{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:07:20Z","timestamp":1789837640378,"version":"4.0.1"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42467058"],"award-info":[{"award-number":["42467058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473583"],"award-info":[{"award-number":["82473583"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A20156"],"award-info":[{"award-number":["U25A20156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018571","name":"Specific Research Project of Guangxi for Research Bases and Talents","doi-asserted-by":"publisher","award":["AD23026163"],"award-info":[{"award-number":["AD23026163"]}],"id":[{"id":"10.13039\/501100018571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.envint.2026.110445","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:04:46Z","timestamp":1785708286000},"page":"110445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Metabolomics insights into the association between organochlorine pesticides, synthetic pyrethroids exposure and thyroid cancer risk"],"prefix":"10.1016","volume":"215","author":[{"given":"Fei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linfang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuling","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisheng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiting","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liufang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunxun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9866-7724","authenticated-orcid":false,"given":"Xiaobo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2026.110445_b0005","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1289\/ehp.1409049","article-title":"Exposure to endocrine-disrupting chemicals during pregnancy and weight at 7 years of age: a multi-pollutant approach","volume":"123","author":"Agay-Shay","year":"2015","journal-title":"Environ. Health Perspect."},{"issue":"Suppl 1","key":"10.1016\/j.envint.2026.110445_b0010","first-page":"39","article-title":"Cancer incidence in the agricultural health study","volume":"31","author":"Alavanja","year":"2005","journal-title":"Scand. J. Work Environ. Health"},{"key":"10.1016\/j.envint.2026.110445_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113935","article-title":"Pyrethroids and developmental neurotoxicity - a critical review of epidemiological studies and supporting mechanistic evidence","volume":"214","author":"Andersen","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2026.110445_b0020","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg6165","article-title":"Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response","volume":"7","author":"Ariav","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.envint.2026.110445_b0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1214\/09-SS054","article-title":"A survey of cross-validation procedures for model selection","volume":"4","author":"Arlot","year":"2010","journal-title":"Stat. Surv."},{"key":"10.1016\/j.envint.2026.110445_b0030","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/joim.20106","article-title":"The TP53 tumor suppressor gene: from molecular biology to clinical investigations","volume":"298","author":"Baliakas","year":"2025","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.envint.2026.110445_b0035","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1001\/jamainternmed.2019.6019","article-title":"Association between exposure to pyrethroid insecticides and risk of all-cause and cause-specific mortality in the General US Adult Population","volume":"180","author":"Bao","year":"2020","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.envint.2026.110445_b0040","article-title":"Risk factors for thyroid cancer: what do we know so far?","author":"Bogovi\u0107","year":"2020","journal-title":"Acta Clin. Croat."},{"key":"10.1016\/j.envint.2026.110445_b0045","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.fct.2004.02.014","article-title":"Toxicity of trans-nonachlor to sprague\u2013dawley rats in a 90-day feeding study","volume":"42","author":"Bondy","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envint.2026.110445_b0050","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1289\/ehp.1408660","article-title":"Effect of organic diet intervention on pesticide exposures in young children living in low-income urban and agricultural communities","volume":"123","author":"Bradman","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2026.110445_b0055","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.envint.2026.110445_b0060","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/S0140-6736(16)30172-6","article-title":"Thyroid cancer","volume":"388","author":"Cabanillas","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.envint.2026.110445_b0065","first-page":"301","article-title":"Organochlorines and breast cancer risk","volume":"52","author":"Calle","year":"2002","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.envint.2026.110445_b0070","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.envint.2017.03.004","article-title":"Current pesticide profiles in blood serum of adults in Jiangsu Province of China and a comparison with other countries","volume":"102","author":"Chang","year":"2017","journal-title":"Environ. Int."},{"issue":"Suppl","key":"10.1016\/j.envint.2026.110445_b0075","first-page":"1","article-title":"Department of Disease Control Ministry of Health, PR China. The guidelines for prevention and control of overweight and obesity in Chinese adults","volume":"17","author":"Chen","year":"2004","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.envint.2026.110445_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.104958","article-title":"Sex and poverty modify associations between maternal peripartum concentrations of DDT\/E and pyrethroid metabolites and thyroid hormone levels in neonates participating in the VHEMBE study, South Africa","volume":"131","author":"Chevrier","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110445_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217069","article-title":"CircPCNXL2 promotes papillary thyroid carcinoma progression by regulating fatty acid metabolism induced by anabolic enzyme ACC1","volume":"598","author":"Chu","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.envint.2026.110445_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.151288","article-title":"Exposure to common-use pesticides, manganese, lead, and thyroid function among pregnant women from the Infants\u2019 Environmental Health (ISA) study, Costa Rica","volume":"810","author":"Corrales Vargas","year":"2022","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.envint.2026.110445_b0095","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S2213-8587(20)30039-5","article-title":"Pyrethroid exposure: not so harmless after all","volume":"8","author":"Demeneix","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.envint.2026.110445_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110333","article-title":"Exposure to polychlorinated biphenyls and organochlorine pesticides and thyroid cancer in Connecticut women","volume":"192","author":"Deziel","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2026.110445_b0105","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3390\/foods13040528","article-title":"Distribution of pesticides and polychlorinated biphenyls in food of animal origin in Croatia","volume":"13","author":"\u0110oki\u0107","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.envint.2026.110445_b0110","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3390\/jox13030028","article-title":"Organochlorine compounds in the Amur (Heilong) River Basin (2000\u20132020): a review","volume":"13","author":"Donets","year":"2023","journal-title":"J Xenobiot"},{"key":"10.1016\/j.envint.2026.110445_b0115","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/toxsci\/kfq120","article-title":"Assessing hormone receptor activities of pyrethroid insecticides and their metabolites in reporter gene assays","volume":"116","author":"Du","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2026.110445_b0120","first-page":"551","article-title":"Environmental non-persistent endocrine-disrupting chemicals exposure and reproductive hormones levels in adult men","volume":"31","author":"Dziewirska","year":"2018","journal-title":"Int. J. Occup. Med. Environ. Health"},{"key":"10.1016\/j.envint.2026.110445_b0125","doi-asserted-by":"crossref","unstructured":"Exploratory Data Analysis. The Concise Encyclopedia of Statistics, Springer, New York, NY; 2008, p. 192\u20134. https:\/\/doi.org\/10.1007\/978-0-387-32833-1_136.","DOI":"10.1007\/978-0-387-32833-1_136"},{"key":"10.1016\/j.envint.2026.110445_b0130","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw5473","article-title":"Metabolic reprogramming and cancer progression","volume":"368","author":"Faubert","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.envint.2026.110445_b0135","article-title":"An insights of organochlorine pesticides categories, properties, eco-toxicity and new developments in bioremediation process","volume":"333","author":"Fc","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2026.110445_b0140","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.46311","article-title":"Association between genetic risk, adherence to healthy lifestyle behavior, and thyroid cancer risk","volume":"5","author":"Feng","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.envint.2026.110445_b0145","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.taap.2006.01.009","article-title":"A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat","volume":"214","author":"Finch","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2026.110445_b0150","article-title":"Bayesian clustering of multiple zero-inflated outcomes","volume":"381","author":"Franzolini","year":"2023","journal-title":"Philos. Trans. A Math. Phys. Eng. Sci."},{"key":"10.1016\/j.envint.2026.110445_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109571","article-title":"Association between organochlorine pesticides and metabolic dysfunction-associated steatotic liver disease: findings from the Dongfeng-Tongji cohort","volume":"201","author":"Guo","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110445_b0160","doi-asserted-by":"crossref","first-page":"9866","DOI":"10.1021\/acs.est.9b02810","article-title":"Associations between exposure to persistent organic pollutants and thyroid function in a case-control study of East China","volume":"53","author":"Han","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2026.110445_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.118781","article-title":"Association between multipollutant exposure and thyroid hormones in elderly people: a cross-sectional study in China","volume":"252","author":"Han","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2026.110445_b0170","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12964-020-00586-x","article-title":"Regulators of glucose uptake in thyroid cancer cell lines","volume":"18","author":"Heydarzadeh","year":"2020","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.envint.2026.110445_b0175","doi-asserted-by":"crossref","DOI":"10.1289\/EHP6960","article-title":"Lifetime pesticide use and monoclonal gammopathy of undetermined significance in a prospective cohort of male farmers","volume":"129","author":"Hofmann","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2026.110445_b0180","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/ijc.31925","article-title":"Serum-plasma matched metabolomics for comprehensive characterization of benign thyroid nodule and papillary thyroid carcinoma","volume":"144","author":"Huang","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.envint.2026.110445_b0185","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.3390\/molecules27041390","article-title":"Molecular pathological diagnosis of thyroid tumors using spatially resolved metabolomics","volume":"27","author":"Huang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.envint.2026.110445_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109366","article-title":"Associations between prenatal exposure to DDT and DDE and allergy symptoms and diagnoses in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE), South Africa","volume":"185","author":"Huq","year":"2020","journal-title":"Environ Res"},{"key":"10.1016\/j.envint.2026.110445_b0195","doi-asserted-by":"crossref","first-page":"8092","DOI":"10.3390\/ijms25158092","article-title":"Functional validation of endogenous redox partner cytochrome P450 reductase reveals the key P450s CYP6P9a\/-b as broad substrate metabolizers conferring cross-resistance to different insecticide classes in Anopheles funestus","volume":"25","author":"Ibrahim","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2026.110445_b0200","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1590\/2359-3997000000257","article-title":"Radiation exposure and thyroid cancer: a review","volume":"61","author":"Iglesias","year":"2017","journal-title":"Arch. Endocrinol. Metab."},{"key":"10.1016\/j.envint.2026.110445_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113330","article-title":"A novel chemo-phenotypic method identifies mixtures of salpn, vitamin D3, and pesticides involved in the development of colorectal and pancreatic cancer","volume":"233","author":"Issa","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envint.2026.110445_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CCO.0000000000001202","article-title":"Insulin resistance and metabolic dysfunction in thyroid nodules and differentiated thyroid cancer","volume":"38","author":"Iuliano","year":"2026","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.envint.2026.110445_b0215","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.tjnut.2024.01.018","article-title":"Interactions of body weight loss with lipophilic toxin storage: commentary","volume":"154","author":"Jandacek","year":"2024","journal-title":"J. Nutr."},{"key":"10.1016\/j.envint.2026.110445_b0220","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s10654-022-00906-0","article-title":"Association between serum pyrethroid insecticide levels and incident type 2 diabetes risk: a nested case\u2013control study in Dongfeng\u2013Tongji cohort","volume":"37","author":"Jia","year":"2022","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.envint.2026.110445_b0225","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0160-4120(02)00072-7","article-title":"Effects of pyrethroid insecticides and estrogen on WNT10B proto-oncogene expression","volume":"28","author":"Kasat","year":"2002","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110445_b0230","article-title":"Current trends in the features of male thyroid cancer: retrospective evaluation of their prognostic value","volume":"98","author":"Kim","year":"2019","journal-title":"Medicine"},{"key":"10.1016\/j.envint.2026.110445_b0235","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1390","article-title":"A sparse PLS for variable selection when integrating omics data","volume":"7","author":"L\u00ea Cao","year":"2008","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"10.1016\/j.envint.2026.110445_b0240","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.683297","article-title":"Early-life exposure to per- and poly-fluorinated alkyl substances and growth, adiposity, and puberty in children: a systematic review","volume":"12","author":"Lee","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.envint.2026.110445_b0245","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/jdi.13976","article-title":"Can lipophilic pollutants in adipose tissue explain weight change-related risk in type 2 diabetes mellitus?","volume":"14","author":"Lee","year":"2023","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.envint.2026.110445_b0250","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.envres.2018.04.012","article-title":"A nested case-control study of polychlorinated biphenyls, organochlorine pesticides, and thyroid cancer in the Janus Serum Bank cohort","volume":"165","author":"Lerro","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2026.110445_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106187","article-title":"Pesticide exposure and incident thyroid cancer among male pesticide applicators in Agricultural Health Study","volume":"146","author":"Lerro","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110445_b0260","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.envint.2018.10.033","article-title":"Urinary concentrations and profiles of organophosphate and pyrethroid pesticide metabolites and phenoxyacid herbicides in populations in eight countries","volume":"121","author":"Li","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110445_b0265","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41419-023-05981-z","article-title":"STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant thyroid cancer cells","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.envint.2026.110445_b0270","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1474-6670(17)33867-3","article-title":"Latent variable selection in partial least squares modelling","volume":"34","author":"Li","year":"2001","journal-title":"IFAC Proceedings Volumes"},{"key":"10.1016\/j.envint.2026.110445_b0275","article-title":"Secular trends in the epidemiologic patterns of thyroid cancer in china over three decades: an updated systematic analysis of global burden of disease study 2019 data","volume":"12","author":"Li","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.envint.2026.110445_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114319","article-title":"Metabolome-wide association study of the relationship between chlorpyrifos exposure and first trimester serum metabolite levels in pregnant Thai farmworkers","volume":"215","author":"Liang","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2026.110445_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170975","article-title":"Metabolomics perspectives into the co-exposure effect of polycyclic aromatic hydrocarbons and metals on renal function: a meet-in-the-middle approach","volume":"921","author":"Liao","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2026.110445_b0290","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/bioinformatics\/btv535","article-title":"Group and sparse group partial least square approaches applied in genomics context","volume":"32","author":"Liquet","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envint.2026.110445_b0295","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12940-017-0298-1","article-title":"A prospective study of cancer risk among Agricultural Health Study farm spouses associated with personal use of organochlorine insecticides","volume":"16","author":"Louis","year":"2017","journal-title":"Environ. Health"},{"key":"10.1016\/j.envint.2026.110445_b0300","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3390\/toxics12080570","article-title":"Effects of insecticide and herbicides on thyroid disturbances in zebrafish","volume":"12","author":"Ma","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.envint.2026.110445_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110764","article-title":"Organochlorine pesticides: agrochemicals with potent endocrine-disrupting properties in fish","volume":"507","author":"Martyniuk","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envint.2026.110445_b0310","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2183\/pjab.95.027","article-title":"Discovery and development of pyrethroid insecticides","volume":"95","author":"Matsuo","year":"2019","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.envint.2026.110445_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106926","article-title":"Associations between persistent organic pollutants and endometriosis: a multiblock approach integrating metabolic and cytokine profiling","volume":"158","author":"Matta","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110445_b0320","doi-asserted-by":"crossref","first-page":"100539","DOI":"10.1007\/s11356-023-29448-y","article-title":"Machine learning strengthened prediction of tracheal, bronchus, and lung cancer deaths due to air pollution","volume":"30","author":"Mogaraju","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envint.2026.110445_b0325","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/00039896.1971.10665848","article-title":"Absorption, storage, and metabolic conversion of ingested DDT and DDT metabolites in man","volume":"22","author":"Morgan","year":"1971","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.envint.2026.110445_b0330","doi-asserted-by":"crossref","first-page":"15907","DOI":"10.1038\/s41598-024-67016-7","article-title":"The empirical effect of agricultural social services on pesticide inputs","volume":"14","author":"Na","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envint.2026.110445_b0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2024.114495","article-title":"Pyrethroid exposure biomarker 3-phenoxybenzoic acid (3-PBA) binds to transthyretin and is positively associated with free T3 in pregnant women","volume":"264","author":"Normann","year":"2025","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.envint.2026.110445_b0340","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/414916a","article-title":"Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage","volume":"414","author":"Ohta","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.envint.2026.110445_b0345","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.freeradbiomed.2017.02.023","article-title":"Synthesis of l-cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome","volume":"106","author":"Ono","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envint.2026.110445_b0350","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/bioinformatics\/btz667","article-title":"A latent unknown clustering integrating multi-omics data (LUCID) with phenotypic traits","volume":"36","author":"Peng","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envint.2026.110445_b0355","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tox.2007.09.031","article-title":"Effect of Pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes","volume":"243","author":"Price","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2026.110445_b0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.apjon.2024.100529","article-title":"Incidence trends and spatial distribution of thyroid cancer in the Chinese female population from 1990 to 2019","volume":"11","author":"Qiao","year":"2024","journal-title":"Asia-Pac J Oncol Nurs"},{"key":"10.1016\/j.envint.2026.110445_b0365","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12943-021-01401-y","article-title":"An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks","volume":"20","author":"Ram\u00edrez-Moya","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.envint.2026.110445_b0370","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ijheh.2016.10.005","article-title":"Organochlorinated pesticides levels in a representative sample of the Spanish adult population: the Bioambient.es project","volume":"220","author":"Ramos","year":"2017","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.envint.2026.110445_b0375","article-title":"Association of metabolic signatures of air pollution with MASLD: Observational and Mendelian randomization study","volume":"S0168","author":"Ran","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.envint.2026.110445_b0380","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10653-023-01797-0","article-title":"Research progress on remediation of organochlorine pesticide contamination in soil","volume":"46","author":"Ren","year":"2024","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.envint.2026.110445_b0385","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12940-024-01068-0","article-title":"Organochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study","volume":"23","author":"Rusiecki","year":"2024","journal-title":"Environ. Health"},{"key":"10.1016\/j.envint.2026.110445_b0390","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ijheh.2015.01.002","article-title":"Pyrethroids: exposure and health effects \u2013 an update","volume":"218","author":"Saillenfait","year":"2015","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.envint.2026.110445_b0395","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.envint.2015.12.015","article-title":"The metabolic fingerprint of p,p\u2019-DDE and HCB exposure in humans","volume":"88","author":"Salihovic","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110445_b0400","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1130794","article-title":"Organochlorine pesticides and epigenetic alterations in thyroid tumors","volume":"14","author":"Salimi","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.envint.2026.110445_b0405","first-page":"333","article-title":"Metabolomics in cancer research and emerging applications in clinical oncology","volume":"71","author":"Schmidt","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.envint.2026.110445_b0410","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1007\/s42452-019-1485-1","article-title":"Worldwide pesticide usage and its impacts on ecosystem","volume":"1","author":"Sharma","year":"2019","journal-title":"SN Appl. Sci."},{"key":"10.1016\/j.envint.2026.110445_b0415","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1186\/s12889-023-16721-5","article-title":"Exposure to pesticides and the risk of hypothyroidism: a systematic review and meta-analysis","volume":"23","author":"Sirikul","year":"2023","journal-title":"BMC Public Health"},{"key":"10.1016\/j.envint.2026.110445_b0420","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000512971","article-title":"Iodine, seaweed, and the thyroid","volume":"10","author":"Smyth","year":"2021","journal-title":"Eur. Thyroid J."},{"key":"10.1016\/j.envint.2026.110445_b0425","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2345283","article-title":"Environmental chemical contaminants in food: review of a global problem","volume":"2019","author":"Thompson","year":"2019","journal-title":"J. Toxicol."},{"key":"10.1016\/j.envint.2026.110445_b0430","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1159\/000528631","article-title":"Persistent organic pollutant exposure and thyroid function among 12-year-old children","volume":"113","author":"Tillaut","year":"2023","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.envint.2026.110445_b0435","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.aquatox.2016.03.006","article-title":"Permethrin is a potential thyroid-disrupting chemical: In vivo and in silico envidence","volume":"175","author":"Tu","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envint.2026.110445_b0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.140598","article-title":"Pesticide lifecycle management in agriculture and public health: where are the gaps?","volume":"742","author":"van den Berg","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2026.110445_b0445","article-title":"Mitochondrial dysfunction in fatty acid oxidation disorders: insights from human and animal studies","volume":"36","author":"Wajner","year":"2015","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.envint.2026.110445_b0450","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.envint.2013.01.003","article-title":"Concentrations of organochlorine pesticides (OCPs) in human blood plasma from Hong Kong: markers of exposure and sources from fish","volume":"54","author":"Wang","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110445_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.169962","article-title":"Risk of papillary thyroid carcinoma and nodular goiter associated with exposure to semi-volatile organic compounds: a multi-pollutant assessment based on machine learning algorithms","volume":"915","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2026.110445_b0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109203","article-title":"Serum metabolome associated with novel and legacy per- and polyfluoroalkyl substances exposure and thyroid cancer risk: a multi-module integrated analysis based on machine learning","volume":"195","author":"Wang","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110445_b0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133707","article-title":"Exploring pollutant joint effects in disease through interpretable machine learning","volume":"467","author":"Wang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2026.110445_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111851","article-title":"Biomonitoring of toxic metals, organochlorine pesticides, and polybrominated biphenyl 153 in Michigan urban anglers","volume":"203","author":"Wattigney","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2026.110445_b0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108090","article-title":"Environmentally relevant exposure to cypermethrin aggravates diet-induced diabetic symptoms in mice: the interaction between environmental chemicals and diet","volume":"178","author":"Wei","year":"2023","journal-title":"Environ. Int."},{"issue":"5","key":"10.1016\/j.envint.2026.110445_b0480","first-page":"487","article-title":"Organochlorines and endometrial cancer risk","volume":"9","author":"Weiderpass","year":"2000","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.envint.2026.110445_b0485","doi-asserted-by":"crossref","first-page":"D801","DOI":"10.1093\/nar\/gks1065","article-title":"HMDB 3.0\u2013The human metabolome database in 2013","volume":"41","author":"Wishart","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envint.2026.110445_b0490","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1109\/TVCG.2019.2921541","article-title":"Visualization and outlier detection for multivariate elastic curve data","volume":"26","author":"Xie","year":"2020","journal-title":"IEEE Trans. Vis. Comput. Graph."},{"key":"10.1016\/j.envint.2026.110445_b0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119282","article-title":"Association between pesticide exposure and thyroid cancer: a systematic review and meta-analysis","volume":"306","author":"Yang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envint.2026.110445_b0500","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1038\/s41467-024-46595-z","article-title":"An exposome atlas of serum reveals the risk of chronic diseases in the Chinese population","volume":"15","author":"You","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envint.2026.110445_b0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153392","article-title":"Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells","volume":"484","author":"Zhang","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2026.110445_b0510","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12020-024-03993-z","article-title":"The influence of cancer on the reprogramming of lipid metabolism in healthy thyroid tissues of patients with papillary thyroid carcinoma","volume":"87","author":"Zwara","year":"2025","journal-title":"Endocrine"}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:41:24Z","timestamp":1789836084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412026004034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":102,"alternative-id":["S0160412026004034"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2026.110445","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics insights into the association between organochlorine pesticides, synthetic pyrethroids exposure and thyroid cancer risk","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2026.110445","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110445"}}