{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:26:36Z","timestamp":1788233196079,"version":"build-2803163510"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2016-05176"],"award-info":[{"award-number":["2016-05176"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2020-03674"],"award-info":[{"award-number":["2020-03674"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019-00869"],"award-info":[{"award-number":["2019-00869"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003170","name":"Knowledge Foundation","doi-asserted-by":"publisher","award":["20220122"],"award-info":[{"award-number":["20220122"]}],"id":[{"id":"10.13039\/501100003170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007797","name":"Helsingin Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["250114"],"award-info":[{"award-number":["250114"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["363417"],"award-info":[{"award-number":["363417"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["2012-17"],"award-info":[{"award-number":["2012-17"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.envint.2026.110080","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:56:23Z","timestamp":1769010983000},"page":"110080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Prenatal exposure to persistent organic pollutants modulates the metabolism and gut microbiota of the offspring"],"prefix":"10.1016","volume":"208","author":[{"given":"Santosh","family":"Lamichhane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Salihovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Sinioja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvi M.","family":"Virtanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommi","family":"Vatanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matej","family":"Ore\u0161i\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Knip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuulia","family":"Hy\u00f6tyl\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.envint.2026.110080_b0005","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.cgh.2023.12.020","article-title":"Per- and poly-fluoroalkyl substances exposure is associated with later occurrence of inflammatory bowel disease","volume":"22","author":"Agrawal","year":"2024","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.envint.2026.110080_b0010","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.envint.2026.110080_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03775","article-title":"Association of plasma levels of lipid and polychlorinated biphenyls in Iranian adult","volume":"6","author":"Aminian","year":"2020","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.envint.2026.110080_b0020","first-page":"185","article-title":"Maternal concentrations of perfluoroalkyl substances and fetal markers of metabolic function and birth weight: the maternal-infant research on environmental chemicals (MIREC) study","volume":"185","author":"Ashley-Martin","year":"2017","journal-title":"Am. J. Epidemiol."},{"issue":"7","key":"10.1016\/j.envint.2026.110080_b0025","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3390\/jcm8070971","article-title":"The lipid status in patients with ulcerative colitis: sphingolipids are disease-dependent regulated","volume":"8","author":"Bazarganipour","year":"2019","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1289\/ehp.11294","article-title":"Prenatal exposure to polychlorinated biphenyls: a neuropsychologic analysis","volume":"117","author":"Boucher","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2026.110080_b0035","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.envint.2016.06.033","article-title":"The influence of maternal dietary exposure to dioxins and PCBs during pregnancy on ADHD symptoms and cognitive functions in Norwegian preschool children","volume":"94","author":"Caspersen","year":"2016","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.envint.2026.110080_b0040","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41370-023-00568-4","article-title":"Prenatal exposure to multiple environmental chemicals and birth size","volume":"34","author":"Chen","year":"2024","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"2","key":"10.1016\/j.envint.2026.110080_b0045","first-page":"269","article-title":"Gut microbiota modulates interactions between polychlorinated biphenyls and bile acid homeostasis","volume":"166","author":"Cheng","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2026.110080_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137688","article-title":"Identification of polychlorinated biphenyls (PCBs) and PCB metabolites associated with changes in the gut microbiome of female mice exposed to an environmental PCB mixture","volume":"489","author":"Dean","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2026.110080_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2020.121982","article-title":"A straightforward LC-MS\/MS analysis to study serum profile of short and medium chain fatty acids","volume":"1154","author":"Dei Cas","year":"2020","journal-title":"J. Chromatogr. B"},{"issue":"28","key":"10.1016\/j.envint.2026.110080_b0060","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2501030122","article-title":"Human milk IgA promotes normal immune development by limiting Th17-inducing Erysipelatoclostridium ramosum in the infant gut","volume":"122","author":"Donald","year":"2025","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.envint.2026.110080_b0065","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1093\/aje\/154.5.466","article-title":"Validity and reproducibility of a food frequency questionnaire for pregnant Finnish women","volume":"154","author":"Erkkola","year":"2001","journal-title":"Am. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.envint.2026.110080_b0070","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1289\/EHP303","article-title":"Early-life exposure to perfluoroalkyl substances and childhood metabolic function","volume":"125","author":"Fleisch","year":"2017","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.envint.2026.110080_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052719","article-title":"Ceramides as mediators of oxidative stress and inflammation in cardiometabolic disease","volume":"23","author":"Gaggini","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.envint.2026.110080_b0080","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3109\/1547691X.2012.755580","article-title":"Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood","volume":"10","author":"Granum","year":"2013","journal-title":"J. Immunotoxicol."},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0085","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s40168-021-01101-1","article-title":"Review: microbial transformations of human bile acids","volume":"9","author":"Guzior","year":"2021","journal-title":"Microbiome"},{"issue":"4","key":"10.1016\/j.envint.2026.110080_b0090","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.envint.2011.01.011","article-title":"Characterisation of human exposure pathways to perfluorinated compounds \u2014 comparing exposure estimates with biomarkers of exposure","volume":"37","author":"Haug","year":"2011","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110080_b0095","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.envint.2018.09.056","article-title":"In-utero and childhood chemical exposome in six European mother-child cohorts","volume":"121","author":"Haug","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110080_b0100","doi-asserted-by":"crossref","DOI":"10.1021\/es802827u","article-title":"Time trends and the influence of age and gender on serum concentrations of perfluorinated compounds in archived human samples","volume":"43","author":"Haug","year":"2009","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.envint.2026.110080_b0105","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1034\/j.1399-0039.2003.00071.x","article-title":"HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: an analysis of 622 nuclear families","volume":"62","author":"Hermann","year":"2003","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.envint.2026.110080_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.133957","article-title":"Metabolomics and lipidomics to identify biomarkers of effect related to exposure to non-dioxin-like polychlorinated biphenyls in pigs","volume":"296","author":"Hern\u00e1ndez-Mesa","year":"2022","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.envint.2026.110080_b0115","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/toxsci\/kfad053","article-title":"Public health evaluation of PFAS exposures and breastfeeding: a systematic literature review","volume":"194","author":"Hoadley","year":"2023","journal-title":"Toxicol. Sci."},{"issue":"10","key":"10.1016\/j.envint.2026.110080_b0120","doi-asserted-by":"crossref","DOI":"10.1289\/EHP12657","article-title":"Assessing metabolic differences associated with exposure to polybrominated biphenyl and polychlorinated biphenyls in the michigan PBB registry","volume":"131","author":"Hoffman","year":"2023","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0125","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in health and diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0130","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/S2542-5196(23)00257-7","article-title":"In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study","volume":"8","author":"Hy\u00f6tyl\u00e4inen","year":"2024","journal-title":"The Lancet Planetary Health"},{"key":"10.1016\/j.envint.2026.110080_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105219","article-title":"Exposures to chemical mixtures during pregnancy and neonatal outcomes: the HOME study","volume":"134","author":"Kalloo","year":"2020","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0140","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s40168-022-01374-0","article-title":"Bifidobacterial carbohydrate\/nucleoside metabolism enhances oxidative phosphorylation in white adipose tissue to protect against diet-induced obesity","volume":"10","author":"Kim","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.envint.2026.110080_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1163\/18762891-bja00092","article-title":"Lactobacillus paragasseri SBT2055 suppressed insulin resistance and fatty liver by inhibiting oxidative stress and inflammation in high-fat diet-induced obese mice","author":"Kim","year":"2025","journal-title":"Benef. Microbes"},{"issue":"9","key":"10.1016\/j.envint.2026.110080_b0150","doi-asserted-by":"crossref","first-page":"8885","DOI":"10.1007\/s11356-019-06723-5","article-title":"The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences","volume":"27","author":"Klocke","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"6","key":"10.1016\/j.envint.2026.110080_b0155","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1097\/MPG.0000000000003756","article-title":"Infant feeding, gut permeability, and gut inflammation markers","volume":"76","author":"Koivusaari","year":"2023","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.envint.2026.110080_b0160","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1527755","article-title":"Unveiling roles of beneficial gut bacteria and optimal diets for health","volume":"16","author":"Kumar","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envint.2026.110080_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107965","article-title":"Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads","volume":"176","author":"Lamichhane","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110080_b0170","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ymeth.2018.04.029","article-title":"Gut metabolome meets microbiome: a methodological perspective to understand the relationship between host and microbe","volume":"149","author":"Lamichhane","year":"2018","journal-title":"Methods"},{"key":"10.1016\/j.envint.2026.110080_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.859627","article-title":"Impact of extensively hydrolyzed infant formula on circulating lipids during early life","volume":"9","author":"Lamichhane","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.envint.2026.110080_b0180","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.683297","article-title":"Early-life exposure to per- and poly-fluorinated alkyl substances and growth, adiposity, and puberty in children: a systematic review","volume":"12","author":"Lee","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0185","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/toxsci\/kfaa090","article-title":"Gut microbiome critically impacts PCB-induced changes in metabolic fingerprints and the hepatic transcriptome in mice","volume":"177","author":"Lim","year":"2020","journal-title":"Toxicol. Sci."},{"issue":"5","key":"10.1016\/j.envint.2026.110080_b0190","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.jhep.2016.01.002","article-title":"Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease","volume":"64","author":"Luukkonen","year":"2016","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.envint.2026.110080_b0195","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrendo.2015.129","article-title":"Acylcarnitines\u2013old actors auditioning for new roles in metabolic physiology","volume":"11","author":"McCoin","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.envint.2026.110080_b0200","unstructured":"McGlinchey, A., Sinioja, T., Lamichhane, S., Bodin, J., Siljander, H., Geng, D., Carlsson, C., Duberg, D., Ilonen, J., Virtanen, S.M., Dirven, H., Berntsen, H.F., Zimmer, K., Nygaard, U.C., Ore\u0161i\u010d, M., Knip, M., Hy\u00f6tyl\u00e4inen, T., 2019. prenatal exposure to environmental chemicals modulates serum phospholipids in newborn infants, increasing later risk of type 1 diabetes. bioRxiv(588350): 588350."},{"key":"10.1016\/j.envint.2026.110080_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105935","article-title":"Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes","volume":"143","author":"McGlinchey","year":"2020","journal-title":"Environ. Int."},{"issue":"9","key":"10.1016\/j.envint.2026.110080_b0210","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1038\/oby.2009.510","article-title":"Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity","volume":"18","author":"Mihalik","year":"2010","journal-title":"Obesity (Silver Spring)"},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0215","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13148-020-00894-6","article-title":"Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation","volume":"12","author":"Ouidir","year":"2020","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.envint.2026.110080_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1348410","article-title":"A review of the mechanisms of abnormal ceramide metabolism in type 2 diabetes mellitus, Alzheimer's disease, and their co-morbidities","volume":"15","author":"Pan","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"W1","key":"10.1016\/j.envint.2026.110080_b0225","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.envint.2026.110080_b0230","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.chom.2024.10.017","article-title":"A metagenome-assembled genome inventory for children reveals early-life gut bacteriome and virome dynamics","volume":"32","author":"Peng","year":"2024","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.envint.2026.110080_b0235","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/1471-2105-11-395","article-title":"MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data","volume":"11","author":"Pluskal","year":"2010","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.envint.2026.110080_b0240","doi-asserted-by":"crossref","unstructured":"Roszczyc-Owsiejczuk, K., Zabielski, P., 2021. Sphingolipids as a culprit of mitochondrial dysfunction in insulin resistance and type 2 diabetes, Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.635175"},{"issue":"7","key":"10.1016\/j.envint.2026.110080_b0245","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.chemosphere.2011.11.006","article-title":"A rapid method for screening of the Stockholm Convention POPs in small amounts of human plasma using SPE and HRGC\/HRMS","volume":"86","author":"Salihovic","year":"2012","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.envint.2026.110080_b0250","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jhep.2021.09.039","article-title":"Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease","volume":"76","author":"Sen","year":"2022","journal-title":"J. Hepatol."},{"issue":"7","key":"10.1016\/j.envint.2026.110080_b0255","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1021\/pr300297z","article-title":"Metabolomic analysis of the effects of polychlorinated biphenyls in nonalcoholic fatty liver disease","volume":"11","author":"Shi","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.envint.2026.110080_b0260","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jpeds.2021.07.042","article-title":"Effect of early feeding on intestinal permeability and inflammation markers in infants with genetic susceptibility to type 1 diabetes: arandomized clinical trial","volume":"238","author":"Siljander","year":"2021","journal-title":"J. Pediatr."},{"key":"10.1016\/j.envint.2026.110080_b0265","doi-asserted-by":"crossref","unstructured":"Sinisalu, L., Sen, P., Salihovic, S., Virtanen, S., Hyoty, H., Ilonen, J., Toppari, J., Veijola, R., Oresic, M., Knip, M., Hyotylainen, T., 2020. Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease, 2020.2004.2002.20051359.","DOI":"10.1101\/2020.04.02.20051359"},{"key":"10.1016\/j.envint.2026.110080_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.104983","article-title":"Prenatal exposure to per- and polyfluoroalkyl substances and infant growth and adiposity: the healthy start study","volume":"131","author":"Starling","year":"2019","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.envint.2026.110080_b0275","doi-asserted-by":"crossref","DOI":"10.1289\/EHP641","article-title":"Perfluoroalkyl substances during pregnancy and offspring weight and adiposity at birth: examining mediation by maternal fasting glucose in the healthy start study","volume":"125","author":"Starling","year":"2017","journal-title":"Environ. Health Perspect."},{"issue":"Suppl 1","key":"10.1016\/j.envint.2026.110080_b0280","article-title":"Prenatal exposure to persistent organic pollutants and childhood obesity: a systematic review and meta-analysis of human studies","volume":"23","author":"Stratakis","year":"2022","journal-title":"Obes. Rev."},{"key":"10.1016\/j.envint.2026.110080_b0285","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.chroma.2018.02.057","article-title":"A method for analysis of marker persistent organic pollutants in low-volume plasma and serum samples using 96-well plate solid phase extraction","volume":"1546","author":"Stubleski","year":"2018","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0290","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/09168451.2015.1079480","article-title":"Biotransformation of (-)-epicatechin, (+)-epicatechin, (-)-catechin, and (+)-catechin by intestinal bacteria involved in isoflavone metabolism","volume":"80","author":"Takagaki","year":"2016","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.envint.2026.110080_b0295","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.envint.2018.11.067","article-title":"The early-life exposome: description and patterns in six European countries","volume":"123","author":"Tamayo-Uria","year":"2019","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0300","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3945\/ajcn.113.066720","article-title":"Association between prenatal polychlorinated biphenyl exposure and obesity development at ages 5 and 7 y: a prospective cohort study of 656 children from the Faroe Islands","volume":"99","author":"Tang-P\u00e9ronard","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.envint.2026.110080_b0305","unstructured":"Team, R.C., 2017. R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing, Vienna, Austria."},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2020.1848209","article-title":"Metabolic impact of persistent organic pollutants on gut microbiota","volume":"12","author":"Tian","year":"2020","journal-title":"Gut Microbes"},{"issue":"15","key":"10.1016\/j.envint.2026.110080_b0315","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158220","article-title":"Early life short-term exposure to polychlorinated biphenyl 126 in mice leads to metabolic dysfunction and microbiota changes in adulthood","volume":"23","author":"Tian","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2026.110080_b0320","doi-asserted-by":"crossref","unstructured":"Tito Damiani A, , Aleksandr Smirnov, S.H., Mokshyna, O., Brungs, C., Korf, A., Smith, J., Stincone, P., Dreolin Author, N., Nothias, L.-F., Hy\u00f6tyl\u00e4inen, T., Ore\u0161i\u010d , M., Karst, U., Dorrestein, P., Petras, D., Du, X., van der Hooft, J., Schmid, R., Pluskal, T., 2024. Reproducible mass spectrometry data processing and compound annotation in MZmine 3, Chemrxiv.","DOI":"10.26434\/chemrxiv-2023-98n6q-v2"},{"issue":"10","key":"10.1016\/j.envint.2026.110080_b0325","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1289\/ehp.1409062","article-title":"Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: the rhea mother-child cohort (Crete, Greece)","volume":"123","author":"Vafeiadi","year":"2015","journal-title":"Environ. Health Perspect."},{"issue":"26","key":"10.1016\/j.envint.2026.110080_b0330","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1016\/j.cell.2022.11.023","article-title":"Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism","volume":"185","author":"Vatanen","year":"2022","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0335","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1289\/ehp.0800003","article-title":"Intrauterine exposure to environmental pollutants and body mass index during the first 3 years of life","volume":"117","author":"Verhulst","year":"2009","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.envint.2026.110080_b0340","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00998-22","article-title":"Multiomics analysis reveals aberrant metabolism and immunity linked gut microbiota with insomnia","volume":"10","author":"Wang","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.envint.2026.110080_b0345","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neuro.2024.06.008","article-title":"Developmental exposure to the Fox River PCB mixture modulates behavior in juvenile mice","volume":"103","author":"Wilson","year":"2024","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0350","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12940-017-0332-3","article-title":"Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study","volume":"16","author":"Woods","year":"2017","journal-title":"Environ. Health"},{"issue":"5","key":"10.1016\/j.envint.2026.110080_b0355","doi-asserted-by":"crossref","first-page":"e01530","DOI":"10.1128\/mBio.01530-14","article-title":"Clostridium ramosum promotes high-fat diet-induced obesity in gnotobiotic mouse models","volume":"5","author":"Woting","year":"2014","journal-title":"MBio"},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0360","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12014-024-09513-5","article-title":"Changes in amino acid concentrations and the gut microbiota composition are implicated in the mucosal healing of ulcerative colitis and can be used as noninvasive diagnostic biomarkers","volume":"21","author":"Wu","year":"2024","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.envint.2026.110080_b0365","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1599931","article-title":"Lactobacillus paragasseri HM018 derived from breast milk ameliorates hyperlipidemia in high-cholesterol rats by modulating bile acid metabolism","volume":"16","author":"Yao","year":"2025","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.envint.2026.110080_b0370","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/s41598-017-01140-5","article-title":"Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children","volume":"7","author":"Zhou","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026000383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026000383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:52:23Z","timestamp":1782913943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412026000383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":74,"alternative-id":["S0160412026000383"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2026.110080","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal exposure to persistent organic pollutants modulates the metabolism and gut microbiota of the offspring","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2026.110080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110080"}}