{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:38:12Z","timestamp":1792715892245,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1300802-4"],"award-info":[{"award-number":["2023YFD1300802-4"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX24_0995"],"award-info":[{"award-number":["KYCX24_0995"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372935"],"award-info":[{"award-number":["32372935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072781"],"award-info":[{"award-number":["32072781"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007166","name":"Jiangsu Province Department of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["KYLH2025004"],"award-info":[{"award-number":["KYLH2025004"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.envint.2026.110519","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:07:27Z","timestamp":1789085247000},"page":"110519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Heat exposure remodels the gut microbiota to promote heat acclimation through a serotonin-mediated gut\u2013brain axis"],"prefix":"10.1016","volume":"216","author":[{"given":"Sheng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Nagaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2026.110519_b0005","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41593-024-01830-0","article-title":"Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance","volume":"28","author":"Ambroziak","year":"2025","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.envint.2026.110519_b0010","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.cbpa.2010.07.011","article-title":"Time course of ROS production in skeletal muscle mitochondria from chronic heat-exposed broiler chicken","volume":"157","author":"Azad","year":"2010","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.envint.2026.110519_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113021","article-title":"Role of gut microbiota in the postnatal thermoregulation of Brandt's voles","volume":"42","author":"Bo","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.envint.2026.110519_b0020","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1038\/s41396-019-0492-y","article-title":"The microbiota-gut-brain interaction in regulating host metabolic adaptation to cold in male Brandt's voles (Lasiopodomys brandtii)","volume":"13","author":"Bo","year":"2019","journal-title":"Isme j."},{"key":"10.1016\/j.envint.2026.110519_b0025","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s41467-023-37055-1","article-title":"Microbiota alters the metabolome in an age- and sex- dependent manner in mice","volume":"14","author":"Brown","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envint.2026.110519_b0030","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4291\/wjgp.v6.i4.110","article-title":"New-found link between microbiota and obesity","volume":"6","author":"Chakraborti","year":"2015","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"10.1016\/j.envint.2026.110519_b0035","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2192155","article-title":"Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes","volume":"15","author":"Chen","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.envint.2026.110519_b0040","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41422-024-01064-6","article-title":"Heat acclimation in mice requires preoptic BDNF neurons and postsynaptic potentiation","volume":"35","author":"Chen","year":"2025","journal-title":"Cell Res."},{"key":"10.1016\/j.envint.2026.110519_b0045","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40168-025-02084-z","article-title":"Effect of inulin supplementation in maternal fecal microbiota transplantation on the early growth of chicks","volume":"13","author":"Chen","year":"2025","journal-title":"Microbiome"},{"key":"10.1016\/j.envint.2026.110519_b0050","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.cell.2015.11.004","article-title":"Gut microbiota orchestrates energy homeostasis during cold","volume":"163","author":"Chevalier","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.envint.2026.110519_b0055","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2018.11.002","article-title":"New advances in adaptive thermogenesis: UCP1 and beyond","volume":"29","author":"Chouchani","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.envint.2026.110519_b0060","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.19697","article-title":"Molecular evolution of TRPC4 regulatory sequences supports a role in mammalian thermoregulatory adaptation","volume":"13","author":"Cornman","year":"2025","journal-title":"PeerJ"},{"key":"10.1016\/j.envint.2026.110519_b0065","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2105-13-113","article-title":"Molecular ecological network analyses","volume":"13","author":"Deng","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.envint.2026.110519_b0070","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1038\/s41467-018-05247-9","article-title":"Structure of the mouse TRPC4 ion channel","volume":"9","author":"Duan","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envint.2026.110519_b0075","doi-asserted-by":"crossref","DOI":"10.1126\/science.abj3986","article-title":"Bacterial sensing via neuronal Nod2 regulates appetite and body temperature","volume":"376","author":"Gabanyi","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.envint.2026.110519_b0080","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/advances\/nmz127","article-title":"Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain","volume":"11","author":"Gao","year":"2020","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.envint.2026.110519_b0085","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1053\/j.gastro.2006.11.002","article-title":"The serotonin signaling system: from basic understanding to drug development for functional GI disorders","volume":"132","author":"Gershon","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.envint.2026.110519_b0090","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s40168-024-01795-z","article-title":"Short-term exposure to antibiotics begets long-term disturbance in gut microbial metabolism and molecular ecological networks","volume":"12","author":"Hong","year":"2024","journal-title":"Microbiome"},{"key":"10.1016\/j.envint.2026.110519_b0095","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41596-022-00767-7","article-title":"Interrogation of the mammalian gut-brain axis using LC-MS\/MS-based targeted metabolomics with in vitro bacterial and organoid cultures and in vivo gnotobiotic mouse models","volume":"18","author":"Horvath","year":"2023","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.envint.2026.110519_b0100","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1016\/j.neuron.2021.10.001","article-title":"A synaptic temperature sensor for body cooling","volume":"109","author":"Kamm","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.envint.2026.110519_b0105","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1362987","article-title":"Direct modulation of TRPC ion channels by G\u03b1 proteins","volume":"15","author":"Kang","year":"2024","journal-title":"Front. Physiol."},{"key":"10.1016\/j.envint.2026.110519_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2022.102591","article-title":"TRP channels in thermosensation","volume":"75","author":"Kashio","year":"2022","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.envint.2026.110519_b0115","first-page":"e00514","volume":"mSystems 5","author":"Khakisahneh","year":"2020","journal-title":"Gut microbiota and host thermoregulation in response to ambient temperature fluctuations."},{"key":"10.1016\/j.envint.2026.110519_b0120","volume":"9","author":"Klaessens","year":"2022","journal-title":"Systemic tryptophan homeostasis. Front. Mol. Biosci."},{"key":"10.1016\/j.envint.2026.110519_b0125","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/239452a0","article-title":"Free tryptophan in plasma and brain tryptophan metabolism","volume":"239","author":"Knott","year":"1972","journal-title":"Nature"},{"key":"10.1016\/j.envint.2026.110519_b0130","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nm.4102","article-title":"CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands","volume":"22","author":"Lamas","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.envint.2026.110519_b0135","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1016\/j.celrep.2019.02.015","article-title":"Microbiota depletion impairs thermogenesis of brown sdipose tissue and browning of white adipose tissue","volume":"26","author":"Li","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.envint.2026.110519_b0140","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.cmet.2017.08.019","article-title":"Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gutmicrobiota","volume":"26","author":"Li","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.envint.2026.110519_b0145","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mam.2019.07.005","article-title":"Switching on the furnace: Regulation of heat production in brown adipose tissue","volume":"68","author":"Li","year":"2019","journal-title":"Mol. Aspects. Med."},{"key":"10.1016\/j.envint.2026.110519_b0150","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s11250-022-03161-3","article-title":"Effects of dietary tryptophan supplementation on body temperature, hormone, and cytokine levels in broilers exposed to acute heat stress","volume":"54","author":"Li","year":"2022","journal-title":"Trop. Anim. Health Prod."},{"key":"10.1016\/j.envint.2026.110519_b0155","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s40104-023-00950-0","article-title":"Gut microbiota intervention attenuates thermogenesis in broilers exposed to high temperature through modulation of the hypothalamic 5-HT pathway","volume":"14","author":"Li","year":"2023","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.envint.2026.110519_b0160","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nprot.2012.013","article-title":"Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice","volume":"7","author":"Lim","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.envint.2026.110519_b0165","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40168-024-02021-6","article-title":"Early fecal microbiota transplantation continuously improves chicken growth performance by inhibiting age-related Lactobacillus decline in jejunum","volume":"13","author":"Liu","year":"2025","journal-title":"Microbiome"},{"key":"10.1016\/j.envint.2026.110519_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104254","article-title":"Early-age heat exposure improved growth performance and heat tolerance in broilers","volume":"103","author":"Liu","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.envint.2026.110519_b0175","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1017\/S1751731114001931","article-title":"Cyclic variations in incubation conditions induce adaptive responses to later heat exposure in chickens: a review","volume":"9","author":"Loyau","year":"2015","journal-title":"Animal"},{"key":"10.1016\/j.envint.2026.110519_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.104886","article-title":"Heat stress in chickens induces temporal changes in the cecal microbiome concomitant with host enteric serotonin responses","volume":"104","author":"Lyte","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.envint.2026.110519_b0185","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.psj.2020.09.090","article-title":"Heat stress alters muscle protein and amino acid metabolism and accelerates liver gluconeogenesis for energy supply in broilers","volume":"100","author":"Ma","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.envint.2026.110519_b0190","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s40168-023-01569-z","article-title":"Fecal microbiota transplantation improves chicken growth performance by balancing jejunal Th17\/Treg cells","volume":"11","author":"Ma","year":"2023","journal-title":"Microbiome"},{"key":"10.1016\/j.envint.2026.110519_b0195","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41583-023-00785-8","article-title":"Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands","volume":"25","author":"Mota","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.envint.2026.110519_b0200","doi-asserted-by":"crossref","first-page":"16065","DOI":"10.1073\/pnas.2535311100","article-title":"Contribution of transient receptor potential channels to the control of GABA release from dendrites","volume":"100","author":"Munsch","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envint.2026.110519_b0205","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3389\/fphys.2017.00889","article-title":"Muscle non-shivering thermogenesis and its role in the evolution of endothermy","volume":"8","author":"Nowack","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.envint.2026.110519_b0210","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41579-024-01136-9","article-title":"Microbiota-neuroepithelial signalling across the gut-brain axis","volume":"23","author":"Ohara","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.envint.2026.110519_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtherbio.2020.102759","article-title":"Repeated thermal conditioning during the neonatal period affects behavioral and physiological responses to acute heat stress in chicks","volume":"94","author":"Ouchi","year":"2020","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.envint.2026.110519_b0220","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1387\/ijdb.170279LP","article-title":"Developmental studies of avian brain organization","volume":"62","author":"Puelles","year":"2018","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.envint.2026.110519_b0225","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1098\/rstb.2012.0007","article-title":"Match and mismatch: conservation physiology, nutritional ecology and the timescales of biological adaptation. Philos","volume":"367","author":"Raubenheimer","year":"2012","journal-title":"Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.envint.2026.110519_b0230","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1126\/science.1205295","article-title":"Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition","volume":"333","author":"Ray","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.envint.2026.110519_b0235","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.cell.2017.09.016","article-title":"Wild mouse gut microbiota promotes host fitness and improves disease resistance","volume":"171","author":"Rosshart","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.envint.2026.110519_b0240","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.3390\/ijms22062973","article-title":"Tryptophan metabolism and gut-brain homeostasis","volume":"22","author":"Roth","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2026.110519_b0245","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s12192-010-0240-8","article-title":"Response of mice to continuous 5-day passive hyperthermia resembles human heat acclimation","volume":"16","author":"Sareh","year":"2011","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.envint.2026.110519_b0250","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/s42255-024-01108-6","article-title":"Feeding gut microbes to nourish the brain: unravelling the diet-microbiota-gut-brain axis","volume":"6","author":"Schneider","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.envint.2026.110519_b0255","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jare.2022.07.005","article-title":"Whole genome analyses reveal novel genes associated with chicken adaptation to tropical and frigid environments","volume":"47","author":"Shi","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.envint.2026.110519_b0260","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.1016\/j.cell.2024.09.029","article-title":"Structural basis of respiratory complex adaptation to cold temperatures","volume":"187","author":"Shin","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.envint.2026.110519_b0265","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1126\/science.aaf7537","article-title":"The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia","volume":"353","author":"Song","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.envint.2026.110519_b0270","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nature19074","article-title":"The TRPM2 ion channel is required for sensitivity to warmth","volume":"536","author":"Tan","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.envint.2026.110519_b0275","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cell.2016.08.028","article-title":"Warm-sensitive neurons that control body temperature","volume":"167","author":"Tan","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.envint.2026.110519_b0280","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1152\/advan.00126.2014","article-title":"Recent advances in thermoregulation","volume":"39","author":"Tansey","year":"2015","journal-title":"Adv. Physiol. Educ."},{"key":"10.1016\/j.envint.2026.110519_b0285","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2120870119","article-title":"TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect G(q\/11)-G(i\/o) coincidence signals of variable strengths","volume":"119","author":"Tian","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envint.2026.110519_b0290","article-title":"TRPV1 and thermosensitivity","volume":"75","author":"Tominaga","year":"2025","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.envint.2026.110519_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101669","article-title":"Central and peripheral effects of L-citrulline on thermal physiology and nitric oxide regeneration in broilers","volume":"101","author":"Uyanga","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.envint.2026.110519_b0300","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.3390\/biom11121914","article-title":"5-HT receptors and temperature homeostasis","volume":"11","author":"Voronova","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.envint.2026.110519_b0305","article-title":"Differential expressions of hypothalamic thermosensitive TRP ion channels may underlie the posthatching ontogeny of brain cooling capacity in broiler chickens","volume":"102","author":"Wang","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.envint.2026.110519_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114053","article-title":"Heat stress-induced intestinal barrier damage and dimethylglycine alleviates via improving the metabolism function of microbiota gut brain axis","volume":"244","author":"Wang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envint.2026.110519_b0315","doi-asserted-by":"crossref","first-page":"16241","DOI":"10.1073\/pnas.1310300110","article-title":"Inappropriate heat dissipation ignites brown fat thermogenesis in mice with a mutant thyroid hormone receptor \u03b11","volume":"110","author":"Warner","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envint.2026.110519_b0320","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2423040","article-title":"B. vulgatus ameliorates high-fat diet-induced obesity through modulating intestinal serotonin synthesis and lipid absorption in mice","volume":"16","author":"Wen","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.envint.2026.110519_b0325","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.chom.2017.06.007","article-title":"Indoleacrylic acid produced by commensal peptostreptococcus species suppresses inflammation","volume":"22","author":"Wlodarska","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.envint.2026.110519_b0330","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3390\/ijms25010438","article-title":"Direct and indirect evidence of effects of Bacteroides spp. on obesity and inflammation","volume":"25","author":"Wu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2026.110519_b0335","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/j.cmet.2021.07.007","article-title":"Intestinal hypoxia-inducible factor 2\u03b1 regulates lactate levels to shape the gut microbiome and alter thermogenesis","volume":"33","author":"Wu","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.envint.2026.110519_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103028","article-title":"Adiponectin inhibits GnRH secretion via activating AMPK and PI3K signaling pathways in chicken hypothalamic neuron cells","volume":"102","author":"Wu","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.envint.2026.110519_b0345","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.3382\/ps\/pez440","article-title":"Changes in the cecal microbiota of laying hens during heat stress is mainly associated with reduced feed intake","volume":"98","author":"Xing","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.envint.2026.110519_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104748","article-title":"Rectal temperature and heat transfer dynamics in the eye, face, and breast of broiler chickens exposed to moderate heat stress","volume":"104","author":"Yehia","year":"2025","journal-title":"Poult. Sci."},{"key":"10.1016\/j.envint.2026.110519_b0355","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.aninu.2023.04.012","article-title":"Lactobacillus johnsonii N5 from heat stress-resistant pigs improves gut mucosal immunity and barrier in dextran sodium sulfate-induced colitis","volume":"15","author":"Yuan","year":"2023","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.envint.2026.110519_b0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2020.1848158","article-title":"Gut Bacteroides species in health and disease","volume":"13","author":"Zafar","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.envint.2026.110519_b0365","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1097540","article-title":"Tryptophan hydroxylase-2 controls brain serotonin synthesis","volume":"305","author":"Zhang","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.envint.2026.110519_b0370","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s40168-025-02112-y","article-title":"Dietary selection of distinct gastrointestinal microorganisms drives fiber utilization dynamics in goats","volume":"13","author":"Zhang","year":"2025","journal-title":"Microbiome"},{"key":"10.1016\/j.envint.2026.110519_b0375","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.neuron.2022.11.008","article-title":"Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice","volume":"111","author":"Zhou","year":"2023","journal-title":"Neuron"}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026004770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:42:51Z","timestamp":1792712571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412026004770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":75,"alternative-id":["S0160412026004770"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2026.110519","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heat exposure remodels the gut microbiota to promote heat acclimation through a serotonin-mediated gut\u2013brain axis","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2026.110519","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110519"}}