{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:37:50Z","timestamp":1792715870526,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["YJS-BD-19"],"award-info":[{"award-number":["YJS-BD-19"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["820809059"],"award-info":[{"award-number":["820809059"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022817","name":"Lanzhou University Second Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.envint.2026.110543","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:01:48Z","timestamp":1790348508000},"page":"110543","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association between per- and polyfluoroalkyl substances exposure and recurrent pregnancy loss: The potential role of oxidative stress and the HIF1\u03b1\u2011GLUT1\/VEGFA axis"],"prefix":"10.1016","volume":"216","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-9339","authenticated-orcid":false,"given":"Ling","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2026.110543_b0005","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/10408444.2016.1182117","article-title":"Perfluoroalkyl and polyfluoroalkyl substances and measures of human fertility: a systematic review","volume":"46","author":"Bach","year":"2016","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envint.2026.110543_b0010","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"R. Statistical Soc. J. Ser. B: Methodol."},{"key":"10.1016\/j.envint.2026.110543_b0015","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/S0140-6736(21)00681-4","article-title":"Recurrent miscarriage: evidence to accelerate action","volume":"397","author":"Coomarasamy","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.envint.2026.110543_b0020","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1172\/JCI84431","article-title":"HIF1\u03b1 and metabolic reprogramming in inflammation","volume":"126","author":"Corcoran","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envint.2026.110543_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146984","article-title":"Association between maternal exposure to perfluoroalkyl and polyfluoroalkyl substances and risks of adverse pregnancy outcomes: A systematic review and meta-analysis","volume":"783","author":"Deji","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2026.110543_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129120","article-title":"A review of recent studies on toxicity, sequestration, and degradation of per- and polyfluoroalkyl substances (PFAS)","volume":"436","author":"Dickman","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2026.110543_b0035","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41572-020-00228-z","article-title":"Recurrent pregnancy loss","volume":"6","author":"Dimitriadis","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.envint.2026.110543_b0040","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/humupd\/dmaa018","article-title":"Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary","volume":"26","author":"Ding","year":"2020","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.envint.2026.110543_b0045","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1518043","article-title":"Metabolomics profiling identifies diagnostic metabolic signatures for pregnancy loss: a cross-sectional study from northwestern China","volume":"16","author":"Ding","year":"2025","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.envint.2026.110543_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2026.141480","article-title":"Biological pathways of per- and polyfluoroalkyl substances (PFAS): A critical review of cellular and molecular toxicity mechanisms","volume":"505","author":"Dunmyer","year":"2026","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2026.110543_b0055","doi-asserted-by":"crossref","DOI":"10.1126\/science.abg9065","article-title":"Per- and polyfluoroalkyl substances in the environment","volume":"375","author":"Evich","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.envint.2026.110543_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109591","article-title":"Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling","volume":"201","author":"Fan","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110543_b0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s13048-024-01528-8","article-title":"N-acetylcysteine supplementation improves endocrine-metabolism profiles and ovulation induction efficacy in polycystic ovary syndrome","volume":"17","author":"Fang","year":"2024","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.envint.2026.110543_b0070","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1007\/s00216-024-05484-6","article-title":"Development and validation of the UHPLC-MS\/MS method for the quantitative determination of 25 PFAS in dried blood spots","volume":"416","author":"Galletto","year":"2024","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.envint.2026.110543_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111632","article-title":"Per- and polyfluoroalkyl substances exposure during pregnancy and adverse pregnancy and birth outcomes: A systematic review and meta-analysis","volume":"201","author":"Gao","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2026.110543_b0080","series-title":"Regression Modeling Strategies: With Applications to Linear Models, Logistic and Ordinal Regression, and Survival Analysis, Springer Series in Statistics","author":"Harrell","year":"2015"},{"key":"10.1016\/j.envint.2026.110543_b0085","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1073\/pnas.95.14.7987","article-title":"Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway","volume":"95","author":"Huang","year":"1998","journal-title":"PNAS"},{"key":"10.1016\/j.envint.2026.110543_b0090","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41419-025-08033-w","article-title":"UHRF1-mediated HIF-1\u03b1 stabilization promotes ovarian cancer through metabolic reprogramming and angiogenesis","volume":"16","author":"Jiang","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.envint.2026.110543_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2026.110046","article-title":"Evaluation of a mother\u2013child dyad toxicokinetic model paired with environmental doses for estimation of serum per- and polyfluoroalkyl substances in early life","volume":"207","author":"Jung","year":"2026","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110543_b0100","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0140-6736(21)00954-5","article-title":"Miscarriage: worldwide reform of care is needed","volume":"397","author":"Lancet","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.envint.2026.110543_b0105","article-title":"Multiomics studies investigating recurrent pregnancy loss: an effective tool for mechanism exploration","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envint.2026.110543_b0110","article-title":"Per- and polyfluoroalkyl substances and female health concern: gender-based accumulation differences, adverse outcomes, and mechanisms","author":"Li","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2026.110543_b0115","first-page":"174","article-title":"Maternal perfluorinated compound exposure and risk of early pregnancy loss: a nested case-control study","volume":"35","author":"Mi","year":"2022","journal-title":"Biomed. Environ. Sci.: BES"},{"key":"10.1016\/j.envint.2026.110543_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108827","article-title":"Perfluoroalkyl substances (PFAS) exposure and preeclampsia risk: impaired angiogenesis through suppression of VEGF signaling","volume":"132","author":"Mishra","year":"2025","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envint.2026.110543_b0125","first-page":"1081","article-title":"Chronic PFOA and PFOS exposure triggers cellular oxidative stress and alters lipid levels as revealed through multi-omics analysis","volume":"5","author":"Paddayuman","year":"2026","journal-title":"Environ. Sci.: Adv."},{"key":"10.1016\/j.envint.2026.110543_b0130","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/S0140-6736(21)00682-6","article-title":"Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss","volume":"397","author":"Quenby","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.envint.2026.110543_b0135","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.tjog.2016.06.019","article-title":"Molecular regulation and role of angiogenesis in reproduction","volume":"56","author":"Rizov","year":"2017","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.envint.2026.110543_b0140","doi-asserted-by":"crossref","first-page":"22642","DOI":"10.1074\/jbc.272.36.22642","article-title":"Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes","volume":"272","author":"Salceda","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envint.2026.110543_b0145","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1042\/bj20031299","article-title":"p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1)","volume":"380","author":"Schmid","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.envint.2026.110543_b0150","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.3390\/ijms27031593","article-title":"Divergent roles of HIF-1\u03b1 and HIF-2\u03b1 in embryonic development and early pregnancy","volume":"27","author":"Shawki","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2026.110543_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2025.179395","article-title":"Antioxidant system alterations and oxidative stress caused by polyfluoroalkyl substances (PFAS) in exposed biota: a review","volume":"977","author":"Soares","year":"2025","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2026.110543_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109593","article-title":"Burden of per- and polyfluoroalkyl substances (PFAS) in human breast milk: Implications for maternal and infant health","volume":"201","author":"Su","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110543_b0165","article-title":"A Chinese longitudinal maternity cohort study (2013-2021) on intrahepatic cholestasis phenotypes: Risk associations from environmental exposure to adverse pregnancy outcomes","volume":"463","author":"Sun","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2026.110543_b0170","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41370-018-0094-1","article-title":"A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects","volume":"29","author":"Sunderland","year":"2019","journal-title":"J. Eposure Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envint.2026.110543_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107541","article-title":"Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with oxidative stress biomarkers during pregnancy","volume":"169","author":"Taibl","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110543_b0180","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1016\/j.mex.2019.11.008","article-title":"Repeated holdout validation for weighted quantile sum regression","volume":"6","author":"Tanner","year":"2019","journal-title":"MethodsX"},{"key":"10.1016\/j.envint.2026.110543_b0185","doi-asserted-by":"crossref","unstructured":"The ESHRE Guideline Group on RPL, Bender Atik, R., Christiansen, O.B., Elson, J., Kolte, A.M., Lewis, S., Middeldorp, S., Mcheik, S., Peramo, B., Quenby, S., Nielsen, H.S., van der Hoorn, M.-L., Vermeulen, N., Goddijn, M., 2022. ESHRE guideline: recurrent pregnancy loss: an update in 2022. Human Reproduction Open 2023, hoad002. Doi: 10.1093\/hropen\/hoad002.","DOI":"10.1093\/hropen\/hoad002"},{"key":"10.1016\/j.envint.2026.110543_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2025.179477","article-title":"Lnc-HZ06 down-regulates HIF1\u03b1 protein levels in CoCl2-exposed hypoxic trophoblast cells and villous tissues of miscarriage patients","volume":"978","author":"Tian","year":"2025","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2026.110543_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106837","article-title":"Early pregnancy loss: Do Per- and polyfluoroalkyl substances matter?","volume":"157","author":"Wang","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2026.110543_b0200","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1165\/rcmb.2022-0481OC","article-title":"P300\/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia","volume":"70","author":"Wang","year":"2024","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.envint.2026.110543_b0205","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1021\/acs.est.6b04806","article-title":"A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)?","volume":"51","author":"Wang","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2026.110543_b0210","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1038\/s41598-021-82748-6","article-title":"Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage","volume":"11","author":"Wikstr\u00f6m","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envint.2026.110543_b0215","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1186\/s12905-024-03206-9","article-title":"Predicting risk of the subsequent early pregnancy loss in women with recurrent pregnancy loss based on preconception data","volume":"24","author":"Yang","year":"2024","journal-title":"BMC Women\u2019s Health"},{"key":"10.1016\/j.envint.2026.110543_b0220","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12014-021-09312-2","article-title":"Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction","volume":"18","author":"Yin","year":"2021","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.envint.2026.110543_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2026.106160","article-title":"Effects of gestational perfluorohexanesulfonic acid exposure at human realistic dose on social communication deficit in mouse offspring","volume":"125","author":"Zhang","year":"2026","journal-title":"EBioMedicine"},{"key":"10.1016\/j.envint.2026.110543_b0230","doi-asserted-by":"crossref","first-page":"7183","DOI":"10.3390\/molecules27217183","article-title":"Paclitaxel Induces the Apoptosis of Prostate Cancer Cells via ROS-Mediated HIF-1\u03b1 Expression","volume":"27","author":"Zhang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.envint.2026.110543_b0235","article-title":"Targeted investigation of per- and polyfluoroalkyl substances from domestic cosmetics and personal care products in China and its implications for human exposure","volume":"176207","author":"Zhao","year":"2024","journal-title":"Sci. Total Environ."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026005015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412026005015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:40:38Z","timestamp":1792712438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412026005015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":47,"alternative-id":["S0160412026005015"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2026.110543","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between per- and polyfluoroalkyl substances exposure and recurrent pregnancy loss: The potential role of oxidative stress and the HIF1\u03b1\u2011GLUT1\/VEGFA axis","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2026.110543","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110543"}}