergistic lysosomal toxicity of chemical mixtures in molluscan blood cells (hemocytes)","volume":"235","author":"Moore","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2025.109467_b0315","doi-asserted-by":"crossref","DOI":"10.3390\/cells9092018","article-title":"A simple differentiation protocol for generation of induced pluripotent stem cell-derived basal forebrain-like cholinergic neurons for Alzheimer\u2019s disease and frontotemporal dementia disease modelling","volume":"9","author":"Mu\u00f1oz","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.envint.2025.109467_b0320","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00538","article-title":"Cytokine secretion in macrophages: SNAREs, Rabs, and membrane trafficking","volume":"5","author":"Murray","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envint.2025.109467_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167038","article-title":"Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment","volume":"905","author":"Mussalo","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2025.109467_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103272","article-title":"Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells \u2013 Implications for Alzheimer\u2019s disease","volume":"75","author":"Mussalo","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.envint.2025.109467_b0335","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2211999119","article-title":"Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer\u2019s disease","volume":"119","author":"Mustaly-Kalimi","year":"2022","journal-title":"PNAS"},{"key":"10.1016\/j.envint.2025.109467_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170893","article-title":"The role of lysosomes in airborne particulate matter-induced pulmonary toxicity","volume":"919","author":"Nie","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2025.109467_b0345","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.scr.2016.09.019","article-title":"Generation of induced pluripotent stem cells derived from a 77-year-old healthy woman as control for age related diseases","volume":"17","author":"Nimsanor","year":"2016","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.envint.2025.109467_b0350","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-49294-9","article-title":"Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson\u2019s disease related transcriptional profile and function","volume":"13","author":"Ohtonen","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envint.2025.109467_b0355","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.stemcr.2017.10.016","article-title":"PSEN1 Mutant iPSC-derived model reveals severe astrocyte pathology in Alzheimer\u2019s disease","volume":"9","author":"Oksanen","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.envint.2025.109467_b0360","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.562813","article-title":"Polycyclic aromatic hydrocarbons: sources, toxicity, and remediation approaches","author":"Patel","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envint.2025.109467_b0365","doi-asserted-by":"crossref","DOI":"10.1186\/s12989-014-0074-0","article-title":"Diesel exhaust particle exposure in vitro impacts T lymphocyte phenotype and function","volume":"11","author":"Pierdominici","year":"2014","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envint.2025.109467_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.apenergy.2019.113636","article-title":"Potential of renewable fuel to reduce diesel exhaust particle emissions","volume":"254","author":"Pirjola","year":"2019","journal-title":"Appl. Energy"},{"key":"10.1016\/j.envint.2025.109467_b0375","doi-asserted-by":"crossref","unstructured":"Qi, Y., Wei, S., Xin, T., Huang, C., Pu, Y., Ma, J., Zhang, C., Liu, Y., Lynch, I., Liu, S., Murphy, C., 2022. Passage of exogeneous fine particles from the lung into the brain in humans and animals. DOi: 10.1073\/pnas.","DOI":"10.1073\/pnas.2117083119"},{"key":"10.1016\/j.envint.2025.109467_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2021.128090","article-title":"Reducing diesel exhaust emissions by optimisation of alcohol oxygenates blend with diesel\/biodiesel","volume":"316","author":"Razak","year":"2021","journal-title":"J. Clean. Prod."},{"issue":"63","key":"10.1016\/j.envint.2025.109467_b0385","first-page":"19","article-title":"Annual review of pharmacology and toxicology lysosomal ion channels: what are they good for and are they druggable targets?","volume":"2023","author":"Riederer","year":"2022","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.envint.2025.109467_b0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123665","article-title":"Towards zero pollution vehicles by advanced fuels and exhaust aftertreatment technologies","volume":"347","author":"Saarikoski","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2025.109467_b0395","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-42096-7","article-title":"Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction","volume":"14","author":"Sabogal-Gu\u00e1queta","year":"2023","journal-title":"Nat. Commun."},{"issue":"325","key":"10.1016\/j.envint.2025.109467_b0400","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"1979","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.envint.2025.109467_b0405","article-title":"Corrigendum to \u201cGeneration of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line.\u201d","volume":"48","author":"Schmid","year":"2020","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.envint.2025.109467_b0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2018.11.010","article-title":"Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line","volume":"34","author":"Schmid","year":"2019","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.envint.2025.109467_b0415","article-title":"Neuro-glia-vascular-on-a-chip system to assess aggravated neurodegeneration via brain endothelial cells upon exposure to diesel exhaust particles","volume":"33","author":"Seo","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.envint.2025.109467_b0420","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.3233\/JAD-220493","article-title":"Neurotoxicity of Diesel Exhaust Particles","volume":"89","author":"Shkirkova","year":"2022","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.envint.2025.109467_b0425","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-019-0347-z","article-title":"Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration","author":"Speicher","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.envint.2025.109467_b0430","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.tins.2021.12.004","article-title":"Lysosomal dysfunction in neurodegeneration: emerging concepts and methods","volume":"45","author":"Udayar","year":"2022","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.envint.2025.109467_b0435","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1038\/s41591-022-02073-x","article-title":"Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes","volume":"28","author":"Ural","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.envint.2025.109467_b0440","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.5678","article-title":"Accumulation of ambient black carbon particles within key memory-related brain regions","author":"Vanbrabant","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.envint.2025.109467_b0445","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.devcel.2019.02.014","article-title":"Clearance by microglia depends on packaging of phagosomes into a unique cellular compartment","volume":"49","author":"Villani","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.envint.2025.109467_b0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101530","article-title":"The aryl hydrocarbon receptor as a target of environmental stressors \u2013 Implications for pollution mediated stress and inflammatory responses","author":"Vogel","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.envint.2025.109467_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.joei.2018.11.006","article-title":"An overview of physical and chemical features of diesel exhaust particles","volume":"92","author":"Wang","year":"2019","journal-title":"J. Energy Inst."},{"key":"10.1016\/j.envint.2025.109467_b0460","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/08958370701498075","article-title":"Diesel exhaust particles","volume":"19","author":"Wichmann","year":"2007","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.envint.2025.109467_b0465","unstructured":"World Health Organization, 2021. WHO global air quality guidelines Particulate matter (PM2.5 and PM10), ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide [WWW Document]. URL https:\/\/iris.who.int\/handle\/10665\/345329 (accessed 12.13.23)."},{"key":"10.1016\/j.envint.2025.109467_b0470","doi-asserted-by":"crossref","unstructured":"World Medical Association, 2013. World Medical Association declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA 310, 2191\u20132194. DOi: 10.1001\/jama.2013.281053.","DOI":"10.1001\/jama.2013.281053"},{"key":"10.1016\/j.envint.2025.109467_b0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106244","article-title":"TMEM175: a lysosomal ion channel associated with neurological diseases","volume":"185","author":"Wu","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.envint.2025.109467_b0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2022.101651","article-title":"Redefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases","volume":"60","author":"Yvanka de Soysa","year":"2022","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.envint.2025.109467_b0485","article-title":"Role of neuroinflammation in neurodegeneration development","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412025002181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412025002181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T04:46:56Z","timestamp":1778388416000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412025002181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":97,"alternative-id":["S0160412025002181"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2025.109467","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2025.109467","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109467"}}