{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:07:44Z","timestamp":1789837664011,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274624"],"award-info":[{"award-number":["82274624"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","award":["2025BEH04083"],"award-info":[{"award-number":["2025BEH04083"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004772","name":"Ningxia Hui Autonomous Region Natural Science Foundation","doi-asserted-by":"publisher","award":["2026AAC030186"],"award-info":[{"award-number":["2026AAC030186"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004179","name":"Ningxia Medical University","doi-asserted-by":"publisher","award":["XT2023028"],"award-info":[{"award-number":["XT2023028"]}],"id":[{"id":"10.13039\/501100004179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004179","name":"Ningxia Medical University","doi-asserted-by":"publisher","award":["XZ2024002"],"award-info":[{"award-number":["XZ2024002"]}],"id":[{"id":"10.13039\/501100004179","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.envint.2026.110477","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:35:14Z","timestamp":1787700914000},"page":"110477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Chronic exposure to environmentally relevant benzophenones induces male reproductive dysfunction via ER-mediated disulfidptosis: therapeutic potential of zeaxanthin dipalmitate"],"prefix":"10.1016","volume":"215","author":[{"given":"Hong-Mei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Qin","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Jia","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xin","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ze","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Nan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Rong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-He","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9170-000X","authenticated-orcid":false,"given":"Hai-Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2026.110477_b0005","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ijheh.2018.02.002","article-title":"Urinary concentrations of benzophenone-type ultra violet light filters and reproductive parameters in young men","volume":"221","author":"Adoamnei","year":"2018","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.envint.2026.110477_b0010","author":"AOP-Wiki"},{"key":"10.1016\/j.envint.2026.110477_b0015","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1476-069X-11-42","article-title":"Developmental origins of non-communicable disease: implications for research and public health","volume":"11","author":"Barouki","year":"2012","journal-title":"Environ. Health."},{"key":"10.1016\/j.envint.2026.110477_b0020","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1210\/jc.2018-00229","article-title":"Testosterone therapy in men with hypogonadism: an endocrine society clinical practice guideline","volume":"103","author":"Bhasin","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.envint.2026.110477_b0025","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.scitotenv.2019.03.023","article-title":"Two-generational effects of benzophenone-3 on the aquatic midge Chironomus riparius","volume":"669","author":"Campos","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2026.110477_b0030","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41419-025-07354-0","article-title":"Targeting estrogen-regulated system xc- promotes ferroptosis and endocrine sensitivity of ER+ breast cancer","volume":"16","author":"Cao","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.envint.2026.110477_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128495","article-title":"Structure-related endocrine-disrupting potential of environmental transformation products of benzophenone-type UV filters: a review","volume":"430","author":"Carstensen","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2026.110477_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145628","article-title":"Trends in environmental and toxicity research on organic ultraviolet filters: a scientometric review","volume":"773","author":"Carve","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2026.110477_b0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40364-024-00593-x","article-title":"Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions","volume":"12","author":"Chen","year":"2024","journal-title":"Biomark. Res."},{"key":"10.1016\/j.envint.2026.110477_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2020.111012","article-title":"Sunscreen active ingredients in loggerhead turtles (Caretta caretta) and their relation to molecular markers of inflammation, oxidative stress and hormonal activity in wild populations","volume":"153","author":"Cocci","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.envint.2026.110477_b0055","author":"European Chemicals Agency"},{"key":"10.1016\/j.envint.2026.110477_b0060","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201801339","article-title":"Wolfberry-derived zeaxanthin dipalmitate attenuates ethanol-induced hepatic damage","volume":"63","author":"Gao","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.envint.2026.110477_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126776","article-title":"Postnatal exposure to various benzophenones at environmentally relevant levels enhances the susceptibility of mammalian testes to cyclophosphamide-induced spermatogenic stress in adulthood","volume":"382","author":"Gao","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2026.110477_b0070","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00002.2020","article-title":"Developmental origins of metabolic diseases","volume":"101","author":"Hoffman","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.envint.2026.110477_b0075","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/andr.13112","article-title":"Busulfan impairs blood-testis barrier and spermatogenesis by increasing noncollagenous 1 domain peptide via matrix metalloproteinase 9","volume":"10","author":"Jiang","year":"2022","journal-title":"Andrology."},{"key":"10.1016\/j.envint.2026.110477_b0080","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.3390\/foods11223670","article-title":"Zeaxanthin dipalmitate-enriched emulsion stabilized with whey protein isolate-gum arabic maillard conjugate improves gut microbiota and inflammation of colitis mice","volume":"11","author":"Kan","year":"2022","journal-title":"Foods."},{"key":"10.1016\/j.envint.2026.110477_b0085","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.envint.2014.05.015","article-title":"Occurrences, toxicities, and ecological risks of benzophenone-3, a common component of organic sunscreen products: a mini-review","volume":"70","author":"Kim","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110477_b0090","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.aquatox.2014.07.004","article-title":"Effects of benzophenone-3 exposure on endocrine disruption and reproduction of Japanese medaka (Oryzias latipes)\u2013a two generation exposure study","volume":"155","author":"Kim","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envint.2026.110477_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117556","article-title":"BP-3 exposure at environmentally relevant concentrations induced male developmental reproductive toxicity via ER\/CCL27\/ROS pathway in mice","volume":"290","author":"Li","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envint.2026.110477_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106371","article-title":"Low concentrations of benzophenone-type UV-filters impair testis development in the amphibian Xenopus laevis","volume":"254","author":"Li","year":"2023","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envint.2026.110477_b0105","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1080\/10286020.2017.1349759","article-title":"Zeaxanthin dipalmitate alleviates hepatic injury induced by superimposed chronic hepatitis B and non-alcoholic steatohepatitis in non-obese mice","volume":"19","author":"Li","year":"2017","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.envint.2026.110477_b0110","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/jnc.15472","article-title":"Wolfberry-derived zeaxanthin dipalmitate delays retinal degeneration in a mouse model of retinitis pigmentosa through modulating STAT3, CCL2 and MAPK pathways","volume":"158","author":"Liu","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.envint.2026.110477_b0115","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.772380","article-title":"The dual regulation effects of ESR1\/NEDD4L on SLC7A11 in breast cancer under ionizing radiation","volume":"9","author":"Liu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.envint.2026.110477_b0120","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41556-023-01091-2","article-title":"Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis","volume":"25","author":"Liu","year":"2023","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.envint.2026.110477_b0125","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.tcb.2023.07.009","article-title":"Disulfidptosis: disulfide stress-induced cell death","volume":"34","author":"Liu","year":"2024","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.envint.2026.110477_b0130","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/andr.70119","article-title":"Lycium barbarum polysaccharides enhance testicular spermatogenesis in d-galactose-induced aging rats via calcium signaling","volume":"14","author":"Ma","year":"2026","journal-title":"Andrology."},{"key":"10.1016\/j.envint.2026.110477_b0135","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41556-023-01100-4","article-title":"Deadly actin collapse by disulfidptosis","volume":"25","author":"Machesky","year":"2023","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.envint.2026.110477_b0140","first-page":"209","article-title":"Occurrence and fate of benzophenone-type UV filters in aquatic environments: a review. Environ. Sci.: Water Res","volume":"5","author":"Mao","year":"2019","journal-title":"Technol."},{"key":"10.1016\/j.envint.2026.110477_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107405","article-title":"Assessment of human exposure to benzophenone-type UV filters: a review","volume":"167","author":"Mao","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110477_b0150","first-page":"420","article-title":"Antitumor mechanisms of lycium barbarum fruit: an overview of in vitro and in vivo potential","volume":"14","author":"Miranda","year":"2024","journal-title":"Life (basel)."},{"key":"10.1016\/j.envint.2026.110477_b0155","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1210\/er.2014-1101","article-title":"The Mammalian Blood-Testis Barrier: its biology and regulation","volume":"36","author":"Mruk","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.envint.2026.110477_b0160","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.juro.2018.03.115","article-title":"Evaluation and management of testosterone deficiency: AUA guideline","volume":"200","author":"Mulhall","year":"2018","journal-title":"J. Urol."},{"key":"10.1016\/j.envint.2026.110477_b0165","first-page":"35","article-title":"Effects of maternal and lactational exposure to 2-hydroxy-4-methoxybenzone on development and reproductive organs in male and female rat offspring. Birth Defects Res","volume":"104","author":"Nakamura","year":"2015","journal-title":"B. Dev. Reprod. Toxicol."},{"key":"10.1016\/j.envint.2026.110477_b0170","doi-asserted-by":"crossref","first-page":"10920","DOI":"10.3390\/ijms231810920","article-title":"Anti-fatigue effects of lycium barbarum polysaccharide and effervescent tablets by regulating oxidative stress and energy metabolism in rats","volume":"23","author":"Peng","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2026.110477_b0175","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1007\/s00204-020-02776-5","article-title":"Dermal exposure to the UV filter benzophenone-3 during early pregnancy affects fetal growth and sex ratio of the progeny in mice","volume":"94","author":"Santamaria","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2026.110477_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160966","article-title":"Environmental impacts of the ultraviolet filter oxybenzone","volume":"863","author":"Scheele","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2026.110477_b0185","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1093\/humrep\/deae143","article-title":"Endocrine disruption and male reproductive disorders: Unanswered questions","volume":"39","author":"Sharpe","year":"2024","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.envint.2026.110477_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107834","article-title":"Target analysis and suspect screening of UV filters, parabens and other chemicals used in personal care products in human cord blood: Prenatal exposure by mother-fetus transfer","volume":"173","author":"Sunyer-Cald\u00fa","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110477_b0195","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.reprotox.2022.10.002","article-title":"Associations between benzophenone-3 and sex steroid hormones among United States adult men","volume":"14","author":"Tao","year":"2022","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envint.2026.110477_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2024.109230","article-title":"A review of lycium barbarum polysaccharides: Extraction, purification, structural-property relationships, and bioactive molecular mechanisms","volume":"544","author":"Wang","year":"2024","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.envint.2026.110477_b0205","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.913502","article-title":"Sertoli cell Immune regulation: a double-edged Sword","volume":"13","author":"Washburn","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envint.2026.110477_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.137241","article-title":"Lycium barbarum polysaccharide alleviates ferroptosis in Sertoli cells through NRF2\/SLC7A11\/GPX4 pathway and ameliorates DEHP-induced male reproductive damage in mice","volume":"282","author":"Yang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.envint.2026.110477_b0215","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.eehl.2023.10.001","article-title":"A review of sources, pathways, and toxic effects of human exposure to benzophenone ultraviolet light filters","volume":"3","author":"Yao","year":"2023","journal-title":"Eco-Environ. Health."},{"key":"10.1016\/j.envint.2026.110477_b0220","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/tox.23375","article-title":"Benzophenone-3 breaches mouse Sertoli cell barrier and alters F-actin organization without evoking apoptosis","volume":"37","author":"Zhang","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envint.2026.110477_b0225","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1021\/acs.jafc.9b06882","article-title":"Lycopene prevents DEHP-induced leydig cell damage with the Nrf2 antioxidant signaling pathway in mice","volume":"68","author":"Zhao","year":"2020","journal-title":"J. Agric. Food Chem."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:41:51Z","timestamp":1789836111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412026004356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":45,"alternative-id":["S0160412026004356"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2026.110477","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic exposure to environmentally relevant benzophenones induces male reproductive dysfunction via ER-mediated disulfidptosis: therapeutic potential of zeaxanthin dipalmitate","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2026.110477","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110477"}}