{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:58:31Z","timestamp":1793228311804,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["GCL2011-29703-C02-02"],"award-info":[{"award-number":["GCL2011-29703-C02-02"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.envpol.2014.07.019","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T09:16:16Z","timestamp":1407489376000},"page":"152-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"special_numbering":"C","title":["Occurrence and removal of drugs of abuse in Wastewater Treatment Plants of Valencia (Spain)"],"prefix":"10.1016","volume":"194","author":[{"given":"Mar\u00eda Jes\u00fas","family":"Andr\u00e9s-Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Rubio-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Morales Su\u00e1rez-Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Pico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2014.07.019_bib1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1006\/eesa.1993.1006","article-title":"Confidence-limits for hazardous concentrations based on logistically distributed noec toxicity data","volume":"25","author":"Aldenberg","year":"1993","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2014.07.019_bib2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.scitotenv.2013.03.043","article-title":"Spatial and temporal occurrence of pharmaceuticals and illicit drugs in the aqueous environment and during wastewater treatment: New developments","volume":"454\u2212455","author":"Baker","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2014.07.019_bib3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.envint.2012.06.014","article-title":"Drugs of abuse in wastewater and suspended particulate matter \u2014 further developments in sewage epidemiology","volume":"48","author":"Baker","year":"2012","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2014.07.019_bib4","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.envpol.2008.11.025","article-title":"The occurrence of illicit and therapeutic pharmaceuticals in wastewater effluent and surface waters in Nebraska","volume":"157","author":"Bartelt-Hunt","year":"2009","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2014.07.019_bib5","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.chemosphere.2010.08.011","article-title":"Analysis of llicit and illicit drugs in waste, surface and lake water samples using large volume direct injection high performance liquid chromatography-electrospray tandem mass spectrometry (HPLC\u2212MS\/MS)","volume":"81","author":"Berset","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2014.07.019_bib6","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.chemosphere.2012.05.110","article-title":"Investigation of drugs of abuse and relevant metabolites in Dutch sewage water by liquid chromatography coupled to high resolution mass spectrometry","volume":"89","author":"Bijlsma","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2014.07.019_bib7","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.scitotenv.2013.11.131","article-title":"Occurrence and behavior of illicit drugs and metabolites in sewage water from the Spanish Mediterranean coast (Valencia region)","volume":"487","author":"Bijlsma","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2014.07.019_bib8","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.watres.2008.11.056","article-title":"Monitoring of opiates, cannabinoids and their metabolites in wastewater, surface water and finished water in Catalonia, Spain","volume":"43","author":"Boleda","year":"2009","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2014.07.019_bib9","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1039\/b702799k","article-title":"Using environmental analytical data to estimate levels of community consumption of illicit drugs and abused pharmaceuticals","volume":"9","author":"Bones","year":"2007","journal-title":"J.\u00a0Environ. Monit."},{"key":"10.1016\/j.envpol.2014.07.019_bib10","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.1021\/ac061095b","article-title":"Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography\u2013tandem mass spectrometry","volume":"78","author":"Castiglioni","year":"2006","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envpol.2014.07.019_bib11","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1021\/es302722f","article-title":"Evaluation of uncertainties associated with the determination of community drug use though the measurement of sewage drug biomarkers","volume":"47","author":"Castiglioni","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2014.07.019_bib12","series-title":"Pharmaceuticals and Personal Care Products in the Environment, Scientific and Regulatory Issues","first-page":"348","author":"Daughton","year":"2001"},{"key":"10.1016\/j.envpol.2014.07.019_bib13","series-title":"The State of the Drugs Problem in Europe. Annual Report 2008","author":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA)","year":"2008"},{"key":"10.1016\/j.envpol.2014.07.019_bib14","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1021\/ac202989e","article-title":"Screening and selective quantification of illicit drugs in wastewater by mixed-mode solid-phase extraction and quadrupole-time-of-flight liquid chromatography-mass spectrometry","volume":"84","author":"Gonz\u00e1lez-Mari\u00f1o","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envpol.2014.07.019_bib15","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.talanta.2005.09.037","article-title":"Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments","volume":"69","author":"Hernando","year":"2006","journal-title":"Talanta"},{"key":"10.1016\/j.envpol.2014.07.019_bib16","series-title":"La Polic\u00eda Nacional desmantela un punto de venta de coca\u00edna ubicado en un domicilio de Manises","author":"Horta Noticias.com","year":"2013"},{"key":"10.1016\/j.envpol.2014.07.019_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.scitotenv.2008.02.057","article-title":"Occurrence of psychoactive stimulatory drugs in wastewaters in north-eastern Spain","volume":"397","author":"Huerta-Fontela","year":"2008","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2014.07.019_bib18","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00244-004-3146-6","article-title":"Polar organic chemical integrative sampling and liquid chromatography\u2013electrospray\/ion-trap mass spectrometry for assessing selected prescription and illicit drugs in treated sewage effluents","volume":"47","author":"Jones-Lepp","year":"2004","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envpol.2014.07.019_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.forsciint.2010.04.007","article-title":"Estimation of illicit drugs consumption by wastewater analysis in Paris area (France)","volume":"200","author":"Karolak","year":"2010","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.envpol.2014.07.019_bib20","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.envpol.2009.03.017","article-title":"Illicit drugs and pharmaceuticals in the environment\u2013forensic applications of environmental data. Part 1: estimation of the usage of drugs in local communities","volume":"157","author":"Kasprzyk-Hordern","year":"2009","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2014.07.019_bib21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.watres.2008.10.047","article-title":"The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters","volume":"43","author":"Kasprzyk-Hordern","year":"2009","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2014.07.019_bib22","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/dar.12061","article-title":"Using quantitative wastewater analysis to measure daily usage of conventional and emerging illicit drugs at an annual music festival","volume":"32","author":"Lai","year":"2013","journal-title":"Drug Alcohol Rev."},{"key":"10.1016\/j.envpol.2014.07.019_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.talanta.2011.03.051","article-title":"Development of a solvent-free method for the simultaneous identification\/quantification of drugs of abuse and their metabolites in environmental water by LC\u2013MS\/MS","volume":"85","author":"Mart\u00ednez Bueno","year":"2011","journal-title":"Talanta"},{"key":"10.1016\/j.envpol.2014.07.019_bib24","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1016\/j.envpol.2010.07.002","article-title":"Illicit drugs in Canadian municipal wastewater and estimates of community drug use","volume":"158","author":"Metcalfe","year":"2010","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2014.07.019_bib25","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.scitotenv.2013.05.038","article-title":"Presence of illicit drugs and metabolites in influents and effluents of 25 sewage water treatment plants and map of drug consumption in France","volume":"461\u2212462","author":"Nefau","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2014.07.019_bib26","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.1021\/es100778d","article-title":"Sampling for PPCPs in wastewater systems: comparison of different sampling modes and optimization strategies","volume":"44","author":"Ort","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2014.07.019_bib27","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1111\/add.12570","article-title":"Spatial differences and temporal changes in illicit drug use in Europe quantified by wastewater analysis","volume":"109","author":"Ort","year":"2014","journal-title":"Addiction"},{"key":"10.1016\/j.envpol.2014.07.019_bib28","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.scitotenv.2013.11.081","article-title":"A\u00a0snapshot of illicit drug use in Sweden acquired through sewage water analysis","volume":"472","author":"\u00d6stman","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2014.07.019_bib29","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1021\/ac702060j","article-title":"Fully automated determination in the low nanogram per liter level of different classes of drugs of abuse in sewage water by on-line solid-phase extraction-liquid chromatography\u2013electrospray-tandem mass spectrometry","volume":"80","author":"Postigo","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envpol.2014.07.019_bib30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.envint.2009.10.004","article-title":"Drugs of abuse and their metabolites in the Ebro River basin: occurrence in sewage and surface water, sewage treatment plants removal efficiency, and collective drug usage estimation","volume":"36","author":"Postigo","year":"2010","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2014.07.019_bib31","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1016\/j.envpol.2010.04.020","article-title":"Illicit drugs in wastewater of the city of Zagreb (Croatia)\u2013estimation of drug abuse in a transition country","volume":"158","author":"Terzic","year":"2010","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2014.07.019_bib32","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.scitotenv.2012.06.069","article-title":"Comparing illicit drug use in 19 European cities through sewage analysis","volume":"432","author":"Thomas","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2014.07.019_bib33","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.watres.2013.01.013","article-title":"Risk assessment for drugs of abuse in the Dutch watercycle","volume":"47","author":"van der Aa","year":"2013","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2014.07.019_bib34","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1016\/j.scitotenv.2010.05.030","article-title":"Illicit drug consumption estimations derived from wastewater analysis: a critical review","volume":"409","author":"Van Nuijs","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2014.07.019_bib35","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1039\/c0em00686f","article-title":"A\u00a0one year investigation of the occurrence of illicit drugs in wastewater from Brussels, Belgium","volume":"13","author":"Van Nuijs","year":"2011","journal-title":"J.\u00a0Environ. Monit."},{"key":"10.1016\/j.envpol.2014.07.019_bib36","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.envint.2010.12.006","article-title":"Sewage epidemiology\u2013a real-time approach to estimate the consumption of illicit drugs in Brussels, Belgium","volume":"37","author":"Van Nuijs","year":"2011","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2014.07.019_bib37","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1360-0443.2009.02523.x","article-title":"Can cocaine use be evaluated through analysis of wastewater? A nation-wide approach conducted in Belgium","volume":"104","author":"Van Nuijs","year":"2009","journal-title":"Addiction"},{"key":"10.1016\/j.envpol.2014.07.019_bib38","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.watres.2008.12.020","article-title":"Spatial and temporal variations in the occurrence of cocaine and benzoylecgonine in waste- and surface water from Belgium and removal during wastewater treatment","volume":"43","author":"Van Nuijs","year":"2009","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2014.07.019_bib39","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1289\/ehp.11022","article-title":"Estimating community drug abuse by wastewater analysis","volume":"116","author":"Zuccato","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2014.07.019_bib40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1476-069X-4-14","article-title":"Cocaine in surface waters: a new evidence-based tool to monitor community drug abuse","volume":"4","author":"Zuccato","year":"2005","journal-title":"Environ. Health"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974911400311X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974911400311X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T02:57:06Z","timestamp":1538362626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026974911400311X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":40,"alternative-id":["S026974911400311X"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2014.07.019","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Occurrence and removal of drugs of abuse in Wastewater Treatment Plants of Valencia (Spain)","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2014.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}