{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:23:32Z","timestamp":1778671412718,"version":"3.51.4"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.envint.2026.110268","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T15:22:27Z","timestamp":1776525747000},"page":"110268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Sulfur quantum dots cause ferroptosis in human placental trophoblast and ovarian granulosa cells and induce mouse adverse pregnancy outcomes"],"prefix":"10.1016","volume":"211","author":[{"given":"Yan","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aixia","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuaishuai","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peimei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7845-3331","authenticated-orcid":false,"given":"Huidong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0340","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.chemphyslip.2004.04.006","article-title":"Active oxygen chemistry within the liposomal bilayer. Part IV: locating 2\u2019,7\u2019-dichlorofluorescein (DCF), 2\u2019,7\u2019-dichlorodihydrofluorescein (DCFH) and 2\u2019,7\u2019-dichlorodihydrofluorescein diacetate (DCFH-DA) in the lipid bilayer","volume":"131","author":"Afri","year":"2004","journal-title":"Chem. Phys. Lipids"},{"issue":"31","key":"10.1016\/j.envint.2026.110268_b0415","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat6114","article-title":"Immune responses at the maternal-fetal interface","volume":"4","author":"Ander","year":"2019","journal-title":"Sci. Immunol."},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0390","first-page":"25","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"The Gene Ontology Consortium. Nat Genet."},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/jat.4333","article-title":"Progress on the toxicity of quantum dots to model organism-zebrafish","volume":"43","author":"Bai","year":"2023","journal-title":"J. Appl. Toxicol."},{"issue":"4","key":"10.1016\/j.envint.2026.110268_b0105","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3390\/antiox14040489","article-title":"Exploring oxidative stress mechanisms of nanoparticles using zebrafish (Danio rerio): toxicological and pharmaceutical insights","volume":"14","author":"Batir-Marin","year":"2025","journal-title":"Antioxidants (basel)."},{"issue":"3","key":"10.1016\/j.envint.2026.110268_b0185","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3390\/nu12030668","article-title":"JNK\/p66Shc\/ITCH signaling pathway mediates angiotensin ii-induced ferritin degradation and labile iron pool increase","volume":"12","author":"Borkowska","year":"2020","journal-title":"Nutrients"},{"issue":"19","key":"10.1016\/j.envint.2026.110268_b0220","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1161\/CIRCULATIONAHA.122.060257","article-title":"Alox15\/15-HpETE aggravates myocardial ischemia-reperfusion injury by promoting cardiomyocyte ferroptosis","volume":"147","author":"Cai","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.envint.2026.110268_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.176644","article-title":"Black phosphorus quantum dots induced neurotoxicity, intestinal microbiome and metabolome dysbiosis in zebrafish (Danio rerio)","volume":"954","author":"Cao","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"23","key":"10.1016\/j.envint.2026.110268_b0005","doi-asserted-by":"crossref","first-page":"12732","DOI":"10.1021\/acs.chemrev.5b00063","article-title":"Colloidal quantum dot solar cells","volume":"115","author":"Carey","year":"2015","journal-title":"Chem. Rev."},{"issue":"21","key":"10.1016\/j.envint.2026.110268_b0060","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1039\/C9CC00461K","article-title":"Sulfur dots-graphene nanohybrid: a metal-free electrocatalyst for efficient N2-to-NH3 fixation under ambient conditions","volume":"55","author":"Chen","year":"2019","journal-title":"Chem. Commun. (Camb)"},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0180","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41418-019-0352-3","article-title":"Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis","volume":"27","author":"Chen","year":"2020","journal-title":"Cell Death Differ."},{"issue":"13","key":"10.1016\/j.envint.2026.110268_b0290","article-title":"Defective homologous recombination repair by Up-regulating Lnc-HZ10\/Ahr loop in human trophoblast cells induced miscarriage","volume":"11","author":"Chen","year":"2024","journal-title":"Adv Sci (weinh)."},{"key":"10.1016\/j.envint.2026.110268_b0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.133035","article-title":"Dichloroacetic acid and trichloroacetic acid as disinfection by-products in drinking water are endocrine-disrupting chemicals","volume":"466","author":"Chen","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2026.110268_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126378","article-title":"\u201cIron -free\u201d CdSe\/ZnS quantum dots disrupt neural differentiation of embryonic stem cells via the induction of ferroptosis","volume":"376","author":"Chen","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2026.110268_b0130","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.semcdb.2022.03.039","article-title":"Human placental development and function","volume":"131","author":"Cindrova-Davies","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"issue":"44","key":"10.1016\/j.envint.2026.110268_b0420","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2205524119","article-title":"Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis","volume":"119","author":"Cloud","year":"2022","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0485","doi-asserted-by":"crossref","first-page":"17009","DOI":"10.1289\/EHP10477","article-title":"BPDE, the migration and invasion of human trophoblast cells, and occurrence of miscarriage in humans: roles of a novel lncRNA-HZ09","volume":"131","author":"Dai","year":"2023","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.envint.2026.110268_b0495","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.envint.2026.110268_b0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2025.101020","article-title":"Tributyltin affects the growth of ovarian granulosa cells in polycystic ovary syndrome by upregulating YY1-mediated CDKN1C via the PI3K\/AKT pathway","volume":"25","author":"Dong","year":"2025","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.envint.2026.110268_b0370","doi-asserted-by":"crossref","first-page":"12326","DOI":"10.1038\/ncomms12326","article-title":"Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal","volume":"7","author":"Du","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0200","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12964-024-01520-1","article-title":"Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis","volume":"22","author":"Du","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.envint.2026.110268_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138516","article-title":"Organ-specific lithium accumulation and its toxic effects on female reproduction","volume":"494","author":"Fan","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"6","key":"10.1016\/j.envint.2026.110268_b0195","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1021\/acscentsci.0c01592","article-title":"Inhibiting ferroptosis through disrupting the NCOA4-FTH1 interaction: a new mechanism of action","volume":"7","author":"Fang","year":"2021","journal-title":"ACS Cent. Sci."},{"issue":"2","key":"10.1016\/j.envint.2026.110268_b0380","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/FJC.0b013e3181c87f8e","article-title":"Preventive effect of a proteasome inhibitor on the formation of accelerated atherosclerosis in rabbits with uremia","volume":"55","author":"Feng","year":"2010","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0385","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12967-024-04946-w","article-title":"Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction","volume":"22","author":"Feng","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.envint.2026.110268_b0120","doi-asserted-by":"crossref","unstructured":"Firouzabadi, A.R., Firouzabadi, A.M., Shayesteh, M.R., 2025. The Impact of Cadmium Telluride Quantum Dots on Male Reproductive Health: A Systematic Review of Toxicological Effects and Mechanisms. World J. Mens Health. Published online July 14, 2025.","DOI":"10.5534\/wjmh.250107"},{"issue":"10","key":"10.1016\/j.envint.2026.110268_b0515","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1016\/j.biomaterials.2012.12.043","article-title":"The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes","volume":"34","author":"Fu","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.envint.2026.110268_b0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123939","article-title":"Perinatal bisphenol S exposure exacerbates the oxidative burden and apoptosis in neonatal ovaries by suppressing the mTOR\/autophagy axis","volume":"349","author":"Gao","year":"2024","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0225","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12035-021-02571-y","article-title":"Ferrostatin-1 alleviates white matter injury via decreasing ferroptosis following spinal cord injury","volume":"59","author":"Ge","year":"2022","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.envint.2026.110268_b0140","first-page":"2072","article-title":"Dysregulation of CD44v6 may lead to recurrent spontaneous abortion by inhibiting the proliferation and migration of trophoblast cells","volume":"11","author":"Hu","year":"2018","journal-title":"Int. J. Clin. Exp. Path."},{"issue":"5","key":"10.1016\/j.envint.2026.110268_b0360","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3390\/nu14051016","article-title":"High-fat diet augments the effect of alcohol on skeletal muscle mitochondrial dysfunction in mice","volume":"14","author":"Ismaeel","year":"2022","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.envint.2026.110268_b0530","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1039\/C5SC00114E","article-title":"Tissue distribution and urinary excretion of intravenously administered chemically functionalized graphene oxide sheets","volume":"6","author":"Jasim","year":"2015","journal-title":"Chem. Sci."},{"issue":"5","key":"10.1016\/j.envint.2026.110268_b0010","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1021\/acs.chemrev.0c00831","article-title":"Colloidal quantum dots as platforms for quantum information science","volume":"121","author":"Kagan","year":"2021","journal-title":"Chem. Rev."},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0580","article-title":"Lipid metabolism in ferroptosis: unraveling key mechanisms and therapeutic potential in cancer","volume":"1880","author":"Lee","year":"2025","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.envint.2026.110268_b0300","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-002195","article-title":"STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer","volume":"9","author":"Lee","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"18","key":"10.1016\/j.envint.2026.110268_b0080","doi-asserted-by":"crossref","first-page":"10763","DOI":"10.3390\/ijms231810763","article-title":"Quantum dots and their interaction with biological systems","volume":"23","author":"Le","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0295","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12989-021-00414-1","article-title":"Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis","volume":"18","author":"Liang","year":"2021","journal-title":"Part. Fibre Toxicol."},{"issue":"43","key":"10.1016\/j.envint.2026.110268_b0430","doi-asserted-by":"crossref","first-page":"31725","DOI":"10.1074\/jbc.M704723200","article-title":"Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human","volume":"282","author":"Li","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envint.2026.110268_b0085","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3389\/fphar.2019.01179","article-title":"Cardiotoxicity of intravenously administered CdSe\/ZnS quantum dots in BALB\/c mice","volume":"10","author":"Li","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.envint.2026.110268_b0165","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1007\/s43032-025-01854-2","article-title":"The role of ovarian granulosa cells related-ncRNAs in ovarian dysfunctions: mechanism research and clinical exploration","volume":"32","author":"Liu","year":"2025","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.envint.2026.110268_b0280","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s11658-020-00205-0","article-title":"Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis","volume":"25","author":"Liu","year":"2020","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"14","key":"10.1016\/j.envint.2026.110268_b0405","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1039\/D1NA00282A","article-title":"Photoluminescence investigations of sulfur quantum dots synthesized by a bubbling-assisted strategy","volume":"3","author":"Liu","year":"2021","journal-title":"Nanoscale Adv."},{"issue":"3","key":"10.1016\/j.envint.2026.110268_b0210","article-title":"GPX4: the hub of lipid oxidation, ferroptosis, disease and treatment","volume":"1878","author":"Liu","year":"2023","journal-title":"Biochim. Biophys. Acta"},{"issue":"33","key":"10.1016\/j.envint.2026.110268_b0045","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.1021\/acs.jpclett.2c02113","article-title":"Investigation on dynamic changes in the morphology and fluorescence properties of sulfur quantum dots","volume":"13","author":"Lu","year":"2022","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.envint.2026.110268_b0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.130613","article-title":"A colorimetric and fluorescence dual-signal determination for iron (II) and H2O2 in food based on sulfur quantum dots","volume":"366","author":"Lu","year":"2022","journal-title":"Food Chem."},{"issue":"4","key":"10.1016\/j.envint.2026.110268_b0450","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3390\/cells11040647","article-title":"Progesterone actions and resistance in gynecological disorders","volume":"11","author":"MacLean","year":"2022","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.envint.2026.110268_b0520","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF02686027","article-title":"Analysis of cadmium and lead in mice organs: effect of Nigella sativa L. (Black Cumin) on the distribution and immunosuppressive effect of cadmium-lead mixture in mice","volume":"115","author":"Massadeh","year":"2007","journal-title":"Biol. Trace Elem. Res."},{"issue":"8","key":"10.1016\/j.envint.2026.110268_b0375","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.envint.2026.110268_b0365","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3390\/antiox11030535","article-title":"The protective effect of anethole against renal ischemia\/reperfusion: the role of the TLR2,4\/MYD88\/NF\u03baB pathway","volume":"11","author":"Mohamed","year":"2022","journal-title":"Antioxidants (basel)."},{"issue":"2","key":"10.1016\/j.envint.2026.110268_b0100","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202306020","article-title":"Comprehensive neurotoxicity of lead halide perovskite nanocrystals in nematode caenorhabditis elegans","volume":"20","author":"Ngo","year":"2024","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0395","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/nar\/27.1.29","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"27","author":"Ogata","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envint.2026.110268_b0410","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1229033","article-title":"The NR2F2-HAND2 signaling axis regulates progesterone actions in the uterus at early pregnancy","volume":"14","author":"Oh","year":"2023","journal-title":"Front Endocrinol (lausanne)."},{"key":"10.1016\/j.envint.2026.110268_b0135","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-nutr-061121-085246","article-title":"The placenta: a maternofetal interface","volume":"43","author":"O\u2019Brien","year":"2023","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.envint.2026.110268_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2020.102274","article-title":"Emergence of sulfur quantum dots: unfolding their synthesis, properties, and applications","volume":"285","author":"Pal","year":"2020","journal-title":"Adv. Colloid Interface Sci."},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0160","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1186\/s12864-024-11122-3","article-title":"Dynamic changes in the transcriptome and metabolome of pig ovaries across developmental stages and gestation","volume":"25","author":"Pan","year":"2024","journal-title":"BMC Genomics"},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0425","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13058-021-01455-2","article-title":"Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland","volume":"23","author":"Ranjan","year":"2021","journal-title":"Breast Cancer Res."},{"issue":"10","key":"10.1016\/j.envint.2026.110268_b0475","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1084\/jem.20022201","article-title":"Steroid hormone synthesis by vaccinia virus suppresses the inflammatory response to infection","volume":"197","author":"Reading","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.envint.2026.110268_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2016.09.021","article-title":"Environmental behaviour and ecotoxicity of quantum dots at various trophic levels: a review","volume":"98","author":"Rocha","year":"2017","journal-title":"Environ. Int."},{"issue":"8","key":"10.1016\/j.envint.2026.110268_b0150","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1080\/10408444.2022.2144711","article-title":"Regulatory roles of non-coding RNAs and m6A modification in trophoblast functions and the occurrence of its related adverse pregnancy outcomes","volume":"52","author":"Rong","year":"2022","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envint.2026.110268_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.174532","article-title":"Multi-omics integration identifies ferroptosis involved in black phosphorus quantum dots-induced renal injury","volume":"947","author":"Ruan","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.envint.2026.110268_b0455","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1095\/biolreprod.103.016873","article-title":"Hormonal induction and stability of monosex populations in the medaka (Oryzias latipes): expression of sex-specific marker genes","volume":"69","author":"Scholz","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.envint.2026.110268_b0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.taap.2019.01.018","article-title":"Quantum dots and mouse strain influence house dust mite-induced allergic airway disease","volume":"368","author":"Scoville","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2026.110268_b0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114919","article-title":"Pubertal lead exposure affects ovary development, folliculogenesis and steroidogenesis by activation of IRE1\u03b1-JNK signaling pathway in rat","volume":"257","author":"Shan","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envint.2026.110268_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102655","article-title":"miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1\/Nrf2\/GPX4 in sepsis lung injury","volume":"62","author":"Shen","year":"2023","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.envint.2026.110268_b0570","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/toxsci\/kfz014","article-title":"Prenatal exposure to bisphenol a analogues on female reproductive functions in mice","volume":"168","author":"Shi","year":"2019","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.envint.2026.110268_b0215","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.envint.2026.110268_b0310","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.placenta.2009.08.007","article-title":"The isolation and characterization of a novel telomerase immortalized first trimester trophoblast cell line, swan 71","volume":"30","author":"Straszewski-Chavez","year":"2009","journal-title":"Placenta"},{"issue":"3 Suppl","key":"10.1016\/j.envint.2026.110268_b0145","first-page":"12","article-title":"Research on apoptotic signaling pathways of recurrent spontaneous abortion caused by dysfunction of trophoblast infiltration","volume":"21","author":"Sun","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.envint.2026.110268_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120614","article-title":"A versatile nanocomposite based on nanoceria for antibacterial enhancement and protection from aPDT-aggravated inflammation via modulation of macrophage polarization","volume":"268","author":"Sun","year":"2021","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.envint.2026.110268_b0015","doi-asserted-by":"crossref","first-page":"708","DOI":"10.3390\/bios13070708","article-title":"Electrochemiluminescence of semiconductor quantum dots and its biosensing applications: a comprehensive review","volume":"13","author":"Sun","year":"2023","journal-title":"Biosensors (basel)."},{"issue":"12","key":"10.1016\/j.envint.2026.110268_b0445","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s12272-022-01417-y","article-title":"Effects of phytoestrogens on reproductive organ health","volume":"45","author":"Swathi Krishna","year":"2022","journal-title":"Arch. Pharm. Res."},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0355","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.jtcvs.2022.04.005","article-title":"Steen solution protects pulmonary microvascular endothelial cells and preserves endothelial barrier after lipopolysaccharide-induced injury","volume":"165","author":"Ta","year":"2023","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.envint.2026.110268_b0480","first-page":"1096","article-title":"Transarterial chemoembolization modulates the exosomal miR-32-5p\/cGAS-STING axis mediated macrophage ferroptosis, triggers immune remodeling, and enhances anti-PD-1\/L1 efficacy in HCC","volume":"9","author":"Tang","year":"2026","journal-title":"Research (wash D c)."},{"key":"10.1016\/j.envint.2026.110268_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.113028","article-title":"BPDE induces human trophoblast cell ferroptosis by up-regulating iron metabolism and promoting GPX4 proteasomal degradation","volume":"228","author":"Tian","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envint.2026.110268_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103073","article-title":"Hypoxia causes trophoblast cell ferroptosis to induce miscarriage through lnc-HZ06\/HIF1\u03b1-SUMO\/NCOA4 axis","volume":"70","author":"Tian","year":"2024","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.envint.2026.110268_b0025","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00204-010-0627-4","article-title":"Differential stability of lead sulfide nanoparticles influences biological responses in embryonic zebrafish","volume":"85","author":"Truong","year":"2011","journal-title":"Arch. Toxicol."},{"issue":"Suppl 2","key":"10.1016\/j.envint.2026.110268_b0155","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1439-0531.2009.01452.x","article-title":"The role of the ovary for the maintenance of pregnancy in cats","volume":"44","author":"Tsutsui","year":"2009","journal-title":"Reprod. Domest. Anim."},{"issue":"10","key":"10.1016\/j.envint.2026.110268_b0440","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2016517118","article-title":"ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development","volume":"118","author":"Varberg","year":"2021","journal-title":"PNAS"},{"issue":"4","key":"10.1016\/j.envint.2026.110268_b0550","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1021\/acsnano.3c11734","article-title":"Polystyrene Nanoplastics Activate Autophagy and Suppress Trophoblast Cell Migration\/Invasion and Migrasome Formation to Induce Miscarriage","volume":"18","author":"Wan","year":"2024","journal-title":"ACS Nano"},{"issue":"10","key":"10.1016\/j.envint.2026.110268_b0115","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.1166\/jnn.2013.7743","article-title":"The capability of quantum dots in crossing the placental barrier and the potential influence on erythrocytes","volume":"13","author":"Wang","year":"2013","journal-title":"J. Nanosci. Nanotechnol."},{"issue":"7","key":"10.1016\/j.envint.2026.110268_b0460","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1093\/nar\/gkaa101","article-title":"FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation","volume":"48","author":"Wang","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"22","key":"10.1016\/j.envint.2026.110268_b0055","doi-asserted-by":"crossref","first-page":"9433","DOI":"10.1021\/acs.nanolett.1c02697","article-title":"Negatively charged sulfur quantum dots for treatment of drug-resistant pathogenic bacterial infections","volume":"21","author":"Wang","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.envint.2026.110268_b0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131543","article-title":"BPDE exposure promotes trophoblast cell pyroptosis and induces miscarriage by up-regulating lnc-HZ14\/ZBP1\/NLRP3 axis","volume":"455","author":"Wang","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2026.110268_b0500","first-page":"0751","article-title":"Long-term cigarette smoke exposure promotes neutrophil ferroptosis resistance, inducing neutrophil extracellular trap formation and driving glucocorticoid resistance in chronic obstructive pulmonary disease","volume":"8","author":"Wang","year":"2025","journal-title":"Research (wash D c)."},{"issue":"3","key":"10.1016\/j.envint.2026.110268_b0325","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.molcel.2020.01.003","article-title":"Maintaining iron homeostasis is the key role of lysosomal acidity for cell proliferation","volume":"77","author":"Weber","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.envint.2026.110268_b0575","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.theriogenology.2019.09.045","article-title":"Maternal exposure to bisphenol a during pregnancy interferes ovaries development of F1 female mice","volume":"142","author":"Wei","year":"2020","journal-title":"Theriogenology"},{"key":"10.1016\/j.envint.2026.110268_b0330","first-page":"547","article-title":"A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme","volume":"21","author":"Wei","year":"2023","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0345","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1038\/s41467-021-21714-2","article-title":"Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics","volume":"12","author":"Weng","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0240","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1038\/s41467-022-31218-2","article-title":"Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity","volume":"13","author":"Wiernicki","year":"2022","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.envint.2026.110268_b0035","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1021\/ar3000585","article-title":"Quantum dot cytotoxicity and ways to reduce it","volume":"46","author":"Winnik","year":"2013","journal-title":"Acc. Chem. Res."},{"issue":"Database issue","key":"10.1016\/j.envint.2026.110268_b0400","doi-asserted-by":"crossref","first-page":"D521","DOI":"10.1093\/nar\/gkl923","article-title":"HMDB: the human metabolome database","volume":"35","author":"Wishart","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"7784","key":"10.1016\/j.envint.2026.110268_b0020","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41586-019-1771-5","article-title":"Highly efficient and stable InP\/ZnSe\/ZnS quantum dot light-emitting diodes","volume":"575","author":"Won","year":"2019","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.envint.2026.110268_b0095","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/jat.3629","article-title":"Transcriptome analysis of different sizes of 3-mercaptopropionic acid-modified cadmium telluride quantum dot-induced toxic effects reveals immune response in rat hippocampus","volume":"38","author":"Wu","year":"2018","journal-title":"J. Appl. Toxicol."},{"issue":"2","key":"10.1016\/j.envint.2026.110268_b0270","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10565-021-09606-z","article-title":"Lnc-HZ08 regulates BPDE-induced trophoblast cell dysfunctions by promoting PI3K ubiquitin degradation and is associated with miscarriage","volume":"38","author":"Xie","year":"2022","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.envint.2026.110268_b0125","doi-asserted-by":"crossref","first-page":"37677","DOI":"10.1038\/srep37677","article-title":"The reproductive toxicity of CdSe\/ZnS quantum dots on the in vivo ovarian function and in vitro fertilization","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.envint.2026.110268_b0175","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1111\/jcmm.14511","article-title":"Molecular mechanisms of ferroptosis and its role in cancer therapy","volume":"23","author":"Xu","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.envint.2026.110268_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145950","article-title":"Lnc-HZ01 with m6A RNA methylation inhibits human trophoblast cell proliferation and induces miscarriage by up-regulating BPDE-activated lnc-HZ01\/MXD1 positive feedback loop","volume":"776","author":"Xu","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0525","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1021\/nn1024303","article-title":"In vivo pharmacokinetics, long-term biodistribution, and toxicology of PEGylated graphene in mice","volume":"5","author":"Yang","year":"2011","journal-title":"ACS Nano"},{"issue":"6","key":"10.1016\/j.envint.2026.110268_b0285","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.kint.2022.07.034","article-title":"Repression of the antiporter SLC7A11\/glutathione\/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification","volume":"102","author":"Ye","year":"2022","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0315","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41467-025-67026-7","article-title":"Lithium exposure causes ferroptosis to induce unexplained miscarriage through non-canonical MBOAT1 pathway","volume":"17","author":"Yi","year":"2025","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.envint.2026.110268_b0470","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.repbio.2020.01.007","article-title":"Gonadal development and sex determination in mouse","volume":"20","author":"Yildirim","year":"2020","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.envint.2026.110268_b0065","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.chemosphere.2015.12.077","article-title":"Bioconcentration of ionic cadmium and cadmium selenide quantum dots in zebrafish larvae","volume":"148","author":"Zarco-Fern\u00e1ndez","year":"2016","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.envint.2026.110268_b0305","doi-asserted-by":"crossref","first-page":"213","DOI":"10.7150\/thno.16044","article-title":"Genome-wide lncRNA microarray profiling identifies novel circulating lncRNAs for detection of gastric cancer","volume":"7","author":"Zhang","year":"2017","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.envint.2026.110268_b0190","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s11427-020-1795-4","article-title":"Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses","volume":"64","author":"Zhang","year":"2021","journal-title":"Sci. China Life Sci."},{"issue":"5","key":"10.1016\/j.envint.2026.110268_b0320","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41419-023-05859-0","article-title":"Chemotherapy impairs ovarian function through excessive ROS-induced ferroptosis","volume":"14","author":"Zhang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.envint.2026.110268_b0335","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuroscience.2023.05.029","article-title":"Deferoxamine promotes peripheral nerve regeneration by enhancing schwann cell function and promoting axon regeneration of dorsal root ganglion","volume":"524","author":"Zhang","year":"2023","journal-title":"Neuroscience"},{"key":"10.1016\/j.envint.2026.110268_b0535","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108237","article-title":"BaP\/BPDE suppressed endothelial cell angiogenesis to induce miscarriage by promoting MARCHF1\/GPX4-mediated ferroptosis","volume":"180","author":"Zhang","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110268_b0070","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.etap.2016.03.013","article-title":"Effect of metal accumulation-associated oxidative stress on the combined toxicity of quantum dots with Cu(2+) to Bacillus subtilis","volume":"44","author":"Zhao","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envint.2026.110268_b0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123847","article-title":"Environmental copper exposure, placental cuproptosis, and miscarriage","volume":"348","author":"Zhao","year":"2024","journal-title":"Environ. Pollut."},{"issue":"6","key":"10.1016\/j.envint.2026.110268_b0235","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.envint.2026.110268_b0585","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/physrev.00031.2024","article-title":"Ferroptosis: when metabolism meets cell death","volume":"105","author":"Zheng","year":"2025","journal-title":"Physiol. Rev."},{"issue":"46","key":"10.1016\/j.envint.2026.110268_b0255","article-title":"Quantum dots-caused retinal degeneration in zebrafish regulated by ferroptosis and mitophagy in retinal pigment epithelial cells through inhibiting spliceosome","volume":"11","author":"Zheng","year":"2024","journal-title":"Adv Sci (weinh)."},{"key":"10.1016\/j.envint.2026.110268_b0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116641","article-title":"Copper exposure induces trophoblast cell cuproptosis by up-regulating lnc-HZ11","volume":"281","author":"Zheng","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envint.2026.110268_b0170","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semcancer.2019.03.002","article-title":"Ferroptosis is a type of autophagy-dependent cell death","volume":"66","author":"Zhou","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.envint.2026.110268_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.129720","article-title":"A ratiometric fluorescent probe based on sulfur quantum dots and calcium ion for sensitive and visual detection of doxycycline in food","volume":"356","author":"Zhuang","year":"2021","journal-title":"Food Chem."},{"issue":"4","key":"10.1016\/j.envint.2026.110268_b0435","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jgg.2021.07.014","article-title":"Human HAND1 inhibits the conversion of cholesterol to steroids in trophoblasts","volume":"49","author":"Zhu","year":"2022","journal-title":"J. Genet. Genomics"}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026002266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026002266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:58:22Z","timestamp":1778669902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412026002266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":116,"alternative-id":["S0160412026002266"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2026.110268","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sulfur quantum dots cause ferroptosis in human placental trophoblast and ovarian granulosa cells and induce mouse adverse pregnancy outcomes","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2026.110268","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110268"}}