{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:04:49Z","timestamp":1789837489385,"version":"4.0.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.envint.2026.110455","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T23:33:56Z","timestamp":1786059236000},"page":"110455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Unraveling the association between triclosan and breast cancer: A multidimensional research strategy integrating machine learning, mendelian randomization, and molecular dynamics simulations"],"prefix":"10.1016","volume":"215","author":[{"given":"Dongyang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaquan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyao","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiucai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.envint.2026.110455_b0155","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1023\/A:1009594727358","article-title":"Estrogen receptor alpha in human breast cancer: occurrence and significance","volume":"5","author":"Ali","year":"2000","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"issue":"7","key":"10.1016\/j.envint.2026.110455_b0250","doi-asserted-by":"crossref","first-page":"687","DOI":"10.15537\/smj.2022.43.7.20220052","article-title":"Cyclooxygenase-2 immunohistochemical expression is associated with worse prognosis in breast cancer: Retrospective study and literature review","volume":"43","author":"Al-Maghrabi","year":"2022","journal-title":"Saudi Med. J."},{"issue":"6","key":"10.1016\/j.envint.2026.110455_b0260","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.156057","article-title":"Stabilization of E-cadherin adhesions by COX-2\/GSK3\u03b2 signaling is a targetable pathway in metastatic breast cancer","volume":"8","author":"Balamurugan","year":"2023","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.envint.2026.110455_b0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.envint.2026.110455_b0135","article-title":"Triclosan is associated with breast cancer via oxidative stress and relative telomere length. Front","volume":"11","author":"Cai","year":"2023","journal-title":"Public Health"},{"issue":"7","key":"10.1016\/j.envint.2026.110455_b0165","doi-asserted-by":"crossref","first-page":"6834","DOI":"10.3390\/ijms24076834","article-title":"A basic review on estrogen receptor signaling pathways in breast cancer","volume":"24","author":"Clusan","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"15","key":"10.1016\/j.envint.2026.110455_b0190","doi-asserted-by":"crossref","first-page":"8806","DOI":"10.1073\/pnas.95.15.8806","article-title":"Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice","volume":"95","author":"Elstner","year":"1998","journal-title":"PNAS"},{"issue":"372","key":"10.1016\/j.envint.2026.110455_b0095","article-title":"Long-term and low-dose exposure to triclosan induces POI phenotype in female offspring mice","volume":"1","author":"Gan","year":"2025","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.envint.2026.110455_b0010","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S1470-2045(25)00730-2","article-title":"Global, regional, and national burden of breast cancer among females, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023","volume":"27","year":"2026","journal-title":"The Lancet. Oncology"},{"issue":"10513","key":"10.1016\/j.envint.2026.110455_b0015","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/S0140-6736(25)01637-X","volume":"406","year":"2025","journal-title":"Lancet (London, England)"},{"issue":"1","key":"10.1016\/j.envint.2026.110455_b0060","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/jat.1316","article-title":"Oestrogenic and androgenic activity of triclosan in breast cancer cells","volume":"28","author":"Gee","year":"2008","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envint.2026.110455_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172782","article-title":"Triclocarban and triclosan promote breast cancer progression in vitro and in vivo via activating G protein-coupled estrogen receptor signaling pathways","volume":"931","author":"He","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2026.110455_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172782","article-title":"Triclocarban and triclosan promote breast cancer progression in vitro and in vivo via activating G protein-coupled estrogen receptor signaling pathways","volume":"931","author":"He","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.envint.2026.110455_b0145","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/jat.1736","article-title":"Comparison of in vitro cytotoxicity, estrogenicity and anti-estrogenicity of triclosan, perfluorooctane sulfonate and perfluorooctanoic acid","volume":"33","author":"Henry","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envint.2026.110455_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.883827","article-title":"The influence of triclosan on the thyroid hormone system in humans - a systematic review","volume":"13","author":"Homburg","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)."},{"issue":"10","key":"10.1016\/j.envint.2026.110455_b0265","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrendo.2015.122","article-title":"Metabolic functions of FABPs\u2013mechanisms and therapeutic implications","volume":"11","author":"Hotamisligil","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"issue":"8","key":"10.1016\/j.envint.2026.110455_b0140","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.3390\/ijerph19084681","article-title":"Urinary concentrations of triclosan, bisphenol a, and brominated flame retardants and the association of triclosan with demographic characteristics and body fatness among women with newly diagnosed breast cancer","volume":"19","author":"Ilozumba","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.envint.2026.110455_b0255","article-title":"Cyclooxygenase-2-Prostaglandin E2 pathway: a key player in tumor-associated immune cells","volume":"13","author":"Jin","year":"2023","journal-title":"Front. Oncol."},{"issue":"9","key":"10.1016\/j.envint.2026.110455_b0280","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.tips.2013.07.003","article-title":"Glucocorticoid receptor signaling in health and disease","volume":"34","author":"Kadmiel","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"issue":"8","key":"10.1016\/j.envint.2026.110455_b0150","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1039\/C5NP00005J","article-title":"Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products","volume":"32","author":"Kibble","year":"2015","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.envint.2026.110455_b0245","first-page":"61","volume":"10","author":"Kochel","year":"2016","journal-title":"Breast Cancer (Auckl.)"},{"issue":"9","key":"10.1016\/j.envint.2026.110455_b0200","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.2174\/187152012803529664","article-title":"The role of peroxisome proliferator-activated receptor-\u03b3 in breast cancer","volume":"12","author":"Kotta-Loizou","year":"2012","journal-title":"Anticancer Agents Med Chem."},{"issue":"5","key":"10.1016\/j.envint.2026.110455_b0125","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1021\/tx5000156","article-title":"Progression of breast cancer cells was enhanced by endocrine-disrupting chemicals, triclosan and octylphenol, via an estrogen receptor-dependent signaling pathway in cellular and mouse xenograft models","volume":"27","author":"Lee","year":"2014","journal-title":"Chem. Res. Toxicol."},{"issue":"454","key":"10.1016\/j.envint.2026.110455_b0090","article-title":"Long-term percutaneous triclosan exposure induces thyroid damage in mice: Interpretation of toxicity mechanism from metabolic and proteomic perspectives","volume":"15","author":"Liang","year":"2023","journal-title":"J. Hazard. Mater."},{"issue":"3","key":"10.1016\/j.envint.2026.110455_b0115","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00280-001-0399-x","article-title":"Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells","volume":"49","author":"Liu","year":"2002","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"1","key":"10.1016\/j.envint.2026.110455_b0120","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/carcin\/bgh278","article-title":"Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer","volume":"26","author":"Lu","year":"2005","journal-title":"Carcinogenesis"},{"issue":"16","key":"10.1016\/j.envint.2026.110455_b0025","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.3390\/cancers17162680","article-title":"Exogenous Estrogens as Breast Cancer Risk Factors: A Perspective","volume":"17","author":"Malik","year":"2025","journal-title":"Cancers"},{"issue":"19","key":"10.1016\/j.envint.2026.110455_b0055","doi-asserted-by":"crossref","first-page":"11427","DOI":"10.3390\/ijms231911427","article-title":"Triclosan and its consequences on the reproductive, cardiovascular and thyroid levels","volume":"23","author":"Marques","year":"2022","journal-title":"int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2026.110455_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2024.106517","article-title":"Estrogen receptor regulation of the immune microenvironment in breast cancer","volume":"240","author":"McGuinness","year":"2024","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.envint.2026.110455_b0300","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mce.2017.07.004","article-title":"Possible roles for glucocorticoid signalling in breast cancer","volume":"466","author":"McNamara","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envint.2026.110455_bib312","doi-asserted-by":"crossref","first-page":"1346745","DOI":"10.3389\/fphar.2024.1346745","article-title":"Role and regulation of FOXO3a: new insights into breast cancer therapy","volume":"15","author":"Mei","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.envint.2026.110455_b0100","doi-asserted-by":"crossref","first-page":"25119","DOI":"10.1007\/s11356-021-17273-0","article-title":"Comprehensive insight into triclosan-from widespread occurrence to health outcomes","volume":"30","author":"Milanovi\u0107","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envint.2026.110455_b0030","doi-asserted-by":"crossref","first-page":"115773","DOI":"10.1016\/j.bcp.2023.115773","article-title":"Mechanisms of breast cancer progression induced by environment-polluting aryl hydrocarbon receptor agonists","volume":"216","author":"Miret","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.envint.2026.110455_b0295","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1582-4934.2007.00177.x","article-title":"The glucocorticoid receptor signalling in breast cancer","volume":"12","author":"Moutsatsou","year":"2008","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.envint.2026.110455_b0285","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/bs.vh.2023.06.005","article-title":"The human glucocorticoid receptor","volume":"123","author":"Nicolaides","year":"2023","journal-title":"Vitam. Horm."},{"issue":"1","key":"10.1016\/j.envint.2026.110455_b0185","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ccr.2011.05.026","article-title":"Targeting androgen receptor in estrogen receptor-negative breast cancer","volume":"20","author":"Ni","year":"2011","journal-title":"Cancer Cell"},{"issue":"9","key":"10.1016\/j.envint.2026.110455_bib313","doi-asserted-by":"crossref","first-page":"5614","DOI":"10.1097\/MS9.0000000000003500","article-title":"Hypoxia-inducible factors in breast cancer: prognostic indicators and emerging biomarkers: narrative review","volume":"87","author":"Obeagu","year":"2025","journal-title":"Ann. Med. Surg."},{"issue":"5","key":"10.1016\/j.envint.2026.110455_b0180","doi-asserted-by":"crossref","first-page":"326","DOI":"10.5144\/0256-4947.2018.326","article-title":"Expression of androgen receptor in invasive ductal breast carcinomas: a clinicopathological study from Jordan","volume":"38","author":"Obeidat","year":"2018","journal-title":"Ann. Saudi Med."},{"issue":"6","key":"10.1016\/j.envint.2026.110455_b0075","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s11356-009-0119-3","article-title":"Effects of triclosan on zebrafish early-life stages and adults","volume":"16","author":"Oliveira","year":"2009","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"8","key":"10.1016\/j.envint.2026.110455_b0175","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1093\/annonc\/mdq678","article-title":"Androgen receptor expression is significantly associated with better outcomes in estrogen receptor-positive breast cancers","volume":"22","author":"Park","year":"2011","journal-title":"Ann. Oncol."},{"issue":"273","key":"10.1016\/j.envint.2026.110455_b0085","article-title":"Triclosan induces liver injury in long-life exposed mice via activation of TLR4\/NF-\u03baB\/NLRP3 pathway","volume":"15","author":"Peng","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envint.2026.110455_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2024.106575","article-title":"Glucocorticoid receptors orchestrate a convergence of host and cellular stress signals in triple negative breast cancer","volume":"243","author":"Posani","year":"2024","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.envint.2026.110455_b0210","doi-asserted-by":"crossref","first-page":"114420","DOI":"10.1016\/j.biopha.2023.114420","article-title":"The emerging role of PPAR-alpha in breast cancer","volume":"161","author":"Qian","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.envint.2026.110455_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.141395","article-title":"Acute\/chronic triclosan exposure induces downregulation of m6A-RNA methylation modification via mettl3 suppression and elicits developmental and immune toxicity to zebrafish","volume":"352","author":"Qian","year":"2024","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.envint.2026.110455_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jox15010001","article-title":"Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary Intake","volume":"15","author":"Singh","year":"2024","journal-title":"J. xenobiot."},{"issue":"2","key":"10.1016\/j.envint.2026.110455_b0240","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0014-4827(03)00269-6","article-title":"Role of prostaglandin E2 receptors in migration of murine and human breast cancer cells","volume":"289","author":"Timoshenko","year":"2003","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.envint.2026.110455_b0305","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13058-019-1164-6","article-title":"Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association","volume":"21","author":"Tonsing-Carter","year":"2019","journal-title":"Breast Cancer Res."},{"issue":"3","key":"10.1016\/j.envint.2026.110455_b0290","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ando.2018.03.001","article-title":"Pathophysiology of Glucocorticoid Signaling","volume":"79","author":"Vitellius","year":"2018","journal-title":"Ann. Endocrinol."},{"issue":"24","key":"10.1016\/j.envint.2026.110455_b0020","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.1080\/10408398.2021.1903382","article-title":"Endocrine disrupting chemicals and breast cancer: a systematic review of epidemiological studies","volume":"62","author":"Wan","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"8","key":"10.1016\/j.envint.2026.110455_b0045","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/10937404.2017.1399306","article-title":"Triclosan exposure, transformation, and human health effects","volume":"20","author":"Weatherly","year":"2017","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"issue":"12","key":"10.1016\/j.envint.2026.110455_b0040","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23506","article-title":"Endocrine-disrupting compounds and metabolomic reprogramming in breast cancer","volume":"37","author":"Winz","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"443","key":"10.1016\/j.envint.2026.110455_b0070","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan4116","article-title":"A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice","volume":"10","author":"Yang","year":"2018","journal-title":"Sci. Transl. Med."},{"issue":"19","key":"10.1016\/j.envint.2026.110455_b0065","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1080\/15287394.2021.1944940","article-title":"In vitro and in vivo estrogenic activity of triclosan","volume":"84","author":"Yoon","year":"2021","journal-title":"J. Toxic. Environ. Health A"},{"key":"10.1016\/j.envint.2026.110455_b0275","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.101221","article-title":"FABP4-mediated lipid accumulation and lipolysis in tumor-associated macrophages promote breast cancer metastasis","volume":"13","author":"Yorek","year":"2024","journal-title":"Elife"},{"issue":"8","key":"10.1016\/j.envint.2026.110455_b0195","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.cellbi.2008.04.011","article-title":"Induction of G1 phase arrest and apoptosis in MDA-MB-231 breast cancer cells by troglitazone, a synthetic peroxisome proliferator-activated receptor gamma (PPARgamma) ligand","volume":"32","author":"Yu","year":"2008","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.envint.2026.110455_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217271","article-title":"FABP4-mediated lipid metabolism promotes TNBC progression and breast cancer stem cell activity","volume":"604","author":"Yu","year":"2024","journal-title":"Cancer Lett."},{"issue":"305","key":"10.1016\/j.envint.2026.110455_b0110","article-title":"Triclosan induced obesity via gut microbiota dysbiosis and butyrate reduction","volume":"15","author":"Yu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.envint.2026.110455_b0205","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3390\/cells12010130","article-title":"The Role of PPARs in Breast Cancer","volume":"12","author":"Zhao","year":"2022","journal-title":"Cells"},{"issue":"290","key":"10.1016\/j.envint.2026.110455_b0105","article-title":"Integrated multi-omics analysis reveals the underlying molecular mechanism for the neurotoxicity of triclosan in zebrafish","volume":"15","author":"Zhao","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"4","key":"10.1016\/j.envint.2026.110455_b0220","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1016\/S1470-2045(23)00676-9","article-title":"Optimal targeting of PI3K-AKT and mTOR in advanced oestrogen receptor-positive breast cancer","volume":"25","author":"Browne","year":"2024","journal-title":"Lancet Oncol."},{"issue":"22","key":"10.1016\/j.envint.2026.110455_b0235","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401257RR","article-title":"Oxidative stress drives endometrial fibrosis via TGF-\u03b21\/MAPK signaling pathway in breast cancer","volume":"38","author":"Chen","year":"2024","journal-title":"FASEB J."},{"issue":"22","key":"10.1016\/j.envint.2026.110455_b0225","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1038\/sj.onc.1210421","article-title":"MAP kinase signalling pathways in cancer","volume":"26","author":"Dhillon","year":"2007","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.envint.2026.110455_b0215","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41392-021-00828-5","article-title":"Targeting PI3K\/Akt signal transduction for cancer therapy","volume":"6","author":"He","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"8","key":"10.1016\/j.envint.2026.110455_b0230","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.bbamcr.2006.10.001","article-title":"Roles of the Raf\/MEK\/ERK pathway in cell growth, malignant transformation and drug resistance","volume":"1773","author":"McCubrey","year":"2007","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:30:17Z","timestamp":1789835417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412026004137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":64,"alternative-id":["S0160412026004137"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2026.110455","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unraveling the association between triclosan and breast cancer: A multidimensional research strategy integrating machine learning, mendelian randomization, and molecular dynamics simulations","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2026.110455","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110455"}}