{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T08:59:44Z","timestamp":1780822784684,"version":"3.54.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2702901"],"award-info":[{"award-number":["2022YFC2702901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504357"],"award-info":[{"award-number":["82504357"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82311530691"],"award-info":[{"award-number":["82311530691"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203990"],"award-info":[{"award-number":["82203990"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20220318"],"award-info":[{"award-number":["BK20220318"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007660","name":"Universiteit Antwerpen","doi-asserted-by":"publisher","award":["36893"],"award-info":[{"award-number":["36893"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.envint.2025.109882","type":"journal-article","created":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:52:57Z","timestamp":1761519177000},"page":"109882","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Risk based ranking of prioritized pesticides: where the exposome meets comparative toxicogenomics"],"prefix":"10.1016","volume":"205","author":[{"given":"Beibei","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Poma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Christia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanquan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongcheng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3919-2586","authenticated-orcid":false,"given":"Weiyue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danrong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0527-1136","authenticated-orcid":false,"given":"Adrian","family":"Covaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-4035","authenticated-orcid":false,"given":"Yankai","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2025.109882_b0005","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.envint.2016.11.019","article-title":"Developmental neurotoxicity of succeeding generations of insecticides","volume":"99","author":"Abreu-Villa\u00e7a","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109882_b0010","unstructured":"Andersen HR. Prioritized substance group: Pesticides: Pyrethroids (group), chlorpyrifos, dimethoate, glyphosate (including the co-formulant POE tallow amine) and fipronil (D.4.5). 2019. https:\/\/www.hbm4eu.eu\/."},{"issue":"10","key":"10.1016\/j.envint.2025.109882_b0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002671","article-title":"Organophosphate exposures during pregnancy and child neurodevelopment: Recommendations for essential policy reforms","volume":"15","author":"Hertz-Picciotto","year":"2018","journal-title":"PLoS Med."},{"issue":"12","key":"10.1016\/j.envint.2025.109882_b0020","doi-asserted-by":"crossref","first-page":"e948","DOI":"10.1016\/S2542-5196(23)00255-3","article-title":"The inadequacy of current pesticide regulations for protecting brain health: the case of glyphosate and Parkinson's disease","volume":"7","author":"Bloem","year":"2023","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.envint.2025.109882_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111193","article-title":"From suspect screening to target analysis: Occurrence of six newly identified compounds in indoor dust from Belgium","volume":"197","author":"Christia","year":"2021","journal-title":"Environ. Res."},{"issue":"Pt 2","key":"10.1016\/j.envint.2025.109882_b0030","article-title":"Identification and semi-quantification of metabolites of new plasticizers in urine collected from flemish adults and children","volume":"307","author":"Christia","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2025.109882_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.135781","article-title":"Identification and semi-quantification of metabolites of new plasticizers in urine collected from Flemish adults and children","volume":"307","author":"Christia","year":"2022","journal-title":"Chemosphere"},{"issue":"D1","key":"10.1016\/j.envint.2025.109882_b0040","doi-asserted-by":"crossref","first-page":"D1138","DOI":"10.1093\/nar\/gkaa891","article-title":"Comparative Toxicogenomics Database (CTD): update 2021","volume":"49","author":"Davis","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.envint.2025.109882_b0045","doi-asserted-by":"crossref","first-page":"D1257","DOI":"10.1093\/nar\/gkac833","article-title":"Comparative Toxicogenomics Database (CTD): update 2023","volume":"51","author":"Davis","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.envint.2025.109882_b0050","doi-asserted-by":"crossref","DOI":"10.1289\/EHP1295","article-title":"Insecticide use and breast cancer risk among farmers\u2019 wives in the agricultural health study","volume":"125","author":"Engel","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2025.109882_b0055","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jes.2021.03.029","article-title":"Development of an analytical method based on solid-phase extraction and LC-MS\/MS for the monitoring of current-use pesticides and their metabolites in human urine","volume":"111","author":"Gao","year":"2022","journal-title":"J. Environ. Sci. (China)"},{"key":"10.1016\/j.envint.2025.109882_b0060","series-title":"Research on exposure of residents to pesticides in the Netherlands: OBO flower bulbs = Onderzoek Bestrijdingsmiddelen en Omwonenden","first-page":"381","author":"Gooijer","year":"2019"},{"issue":"6680","key":"10.1016\/j.envint.2025.109882_b0065","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.ado0969","article-title":"EPA scraps plan to end all testing in mammals by 2035","volume":"383","author":"Grimm","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.envint.2025.109882_b0070","series-title":"Biomarkers in Toxicology","first-page":"389","article-title":"Insecticides","author":"Gupta","year":"2014"},{"issue":"18","key":"10.1016\/j.envint.2025.109882_b0075","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1093\/bioinformatics\/bty326","article-title":"CTDquerier: a bioconductor R package for Comparative Toxicogenomics DatabaseTM data extraction, visualization and enrichment of environmental and toxicological studies","volume":"34","author":"Hernandez-Ferrer","year":"2018","journal-title":"Bioinformatics"},{"issue":"Pt 2","key":"10.1016\/j.envint.2025.109882_b0080","article-title":"Phthalates in house dust in Chinese urban residences: Concentrations, partition, origin and determinants","volume":"286","author":"Huang","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2025.109882_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146806","article-title":"Exposure to phthalates and correlations with phthalates in dust and air in South China homes","volume":"782","author":"Huang","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.envint.2025.109882_b0090","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/S2542-5196(23)00257-7","article-title":"In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study","volume":"8","author":"Hy\u00f6tyl\u00e4inen","year":"2024","journal-title":"Lancet Planet Health"},{"issue":"11","key":"10.1016\/j.envint.2025.109882_b0095","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1021\/acs.chemrestox.3c00206","article-title":"Human metabolism and urinary elimination kinetics of the fragrance geraniol after oral dosage","volume":"36","author":"J\u00e4ger","year":"2023","journal-title":"Chem. Res. Toxicol."},{"issue":"4","key":"10.1016\/j.envint.2025.109882_b0100","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1289\/ehp.0901392","article-title":"In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project","volume":"118","author":"Judson","year":"2010","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.envint.2025.109882_b0105","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1016\/S2542-5196(17)30049-9","article-title":"Bisphenol a substitutes and obesity in US adults: analysis of a population-based, cross-sectional study","volume":"1","author":"Liu","year":"2017","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.envint.2025.109882_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107616","article-title":"Seasonal variation of short-, medium- and long-chain chlorinated paraffin distribution in Belgian indoor dust","volume":"170","author":"McGrath","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109882_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121994","article-title":"An international investigation of chlorinated paraffin concentrations and homologue distributions in indoor dust","volume":"333","author":"McGrath","year":"2023","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.envint.2025.109882_b0120","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1038\/s41467-023-38215-z","article-title":"A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides","volume":"14","author":"Paul","year":"2023","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.envint.2025.109882_b0125","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/ina.12813","article-title":"Indoor phthalate exposure and contributions to total intake among pregnant women in the SELMA study","volume":"31","author":"Preece","year":"2021","journal-title":"Indoor Air"},{"key":"10.1016\/j.envint.2025.109882_b0130","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.tiv.2016.02.020","article-title":"The estrogenic and androgenic potential of pyrethroids in vitro. Review","volume":"34","author":"Saillenfait","year":"2016","journal-title":"Toxicol. In Vitro"},{"issue":"3","key":"10.1016\/j.envint.2025.109882_b0135","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4300\/JGME-D-12-00156.1","article-title":"Using effect size-or why the P value is not enough","volume":"4","author":"Sullivan","year":"2012","journal-title":"J. Grad. Med. Educ."},{"issue":"17","key":"10.1016\/j.envint.2025.109882_b0140","doi-asserted-by":"crossref","first-page":"12190","DOI":"10.1021\/acs.est.2c02106","article-title":"Emerging plasticizers in South China house dust and hand wipes: calling for potential concern?","volume":"56","author":"Tao","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.envint.2025.109882_b0145","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1016\/S2542-5196(23)00270-X","article-title":"Prenatal phthalate exposure and adverse birth outcomes in the USA: a prospective analysis of births and estimates of attributable burden and costs","volume":"8","author":"Trasande","year":"2024","journal-title":"Lancet Planet Health"},{"issue":"1","key":"10.1016\/j.envint.2025.109882_b0150","doi-asserted-by":"crossref","first-page":"e282","DOI":"10.1097\/EE9.0000000000000282","article-title":"Child exposure to organophosphate and pyrethroid insecticides measured in urine, wristbands, and household dust and its implications for child health in South Africa: a panel study","volume":"8","author":"Veludo","year":"2023","journal-title":"Environ. Epidemiol."},{"issue":"7","key":"10.1016\/j.envint.2025.109882_b0155","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1002\/tox.22407","article-title":"Cis\u2010bifenthrin induces immunotoxicity in adolescent male C57BL\/6 mice","volume":"32","author":"Wang","year":"2017","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envint.2025.109882_b0160","unstructured":"WHO. Health data: A critical element to meet the SDGs. 2020. https:\/\/www.who.int\/data\/stories\/health-data-a-critical-element-to-meet-the-sdgs."},{"issue":"48","key":"10.1016\/j.envint.2025.109882_b0165","doi-asserted-by":"crossref","first-page":"19285","DOI":"10.1021\/acs.est.3c05040","article-title":"Quantitative metabolism and urinary elimination kinetics of seven neonicotinoids and neonicotinoid-like compounds in humans","volume":"57","author":"Wrobel","year":"2023","journal-title":"Environ. Sci. Technol."},{"issue":"W1","key":"10.1016\/j.envint.2025.109882_b0170","doi-asserted-by":"crossref","first-page":"W5","DOI":"10.1093\/nar\/gkab255","article-title":"ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties","volume":"49","author":"Xiong","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envint.2025.109882_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.133701","article-title":"Bisphenol a and its analogues in paired urine and house dust from South China and implications for children's exposure","volume":"294","author":"Yang","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2025.109882_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111175","article-title":"Occurrence and distribution of neonicotinoids and characteristic metabolites in paired urine and indoor dust from young adults: Implications for human exposure","volume":"199","author":"Zhang","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2025.109882_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107557","article-title":"Distribution of flame retardants among indoor dust, airborne particles and vapour phase from Beijing: spatial-temporal variation and human exposure characteristics","volume":"170","author":"Zhang","year":"2022","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.envint.2025.109882_b0190","doi-asserted-by":"crossref","first-page":"47014","DOI":"10.1289\/EHP7722","article-title":"Risk-based chemical ranking and generating a prioritized human exposome database","volume":"129","author":"Zhao","year":"2021","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.envint.2025.109882_b0195","doi-asserted-by":"crossref","first-page":"37009","DOI":"10.1289\/EHP11305","article-title":"HExpPredict: in vivo exposure prediction of human blood exposome using a random forest model and its application in chemical risk prioritization","volume":"131","author":"Zhao","year":"2023","journal-title":"Environ. Health Perspect."}],"updated-by":[{"DOI":"10.1016\/j.envint.2025.109919","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000}},{"DOI":"10.1016\/j.envint.2026.110051","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000}},{"DOI":"10.1016\/j.envint.2026.110051","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000}}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412025006336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412025006336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T08:26:43Z","timestamp":1780820803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412025006336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":39,"alternative-id":["S0160412025006336"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2025.109882","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk based ranking of prioritized pesticides: where the exposome meets comparative toxicogenomics","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2025.109882","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109882"}}