{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:07:44Z","timestamp":1789837664064,"version":"4.0.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00240942"],"award-info":[{"award-number":["RS-2023-00240942"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00462450"],"award-info":[{"award-number":["RS-2024-00462450"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.envint.2026.110485","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:28:29Z","timestamp":1787786909000},"page":"110485","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Environmental acetylcholinesterase blockade impairs conserved gut-metabolic resilience in a soil nematode sentinel"],"prefix":"10.1016","volume":"215","author":[{"given":"Juil","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8401-6441","authenticated-orcid":false,"given":"Seung Jun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govindhan","family":"Thiruppathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4426-2818","authenticated-orcid":false,"given":"Dasom","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8686-8166","authenticated-orcid":false,"given":"Yuseok","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2026.110485_b0005","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/1365-2664.14437","article-title":"Pesticide effects on soil fauna communities-a meta-analysis","volume":"60","author":"Beaumelle","year":"2023","journal-title":"J. Appl. Ecol."},{"key":"10.1016\/j.envint.2026.110485_b0010","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0929-1393(03)00047-7","article-title":"Effects of long-term crop management on nematode trophic levels other than plant feeders disappear after 1 year of disruptive soil management","volume":"23","author":"Berkelmans","year":"2003","journal-title":"Appl. Soil Ecol."},{"key":"10.1016\/j.envint.2026.110485_b0015","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nature05904","article-title":"Two neurons mediate diet-restriction-induced longevity in C. elegans","volume":"447","author":"Bishop","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.envint.2026.110485_b0020","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.envint.2026.110485_b0025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0079-6123(08)60439-2","article-title":"Metabotropic glutamate receptors and neurodegeneration","volume":"116","author":"Bruno","year":"1998","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.envint.2026.110485_b0030","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.envint.2026.110485_b0035","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.18459","article-title":"Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging","volume":"6","author":"Chang","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.envint.2026.110485_b0040","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0074-7696(01)09013-1","article-title":"Acetylcholinesterase genes in the nematode Caenorhabditis elegans","volume":"209","author":"Combes","year":"2001","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.envint.2026.110485_b0045","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1046\/j.1460-9568.2003.02749.x","article-title":"Multiple ace genes encoding acetylcholinesterases of Caenorhabditis elegans have distinct tissue expression","volume":"18","author":"Combes","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.envint.2026.110485_b0050","doi-asserted-by":"crossref","first-page":"20774","DOI":"10.1007\/s11356-025-36888-1","article-title":"Exposure to chlorpyrifos pesticide at a realistic dose modulates gut microbiome and induces non-obese associated diabetes","volume":"32","author":"Durairaj","year":"2025","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envint.2026.110485_b0055","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0140-6736(02)11204-9","article-title":"Pesticide poisoning in the developing world\u2014a minimum pesticides list","volume":"360","author":"Eddleston","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.envint.2026.110485_b0060","series-title":"Effects of chlorpyrifos, an organophosphate pesticide on the intestinal barrier of Atlantic salmon (Salmo salar)","author":"Fernando","year":"2021"},{"key":"10.1016\/j.envint.2026.110485_b0065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/toxsci\/kfj069","article-title":"Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat","volume":"90","author":"Fisher","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2026.110485_b0070","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cell.2015.02.020","article-title":"Promoting health and longevity through diet: from model organisms to humans","volume":"161","author":"Fontana","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.envint.2026.110485_b0075","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1289\/ehp.9087245","article-title":"Mechanism of action of organophosphorus and carbamate insecticides","volume":"87","author":"Fukuto","year":"1990","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2026.110485_b0080","article-title":"Intestinal autophagy improves healthspan and longevity in C. elegans during dietary restriction","volume":"12","author":"Gelino","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.envint.2026.110485_b0085","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0531-5565(78)90047-5","article-title":"Sterilization and growth inhibition of Caenorhabditis elegans by 5-fluorodeoxyuridine","volume":"13","author":"Hosono","year":"1978","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.envint.2026.110485_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102217","article-title":"Increased gut permeability and bacterial translocation after chronic chlorpyrifos exposure in rats","volume":"9","author":"Joly Condette","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envint.2026.110485_b0095","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1474-9726.2006.00238.x","article-title":"Lifespan extension in Caenorhabditis elegans by complete removal of food","volume":"5","author":"Kaeberlein","year":"2006","journal-title":"Aging Cell"},{"key":"10.1016\/j.envint.2026.110485_b0105","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1474-9726.2006.00241.x","article-title":"Dietary deprivation extends lifespan in Caenorhabditis elegans","volume":"5","author":"Lee","year":"2006","journal-title":"Aging Cell"},{"key":"10.1016\/j.envint.2026.110485_b0100","doi-asserted-by":"crossref","DOI":"10.3791\/60419","article-title":"Measuring the effects of bacteria and chemicals on the intestinal permeability of Caenorhabditis elegans","author":"Le","year":"2019","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.envint.2026.110485_b0110","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-019-0635-4","article-title":"Organophosphorus pesticide chlorpyrifos intake promotes obesity and insulin resistance through impacting gut and gut microbiota","volume":"7","author":"Liang","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.envint.2026.110485_b0115","article-title":"Organophosphorus nematicide potentiated nematicidal effect by changing rhizosphere bacterial and fungal communities","volume":"31","author":"Liu","year":"2024","journal-title":"Rhizosphere-Neth"},{"key":"10.1016\/j.envint.2026.110485_b0120","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.envint.2026.110485_b0125","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrd4391","article-title":"Caloric restriction mimetics: towards a molecular definition","volume":"13","author":"Madeo","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.envint.2026.110485_b0130","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1146\/annurev.biochem.77.061206.171059","article-title":"Aging and survival: the genetics of life span extension by dietary restriction","volume":"77","author":"Mair","year":"2008","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.envint.2026.110485_b0135","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrn.2017.156","article-title":"Intermittent metabolic switching, neuroplasticity and brain health","volume":"19","author":"Mattson","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.envint.2026.110485_b0140","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s12020-022-03229-y","article-title":"Pesticides as endocrine disruptors: programming for obesity and diabetes","volume":"79","author":"Miranda","year":"2023","journal-title":"Endocrine"},{"key":"10.1016\/j.envint.2026.110485_b0145","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/geronj\/34.1.28","article-title":"Synchronous growth and aging of Caenorhabditis elegans in the presence of fluorodeoxyuridine","volume":"34","author":"Mitchell","year":"1979","journal-title":"J. Gerontol."},{"key":"10.1016\/j.envint.2026.110485_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114933","article-title":"Chlorpyrifos induces cytotoxicity via oxidative stress and mitochondrial dysfunction in HepG2 cells","volume":"192","author":"Montanar\u00ed","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envint.2026.110485_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2025.180649","article-title":"The soil nematode exposome: Unraveling the impacts of particulate plastics from agroecosystems to one health","volume":"1003","author":"Moon","year":"2025","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2026.110485_b0160","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature14300","article-title":"Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans","volume":"521","author":"Palikaras","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.envint.2026.110485_b0165","first-page":"483","article-title":"Carbamate and organo-phosphorus nematicides - acetylcholinesterase inhibition and effects on dispersal","volume":"21","author":"Pree","year":"1989","journal-title":"J. Nematol."},{"key":"10.1016\/j.envint.2026.110485_b0170","doi-asserted-by":"crossref","first-page":"21528","DOI":"10.1073\/pnas.1215849110","article-title":"Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila","volume":"109","author":"Rera","year":"2012","journal-title":"PNAS"},{"key":"10.1016\/j.envint.2026.110485_b0175","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","article-title":"Autophagy and aging","volume":"146","author":"Rubinsztein","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.envint.2026.110485_b0180","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3390\/antiox14080905","article-title":"Aryl hydrocarbon receptor is required for fasting-induced improvement of gut barrier integrity in Caenorhabditis elegans","volume":"14","author":"Sun","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.envint.2026.110485_b0185","doi-asserted-by":"crossref","unstructured":"Supreeth, M., Chandrashekar, M.A., Sachin, N., Raju, N.S., 2016. Effect of chlorpyrifos on soil microbial diversity and its biotransformation by Streptomyces sp. HP-11. 3 Biotech 6:147.","DOI":"10.1007\/s13205-016-0462-2"},{"key":"10.1016\/j.envint.2026.110485_b0190","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ijscr.2018.06.032","article-title":"Laparoscopic repair with cone-shaped mesh implantation for perineal hernia occurred after laparoscopic abdominoperineal resection","volume":"49","author":"Teramura","year":"2018","journal-title":"Int. J. Surg. Case Rep."},{"key":"10.1016\/j.envint.2026.110485_b0195","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/27579","article-title":"Specific interference by ingested dsRNA","volume":"395","author":"Timmons","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.envint.2026.110485_b0200","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.celrep.2012.12.018","article-title":"A fasting-responsive signaling pathway that extends life span in C. elegans","volume":"3","author":"Uno","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.envint.2026.110485_b0205","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1038\/s41467-021-25384-y","article-title":"The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envint.2026.110485_b0210","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.toxlet.2025.03.011","article-title":"Dose-dependent effects of chlorpyrifos on liver injury, intestinal dysbiosis, and metabolic perturbations in C57BL\/6J mice","volume":"407","author":"Wei","year":"2025","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envint.2026.110485_b0215","doi-asserted-by":"crossref","unstructured":"Wolejko, E., Lozowicka, B., Jablonska-Trypuc, A., Pietruszynska, M., Wydro, U., 2022. Chlorpyrifos occurrence and toxicological risk assessment: a review. Int. J. Environ. Res. Public Health 19.","DOI":"10.3390\/ijerph191912209"},{"key":"10.1016\/j.envint.2026.110485_b0220","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.mad.2006.07.002","article-title":"Age-related changes of mitochondrial structure and function in Caenorhabditis elegans","volume":"127","author":"Yasuda","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.envint.2026.110485_b0225","first-page":"315","article-title":"Feeding habits in soil nematode families and genera-an outline for soil ecologists","volume":"25","author":"Yeates","year":"1993","journal-title":"J. Nematol."},{"key":"10.1016\/j.envint.2026.110485_b0230","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.envint.2026.110485_b0235","first-page":"9","article-title":"Guidelines for monitoring autophagy in Caenorhabditis elegans","volume":"11","author":"Zhang","year":"2015","journal-title":"Autophagy"}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:42:31Z","timestamp":1789836151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412026004435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":47,"alternative-id":["S0160412026004435"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2026.110485","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmental acetylcholinesterase blockade impairs conserved gut-metabolic resilience in a soil nematode sentinel","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2026.110485","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110485"}}