{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:53:44Z","timestamp":1791122024111,"version":"4.1.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2021-02806"],"award-info":[{"award-number":["RGPIN-2021-02806"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs Program","doi-asserted-by":"publisher","award":["CRC-2020-00060"],"award-info":[{"award-number":["CRC-2020-00060"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["1021737"],"award-info":[{"award-number":["1021737"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012171","name":"Ontario Research Foundation","doi-asserted-by":"publisher","award":["40569"],"award-info":[{"award-number":["40569"]}],"id":[{"id":"10.13039\/100012171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["43247"],"award-info":[{"award-number":["43247"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["233109"],"award-info":[{"award-number":["233109"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008572","name":"University of Ottawa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008572","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.envint.2026.110516","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:42:12Z","timestamp":1788882132000},"page":"110516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Prolonged benzo[b]fluoranthene exposure increases tissue-specific mutational burden, expansion of mutant cells, and mutagenic potency"],"prefix":"10.1016","volume":"216","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6316-4358","authenticated-orcid":false,"given":"D.M.","family":"Schuster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.P.M.","family":"LeBlanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8199-8754","authenticated-orcid":false,"given":"M.J.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.E.","family":"Dodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3565-6347","authenticated-orcid":false,"given":"A.","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7637-7686","authenticated-orcid":false,"given":"A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-2565","authenticated-orcid":false,"given":"D.C.","family":"Eickmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2814-6126","authenticated-orcid":false,"given":"S.","family":"Kehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Funk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9435-4867","authenticated-orcid":false,"given":"F.","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6725-3454","authenticated-orcid":false,"given":"C.L.","family":"Yauk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7463","key":"10.1016\/j.envint.2026.110516_b0205","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.envint.2026.110516_b0230","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/carcin\/3.2.171","article-title":"Identification of metabolites of benzo[b]fluoranthene","volume":"3","author":"Amin","year":"1982","journal-title":"Carcinogenesis"},{"issue":"7","key":"10.1016\/j.envint.2026.110516_b0235","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1093\/carcin\/6.7.1023","article-title":"Mutagenicity and tumor initiating activity of methylated benzo[b]fluoranthenes","volume":"6","author":"Amin","year":"1985","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.envint.2026.110516_b0395","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-025-04121-0","article-title":"Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis","author":"Ashford","year":"2025","journal-title":"Arch. Toxicol."},{"issue":"41","key":"10.1016\/j.envint.2026.110516_b0320","doi-asserted-by":"crossref","first-page":"17604","DOI":"10.1073\/pnas.1009117107","article-title":"A mathematical framework to determine the temporal sequence of somatic genetic events in cancer","volume":"107","author":"Attolini","year":"2010","journal-title":"PNAS"},{"key":"10.1016\/j.envint.2026.110516_b0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrgentox.2023.503685","article-title":"Comparison of the transgenic rodent mutation assay, error corrected next generation duplex sequencing, and the alkaline comet assay to detect dose-related mutations following exposure to N-nitrosodiethylamine","volume":"891","author":"Bercu","year":"2023","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"issue":"1","key":"10.1016\/j.envint.2026.110516_b0300","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/imr.12693","article-title":"Current best estimates for the average lifespans of mouse and human leukocytes: reviewing two decades of deuterium-labeling experiments","volume":"285","author":"Borghans","year":"2018","journal-title":"Immunol. Rev."},{"issue":"Suppl 3","key":"10.1016\/j.envint.2026.110516_b0025","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1289\/ehp.110-1241197","article-title":"Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air","volume":"110 Suppl 3","author":"Bostr\u00f6m","year":"2002","journal-title":"Environ. Health Perspect."},{"issue":"7779","key":"10.1016\/j.envint.2026.110516_b0310","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41586-019-1670-9","article-title":"Somatic mutations and clonal dynamics in healthy and cirrhotic human liver","volume":"574","author":"Brunner","year":"2019","journal-title":"Nature"},{"issue":"7906","key":"10.1016\/j.envint.2026.110516_b0350","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41586-022-04618-z","article-title":"Somatic mutation rates scale with lifespan across mammals","volume":"604","author":"Cagan","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.envint.2026.110516_b0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrgentox.2023.503649","article-title":"Error-corrected duplex sequencing enables direct detection and quantification of mutations in human TK6 cells with strong inter-laboratory consistency","volume":"889","author":"Cho","year":"2023","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"issue":"2\u20133","key":"10.1016\/j.envint.2026.110516_b0120","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/(SICI)1098-2280(1999)34:2\/3<208::AID-EM21>3.0.CO;2-1","article-title":"Effects of extended chronic exposures on endogenous and transgenic loci: implications for low-dose extrapolations","volume":"34","author":"Cosentino","year":"1999","journal-title":"Environ. Mol. Mutagen."},{"issue":"8","key":"10.1016\/j.envint.2026.110516_b0175","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1007\/s00204-023-03527-y","article-title":"Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the BM of MutaMouse males exposed to procarbazine hydrochloride","volume":"97","author":"Dodge","year":"2023","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.envint.2026.110516_b0180","doi-asserted-by":"crossref","DOI":"10.1093\/bioadv\/vbaf265","article-title":"MutSeqR: an open source R package for standardized analysis of error-corrected next-generation sequencing data in genetic toxicology","volume":"5","author":"Dodge","year":"2025","journal-title":"Bioinform. Adv."},{"issue":"1","key":"10.1016\/j.envint.2026.110516_b0190","doi-asserted-by":"crossref","DOI":"10.2903\/j.efsa.2017.4658","article-title":"Update: use of the benchmark dose approach in risk assessment","volume":"15","author":"EFSA Scientific Committee","year":"2017","journal-title":"EFSA J."},{"issue":"Suppl 2","key":"10.1016\/j.envint.2026.110516_b0270","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF03165135","article-title":"Research within the field of blood and marrow transplantation nursing: how can it contribute to higher quality of care?","volume":"76","author":"Fliedner","year":"2002","journal-title":"Int. J. Hematol."},{"issue":"22","key":"10.1016\/j.envint.2026.110516_b0380","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1093\/nar\/gkm756","article-title":"Changes in DNA repair during aging","volume":"35","author":"Gorbunova","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.envint.2026.110516_b0335","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1021\/tx700079z","article-title":"Cytochrome p450 and chemical toxicology","volume":"21","author":"Guengerich","year":"2008","journal-title":"Chem. Res. Toxicol."},{"issue":"5","key":"10.1016\/j.envint.2026.110516_b0135","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.envint.2026.110516_b0370","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nrm2549","article-title":"Transcription-coupled DNA repair: two decades of progress and surprises","volume":"9","author":"Hanawalt","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.envint.2026.110516_b0095","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/toxsci\/kfh030","article-title":"DNA adduct formation in precision-cut rat liver and lung slices exposed to benzo[a]pyrene","volume":"77","author":"Harrigan","year":"2004","journal-title":"Toxicol. Sci."},{"issue":"8","key":"10.1016\/j.envint.2026.110516_b0125","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/em.20335","article-title":"Mutations in the lungs of gpt delta transgenic mice following inhalation of diesel exhaust","volume":"48","author":"Hashimoto","year":"2007","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.envint.2026.110516_b0020","unstructured":"Health Impacts of Air Pollution in Canada: Estimates of morbidity and premature mortality outcomes \u2013 2021 Report."},{"issue":"3","key":"10.1016\/j.envint.2026.110516_b0360","doi-asserted-by":"crossref","first-page":"96","DOI":"10.18001\/TRS.4.3.9","article-title":"Multi-year study of PAHs in mainstream cigarette smoke","volume":"4","author":"Hearn","year":"2018","journal-title":"Tob. Regul. Sci."},{"issue":"5","key":"10.1016\/j.envint.2026.110516_b0225","article-title":"Tissue specificity of DNA damage and repair","volume":"38","author":"Hoch","year":"2023","journal-title":"Physiology (Bethesda)"},{"issue":"1","key":"10.1016\/j.envint.2026.110516_b0015","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/ije\/dyr154","article-title":"Environmental chemical exposures and human epigenetics","volume":"41","author":"Hou","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.envint.2026.110516_b0035","unstructured":"IARC, 1985. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Tobacco Habits Other than Smoking; Betel-Quid and Areca-Nut Chewing; and Some Related Nitrosamines; IARC Press: Lyon, France, Vol. 37."},{"key":"10.1016\/j.envint.2026.110516_b0040","unstructured":"IARC, 2010. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Some Non-heterocyclic Polycyclic Aromatic Hydrocarbons and Some Related Exposures; IARC Press: Lyon, France, Vol. 92."},{"key":"10.1016\/j.envint.2026.110516_b0045","unstructured":"IARC, 2023. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Occupational Exposure as a Firefighter; IARC Press: Lyon, France, Vol. 132."},{"issue":"11","key":"10.1016\/j.envint.2026.110516_b0185","article-title":"Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor","volume":"2","author":"Islam","year":"2022","journal-title":"Cell Genom."},{"issue":"26","key":"10.1016\/j.envint.2026.110516_b0275","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"Jaiswal","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.envint.2026.110516_b0075","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1021\/es60152a601","article-title":"ES&T Special Report: Priority pollutants: I-a perspective view","volume":"13","author":"Keith","year":"1979","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2026.110516_b0255","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mrrev.2015.11.001","article-title":"Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents","volume":"767","author":"Klapacz","year":"2016","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"issue":"3","key":"10.1016\/j.envint.2026.110516_b0115","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/tcm.1770080302","article-title":"Effect of duration of exposure to benzo(a)pyrene diol-epoxide on neoplastic transformation, mutagenesis, cytotoxicity, and total covalent binding to DNA of rodent cells","volume":"8","author":"Krolewski","year":"1988","journal-title":"Teratog. Carcinog. Mutagen."},{"issue":"4","key":"10.1016\/j.envint.2026.110516_b0215","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2019.03.001","article-title":"A compendium of mutational signatures of environmental agents","volume":"177","author":"Kucab","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.envint.2026.110516_b0150","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1186\/s12864-022-08752-w","article-title":"Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations","volume":"23","author":"LeBlanc","year":"2022","journal-title":"BMC Genomics"},{"key":"10.1016\/j.envint.2026.110516_b0105","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.freeradbiomed.2025.10.008","article-title":"BbF-induced liver injury in Balb\/c mice: AhR activation as the conductor of metabolism, oxidative stress, lipid metabolism disorder, and inflammatory response","volume":"241","author":"Liu","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envint.2026.110516_b0030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.taap.2015.11.010","article-title":"Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta\u2122Mouse transgenic rodent assay","volume":"290","author":"Long","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2026.110516_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145770","article-title":"Inhalation bioaccessibility and absorption of polycyclic aromatic hydrocarbons (PAHs) in indoor PM2.5 and its implication in risk assessment","volume":"774","author":"Luo","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2026.110516_b0305","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1001\/archinte.1961.03620030023003","article-title":"\u201cLifespan\u201d of liver cells. Autoradio-graphic study using tritiated thymidine in normal, cirrhotic, and partially hepatectomized rats","volume":"107","author":"MacDonald","year":"1961","journal-title":"Arch. Intern. Med."},{"issue":"3","key":"10.1016\/j.envint.2026.110516_b0265","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00204-021-02977-6","article-title":"The 28\u2009+\u200928 day design is an effective sampling time for analyzing mutant frequencies in rapidly proliferating tissues of MutaMouse animals","volume":"95","author":"Marchetti","year":"2021","journal-title":"Arch. Toxicol."},{"issue":"8","key":"10.1016\/j.envint.2026.110516_b0080","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/carcin\/17.8.1701","article-title":"Benzo[b]fluoranthene: tumorigenicity in strain A\/J mouse lungs, DNA adducts and mutations in the Ki-ras oncogene","volume":"17","author":"Mass","year":"1996","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.envint.2026.110516_b0355","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1289\/EHP211","article-title":"In utero exposure to benzo[a]pyrene increases mutation burden in the soma and sperm of adult mice","volume":"125","author":"Meier","year":"2017","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.envint.2026.110516_b0155","doi-asserted-by":"crossref","first-page":"13775","DOI":"10.1038\/s41598-019-50302-0","article-title":"Whole genome sequencing of the mutamouse model reveals strain- and colony-level variation, and genomic features of the transgene integration site","volume":"9","author":"Meier","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.envint.2026.110516_b0340","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/kfv040","article-title":"Polycyclic aromatic hydrocarbons: from metabolism to lung cancer","volume":"145","author":"Moorthy","year":"2015","journal-title":"Toxicol. Sci."},{"issue":"5","key":"10.1016\/j.envint.2026.110516_b0200","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.cell.2012.04.024","article-title":"Mutational processes molding the genomes of 21 breast cancers","volume":"149","author":"Nik-Zainal","year":"2012","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.envint.2026.110516_b0210","first-page":"763","article-title":"The genome as a record of environmental exposure","volume":"30","author":"Nik-Zainal","year":"2015","journal-title":"Mutagenesis"},{"key":"10.1016\/j.envint.2026.110516_b0065","doi-asserted-by":"crossref","unstructured":"OECD (2016), Test No. 474: Mammalian Erythrocyte Micronucleus Test, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris, Doi:10.1787\/9789264264762-en.","DOI":"10.1787\/9789264264762-en"},{"key":"10.1016\/j.envint.2026.110516_b0165","doi-asserted-by":"crossref","unstructured":"OECD, 2018. Test No. 452: Chronic Toxicity Studies, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris, Doi:10.1787\/9789264071209-en.","DOI":"10.1787\/9789264071209-en"},{"key":"10.1016\/j.envint.2026.110516_b0060","doi-asserted-by":"crossref","unstructured":"OECD (2025), Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris, Doi:10.1787\/9789264203907-en.","DOI":"10.1787\/9789264203907-en"},{"key":"10.1016\/j.envint.2026.110516_b0070","doi-asserted-by":"crossref","unstructured":"OECD, 2025. Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris, Doi:10.1787\/4faea90e-en.","DOI":"10.1787\/4faea90e-en"},{"key":"10.1016\/j.envint.2026.110516_b0160","doi-asserted-by":"crossref","unstructured":"OECD, 2025. Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris, Doi:10.1787\/9789264070707-en.","DOI":"10.1787\/9789264070707-en"},{"issue":"Suppl 3","key":"10.1016\/j.envint.2026.110516_b0375","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/bcpt.12806","article-title":"The pig-a gene mutation assay in mice and human cells: a review","volume":"121","author":"Olsen","year":"2017","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.envint.2026.110516_b0290","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/mutage\/17.3.219","article-title":"Griseofulvin induces mitotic delay and aneuploidy in bone marrow cells of orally treated mice","volume":"17","author":"Pacchierotti","year":"2002","journal-title":"Mutagenesis"},{"key":"10.1016\/j.envint.2026.110516_b0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrrev.2018.05.001","article-title":"Multiclonal tumor origin: evidence and implications","volume":"777","author":"Parsons","year":"2018","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"issue":"8","key":"10.1016\/j.envint.2026.110516_b0085","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1021\/acs.chemrestox.9b00213","article-title":"Bioaccumulation of polycyclic aromatic hydrocarbons for forensic assessment using gas chromatography-mass spectrometry","volume":"32","author":"Pastor-Belda","year":"2019","journal-title":"Chem. Res. Toxicol."},{"issue":"5","key":"10.1016\/j.envint.2026.110516_b0240","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1365-2559.1995.tb00302.x","article-title":"Assessment of cell proliferation in normal and pathological BM biopsies: a study using double sequential immunophenotyping on paraffin sections","volume":"27","author":"Pellegrini","year":"1995","journal-title":"Histopathology"},{"issue":"5","key":"10.1016\/j.envint.2026.110516_b0050","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/10915810490517063","article-title":"Bioavailability and risk assessment of orally ingested polycyclic aromatic hydrocarbons","volume":"23","author":"Ramesh","year":"2004","journal-title":"Int. J. Toxicol."},{"issue":"36","key":"10.1016\/j.envint.2026.110516_b0145","doi-asserted-by":"crossref","first-page":"14508","DOI":"10.1073\/pnas.1208715109","article-title":"Detection of ultra-rare mutations by next-generation sequencing","volume":"109","author":"Schmitt","year":"2012","journal-title":"PNAS"},{"issue":"4","key":"10.1016\/j.envint.2026.110516_b0130","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nrc.2017.5","article-title":"Tissue-specific tumorigenesis: context matters","volume":"17","author":"Schneider","year":"2017","journal-title":"Nat. Rev. Cancer"},{"issue":"49","key":"10.1016\/j.envint.2026.110516_b0110","doi-asserted-by":"crossref","first-page":"21450","DOI":"10.1021\/acs.est.4c07236","article-title":"Dose-related mutagenic and clastogenic effects of Benzo[b]fluoranthene IN mouse somatic tissues detected by duplex sequencing and the micronucleus assay","volume":"58","author":"Schuster","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"8013","key":"10.1016\/j.envint.2026.110516_b0220","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/s41586-024-07368-2","article-title":"Geographic variation of mutagenic exposures in kidney cancer genomes","volume":"629","author":"Senkin","year":"2024","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.envint.2026.110516_b0330","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2133\/dmpk.21.257","article-title":"Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons","volume":"21","author":"Shimada","year":"2006","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"1\u20132","key":"10.1016\/j.envint.2026.110516_b0005","first-page":"71","article-title":"Effects of environmental air pollution on endogenous oxidative DNA damage in humans","volume":"620","author":"Singh","year":"2007","journal-title":"Mutat. Res."},{"issue":"9","key":"10.1016\/j.envint.2026.110516_b0260","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1021\/acs.chemrestox.1c00235","article-title":"Exposure to an environmental mixture of polycyclic aromatic hydrocarbons induces hepatic cytochrome P450 enzymes in mice","volume":"34","author":"Stoddard","year":"2021","journal-title":"Chem. Res. Toxicol."},{"issue":"2\u20133","key":"10.1016\/j.envint.2026.110516_b0010","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.mrrev.2003.06.010","article-title":"Linking exposure to environmental pollutants with biological effects","volume":"544","author":"S\u00f8rensen","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envint.2026.110516_b0315","series-title":"Principles of Molecular Diagnostics and Personalized Cancer Medicine","first-page":"12","year":"2013"},{"issue":"6217","key":"10.1016\/j.envint.2026.110516_b0140","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.1260825","article-title":"Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions","volume":"347","author":"Tomasetti","year":"2015","journal-title":"Science"},{"issue":"52","key":"10.1016\/j.envint.2026.110516_b0170","doi-asserted-by":"crossref","first-page":"33414","DOI":"10.1073\/pnas.2013724117","article-title":"Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing","volume":"117","author":"Valentine","year":"2020","journal-title":"PNAS"},{"issue":"23","key":"10.1016\/j.envint.2026.110516_b0295","doi-asserted-by":"crossref","first-page":"12595","DOI":"10.1073\/pnas.220430497","article-title":"Timing of hepatocyte entry into DNA synthesis after partial hepatectomy is cell autonomous","volume":"97","author":"Weglarz","year":"2000","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.envint.2026.110516_b0285","first-page":"299","article-title":"Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta\u2122Mouse tissues and cultured cells exposed to 3-nitrobenzanthrone","volume":"32","author":"White","year":"2017","journal-title":"Mutagenesis"},{"issue":"4","key":"10.1016\/j.envint.2026.110516_b0195","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/em.70006","article-title":"Benchmark response (BMR) values for in vivo mutagenicity endpoints","volume":"66","author":"White","year":"2025","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.envint.2026.110516_b0345","first-page":"510","article-title":"The repair of 5-methylcytosine deamination damage","volume":"64","author":"Wiebauer","year":"1993","journal-title":"EXS"},{"issue":"6","key":"10.1016\/j.envint.2026.110516_b0250","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.cell.2008.10.048","article-title":"Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair","volume":"135","author":"Wilson","year":"2008","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.envint.2026.110516_b0280","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/nm.3733","article-title":"Age-related mutations associated with clonal hematopoietic expansion and malignancies","volume":"20","author":"Xie","year":"2014","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.envint.2026.110516_b0090","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0006-2952(88)90755-1","article-title":"Stereoselectivity of cytochrome P-450 isozymes and epoxide hydrolase in the metabolism of polycyclic aromatic hydrocarbons","volume":"37","author":"Yang","year":"1988","journal-title":"Biochem. Pharmacol."},{"issue":"11","key":"10.1016\/j.envint.2026.110516_b0100","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1002\/jat.4497","article-title":"Metabolism and elimination kinetics of mono-hydroxylated PAHs metabolites following single exposure to different combinations of PAH4 in rats","volume":"43","author":"Yang","year":"2023","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envint.2026.110516_b0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2025.105985","article-title":"Application of error-corrected sequencing technologies for in vivo regulatory mutagenicity assessment","volume":"164","author":"Yauk","year":"2026","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.envint.2026.110516_b0245","doi-asserted-by":"crossref","DOI":"10.1177\/09636897231221878","article-title":"Proliferation and differentiation potential of BM-derived mesenchymal stem cells from children with polydactyly and adults with basal joint arthritis","volume":"33","author":"Yeh","year":"2024","journal-title":"Cell Transplant."},{"issue":"5\u20137","key":"10.1016\/j.envint.2026.110516_b0365","article-title":"Benzo[b]fluoranthene induces mutation accumulation and cancer-relevant mutational signatures in mouse lung alongside steady state levels of chromosome damage in blood","volume":"67","author":"Zhang","year":"2026","journal-title":"Environ. Mol. Mutagen."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:47:35Z","timestamp":1791121655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412026004745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":80,"alternative-id":["S0160412026004745"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2026.110516","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prolonged benzo[b]fluoranthene exposure increases tissue-specific mutational burden, expansion of mutant cells, and mutagenic potency","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2026.110516","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110516"}}