{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:44:22Z","timestamp":1786988662068,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2016-05176"],"award-info":[{"award-number":["2016-05176"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2020-03674"],"award-info":[{"award-number":["2020-03674"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","award":["101136259"],"award-info":[{"award-number":["101136259"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003170","name":"Stiftelsen f\u00f6r Kunskaps- och Kompetensutveckling","doi-asserted-by":"publisher","award":["20220122"],"award-info":[{"award-number":["20220122"]}],"id":[{"id":"10.13039\/501100003170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF21OC0070309"],"award-info":[{"award-number":["NNF21OC0070309"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF20OC0063971"],"award-info":[{"award-number":["NNF20OC0063971"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.envint.2026.110112","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T07:40:07Z","timestamp":1769672407000},"page":"110112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Metabolic effects and biotransformation of perfluorohexyloctane in human hepatocytes"],"prefix":"10.1016","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2403-7989","authenticated-orcid":false,"given":"Andi","family":"Alijagic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Chaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3560-5838","authenticated-orcid":false,"given":"Jo\u00e3o Marcos G.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Duberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9535-6821","authenticated-orcid":false,"given":"Victor","family":"Castro-Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex M.","family":"Dickens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2856-9165","authenticated-orcid":false,"given":"Matej","family":"Ore\u0161i\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1389-8302","authenticated-orcid":false,"given":"Tuulia","family":"Hy\u00f6tyl\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.envint.2026.110112_b0095","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3390\/cells12020281","article-title":"A novel nanosafety approach using cell painting, metabolomics, and lipidomics captures the cellular and molecular phenotypes induced by the unintentionally formed metal-based (nano) particles","volume":"12","author":"Alijagic","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.envint.2026.110112_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108820","article-title":"Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models","volume":"190","author":"Alijagic","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110112_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108820","article-title":"Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models","volume":"190","author":"Alijagic","year":"2024","journal-title":"Environment International"},{"issue":"6","key":"10.1016\/j.envint.2026.110112_b0140","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.2337\/dc17-1318","article-title":"Specific hepatic sphingolipids relate to insulin resistance, oxidative stress, and inflammation in nonalcoholic steatohepatitis","volume":"41","author":"Apostolopoulou","year":"2018","journal-title":"Diabetes Care"},{"issue":"23","key":"10.1016\/j.envint.2026.110112_b0145","doi-asserted-by":"crossref","first-page":"15442","DOI":"10.3390\/ijms232315442","article-title":"Glycosphingolipids in diabetes, oxidative stress, and cardiovascular disease: prevention in experimental animal models","volume":"23","author":"Balram","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.envint.2026.110112_b0055","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0013-9351(86)80020-2","article-title":"Metabolism of n-alkanes and their incorporation into lipids in the rainbow trout","volume":"39","author":"Cravedi","year":"1986","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.envint.2026.110112_b0075","first-page":"11","article-title":"Incorporation of semi-fluorinated alkanes in the bilayer of small unilamellar vesicles of phosphatidylserine: impact on fusion kinetics. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of","volume":"1581","author":"Ferro","year":"2002","journal-title":"Lipids"},{"issue":"3","key":"10.1016\/j.envint.2026.110112_b0150","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.3390\/ijms24033013","article-title":"Plasma sphingoid base profiles of patients diagnosed with intrinsic or idiosyncratic drug-induced liver injury","volume":"24","author":"Gai","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.envint.2026.110112_b0175","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ecoenv.2018.12.040","article-title":"Effect of perfluorooctanesulfonic acid (PFOS) on the liver lipid metabolism of the developing chicken embryo","volume":"170","author":"Geng","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.envint.2026.110112_b0085","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cbi.2006.12.003","article-title":"The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics","volume":"168","author":"Guillouzo","year":"2007","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.envint.2026.110112_b0170","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/metabo7020015","article-title":"Analysis of sub-lethal toxicity of perfluorooctane sulfonate (PFOS) to Daphnia magna using 1H nuclear magnetic resonance-based metabolomics","volume":"7","author":"Kariuki","year":"2017","journal-title":"Metabolites"},{"key":"10.1016\/j.envint.2026.110112_b0185","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.envpol.2017.10.124","article-title":"Evolutionarily adapted hormesis-inducing stressors can be a practical solution to mitigate harmful effects of chronic exposure to low dose chemical mixtures","volume":"233","author":"Kim","year":"2018","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.envint.2026.110112_b0040","first-page":"2656","article-title":"Ocular and systemic distribution of 14C-perfluorohexyloctane following topical ocular administration to rabbits","volume":"59","author":"Kroesser","year":"2018","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"7","key":"10.1016\/j.envint.2026.110112_b0045","first-page":"370","article-title":"Ocular Pharmacokinetics and Biodistribution of Perfluorohexyloctane after Topical Administration to Rabbits","volume":"41","author":"Kr\u00f6sser","year":"2025","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.envint.2026.110112_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113582","article-title":"Comparison of sub-lethal metabolic perturbations of select legacy and novel perfluorinated alkyl substances (PFAS) in Daphnia magna","volume":"212","author":"Labine","year":"2022","journal-title":"Environ. Res."},{"issue":"7","key":"10.1016\/j.envint.2026.110112_b0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003123","article-title":"Predicting network activity from high throughput metabolomics","volume":"9","author":"Li","year":"2013","journal-title":"PLoS Comput. Biol."},{"issue":"1","key":"10.1016\/j.envint.2026.110112_b0115","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbac553","article-title":"Comprehensive investigation of pathway enrichment methods for functional interpretation of LC\u2013MS global metabolomics data","volume":"24","author":"Lu","year":"2022","journal-title":"Brief. Bioinform."},{"issue":"1","key":"10.1016\/j.envint.2026.110112_b0060","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0926-6542(64)90102-7","article-title":"Mammalian metabolism of straight-chain saturated hydrocarbons","volume":"84","author":"McCarthy","year":"1964","journal-title":"Biochimica et Biophysica Acta (BBA)-Specialized Section on Lipids and Related Subjects"},{"issue":"12","key":"10.1016\/j.envint.2026.110112_b0030","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00417-002-0561-0","article-title":"Evidence of toxic side effects of perfluorohexyloctane after vitreoretinal surgery as well as in previously established in vitro models with ocular cell types","volume":"240","author":"Mertens","year":"2002","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"11","key":"10.1016\/j.envint.2026.110112_b0135","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/rcm.1290071110","article-title":"Mass spectrometric studies on some F(CF2)n(CH2)mH semifluorinated alkanes","volume":"7","author":"Napoli","year":"1993","journal-title":"Rapid Commun. Mass Spectrom."},{"issue":"W1","key":"10.1016\/j.envint.2026.110112_b0110","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.envint.2026.110112_b0015","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1021\/ac1005519","article-title":"Trace analytical methods for semifluorinated n-alkanes in snow, soil, and air","volume":"82","author":"Plassmann","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envint.2026.110112_b0020","unstructured":"Rhea Lloyd, W. B., Wiley Chambers, Charles Ganley. Summary Review of NDA 216675. FDA: 2023."},{"issue":"1","key":"10.1016\/j.envint.2026.110112_b0090","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00204-021-03178-x","article-title":"DMSO-free highly differentiated HepaRG spheroids for chronic toxicity, liver functions and genotoxicity studies","volume":"96","author":"Rose","year":"2022","journal-title":"Arch. Toxicol."},{"issue":"19","key":"10.1016\/j.envint.2026.110112_b0190","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.3390\/ijms21197053","article-title":"The molecular mechanisms of adaptive response related to environmental stress","volume":"21","author":"Rossnerova","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2026.110112_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.176004","article-title":"Metabolic changes associated with PFAS exposure in firefighters: A pilot study","volume":"953","author":"Rotander","year":"2024","journal-title":"Sci Total Environ"},{"issue":"1","key":"10.1016\/j.envint.2026.110112_b0070","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.colsurfb.2005.11.022","article-title":"Characterization of phospholipid+semifluorinated alkane vesicle system","volume":"47","author":"Sab\u00edn","year":"2006","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"4","key":"10.1016\/j.envint.2026.110112_b0105","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41587-023-01690-2","article-title":"Integrative analysis of multimodal mass spectrometry data in MZmine 3","volume":"41","author":"Schmid","year":"2023","journal-title":"Nat. Biotechnol."},{"issue":"8","key":"10.1016\/j.envint.2026.110112_b0005","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1089\/jop.2015.0048","article-title":"Semifluorinated alkane eye drops for treatment of dry eye disease\u2013a prospective, multicenter noninterventional study","volume":"31","author":"Steven","year":"2015","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.envint.2026.110112_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.curtheres.2023.100705","article-title":"Oxygen-carrying capacity of perfluorohexyloctane, a novel eye drop for dry eye disease","volume":"98","author":"Stolowich","year":"2023","journal-title":"Curr. Ther. Res. Clin. Exp."},{"issue":"3","key":"10.1016\/j.envint.2026.110112_b0100","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","article-title":"Proposed minimum reporting standards for chemical analysis chemical analysis working group (CAWG) metabolomics standards initiative (MSI)","volume":"3","author":"Sumner","year":"2007","journal-title":"Metabolomics"},{"issue":"5","key":"10.1016\/j.envint.2026.110112_b0010","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ophtha.2022.12.021","article-title":"NOV03 for dry eye disease associated with meibomian gland dysfunction: results of the randomized phase 3 GOBI study","volume":"130","author":"Tauber","year":"2023","journal-title":"Ophthalmology"},{"key":"10.1016\/j.envint.2026.110112_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128615","article-title":"Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish","volume":"431","author":"Truong","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.envint.2026.110112_b0025","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijpharm.2015.03.037","article-title":"Evaluation of pharmacokinetic properties and anaesthetic effects of propofol in a new perfluorohexyloctane (F6H8) emulsion in rats \u2013 a comparative study","volume":"486","author":"Tsagogiorgas","year":"2015","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.envint.2026.110112_b0065","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/BF02533251","article-title":"Metabolism of an n-paraffin, heptadecane, in rats","volume":"13","author":"Tulliez","year":"1978","journal-title":"Lipids"},{"issue":"51","key":"10.1016\/j.envint.2026.110112_b0125","doi-asserted-by":"crossref","first-page":"22766","DOI":"10.1021\/acs.est.4c08442","article-title":"Unravel the in-source fragmentation patterns of per- and polyfluoroalkyl substances during analysis by LC-ESI-HRMS","volume":"58","author":"Wang","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.envint.2026.110112_b0050","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1023\/A:1018914215345","article-title":"Biodistribution of mixed fluorocarbon\u2013hydrocarbon dowel molecules used as stabilizers of fluorocarbon emulsions: a quantitative study by fluorine nuclear magnetic resonance (NMR)","volume":"11","author":"Zarif","year":"1994","journal-title":"Pharm. Res."},{"issue":"30","key":"10.1016\/j.envint.2026.110112_b0130","doi-asserted-by":"crossref","first-page":"10788","DOI":"10.1021\/acs.analchem.2c01521","article-title":"FindPF\u0394S: non-target screening for PFAS\u2500comprehensive data mining for MS2 fragment mass differences","volume":"94","author":"Zweigle","year":"2022","journal-title":"Anal. Chem."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016041202600070X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016041202600070X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:12:09Z","timestamp":1782915129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016041202600070X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":38,"alternative-id":["S016041202600070X"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2026.110112","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic effects and biotransformation of perfluorohexyloctane in human hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2026.110112","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110112"}}