{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:06:53Z","timestamp":1789837613140,"version":"4.0.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["23 2761 Pj"],"award-info":[{"award-number":["23 2761 Pj"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.envint.2026.110501","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:26:50Z","timestamp":1788305210000},"page":"110501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Long-term exposure to trihalomethanes in drinking water and risk of liver and kidney cancer: a population-based cohort study"],"prefix":"10.1016","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7062-5968","authenticated-orcid":false,"given":"Emilie","family":"Helte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melle","family":"S\u00e4ve-S\u00f6derbergh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9594-4140","authenticated-orcid":false,"given":"Agneta","family":"\u00c5kesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.envint.2026.110501_b0005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/02841860802247664","article-title":"The completeness of the Swedish Cancer Register \u2013 a sample survey for year 1998","volume":"48","author":"Barlow","year":"2009","journal-title":"Acta Oncol."},{"issue":"11","key":"10.1016\/j.envint.2026.110501_b0010","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1289\/ehp.1002206","article-title":"Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain","volume":"118","author":"Cantor","year":"2010","journal-title":"Environ. Health Perspect."},{"issue":"12","key":"10.1016\/j.envint.2026.110501_b0015","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1093\/jnci\/djad145","article-title":"Disinfection by-products in drinking water and risk of colorectal cancer: a population-based cohort study","volume":"115","author":"Helte","year":"2023","journal-title":"J. Natl Cancer Inst."},{"issue":"1","key":"10.1016\/j.envint.2026.110501_b0020","doi-asserted-by":"crossref","first-page":"16001","DOI":"10.1289\/EHP14505","article-title":"Exposure to drinking water trihalomethanes and risk of cancer: a systematic review of the epidemiologic evidence and dose-response meta-analysis","volume":"133","author":"Helte","year":"2025","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.envint.2026.110501_b0025","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/EDE.0000000000000647","article-title":"Ingested nitrate, disinfection by-products, and kidney cancer risk in older women","volume":"28","author":"Jones","year":"2017","journal-title":"Epidemiology"},{"key":"10.1016\/j.envint.2026.110501_b0030","unstructured":"Lash TL, VanderWeele TJ, Haneuse S, et al. Modern Epidemiology. Fourth edition. ed. Philadelphia: Wolters Kluwer \/ Lippincott Williams & Wilkins; 2021."},{"issue":"6","key":"10.1016\/j.envint.2026.110501_b0035","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/15287394.2012.668162","article-title":"Trihalomethanes in drinking water and the risk of death from kidney cancer: does hardness in drinking water matter?","volume":"75","author":"Liao","year":"2012","journal-title":"J. Toxicol. Environ. Health - Part A: Current Issues"},{"issue":"7","key":"10.1016\/j.envint.2026.110501_b0040","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.18513","article-title":"Community water trihalomethanes and chronic kidney disease","volume":"8","author":"Medgyesi","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.envint.2026.110501_b0045","first-page":"1","article-title":"NTP Toxicology and carcinogenesis studies of bromodichloromethane (CAS No. 75-27-4) in F344\/N rats and B6C3F1 mice (gavage studies)","volume":"321","author":"Ntp","year":"1987","journal-title":"Natl. Toxicol. Program Tech. Rep. Ser."},{"key":"10.1016\/j.envint.2026.110501_b0050","first-page":"1","article-title":"NTP toxicology and carcinogenesis studies of tribromomethane (Bromoform) (CAS No. 75-25-2) in F344\/N rats and B6C3F1 mice (gavage studies)","volume":"350","author":"Ntp","year":"1989","journal-title":"Natl. Toxicol. Program Tech. Rep. Ser."},{"issue":"1\u20133","key":"10.1016\/j.envint.2026.110501_b0055","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.mrrev.2007.09.001","article-title":"Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research","volume":"636","author":"Richardson","year":"2007","journal-title":"Mutat. Res."},{"issue":"12","key":"10.1016\/j.envint.2026.110501_b0060","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1001\/jama.2024.12848","article-title":"Renal Cell carcinoma: a review","volume":"332","author":"Rose","year":"2024","journal-title":"J. Am. Med. Assoc."},{"issue":"2","key":"10.1016\/j.envint.2026.110501_b0065","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.taap.2003.11.019","article-title":"In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane: DNA binding mediated by glutathione transferase theta 1-1","volume":"195","author":"Ross","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2026.110501_b0070","unstructured":"Socialstyrelsen, 2023. Det statistiska registrets framst\u00e4llning och kvalitet \u2013 Cancerregistret. Stockholm."},{"issue":"3","key":"10.1016\/j.envint.2026.110501_b0075","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/joneph\/23.3.253","article-title":"Chronic kidney disease and cancer: a troubling connection","volume":"23","author":"Stengel","year":"2010","journal-title":"J. Nephrol."},{"issue":"27","key":"10.1016\/j.envint.2026.110501_b0080","doi-asserted-by":"crossref","first-page":"11958","DOI":"10.1021\/acs.est.4c01894","article-title":"Climate-driven increases in source water natural organic matter: implications for the sustainability of drinking water treatment","volume":"58","author":"Swinamer","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2026.110501_b0085","doi-asserted-by":"crossref","DOI":"10.1186\/s13293-026-00843-7","article-title":"Sexual dimorphism in cancer: molecular mechanisms and precision oncology perspectives","author":"Wang","year":"2026","journal-title":"Biol. Sex Differ."},{"issue":"1","key":"10.1016\/j.envint.2026.110501_b0090","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2166\/bgs.2024.008","article-title":"Bio-safe drinking water with or without chlorine: a review","volume":"6","author":"Wang","year":"2024","journal-title":"Blue-Green Syst."},{"key":"10.1016\/j.envint.2026.110501_b0095","unstructured":"World Health Organization. Trihalomethanes in Drinking\u2011water: Background document for development of WHO Guidelines for Drinking\u2011Water Quality. Geneva; 2004."},{"issue":"2","key":"10.1016\/j.envint.2026.110501_b0100","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s40726-023-00255-w","article-title":"Impacts of extreme weather on microbiological risks of drinking water in coastal cities: a review","volume":"9","author":"Xiao","year":"2023","journal-title":"Curr. Pollut. Rep."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:42:55Z","timestamp":1789836175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412026004599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":20,"alternative-id":["S0160412026004599"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2026.110501","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term exposure to trihalomethanes in drinking water and risk of liver and kidney cancer: a population-based cohort study","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2026.110501","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110501"}}