{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:13:58Z","timestamp":1791386038888,"version":"4.3.3"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Natural Science Foundation of China"},{"name":"41171382"},{"name":"21137001"},{"name":"21077020"},{"name":"China Environmental Protection Foundation"},{"name":"CEPF2008-123-2-13"},{"name":"International Foundation for Science"},{"name":"F\/4580-1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.envpol.2012.03.009","type":"journal-article","created":{"date-parts":[[2012,4,2]],"date-time":"2012-04-02T17:53:37Z","timestamp":1333389217000},"page":"48-56","source":"Crossref","is-referenced-by-count":219,"special_numbering":"C","title":["Insights into aquatic toxicities of the antibiotics oxytetracycline and ciprofloxacin in the presence of metal: Complexation versus mixture"],"prefix":"10.1016","volume":"166","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianming","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianliang","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2012.03.009_bib1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrmicro2312","article-title":"Call of the wild: antibiotic resistance genes in natural environments","volume":"8","author":"Allen","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.envpol.2012.03.009_bib2","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0278-6915(97)00088-4","article-title":"Regulations for combined effects of pollutants: consequences from risk assessment in aquatic toxicology","volume":"34","author":"Altenburger","year":"1996","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envpol.2012.03.009_bib3","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1897\/01-386","article-title":"Mixture toxicity and its modeling by quantitative structure-activity relationships","volume":"22","author":"Altenburger","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2012.03.009_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF02999866","article-title":"Involvement of plasma copper, zinc and cadmium in human carcinoma of uterine cervix","volume":"11","author":"Balasubramaniyan","year":"1994","journal-title":"Med. Oncol."},{"key":"10.1016\/j.envpol.2012.03.009_bib5","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2136\/sssaj2009.0402","article-title":"Effects of soil\/solution ratios and cation types on adsorption and desorption of tetracycline in soils","volume":"74","author":"Bao","year":"2010","journal-title":"Soil Sci. Soc. Am. J."},{"key":"10.1016\/j.envpol.2012.03.009_bib6","series-title":"The Level Concentration of Lead, Cadmium, Copper, Zinc and Phenols in the Water River of Sitnica","author":"Berisha","year":"2008"},{"key":"10.1016\/j.envpol.2012.03.009_bib7","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1021\/jf0728855","article-title":"Enantioselective degradation and ecotoxicity of the chiral herbicide diclofop in three freshwater alga cultures","volume":"56","author":"Cai","year":"2008","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.envpol.2012.03.009_bib8","first-page":"64","article-title":"Assessment of aquatic pollution of heavy metals in a copper-iron area","volume":"29","author":"Chen","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2012.03.009_bib9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1021\/es802295r","article-title":"Transformation of tetracyclines mediated by Mn(II) and Cu(II) ions in the presence of oxygen","volume":"43","author":"Chen","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2012.03.009_bib10","series-title":"GB\/T15441-1995, Water Quality Determination of the Acute Toxicity Luminescent Bacteria Test","author":"Chinese Environmental Protection Agency (CEPA)","year":"1995"},{"key":"10.1016\/j.envpol.2012.03.009_bib11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/jac\/29.3.245","article-title":"Tetracyclines, molecular and clinical aspects","volume":"29","author":"Chopra","year":"1992","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.envpol.2012.03.009_bib12","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1128\/MMBR.65.2.232-260.2001","article-title":"Tetracycline antibiotics: mode of action, applications, molecular biology and epidemiology of bacterial resistance","volume":"65","author":"Chopra","year":"2001","journal-title":"Microbio. Mol. Biol. Rev."},{"key":"10.1016\/j.envpol.2012.03.009_bib13","first-page":"195","article-title":"Degradation of oxytetracycline hydrochloride in fresh- and seawater","volume":"7","author":"Choo","year":"1994","journal-title":"Asian Fish. Sci."},{"key":"10.1016\/j.envpol.2012.03.009_bib14","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.envpol.2010.09.036","article-title":"Toxicity profile of labile preservative bronopol in water: the role of more persistent and toxic transformation products","volume":"159","author":"Cui","year":"2011","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2012.03.009_bib15","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/etc.5620201034","article-title":"Biotic ligand model of the acute toxicity of metals. 1. Technical basis","volume":"20","author":"Di Toro","year":"2001","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2012.03.009_bib16","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1016\/j.bmcl.2006.04.034","article-title":"Crystal structure, spectroscopic, and biological study of the copper(II) complex with third-generation quinolone antibiotic sparfloxacin","volume":"16","author":"Efthimiadou","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.envpol.2012.03.009_bib17","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1021\/es902852v","article-title":"Aquatic photochemistry of fluoroquinolone antibiotics: kinetics, pathways, and multivariate effects of main water constituents","volume":"44","author":"Ge","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2012.03.009_bib18","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/380430a0","article-title":"Predicting animal cadmium concentrations in lakes","volume":"380","author":"Hare","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2012.03.009_bib19","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1021\/es900061t","article-title":"Accumulation, subcellular distribution and toxicity of copper in earthworm (Eisenia fetida) in the presence of ciprofloxacin","volume":"43","author":"Huang","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2012.03.009_bib20","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chemosphere.2008.11.086","article-title":"Antibiotics in the aquatic environment \u2013 A review \u2013 Part I","volume":"75","author":"K\u00fcmmerer","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2012.03.009_bib21","first-page":"285","article-title":"The problem of synergism and antagonism of combined drugs","volume":"3","author":"Loewe","year":"1953","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.envpol.2012.03.009_bib22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0162-0134(02)00487-7","article-title":"Interactions of metal ions with two quinolone antimicrobial agents (cinoxacin and ciprofloxacin) Spectroscopic and X-ray structural characterization. Antibacterial studies","volume":"92","author":"L\u00f3pez-Gresa","year":"2002","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.envpol.2012.03.009_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10661-009-1051-1","article-title":"Aeromonas and Pseudomonas: antibiotic and heavy metal resistance species from Iskendrum Bay, Turkey (Northeast Mediterranean Sea)","volume":"167","author":"Matyar","year":"2010","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.envpol.2012.03.009_bib24","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1126\/science.287.5457.1493","article-title":"General acid\u2013base catalysis in the mechanism of a hepatitis delta virus ribozyme","volume":"287","author":"Nakano","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.envpol.2012.03.009_bib25","series-title":"Freshwater Alga and Cyanobacteria, Growth Inhibition Test","author":"OECD Guideline for Testing of Chemicals","year":"2002"},{"key":"10.1016\/j.envpol.2012.03.009_bib26","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00775-008-0395-2","article-title":"Specific binding of divalent metal ions to tetracycline and to the Tet repressor\/tetracycline complex","volume":"13","author":"Palm","year":"2008","journal-title":"J.\u00a0Biol. Inorg. Chem."},{"key":"10.1016\/j.envpol.2012.03.009_bib28","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1289\/ehp.5840","article-title":"Impact of metals on the biodegradation of organic pollutants","volume":"111","author":"Sandrin","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2012.03.009_bib29","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s002030050339","article-title":"Tetracyclines: antibiotic action, uptake, and resistance mechanisms","volume":"165","author":"Schnappinger","year":"1996","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.envpol.2012.03.009_bib30","series-title":"Draft Opinion on Combination Effects","author":"SCHER","year":"2011"},{"key":"10.1016\/j.envpol.2012.03.009_bib31","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1126\/science.1127291","article-title":"The challenge of micropollutants in aquatic systems","volume":"313","author":"Schwarzenbach","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.envpol.2012.03.009_bib32","doi-asserted-by":"crossref","first-page":"7303","DOI":"10.1021\/jf2013937","article-title":"Occurrence and risk assessment of four typical fluoroquinolone antibiotics in raw and treated sewage and in receiving waters in Hangzhou, China","volume":"59","author":"Tong","year":"2011","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.envpol.2012.03.009_bib33","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00248-007-9303-5","article-title":"Spatial analysis of antibiotic resistance along metal contaminated streams","volume":"55","author":"Tuckfield","year":"2008","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.envpol.2012.03.009_bib34","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1023\/B:JTAN.0000046115.64116.95","article-title":"Complexes of dicamba with cadmium(II), copper(II), mercury(II), lead(II) and zinc(II) synthesis and properties","volume":"78","author":"Turek","year":"2004","journal-title":"J.\u00a0Therm. Anal. Calorim."},{"key":"10.1016\/j.envpol.2012.03.009_bib35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0010-8545(02)00027-9","article-title":"The interactions of metal ions with quinolone antibacterial agents","volume":"232","author":"Turel","year":"2002","journal-title":"Coordin. Chem. Rev."},{"key":"10.1016\/j.envpol.2012.03.009_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0162-0134(95)00082-8","article-title":"Copper complexes of the fluoroquinolone antimicrobial ciprofloxacin, synthesis, X-Ray structural characterization, and potentiometric study","volume":"62","author":"Wallis","year":"1996","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.envpol.2012.03.009_bib37","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1021\/es702641a","article-title":"Adsorption and cosorption of tetracycline and copper(II) on montmorillonite as affected by solution pH","volume":"42","author":"Wang","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2012.03.009_bib38","first-page":"999","article-title":"Assessing toxicity of selected transformation products of the preservative bronopol to Vibrio fischeri","volume":"28","author":"Wang","year":"2008","journal-title":"China Environ. Sci."},{"key":"10.1016\/j.envpol.2012.03.009_bib39","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1021\/es104034g","article-title":"Effect of complexation on the accumulation and elimination kinetics of cadmium and ciprofloxacin in the earthworm Eisenia fetida","volume":"45","author":"Wen","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2012.03.009_bib40","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.bbrc.2006.09.006","article-title":"Inhibition of the catalytic activity of trans-acting antigenomic \u03b4 ribozyme by selected antibiotics and their Cu2+ complexes","volume":"349","author":"Wrzesinski","year":"2006","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"10.1016\/j.envpol.2012.03.009_bib41","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.jhazmat.2010.11.081","article-title":"Differential enantioselectivity of quizalofop ethyl and its acidic metabolite: direct enantiomeric separation and assessment of multiple toxicological endpoints","volume":"186","author":"Zhang","year":"2011","journal-title":"J.\u00a0Hazard. Mater."},{"key":"10.1016\/j.envpol.2012.03.009_bib42","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jcis.2011.05.051","article-title":"Adsorption of tetracycline onto goethite in the presence of metal cations and humic substances","volume":"361","author":"Zhao","year":"2011","journal-title":"J.\u00a0Colloid Interf. Sci."},{"key":"10.1016\/j.envpol.2012.03.009_bib43","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1039\/B208012E","article-title":"A\u00a0dansylated peptide for the selective detection of copper ions","volume":"20","author":"Zheng","year":"2002","journal-title":"Chem. Commun."},{"key":"10.1016\/j.envpol.2012.03.009_bib44","first-page":"549","article-title":"Influence of Cu, Zn, Pb, Cd and their heavy metal ion mixture on the DNA methylation level of the fish (Carassius uratus)","volume":"21","author":"Zhou","year":"2001","journal-title":"China Environ. Sci."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749112001212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749112001212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T07:23:59Z","timestamp":1543044239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749112001212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":43,"alternative-id":["S0269749112001212"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2012.03.009","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}