{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:03:57Z","timestamp":1792461837304,"version":"4.5.0"},"reference-count":132,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5UG3OD035508"],"award-info":[{"award-number":["5UG3OD035508"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH3OD023271"],"award-info":[{"award-number":["UH3OD023271"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES033785"],"award-info":[{"award-number":["R01ES033785"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES007033"],"award-info":[{"award-number":["P30ES007033"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.envint.2025.109949","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T02:36:00Z","timestamp":1763692560000},"page":"109949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The placental transcriptome serves as a mechanistic link between prenatal phthalate exposure and placental efficiency"],"prefix":"10.1016","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4052-176X","authenticated-orcid":false,"given":"Mariana","family":"Parenti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6299-7633","authenticated-orcid":false,"given":"Samantha","family":"Lapehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-7626","authenticated-orcid":false,"given":"James","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-2825","authenticated-orcid":false,"given":"Theo","family":"Bammler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Szpiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marnie","family":"Hazlehurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2606-2050","authenticated-orcid":false,"given":"Drew B.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5734-8508","authenticated-orcid":false,"given":"Ciara","family":"Thoreson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurunthachalam","family":"Kannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0217-9975","authenticated-orcid":false,"given":"Nicole R.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaja Z.","family":"LeWinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheela","family":"Sathyanarayana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison G.","family":"Paquette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2025.109949_b0005","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1289\/ehp.0900788","article-title":"Transcriptional biomarkers of steroidogenesis and trophoblast differentiation in the placenta in relation to prenatal phthalate exposure","volume":"118","author":"Adibi","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2025.109949_b0010","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.placenta.2008.12.001","article-title":"Adhesion molecules in human trophoblast \u2013 a review I. Villous Trophoblast","volume":"30","author":"Aplin","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109949_b0015","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tips.2015.09.001","article-title":"Smoothened regulation: a tale of two signals","volume":"37","author":"Arensdorf","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.envint.2025.109949_b0020","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100144RRR","article-title":"Placental gene network modules are associated with maternal stress during pregnancy and infant temperament","volume":"35","author":"Aushev","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.envint.2025.109949_b0025","doi-asserted-by":"crossref","first-page":"S928","DOI":"10.1016\/j.ajog.2020.11.005","article-title":"Placental energy metabolism in health and disease\u2014significance of development and implications for preeclampsia","volume":"226","author":"Aye","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.envint.2025.109949_b0030","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/14767058.2020.1722632","article-title":"Metabolomic identification of placental alterations in fetal growth restriction","volume":"35","author":"Bahado-Singh","year":"2022","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.envint.2025.109949_b0035","doi-asserted-by":"crossref","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Roy. Statist. Soc. B"},{"key":"10.1016\/j.envint.2025.109949_b0040","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1056\/NEJMms2029562","article-title":"Race and genetic ancestry in medicine \u2014 a time for reckoning with racism","volume":"384","author":"Borrell","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envint.2025.109949_b0045","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12940-018-0400-3","article-title":"Associations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores","volume":"17","author":"Boss","year":"2018","journal-title":"Environ. Health"},{"key":"10.1016\/j.envint.2025.109949_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2023.108354","article-title":"Maternal exposure to phthalates and total gestational weight gain in the LIFECODES birth cohort","volume":"117","author":"Boyer","year":"2023","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envint.2025.109949_b0055","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat Biotech"},{"key":"10.1016\/j.envint.2025.109949_b0060","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1289\/EHP595","article-title":"Small-Magnitude effect Sizes in Epigenetic End Points are Important in Children\u2019s Environmental Health Studies: the Children\u2019s Environmental Health and Disease Prevention Research Center\u2019s Epigenetics Working Group","volume":"125","author":"Breton","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2025.109949_b0065","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13293-016-0119-1","article-title":"Sex-specific differences in fetal and infant growth patterns: a prospective population-based cohort study","volume":"7","author":"Broere-Brown","year":"2016","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.envint.2025.109949_b0070","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1093\/bioinformatics\/btx373","article-title":"FQC Dashboard: integrates FastQC results into a web-based, interactive, and extensible FASTQ quality control tool","volume":"33","author":"Brown","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envint.2025.109949_b0075","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/jamapsychiatry.2021.2877","article-title":"Race as a social construct in psychiatry research and practice","volume":"79","author":"Bryant","year":"2022","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.envint.2025.109949_b0080","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/EDE.0000000000000436","article-title":"Prenatal phthalate exposures and body mass index among 4- to 7-year-old children: a pooled analysis","volume":"27","author":"Buckley","year":"2016","journal-title":"Epidemiology"},{"key":"10.1016\/j.envint.2025.109949_b0085","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","article-title":"Placental origins of chronic disease","volume":"96","author":"Burton","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.envint.2025.109949_b0090","first-page":"S6","article-title":"What is the placenta?","volume":"213, S6.e1","author":"Burton","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.envint.2025.109949_b0095","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s42003-023-04623-6","article-title":"Placental cell type deconvolution reveals that cell proportions drive preeclampsia gene expression differences","volume":"6","author":"Campbell","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.envint.2025.109949_b0100","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/1354750X.2010.533285","article-title":"Meeting-in-the-middle using metabolic profiling - a strategy for the identification of intermediate biomarkers in cohort studies","volume":"16","author":"Chadeau-Hyam","year":"2011","journal-title":"Biomarkers"},{"key":"10.1016\/j.envint.2025.109949_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.151261","article-title":"The sex-specific association of prenatal phthalate exposure with low birth weight and small for gestational age: a nationwide survey by the Taiwan Maternal and Infant Cohort Study (TMICS)","volume":"806","author":"Chang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2025.109949_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106964","article-title":"Per- and polyfluoroalkyl substance (PFAS) exposure, maternal metabolomic perturbation, and fetal growth in African American women: a meet-in-the-middle approach","volume":"158","author":"Chang","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109949_b0115","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1021\/acs.chemrestox.0c00333","article-title":"Linking coregulated gene modules with polycyclic aromatic hydrocarbon-related cancer risk in the 3D human bronchial epithelium","volume":"34","author":"Chang","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envint.2025.109949_b0120","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10061411","article-title":"A Metabolomic profiling of intra-uterine growth restriction in placenta and cord blood points to an impairment of lipid and energetic metabolism","volume":"10","author":"Chao de la Barca","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.envint.2025.109949_b0125","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/jhg.2014.63","article-title":"Alterations to DNA methylation and expression of CXCL14 are associated with suboptimal birth outcomes","volume":"59","author":"Cheong","year":"2014","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.envint.2025.109949_b0130","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.placenta.2018.06.311","article-title":"The problem with using the birthweight:placental weight ratio as a measure of placental efficiency","volume":"68","author":"Christians","year":"2018","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109949_b0135","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/mutage\/gex001","article-title":"Infant birth outcomes are associated with DNA damage biomarkers as measured by the cytokinesis block micronucleus cytome assay: the DADHI study","volume":"32","author":"Dass Singh","year":"2017","journal-title":"Mutagenesis"},{"key":"10.1016\/j.envint.2025.109949_b0140","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mce.2009.02.017","article-title":"PPAR-mediated activity of phthalates: a link to the obesity epidemic?","volume":"304","author":"Desvergne","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envint.2025.109949_b0145","doi-asserted-by":"crossref","first-page":"E519","DOI":"10.1152\/ajpendo.90436.2008","article-title":"Fetal growth restriction triggered by polycyclic aromatic hydrocarbons is associated with altered placental vasculature and AhR-dependent changes in cell death","volume":"295","author":"Detmar","year":"2008","journal-title":"Am. J. Physiol.-Endocrinol. Metabol."},{"key":"10.1016\/j.envint.2025.109949_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111342","article-title":"Placental gene networks at the interface between maternal PM2.5 exposure early in gestation and reduced infant birthweight","volume":"199","author":"Deyssenroth","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2025.109949_b0155","doi-asserted-by":"crossref","first-page":"E1468","DOI":"10.1210\/jc.2012-1064","article-title":"Placental expression of peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3): relation to placental and fetal growth","volume":"97","author":"D\u00edaz","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.envint.2025.109949_b0160","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/03602532.2019.1620762","article-title":"A review of phthalate pharmacokinetics in human and rat: what factors drive phthalate distribution and partitioning?","volume":"51","author":"Dom\u00ednguez-Romero","year":"2019","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.envint.2025.109949_b0165","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.toxlet.2017.08.002","article-title":"Cell-specific and dose-dependent effects of PAHs on proliferation, cell cycle, and apoptosis protein expression and hormone secretion by placental cell lines","volume":"280","author":"Drwal","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envint.2025.109949_b0170","article-title":"Placental single cell transcriptomics: Opportunities for endocrine disrupting chemical toxicology","volume":"112066","author":"Elkin","year":"2023","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envint.2025.109949_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107310","article-title":"Prenatal exposure to particulate matter and placental gene expression","volume":"165","author":"Enquobahrie","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109949_b0180","doi-asserted-by":"crossref","DOI":"10.1007\/s40572-018-0204-1","article-title":"Integrating -omics approaches into human population-based studies of prenatal and early-life exposures","author":"Everson","year":"2018","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.envint.2025.109949_b0185","doi-asserted-by":"crossref","first-page":"47006","DOI":"10.1289\/EHP10077","article-title":"Prenatal phthalate exposure and child weight and adiposity from in utero to 6 years of age","volume":"130","author":"Ferguson","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2025.109949_b0190","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.placenta.2015.04.002","article-title":"Phthalate metabolites and bisphenol-a in association with circulating angiogenic biomarkers across pregnancy","volume":"36","author":"Ferguson","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109949_b0195","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.envint.2014.05.016","article-title":"Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth","volume":"70","author":"Ferguson","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109949_b0200","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1001\/jamapediatrics.2013.3699","article-title":"Environmental phthalate exposure and preterm birth","volume":"168","author":"Ferguson","year":"2014","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.envint.2025.109949_b0205","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.envint.2016.06.013","article-title":"Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth","volume":"94","author":"Ferguson","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109949_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105099","article-title":"Environmental phthalate exposure and preterm birth in the PROTECT birth cohort","volume":"132","author":"Ferguson","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109949_b0215","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1113\/jphysiol.2009.173013","article-title":"Placental efficiency and adaptation: endocrine regulation","volume":"587","author":"Fowden","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.envint.2025.109949_b0220","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jri.2011.02.004","article-title":"DNA damage and health in pregnancy","volume":"89","author":"Furness","year":"2011","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.envint.2025.109949_b0225","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.taap.2017.04.014","article-title":"Mono-2-ethylhexyl phthalate inhibits human extravillous trophoblast invasion via the PPARgamma pathway","volume":"327","author":"Gao","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2025.109949_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108930","article-title":"Integrating multi-omics with environmental data for precision health: a novel analytic framework and case study on prenatal mercury induced childhood fatty liver disease","volume":"190","author":"Goodrich","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109949_b0235","doi-asserted-by":"crossref","DOI":"10.3390\/metabo9080157","article-title":"Bronchoalveolar lavage fluid from COPD patients reveals more compounds associated with disease than matched plasma","volume":"9","author":"Halper-Stromberg","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.envint.2025.109949_b0240","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/biostatistics\/kxr054","article-title":"Removing technical variability in RNA-seq data using conditional quantile normalization","volume":"13","author":"Hansen","year":"2012","journal-title":"Biostatistics"},{"key":"10.1016\/j.envint.2025.109949_b0245","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fphys.2016.00028","article-title":"Placental adaptation: what can we learn from birthweight: placental weight ratio?","volume":"7","author":"Hayward","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.envint.2025.109949_b0250","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1038\/s41467-025-57273-z","article-title":"Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment","volume":"16","author":"Hoffman","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envint.2025.109949_b0255","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/toxsci\/kfg145","article-title":"Activation of PPARalpha and PPARgamma by environmental phthalate monoesters","volume":"74","author":"Hurst","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2025.109949_b0260","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1093\/aje\/kwm327","article-title":"The missing data problem in birth weight percentiles and thresholds for \u201csmall-for-gestational-age","volume":"167","author":"Hutcheon","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envint.2025.109949_b0265","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12884-024-06431-0","article-title":"Smoking during pregnancy and its effect on placental weight: a Mendelian randomization study","volume":"24","author":"Jaitner","year":"2024","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.envint.2025.109949_b0270","doi-asserted-by":"crossref","unstructured":"Jovanovic, N., Mustieles, V., Althuser, M., Lyon-Caen, S., Alfaidy, N., Thomsen, C., Sakhi, A.K., Sabaredzovic, A., Bayat, S., Couturier-Tarrade, A., Slama, R., Philippat, C., 2024. Associations between synthetic phenols, phthalates, and placental growth\/function: a longitudinal cohort with exposure assessment in early pregnancy. Human Reproduction Open 2024, hoae018. Doi: 10.1093\/hropen\/hoae018.","DOI":"10.1093\/hropen\/hoae018"},{"key":"10.1016\/j.envint.2025.109949_b0275","doi-asserted-by":"crossref","first-page":"47011","DOI":"10.1289\/EHP11559","article-title":"High-dimensional mediation analysis: a new method applied to maternal smoking, placental DNA methylation, and birth outcomes","volume":"131","author":"Jumentier","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2025.109949_b0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12940-019-0480-8","article-title":"Fetal growth in environmental epidemiology: mechanisms, limitations, and a review of associations with biomarkers of non-persistent chemical exposures during pregnancy","volume":"18","author":"Kamai","year":"2019","journal-title":"Environ. Health"},{"key":"10.1016\/j.envint.2025.109949_b0285","doi-asserted-by":"crossref","first-page":"47004","DOI":"10.1289\/EHP5838","article-title":"A quantile-based g-computation approach to addressing the effects of exposure mixtures","volume":"128","author":"Keil","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2025.109949_b0290","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13072-023-00507-5","article-title":"The application of epiphenotyping approaches to DNA methylation array studies of the human placenta","volume":"16","author":"Khan","year":"2023","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.envint.2025.109949_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108862","article-title":"Prenatal exposure to environmental phenols and phthalates and altered patterns of DNA methylation in childhood","volume":"190","author":"Khodasevich","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109949_b0300","doi-asserted-by":"crossref","first-page":"358","DOI":"10.5468\/ogs.2014.57.5.358","article-title":"The significance of placental ratios in pregnancies complicated by small for gestational age, preeclampsia, and gestational diabetes mellitus","volume":"57","author":"Kim","year":"2014","journal-title":"Obstet Gynecol Sci"},{"key":"10.1016\/j.envint.2025.109949_b0305","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2605.2005.00607.x","article-title":"Di(2-ethylhexyl)phthalate (DEHP): human metabolism and internal exposure\u2013 an update and latest results","volume":"29","author":"Koch","year":"2006","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.envint.2025.109949_b0310","doi-asserted-by":"crossref","first-page":"5596","DOI":"10.1210\/en.2009-0570","article-title":"The cytokine gene CXCL14 restricts human trophoblast cell invasion by suppressing gelatinase activity","volume":"150","author":"Kuang","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.envint.2025.109949_b0315","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/EDE.0000000000001496","article-title":"Combining urinary biomarker data from studies with different measures of urinary dilution","volume":"33","author":"Kuiper","year":"2022","journal-title":"Epidemiology"},{"key":"10.1016\/j.envint.2025.109949_b0320","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.envint.2025.109949_b0325","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-023-03444-0","article-title":"Mono(2-ethylhexyl) phthalate induces transcriptomic changes in placental cells based on concentration, fetal sex, and trophoblast cell type","author":"Lapehn","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2025.109949_b0330","doi-asserted-by":"crossref","DOI":"10.1007\/s40572-022-00354-8","article-title":"The placental epigenome as a molecular link between prenatal exposures and fetal health outcomes through the DOHaD hypothesis","author":"Lapehn","year":"2022","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.envint.2025.109949_b0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109402","article-title":"An assessment of organophosphate ester mixtures and the placental transcriptome","volume":"198","author":"Lapehn","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109949_b0340","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/uog.27610","article-title":"Assessment of fetal growth trajectory identifies infants at high risk of perinatal mortality","volume":"63","author":"Larsen","year":"2024","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.envint.2025.109949_b0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.envint.2025.109949_b0350","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-064288","article-title":"Cohort profile: the ECHO prenatal and early childhood pathways to health consortium (ECHO-PATHWAYS)","volume":"12","author":"LeWinn","year":"2022","journal-title":"BMJ Open"},{"key":"10.1016\/j.envint.2025.109949_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.115490","article-title":"Associations between prenatal organophosphate pesticide exposure and placental gene networks","volume":"224","author":"Li","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2025.109949_b0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.119458","article-title":"Comparative cytotoxicity, endocrine-disrupting effects, oxidative stress of halophenolic disinfection byproducts and the underlying molecular mechanisms revealed by transcriptome analysis","volume":"229","author":"Li","year":"2023","journal-title":"Water Res."},{"key":"10.1016\/j.envint.2025.109949_b0365","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41420-023-01670-0","article-title":"A comprehensive review of human trophoblast fusion models: recent developments and challenges","volume":"9","author":"Li","year":"2023","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.envint.2025.109949_b0370","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13287-016-0340-1","article-title":"Single-stranded DNA binding protein Ssbp3 induces differentiation of mouse embryonic stem cells into trophoblast-like cells","volume":"7","author":"Liu","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.envint.2025.109949_b0375","doi-asserted-by":"crossref","first-page":"e2966","DOI":"10.1038\/cddis.2017.350","article-title":"Di (2-ethylhexyl) phthalate exposure impairs meiotic progression and DNA damage repair in fetal mouse oocytes in vitro","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.envint.2025.109949_b0380","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1477-7827-5-6","article-title":"Control of human trophoblast function","volume":"5","author":"Lunghi","year":"2007","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.envint.2025.109949_b0385","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1055\/s-0038-1627473","article-title":"Differential methylation of syncytin-1 and 2 distinguishes fetal growth restriction from physiologic small for gestational age","volume":"8","author":"Makaroun","year":"2018","journal-title":"AJP Rep"},{"key":"10.1016\/j.envint.2025.109949_b0390","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1289\/ehp.1408750","article-title":"Prenatal exposure to phthalates and childhood body size in an urban cohort","volume":"124","author":"Maresca","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2025.109949_b0395","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ygcen.2014.11.003","article-title":"Plasticizer endocrine disruption: highlighting developmental and reproductive effects in mammals and non-mammalian aquatic species","volume":"219","author":"Mathieu-Denoncourt","year":"2015","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.envint.2025.109949_b0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108678","article-title":"Urinary concentrations of phthalate metabolites in relation to preeclampsia and other hypertensive disorders of pregnancy in the environmental influences on child health outcomes (ECHO) program","volume":"187","author":"Meeker","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109949_b0405","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.placenta.2009.09.008","article-title":"Non-linear and gender-specific relationships among placental growth measures and the fetoplacental weight ratio","volume":"30","author":"Misra","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109949_b0410","doi-asserted-by":"crossref","first-page":"C694","DOI":"10.1152\/ajpcell.00177.2021","article-title":"Syncytialization alters the extracellular matrix and barrier function of placental trophoblasts","volume":"321","author":"Moore","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.envint.2025.109949_b0415","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1542\/neo.17-2-e70","article-title":"Impact of obesity on uteroplacental immunology and placental pathology","volume":"17","author":"Morgan","year":"2016","journal-title":"NeoReviews"},{"key":"10.1016\/j.envint.2025.109949_b0420","doi-asserted-by":"crossref","first-page":"e518","DOI":"10.1542\/neo.15-12-e518","article-title":"Placental insufficiency is a leading cause of preterm labor","volume":"15","author":"Morgan","year":"2014","journal-title":"NeoReviews"},{"key":"10.1016\/j.envint.2025.109949_b0425","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.placenta.2021.01.007","article-title":"Placental blood flow sensing and regulation in fetal growth restriction","volume":"113","author":"Morley","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109949_b0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.115227","article-title":"Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment","volume":"220","author":"Mouat","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2025.109949_b0435","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.envres.2018.11.022","article-title":"Placental weight in relation to maternal and paternal preconception and prenatal urinary phthalate metabolite concentrations among subfertile couples","volume":"169","author":"Mustieles","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2025.109949_b0440","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1242\/dev.01844","article-title":"Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex","volume":"132","author":"Nishioka","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.envint.2025.109949_b0445","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1289\/ehp.1509693","article-title":"Environmental chemicals in urine and blood: improving methods for creatinine and lipid adjustment","volume":"124","author":"O\u2019Brien","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2025.109949_b0450","doi-asserted-by":"crossref","first-page":"57002","DOI":"10.1289\/EHP13644","article-title":"Fetal and infancy exposure to phenols, parabens, and phthalates and anthropometric measurements up to 36 months, in the longitudinal SEPAGES Cohort","volume":"132","author":"Ouidir","year":"2024","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2025.109949_b0455","article-title":"Placental transcriptomic signatures of spontaneous preterm birth","author":"Paquette","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.envint.2025.109949_b0460","doi-asserted-by":"crossref","first-page":"097003","DOI":"10.1289\/EHP8973","article-title":"A Comprehensive assessment of associations between prenatal phthalate exposure and the placental transcriptomic landscape","volume":"129","author":"Paquette","year":"2021","journal-title":"Environ. Health Perspect"},{"key":"10.1016\/j.envint.2025.109949_b0470","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3390\/metabo12090829","article-title":"Maternal serum and placental metabolomes in association with prenatal phthalate exposure and neurodevelopmental outcomes in the MARBLES Cohort","volume":"12","author":"Parenti","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.envint.2025.109949_b0475","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/aje\/kwae073","article-title":"How the Environmental Influences on Child Health Outcome (ECHO) cohort can spur discoveries in environmental epidemiology","volume":"193","author":"Park","year":"2024","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envint.2025.109949_b0480","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/EDE.0000000000000460","article-title":"Within-subject pooling of biological samples to reduce exposure misclassification in biomarker-based studies","volume":"27","author":"Perrier","year":"2016","journal-title":"Epidemiology"},{"key":"10.1016\/j.envint.2025.109949_b0485","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/molehr\/gau102","article-title":"Trophoblast syncytialisation necessitates mitochondrial function through estrogen-related receptor-\u03b3 activation","volume":"21","author":"Poidatz","year":"2015","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.envint.2025.109949_b0490","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13293-022-00445-z","article-title":"Fetal sex impacts birth to placental weight ratio and umbilical cord oxygen values with implications for regulatory mechanisms","volume":"13","author":"Richardson","year":"2022","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.envint.2025.109949_b0495","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/aje\/kwp182","article-title":"Placental weight relative to birth weight and long-term cardiovascular mortality: findings from a cohort of 31,307 men and women","volume":"170","author":"Risnes","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envint.2025.109949_b0500","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000047129","article-title":"Relation between birth weight and placenta weight","volume":"80","author":"Sanin","year":"2001","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.envint.2025.109949_b0505","first-page":"34","article-title":"Phthalates and Children\u2019s health","volume":"38","author":"Sathyanarayana","year":"2008","journal-title":"Curr. Probl. Pediatr. Adolesc. Health Care"},{"key":"10.1016\/j.envint.2025.109949_b0510","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/toxsci\/kfac060","article-title":"Phthalate exposures and placental health in animal models and humans: a systematic review","volume":"188","author":"Seymore","year":"2022","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2025.109949_b0515","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-0897.2010.00837.x","article-title":"Placental apoptosis in health and disease","volume":"64","author":"Sharp","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.envint.2025.109949_b0520","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1471-0528.2011.02892.x","article-title":"Placenta\/birthweight ratio and perinatal outcome: a retrospective cohort analysis","volume":"118","author":"Shehata","year":"2011","journal-title":"BJOG"},{"key":"10.1016\/j.envint.2025.109949_b0525","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10120754","article-title":"Associations between phthalate exposure and gestational age at delivery in a diverse pregnancy cohort","volume":"10","author":"Sienas","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.envint.2025.109949_b0530","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/tropej\/fmt030","article-title":"Placental weight: Relation to maternal weight and growth parameters of full-term babies at birth and during childhood","volume":"59","author":"Soliman","year":"2013","journal-title":"J. Trop. Pediatr."},{"key":"10.1016\/j.envint.2025.109949_b0535","doi-asserted-by":"crossref","unstructured":"Soneson, C., Love, M., Robinson, M., 2015. Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences [version 1; referees: 2 approved]. F1000Research 4. Doi: 10.12688\/f1000research.7563.1.","DOI":"10.12688\/f1000research.7563.1"},{"key":"10.1016\/j.envint.2025.109949_b0540","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2350\/13-09-1378-OA.1","article-title":"Histologic differences in placentas of preeclamptic\/eclamptic gestations by birthweight, placental weight, and time of onset","volume":"17","author":"Stark","year":"2014","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.envint.2025.109949_b0545","doi-asserted-by":"crossref","first-page":"87017","DOI":"10.1289\/EHP12500","article-title":"Midpregnancy phthalate and phenol biomarkers in relation to infant body composition: the healthy start prospective cohort","volume":"131","author":"Stevens","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2025.109949_b0550","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/toxsci\/kfy224","article-title":"Using experimental models to assess effects of Bisphenol A (BPA) and phthalates on the placenta: challenges and perspectives","volume":"166","author":"Strakovsky","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2025.109949_b0555","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1038\/s41467-023-38710-3","article-title":"Newborn metabolomic signatures of maternal per- and polyfluoroalkyl substance exposure and reduced length of gestation","volume":"14","author":"Taibl","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envint.2025.109949_b0560","first-page":"1438","article-title":"Hedgehog signaling through GLI1 and GLI2 is required for epithelial-mesenchymal transition in human trophoblasts","volume":"1850","author":"Tang","year":"2015","journal-title":"BBA"},{"key":"10.1016\/j.envint.2025.109949_b0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107678","article-title":"Increased maternal non-oxidative energy metabolism mediates association between prenatal di-(2-ethylhexyl) phthalate (DEHP) exposure and offspring autism spectrum disorder symptoms in early life: a birth cohort study","volume":"171","author":"Thomson","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109949_b0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105508","article-title":"Selenium-associated DNA methylation modifications in placenta and neurobehavioral development of newborns: an epigenome-wide study of two U.S. birth cohorts","volume":"137","author":"Tian","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2025.109949_b0575","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1016\/S2542-5196(23)00270-X","article-title":"Prenatal phthalate exposure and adverse birth outcomes in the USA: a prospective analysis of births and estimates of attributable burden and costs","volume":"8","author":"Trasande","year":"2024","journal-title":"The Lancet Planetary Health"},{"key":"10.1016\/j.envint.2025.109949_b0580","unstructured":"United States Environmental Protection Agency, 2025. Risk Evaluation for Diisodecyl Phthalate (DIDP)."},{"key":"10.1016\/j.envint.2025.109949_b0585","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2025.108835","article-title":"The associations between prenatal plastic phthalate exposure and lipid acylcarnitine levels in humans and mice","volume":"132","author":"Vacy","year":"2025","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envint.2025.109949_b0590","doi-asserted-by":"crossref","DOI":"10.1080\/15592294.2024.2318516","article-title":"The one-carbon metabolism as an underlying pathway for placental DNA methylation - a systematic review","volume":"19","author":"van Vliet","year":"2024","journal-title":"Epigenetics"},{"key":"10.1016\/j.envint.2025.109949_b0595","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.envint.2025.109949_b0600","doi-asserted-by":"crossref","unstructured":"Welch, B.M., Keil, A.P., Buckley, J.P., Calafat, A.M., Christenbury, K.E., Engel, S.M., O\u2019Brien, K.M., Rosen, E.M., James-Todd, T., Zota, A.R., Ferguson, K.K., Pooled Phthalate Exposure and Preterm Birth Study Group, Alshawabkeh, A.N., Cordero, J.F., Meeker, J.D., Barrett, E.S., Bush, N.R., Nguyen, R.H.N., Sathyanarayana, S., Swan, S.H., Cantonwine, D.E., McElrath, T.F., Aalborg, J., Dabelea, D., Starling, A.P., Hauser, R., Messerlian, C., Zhang, Y., Bradman, A., Eskenazi, B., Harley, K.G., Holland, N., Bloom, M.S., Newman, R.B., Wenzel, A.G., Braun, J.M., Lanphear, B.P., Yolton, K., Factor-Litvak, P., Herbstman, J.B., Rauh, V.A., Drobnis, E.Z., Sparks, A.E., Redmon, J.B., Wang, C., Binder, A.M., Michels, K.B., Baird, D.D., Jukic, A.M.Z., Weinberg, C.R., Wilcox, A.J., Rich, D.Q., Weinberger, B., Padmanabhan, V., Watkins, D.J., Hertz-Picciotto, I., Schmidt, R.J., 2022. Associations between prenatal urinary biomarkers of phthalate exposure and preterm birth: a pooled study of 16 US cohorts. JAMA Pediatr 176, 895\u2013905. Doi: 10.1001\/jamapediatrics.2022.2252.","DOI":"10.1001\/jamapediatrics.2022.2252"},{"key":"10.1016\/j.envint.2025.109949_b0605","doi-asserted-by":"crossref","DOI":"10.1038\/s41370-024-00696-5","article-title":"Maternal phthalate exposure and BMI trajectory in children\u2014an 18-year birth cohort follow-up study","author":"Wen","year":"2024","journal-title":"J. Eposure Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envint.2025.109949_b0610","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1093\/aje\/kwr230","article-title":"On the pitfalls of adjusting for gestational age at birth","volume":"174","author":"Wilcox","year":"2011","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envint.2025.109949_b0615","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12940-019-0535-x","article-title":"Transcriptome-wide analysis of changes in the fetal placenta associated with prenatal arsenic exposure in the New Hampshire Birth Cohort Study","volume":"18","author":"Winterbottom","year":"2019","journal-title":"Environ. Health"},{"key":"10.1016\/j.envint.2025.109949_b0620","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s12640-016-9665-x","volume":"31","author":"W\u00f3jtowicz","year":"2017","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.envint.2025.109949_b0625","first-page":"641","article-title":"Effect of mono-2-ethyhexyl phthalate on DNA methylation in human prostate cancer LNCaP cells","volume":"30","author":"Wu","year":"2017","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.envint.2025.109949_b0630","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2020.105469","article-title":"Exposure to phthalates impaired neurodevelopment through estrogenic effects and induced DNA damage in neurons","volume":"222","author":"Xu","year":"2020","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envint.2025.109949_b0635","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.placenta.2021.12.014","article-title":"Placental characteristics and risks of maternal mortality 50 years after delivery","volume":"117","author":"Yeung","year":"2022","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2025.109949_b0640","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tiv.2015.12.012","article-title":"Mono-2-ethyhexyl phthalate advancing the progression of prostate cancer through activating the hedgehog pathway in LNCaP cells","volume":"32","author":"Yong","year":"2016","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.envint.2025.109949_b0645","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12885-021-07972-9","article-title":"Identification and validation of a five-lncRNA prognostic signature related to Glioma using bioinformatics analysis","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Can."},{"key":"10.1016\/j.envint.2025.109949_b0650","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1093\/bioinformatics\/btw351","article-title":"Estimating and testing high-dimensional mediation effects in epigenetic studies","volume":"32","author":"Zhang","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envint.2025.109949_b0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102414","article-title":"Compartmentalized regulation of NAD(+) by Di (2-ethyl-hexyl) phthalate induces DNA damage in placental trophoblast","volume":"55","author":"Zhao","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.envint.2025.109949_b0660","article-title":"Regulators involved in trophoblast syncytialization in the placenta of intrauterine growth restriction","volume":"14","author":"Zhou","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.envint.2025.109949_b0665","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jhazmat.2015.04.065","article-title":"Maternal exposure to di-(2-ethylhexyl) phthalate disrupts placental growth and development in pregnant mice","volume":"297","author":"Zong","year":"2015","journal-title":"J. Hazard. Mater."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412025007007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412025007007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:43:53Z","timestamp":1781325833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412025007007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":132,"alternative-id":["S0160412025007007"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2025.109949","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The placental transcriptome serves as a mechanistic link between prenatal phthalate exposure and placental efficiency","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2025.109949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109949"}}