{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:49:30Z","timestamp":1788234570499,"version":"build-2803163510"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.envint.2026.110411","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:20:38Z","timestamp":1783603238000},"page":"110411","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Multi-omics reveals Piezo1-driven pulmonary fibrosis induced by exposure to lithium-ion batteries related metals"],"prefix":"10.1016","volume":"214","author":[{"given":"Qingping","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuecai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2026.110411_b0005","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12944-020-01278-8","article-title":"Alveolar lipids in pulmonary disease. A review","volume":"19","author":"Agudelo","year":"2020","journal-title":"Lipids Health Dis."},{"issue":"2","key":"10.1016\/j.envint.2026.110411_bib341","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/toxsci\/kfaf140","article-title":"Contribution of particle-induced lysosome membrane permeabilization to NLRP3 inflammasome activation and mitochondrial ROS production","volume":"208","author":"Albright","year":"2025","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2026.110411_b0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1165\/rcmb.2018-0180OC","article-title":"Glutaminolysis epigenetically regulates antiapoptotic gene expression in idiopathic pulmonary fibrosis fibroblasts","volume":"60","author":"Bai","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.envint.2026.110411_b0015","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41893-018-0139-4","article-title":"Sustainability of artisanal mining of cobalt in dr congo","volume":"1","author":"Banza Lubaba Nkulu","year":"2018","journal-title":"Nat. Sustain."},{"key":"10.1016\/j.envint.2026.110411_b0020","doi-asserted-by":"crossref","DOI":"10.3390\/cells14161233","article-title":"Multi-omic characterization of epithelial-mesenchymal transition: Lipidomic and metabolomic profiles as key markers of tgf-\u03b2-induced transition in huh7 hepatocellular carcinoma","volume":"14","author":"Bertoldi","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.envint.2026.110411_b0025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12995-024-00433-6","article-title":"Occupational, environmental, and toxicological health risks of mining metals for lithium-ion batteries: A narrative review of the pubmed database","volume":"19","author":"Brown","year":"2024","journal-title":"J. Occupat. Med. Toxicol."},{"key":"10.1016\/j.envint.2026.110411_b0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41540-023-00274-9","article-title":"High-throughput metabolomics for the design and validation of a diauxic shift model","volume":"9","author":"Brunns\u00e5ker","year":"2023","journal-title":"NPJ Syst. Biol. Appl."},{"issue":"6","key":"10.1016\/j.envint.2026.110411_bib342","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1002\/tox.24229","article-title":"Nickel induces epithelial-mesenchymal transition in pulmonary fibrosis in mice via activation of the oxidative stress-mediated TGF-\u03b21\/Smad signaling pathway","volume":"39","author":"Cao","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envint.2026.110411_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2022.101198","article-title":"Endoplasmic reticulum stress and lipids in health and diseases","volume":"89","author":"Celik","year":"2023","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.envint.2026.110411_b0040","first-page":"e2303369","article-title":"Actomyosin activity and piezo1 activity synergistically drive urinary system fibroblast activation","volume":"10","author":"Chen","year":"2023","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.envint.2026.110411_b0045","article-title":"Associations of occupational exposure to micro-linicomno(2) particles with systemic inflammation and cardiac dysfunction in cathode material production for lithium batteries","volume":"359","author":"Deng","year":"2024","journal-title":"Environ. Pollut. (Barking, Essex : 1987)"},{"key":"10.1016\/j.envint.2026.110411_b0050","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1111\/epi.17596","article-title":"Natural history of epilepsy in argininosuccinic aciduria provides new insights into pathophysiology: a retrospective international study","volume":"64","author":"Elkhateeb","year":"2023","journal-title":"Epilepsia"},{"key":"10.1016\/j.envint.2026.110411_b0055","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jare.2022.12.006","article-title":"Mechanosensitive ion channel piezo1 mediates mechanical ventilation-exacerbated ards-associated pulmonary fibrosis","volume":"53","author":"Fang","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.envint.2026.110411_b0060","article-title":"Life cycle assessment of lithium nickel cobalt manganese oxide batteries and lithium iron phosphate batteries for electric vehicles in China","volume":"52","author":"Feng","year":"2022","journal-title":"J. Storage Mater."},{"key":"10.1016\/j.envint.2026.110411_b0065","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature21407","article-title":"Mechanical stretch triggers rapid epithelial cell division through piezo1","volume":"543","author":"Gudipaty","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.envint.2026.110411_b0070","article-title":"Microtopography enhances intestinal drug absorption via piezo1\u2010mediated tight junction modulation","author":"Hu","year":"2025","journal-title":"J. BMEMat."},{"key":"10.1016\/j.envint.2026.110411_b0075","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1039\/D0EM00104J","article-title":"Compound health risk assessment of cumulative heavy metal exposure: A case study of a village near a battery factory in henan province, china","volume":"22","author":"Jiang","year":"2020","journal-title":"Environ. Sci. Processes Impacts"},{"key":"10.1016\/j.envint.2026.110411_b0080","article-title":"Stereological estimates of alveolar number and size and capillary length and surface area in mice lungs","volume":"292","author":"Juliane","year":"2008","journal-title":"J. Anat. Rec."},{"key":"10.1016\/j.envint.2026.110411_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.121637","article-title":"Impact of manganese and metal mixtures in blood, hair, and soil on child adaptive behaviors in southeast side chicago","volume":"278","author":"Kim","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2026.110411_b0090","first-page":"2499","article-title":"The role of phospholipids in the biological activity and structure of the endoplasmic reticulum","volume":"1833","author":"Lagace","year":"2013","journal-title":"BBA"},{"key":"10.1016\/j.envint.2026.110411_b0095","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cmet.2020.05.017","article-title":"Distinct inkt cell populations use ifn\u03b3 or er stress-induced il-10 to control adipose tissue homeostasis","volume":"32","author":"LaMarche","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.envint.2026.110411_b0100","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jconrel.2022.12.059","article-title":"Delivery of nitric oxide with a ph-responsive nanocarrier for the treatment of renal fibrosis","volume":"354","author":"Lee","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.envint.2026.110411_b0105","article-title":"Mechano-iontronic hydrogels generating biomimetic endogenous bioelectricity for promoting cartilage regeneration","volume":"38","author":"Li","year":"2026","journal-title":"Adv. Mater. (Deerfield Beach, Fla)"},{"key":"10.1016\/j.envint.2026.110411_b0110","article-title":"Vmp1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms","volume":"42","author":"Li","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.envint.2026.110411_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139964","article-title":"The sustaining effects of e-waste-related metal exposure on hypothalamus-pituitary-adrenal axis reactivity and oxidative stress","volume":"739","author":"Li","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2026.110411_b0120","doi-asserted-by":"crossref","first-page":"W199","DOI":"10.1093\/nar\/gkz401","article-title":"Webgestalt 2019: Gene set analysis toolkit with revamped uis and apis","volume":"47","author":"Liao","year":"2019","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.envint.2026.110411_b0125","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2503033122","article-title":"Onset of cavitation and vapor bubble development over hydrophilic and hydrophobic surfaces","volume":"122","author":"Lin","year":"2025","journal-title":"PNAS"},{"key":"10.1016\/j.envint.2026.110411_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134786","article-title":"Gas6-axl signal promotes indoor vocs exposure-induced pulmonary fibrosis via pulmonary microvascular endothelial cells-fibroblasts cross-talk","volume":"474","author":"Liu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2026.110411_b0135","doi-asserted-by":"crossref","first-page":"e701","DOI":"10.1002\/mco2.701","article-title":"Endoplasmic reticulum stress in diseases","volume":"5","author":"Liu","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.envint.2026.110411_b0140","doi-asserted-by":"crossref","first-page":"7046","DOI":"10.1021\/acsnano.3c10547","article-title":"Targeting senescent alveolar epithelial cells using engineered mesenchymal stem cell-derived extracellular vesicles to treat pulmonary fibrosis","volume":"18","author":"Long","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.envint.2026.110411_b0145","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12989-018-0260-6","article-title":"Predicting the in vivo pulmonary toxicity induced by acute exposure to poorly soluble nanomaterials by using advanced in vitro methods","volume":"15","author":"Loret","year":"2018","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envint.2026.110411_b0150","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202005725","article-title":"The use of nanomaterial in vivo organ burden data for in vitro dose setting","volume":"17","author":"Ma-Hock","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.envint.2026.110411_b0155","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.envint.2018.09.045","article-title":"Association of heavy metals with measures of pulmonary function in children and youth: Results from the national health and nutrition examination survey (nhanes)","volume":"121","author":"Madrigal","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110411_b0160","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41573-021-00320-3","article-title":"Pharmacological targeting of endoplasmic reticulum stress in disease","volume":"21","author":"Marciniak","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.envint.2026.110411_b0165","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.freeradbiomed.2025.03.013","article-title":"Role of manganese in brain health and disease: focus on oxidative stress","volume":"232","author":"Martins","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envint.2026.110411_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109466","article-title":"Evaluating inhalation risks and toxicological impacts of lithium-ion battery thermal runaway emissions","volume":"199","author":"Meister","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110411_b0175","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12989-024-00584-8","article-title":"Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro","volume":"21","author":"Meldrum","year":"2024","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envint.2026.110411_b0180","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giz061","article-title":"Lion\/web: A web-based ontology enrichment tool for lipidomic data analysis","volume":"8","author":"Molenaar","year":"2019","journal-title":"GigaScience"},{"key":"10.1016\/j.envint.2026.110411_b0185","article-title":"A highland-adaptation variant near mcur1 reduces its transcription and attenuates erythrogenesis in tibetans","volume":"5","author":"Ping","year":"2025","journal-title":"Cell Genom."},{"key":"10.1016\/j.envint.2026.110411_b0190","article-title":"Intestinal epithelial-derived usp13 alleviates colonic inflammation by suppressing grp78-mediated endoplasmic reticulum stress","volume":"12","author":"Qian","year":"2025","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.envint.2026.110411_bib345","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.tox.2016.09.016","article-title":"The pulmonary phagocytosis response to separate and combined impacts of manganese (IV) and chromium (VI) containing particulates","volume":"370","author":"Privalova","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2026.110411_b0195","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj20031253","article-title":"Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis","volume":"377","author":"Rejman","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.envint.2026.110411_b0200","article-title":"Bioaccessibilities of metal(loid)s and organic contaminants in particulates measured in simulated human lung fluids: A critical review","volume":"265","author":"Ren","year":"2020","journal-title":"Environ. Pollut. (Barking, Essex : 1987)"},{"key":"10.1016\/j.envint.2026.110411_b0205","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1006\/enrs.2000.4108","article-title":"Exposure to manganese: Health effects on the general population, a pilot study in central mexico","volume":"85","author":"Santos-Burgoa","year":"2001","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2026.110411_b0210","doi-asserted-by":"crossref","first-page":"L1079","DOI":"10.1152\/ajplung.00484.2001","article-title":"Altered fatty acid composition of lung surfactant phospholipids in interstitial lung disease","volume":"283","author":"Schmidt","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.envint.2026.110411_b0215","doi-asserted-by":"crossref","first-page":"8581","DOI":"10.1038\/s41467-025-63616-7","article-title":"Molecular mechanisms of slc30a10-mediated manganese transport","volume":"16","author":"Shen","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envint.2026.110411_b0220","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12989-019-0319-z","article-title":"Hif-1\u03b1 is a key mediator of the lung inflammatory potential of lithium-ion battery particles","volume":"16","author":"Sironval","year":"2019","journal-title":"Part. Fibre Toxicol."},{"issue":"1","key":"10.1016\/j.envint.2026.110411_bib344","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12989-016-0155-3","article-title":"Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice","volume":"13","author":"Sisler","year":"2016","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envint.2026.110411_b0225","doi-asserted-by":"crossref","unstructured":"Tlatelpa-Romero B, C\u00e1zares-Ordo\u00f1ez V, Oyarz\u00e1bal LF, V\u00e1zquez-de-Lara LG. 2022. The role of pulmonary surfactant phospholipids in fibrotic lung diseases. International journal of molecular sciences 24.","DOI":"10.3390\/ijms24010326"},{"issue":"10","key":"10.1016\/j.envint.2026.110411_bib343","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1007\/s00204-021-03146-5","article-title":"Cobalt-induced oxidative stress contributes to alveolar\/bronchiolar carcinogenesis in B6C3F1\/N mice","volume":"95","author":"Ton","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2026.110411_b0230","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41560-019-0368-4","article-title":"Deep eutectic solvents for cathode recycling of li-ion batteries","volume":"4","author":"Tran","year":"2019","journal-title":"Nat. Energy"},{"key":"10.1016\/j.envint.2026.110411_b0235","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.chest.2019.04.114","article-title":"Common pathogenic mechanisms between idiopathic pulmonary fibrosis and lung cancer","volume":"156","author":"Tzouvelekis","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.envint.2026.110411_b0240","article-title":"Airway exposure to lithium nickel manganese cobalt oxide particles induces alterations in lung microenvironment and potential kidney and liver damage in mice","volume":"511","author":"Wang","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2026.110411_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122439","article-title":"Ambient particulate matter triggers dysfunction of subcellular structures and endothelial cell apoptosis through disruption of redox equilibrium and calcium homeostasis","volume":"394","author":"Wang","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2026.110411_b0250","doi-asserted-by":"crossref","DOI":"10.4028\/b-wjQRP6","article-title":"Stiffness sensing via piezo1 enhances macrophage efferocytosis and promotes the resolution of liver fibrosis","volume":"10","author":"Wang","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.envint.2026.110411_b0255","article-title":"L-arginine-loaded gold nanocages ameliorate myocardial ischemia\/reperfusion injury by promoting nitric oxide production and maintaining mitochondrial function","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.envint.2026.110411_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115721","article-title":"Piezo1-mediated endoplasmic reticulum stress-dependent apoptosis exacerbates intestinal epithelial barrier disruption in necrotizing enterocolitis","volume":"167","author":"Wei","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.envint.2026.110411_b0265","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax7525","article-title":"Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition","volume":"5","author":"Wu","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.envint.2026.110411_b0270","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/s41580-024-00773-5","article-title":"Mechanisms of mechanotransduction and physiological roles of piezo channels","volume":"25","author":"Xiao","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envint.2026.110411_b0275","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.1038\/s41467-022-32158-7","article-title":"Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells","volume":"13","author":"Xu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envint.2026.110411_b0280","doi-asserted-by":"crossref","DOI":"10.1172\/JCI184158","article-title":"Piezo1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice","volume":"135","author":"Xu","year":"2025","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envint.2026.110411_b0285","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1038\/s41467-025-59093-7","article-title":"Targeted immunotherapy rescues pulmonary fibrosis by reducing activated fibroblasts and regulating alveolar cell profile","volume":"16","author":"Yan","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envint.2026.110411_b0290","doi-asserted-by":"crossref","first-page":"11637","DOI":"10.1021\/acs.est.4c00225","article-title":"Lithium pollution and its associated health risks in the largest lithium extraction industrial area in china","volume":"58","author":"Yang","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2026.110411_b0295","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41570-025-00742-2","article-title":"The li-ion battery industry and its challenges","volume":"9","author":"Yang","year":"2025","journal-title":"Nat. Rev. Chem."},{"key":"10.1016\/j.envint.2026.110411_b0300","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41419-024-06515-x","article-title":"Endoplasmic reticulum stress and the unfolded protein response: Emerging regulators in progression of traumatic brain injury","volume":"15","author":"Yang","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.envint.2026.110411_b0305","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.7150\/thno.70974","article-title":"Norepinephrine acting on adventitial fibroblasts stimulates vascular smooth muscle cell proliferation via promoting small extracellular vesicle release","volume":"12","author":"Ye","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.envint.2026.110411_b0310","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/17435390.2024.2404074","article-title":"Hmgb1 derived from lung epithelial cells after cobalt nanoparticle exposure promotes the activation of lung fibroblasts","volume":"18","author":"Yuan","year":"2024","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.envint.2026.110411_b0315","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00432-015-2044-9","article-title":"Norepinephrine induced epithelial-mesenchymal transition in ht-29 and a549 cells in vitro","volume":"142","author":"Zhang","year":"2016","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.envint.2026.110411_b0320","doi-asserted-by":"crossref","first-page":"77006","DOI":"10.1289\/EHP12259","article-title":"Assessing the effects of nicotinamide mononucleotide supplementation on pulmonary inflammation in male mice subchronically exposed to ambient particulate matter","volume":"131","author":"Zhang","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2026.110411_b0325","article-title":"Respiratory exposure to lithium nickel manganese cobalt oxide particles: Evidence for toxicity and disruption of metal homeostasis in mice","author":"Zhang","year":"2025","journal-title":"Environ. Health."},{"key":"10.1016\/j.envint.2026.110411_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116963","article-title":"Associations between blood nickel and lung function in young chinese: An observational study combining epidemiology and metabolomics","volume":"284","author":"Zhao","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envint.2026.110411_b0335","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/toxsci\/kfac092","article-title":"Lncrna hotairm1 involved in nano nio-induced pulmonary fibrosis via regulating prkcb DNA methylation-mediated jnk\/c-jun pathway","volume":"190","author":"Zheng","year":"2022","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2026.110411_b0340","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12951-024-02407-6","article-title":"Novel inhalation therapy in pulmonary fibrosis: Principles, applications and prospects","volume":"22","author":"Zheng","year":"2024","journal-title":"J. Nanobiotechnol."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026003697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026003697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:15:04Z","timestamp":1785330904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412026003697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":73,"alternative-id":["S0160412026003697"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2026.110411","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omics reveals Piezo1-driven pulmonary fibrosis induced by exposure to lithium-ion batteries related metals","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2026.110411","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110411"}}