{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:28:17Z","timestamp":1793734097017,"version":"4.6.1"},"reference-count":159,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["355254"],"award-info":[{"award-number":["355254"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Minist\u00e8re des Relations internationales du Qu\u00e9bec","award":["01.801-23525"],"award-info":[{"award-number":["01.801-23525"]}]},{"DOI":"10.13039\/501100003150","name":"FQRNT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.envpol.2016.12.017","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T03:30:43Z","timestamp":1482204643000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":276,"special_numbering":"C","title":["Tetracyclines metal complexation: Significance and fate of mutual existence in the environment"],"prefix":"10.1016","volume":"221","author":[{"given":"Rama","family":"Pulicharla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnamoorthy","family":"Hegde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satinder Kaur","family":"Brar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rao Y.","family":"Surampalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2016.12.017_bib1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/jac\/dkl224","article-title":"Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines","volume":"58","author":"Agwuh","year":"2006","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.envpol.2016.12.017_bib2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1387-7003(02)00427-6","article-title":"Synthesis and spectroscopic properties of anhydrotetracyclineplatinum (II) dichloride","volume":"5","author":"Aly","year":"2002","journal-title":"Inorg. Chem. Commun."},{"key":"10.1016\/j.envpol.2016.12.017_bib3","doi-asserted-by":"crossref","first-page":"8392","DOI":"10.1021\/bi200593m","article-title":"Structural and biochemical characterization of ZhuI aromatase\/cyclase from the R1128 polyketide pathway","volume":"50","author":"Ames","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.envpol.2016.12.017_bib4","doi-asserted-by":"crossref","first-page":"868","DOI":"10.2134\/jeq2008.0316","article-title":"Induction of lead-binding phytochelatins in Vetiver Grass [(L.)]","volume":"38","author":"Andra","year":"2009","journal-title":"J.\u00a0Environ. Qual."},{"key":"10.1016\/j.envpol.2016.12.017_bib5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ica.2015.10.037","article-title":"Minocycline and tigecycline form higher-order Ca2+ complexes of stronger affinity than tetracycline","volume":"441","author":"Arias","year":"2016","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.envpol.2016.12.017_bib6","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s11094-015-1190-3","article-title":"Thermodynamic studies of metal complexes of tetracycline and its application in drug analysis","volume":"48","author":"Bagheri","year":"2015","journal-title":"Pharm. Chem. J."},{"key":"10.1016\/j.envpol.2016.12.017_bib7","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1021\/ja00958a041","article-title":"Metal binding in tetracyclines. Cobalt (II) and nickel (II) complexes1","volume":"88","author":"Baker","year":"1966","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.envpol.2016.12.017_bib8","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.4236\/health.2013.512276","article-title":"Green remediation of tetracyclines in soil-water systems","volume":"5","author":"Bansal","year":"2013","journal-title":"Health"},{"key":"10.1016\/j.envpol.2016.12.017_bib9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF01966597","article-title":"Metal ion-tetracycline interactions in biological fluids. Part 5. Formation of zinc complexes with tetracycline and some of its derivatives and assessment of their biological significance","volume":"17","author":"Brion","year":"1985","journal-title":"Agents Actions"},{"key":"10.1016\/j.envpol.2016.12.017_bib10","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0092-8674(00)00216-6","article-title":"The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit","volume":"103","author":"Brodersen","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2016.12.017_bib11","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.scitotenv.2005.10.007","article-title":"Occurrence of antibiotics in hospital, residential, and dairy effluent, municipal wastewater, and the Rio Grande in New Mexico","volume":"366","author":"Brown","year":"2006","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2016.12.017_bib12","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1039\/C1CP22703C","article-title":"Complexes of tetracyclines with divalent metal cations investigated by stationary and femtosecond-pulsed techniques","volume":"14","author":"Carlotti","year":"2012","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.envpol.2016.12.017_bib13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.biortech.2012.03.066","article-title":"Potential of Phragmites australis for the removal of veterinary pharmaceuticals from aquatic media","volume":"116","author":"Carvalho","year":"2012","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.envpol.2016.12.017_bib14","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.niox.2012.01.009","article-title":"Doxycycline ameliorates 2K-1C hypertension-induced vascular dysfunction in rats by attenuating oxidative stress and improving nitric oxide bioavailability","volume":"26","author":"Castro","year":"2012","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.envpol.2016.12.017_bib15","first-page":"23","article-title":"Detection of oxytetracycline and chlortetracycline residues in agricultural fields in Turkey","volume":"4","author":"Cengiz","year":"2010","journal-title":"J.\u00a0Biol. Environ. Sci."},{"key":"10.1016\/j.envpol.2016.12.017_bib16","doi-asserted-by":"crossref","first-page":"8601","DOI":"10.1021\/jp502278z","article-title":"Spectroscopic investigation of the pH controlled inclusion of doxycycline and oxytetracycline antibiotics in cationic micelles and their magnesium driven release","volume":"118","author":"Cesaretti","year":"2014","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.envpol.2016.12.017_bib17","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1021\/es802295r","article-title":"Transformation of tetracyclines mediated by Mn\u00a0+2 and Cu\u00a0+2 ions in the presence of oxygen","volume":"43","author":"Chen","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2016.12.017_bib18","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.envpol.2011.02.027","article-title":"Transformation kinetics and pathways of tetracycline antibiotics with manganese oxide","volume":"159","author":"Chen","year":"2011","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2016.12.017_bib19","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/S1001-0742(10)60625-0","article-title":"Photoproducts of tetracycline and oxytetracycline involving self-sensitized oxidation in aqueous solutions: effects of Ca2+ and Mg2+","volume":"23","author":"Chen","year":"2011","journal-title":"J.\u00a0Environ. Sci."},{"key":"10.1016\/j.envpol.2016.12.017_bib20","series-title":"Mode of Action of the Tetracyclines and the Nature of Bacterial Resistance to Them, the Tetracyclines","first-page":"317","author":"Chopra","year":"1985"},{"key":"10.1016\/j.envpol.2016.12.017_bib21","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1128\/MMBR.65.2.232-260.2001","article-title":"Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance","volume":"65","author":"Chopra","year":"2001","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.envpol.2016.12.017_bib22","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/0006-2952(79)90439-8","article-title":"Binding of the alkali metal cations to tetracycline","volume":"28","author":"Coibion","year":"1979","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.envpol.2016.12.017_bib23","series-title":"Antibiotic Resistance Threats in the United States, 2013","author":"Control, C.f.D., Prevention","year":"2013"},{"key":"10.1016\/j.envpol.2016.12.017_bib24","first-page":"1","article-title":"Metal complexes of tetracyclines Ill\u2014formation of metal complexes and biological activity of tetracyclines","volume":"15","author":"da Silva","year":"1973","journal-title":"Rev. Port. Quim."},{"key":"10.1016\/j.envpol.2016.12.017_bib25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10311-013-0404-8","article-title":"Tetracycline antibiotics in the environment: a review","volume":"11","author":"Daghrir","year":"2013","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.envpol.2016.12.017_bib26","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1080\/15226510902787302","article-title":"Vetiver grass, Vetiveria zizanioides: a choice plant for phytoremediation of heavy metals and organic wastes","volume":"11","author":"Danh","year":"2009","journal-title":"Int. J. Phytoremediation"},{"key":"10.1016\/j.envpol.2016.12.017_bib27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/15226514.2012.702803","article-title":"Phytoremediation potential of vetiver grass [Chrysopogon zizanioides (L.)] for tetracycline","volume":"15","author":"Datta","year":"2013","journal-title":"Int. J. Phytoremediation"},{"key":"10.1016\/j.envpol.2016.12.017_bib28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1136\/vr.102462","article-title":"Antibiotics used most commonly to treat animals in Europe","volume":"175","author":"De Briyne","year":"2014","journal-title":"Vet. Rec."},{"key":"10.1016\/j.envpol.2016.12.017_bib29","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jhazmat.2012.05.106","article-title":"Tetracycline removal during wastewater treatment in high-rate algal ponds","volume":"229","author":"de Godos","year":"2012","journal-title":"J.\u00a0Hazard. Mater."},{"key":"10.1016\/j.envpol.2016.12.017_bib30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/jps.2600830306","article-title":"Metal complexes of anhydrotetracycline. 1. A Spectrometric study of the Cu (II) and Ni (II) complexes","volume":"83","author":"De Siqueira","year":"1994","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.envpol.2016.12.017_bib31","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1039\/c2dt12188c","article-title":"Chelation therapy in Wilson's disease: from d-penicillamine to the design of selective bioinspired intracellular Cu (I) chelators","volume":"41","author":"Delangle","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.envpol.2016.12.017_bib32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1021\/jm00337a003","article-title":"Metal complexation of the tetracycline hydrochlorides","volume":"6","author":"Doluisio","year":"1963","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib33","author":"druginfosys"},{"key":"10.1016\/j.envpol.2016.12.017_bib34","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1086\/367622","article-title":"Tetracycline therapy: update","volume":"36","author":"Eliopoulos","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.envpol.2016.12.017_bib35","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1021\/es061651j","article-title":"Chlortetracycline detoxification in maize via induction of glutathione S-transferases after antibiotic exposure","volume":"41","author":"Farkas","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2016.12.017_bib36","series-title":"Animals Consume Lion's Share of Antibiotics","author":"FDA","year":"2009"},{"key":"10.1016\/j.envpol.2016.12.017_bib37","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/jctb.3990","article-title":"Tetracycline degradation and mineralization by the coupling of an electro-Fenton pretreatment and a biological process","volume":"88","author":"Ferrag-Siagh","year":"2013","journal-title":"J.\u00a0Chem. Technol. Biotechnol."},{"key":"10.1016\/j.envpol.2016.12.017_bib39","series-title":"The Molecular Basis of Antibiotic Action","author":"Gale","year":"1972"},{"key":"10.1016\/j.envpol.2016.12.017_bib40","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/jps.2600520819","article-title":"Variation of pKa'-values of tetracyclines in dimethylformamide-water solvents","volume":"52","author":"Garrett","year":"1963","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.envpol.2016.12.017_bib41","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF01045296","article-title":"Potentiometric studies on the complexes of tetracycline (TC) and oxytetracyclin (OTC) with some metal ions","volume":"123","author":"Ghandour","year":"1992","journal-title":"Monatsh. f\u00fcr Chemie\/Chem. Mon."},{"key":"10.1016\/j.envpol.2016.12.017_bib42","doi-asserted-by":"crossref","first-page":"fiv059","DOI":"10.1093\/femsec\/fiv059","article-title":"Transformation of tetracycline by TetX and its subsequent degradation in a heterologous host","volume":"91","author":"Ghosh","year":"2015","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.envpol.2016.12.017_bib43","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1021\/bi00271a020","article-title":"Photoincorporation of tetracycline into Escherichia coli ribosomes. Identification of the major proteins photolabeled by native tetracycline and tetracycline photoproducts and implications for the inhibitory action of tetracycline on protein synthesis","volume":"22","author":"Goldman","year":"1983","journal-title":"Biochemistry"},{"key":"10.1016\/j.envpol.2016.12.017_bib44","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1128\/AAC.44.3.763-766.2000","article-title":"Iron-chelating activity of tetracyclines and its impact on the susceptibility of actinobacillus actinomycetemcomitansto these antibiotics","volume":"44","author":"Grenier","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.envpol.2016.12.017_bib45","doi-asserted-by":"crossref","first-page":"C539","DOI":"10.1152\/ajpcell.00047.2010","article-title":"Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature","volume":"299","author":"Griffin","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.envpol.2016.12.017_bib46","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.phrs.2010.10.004","article-title":"Tetracycline compounds with non-antimicrobial organ protective properties: possible mechanisms of action","volume":"63","author":"Griffin","year":"2011","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.envpol.2016.12.017_bib47","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1021\/es048603o","article-title":"Interaction of tetracycline with aluminum and iron hydrous oxides","volume":"39","author":"Gu","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2016.12.017_bib48","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.chemosphere.2006.08.028","article-title":"Complexation of the antibiotic tetracycline with humic acid","volume":"66","author":"Gu","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2016.12.017_bib49","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.phrs.2011.05.011","article-title":"Chemically modified tetracycline-3 (CMT-3): a novel inhibitor of the serine proteinase, elastase","volume":"64","author":"Gu","year":"2011","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.envpol.2016.12.017_bib50","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1016\/j.jinorgbio.2005.09.001","article-title":"Synthesis, characterization, and antibacterial activity of three palladium\u00a0+2 complexes of tetracyclines","volume":"99","author":"Guerra","year":"2005","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.envpol.2016.12.017_bib51","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1590\/S0103-50532006000800021","article-title":"Three new complexes of platinum (II) with doxycycline, oxytetracycline and chlortetracycline and their antimicrobial activity","volume":"17","author":"Guerra","year":"2006","journal-title":"J.\u00a0Braz. Chem. Soc."},{"key":"10.1016\/j.envpol.2016.12.017_bib52","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0921-8009(98)00069-X","article-title":"Evaluation of risks of metal flows and accumulation in economy and environment","volume":"30","author":"Guin\u00e9e","year":"1999","journal-title":"Ecol. Econ."},{"key":"10.1016\/j.envpol.2016.12.017_bib53","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/16226510590950405","article-title":"Phytoremediation potential of Myriophyllum aquaticum and Pistia stratiotes to modify antibiotic growth promoters, tetracycline, and oxytetracycline, in aqueous wastewater systems","volume":"7","author":"Gujarathi","year":"2005","journal-title":"Int. J. Phytoremediation"},{"key":"10.1016\/j.envpol.2016.12.017_bib54","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1021\/ja00421a049","article-title":"Effect of added electrolyte on the binding of tetracycline to paramagnetic ion probes. A carbon-13 and proton nuclear magnetic resonance study","volume":"98","author":"Gulbis","year":"1976","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.envpol.2016.12.017_bib55","doi-asserted-by":"crossref","first-page":"e1002158","DOI":"10.1371\/journal.ppat.1002158","article-title":"Selection of resistant bacteria at very low antibiotic concentrations","volume":"7","author":"Gullberg","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.envpol.2016.12.017_bib56","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nano.2011.05.007","article-title":"Synthesis and antibacterial activity of silver nanoparticles against gram-positive and gram-negative bacteria","volume":"8","author":"Guzman","year":"2012","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.envpol.2016.12.017_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jexbot\/53.366.1","article-title":"Cellular mechanisms for heavy metal detoxification and tolerance","volume":"53","author":"Hall","year":"2002","journal-title":"J.\u00a0Exp. Bot."},{"key":"10.1016\/j.envpol.2016.12.017_bib58","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1021\/ac015588m","article-title":"Determination of persistent tetracycline residues in soil fertilized with liquid manure by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry","volume":"74","author":"Hamscher","year":"2002","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib59","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jhazmat.2013.09.066","article-title":"Uptake of zwitterionic antibiotics by rice (Oryza sativa L.) in contaminated soil","volume":"263","author":"Hawker","year":"2013","journal-title":"J.\u00a0Hazard. Mater."},{"key":"10.1016\/j.envpol.2016.12.017_bib60","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0039-9140(98)00297-5","article-title":"Equilibrium studies of the binary and ternary complexes involving tetracycline and amino acid or DNA constituents","volume":"48","author":"Hosny","year":"1999","journal-title":"Talanta"},{"key":"10.1016\/j.envpol.2016.12.017_bib61","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF02990823","article-title":"Effects of tetracycline on the soil microflora: function, diversity, resistance","volume":"4","author":"Hund-Rinke","year":"2004","journal-title":"J.\u00a0Soils Sediments"},{"key":"10.1016\/j.envpol.2016.12.017_bib62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1432-1033.1970.tb00258.x","article-title":"Relationship between sites 1, 2 and acceptor, donor sites for the binding of aminoacyl tRNA to ribosomes","volume":"14","author":"Igarashi","year":"1970","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.envpol.2016.12.017_bib63","series-title":"Handbook of Clinical Pharmacokinetic Data","author":"Jack","year":"1993"},{"key":"10.1016\/j.envpol.2016.12.017_bib64","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.chemosphere.2009.11.024","article-title":"Degradation of tetracycline antibiotics: mechanisms and kinetic studies for advanced oxidation\/reduction processes","volume":"78","author":"Jeong","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2016.12.017_bib65","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1021\/ic00056a015","volume":"32","author":"Jezowska-Bojczuk","year":"1993","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib66","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bpc.2007.04.005","article-title":"Ca2+ and Mg2+ bind tetracycline with distinct stoichiometries and linked deprotonation","volume":"128","author":"Jin","year":"2007","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib67","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1021\/bi048548w","article-title":"Kinetic and thermodynamic studies of tet repressor-tetracycline interaction","volume":"44","author":"Kedracka-Krok","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.envpol.2016.12.017_bib68","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0141-8130(03)00066-7","article-title":"Interactions of tetracycline and its derivatives with DNA in\u00a0vitro in presence of metal ions","volume":"33","author":"Khan","year":"2003","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.envpol.2016.12.017_bib69","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1080\/15216549800204492","article-title":"Interactions of photosensitized tetracycline with serum albumin","volume":"46","author":"Khan","year":"1998","journal-title":"IUBMB Life"},{"key":"10.1016\/j.envpol.2016.12.017_bib70","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jhazmat.2010.05.063","article-title":"Tetracycline degradation by ozonation in the aqueous phase: proposed degradation intermediates and pathway","volume":"181","author":"Khan","year":"2010","journal-title":"J.\u00a0Hazard. Mater."},{"key":"10.1016\/j.envpol.2016.12.017_bib71","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1006\/jmbi.1994.0138","article-title":"The complex formed between Tet repressor and tetracycline-Mg 2| ihsbop|+ reveals mechanism of antibiotic resistance","volume":"247","author":"Kisker","year":"1995","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.envpol.2016.12.017_bib72","series-title":"Mediation of Divalent Metal Ions in the Binding of Tetracycline to Macromolecules","author":"Kohn","year":"1961"},{"key":"10.1016\/j.envpol.2016.12.017_bib73","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.2134\/jeq2005.0026","article-title":"Antibiotic uptake by plants from soil fertilized with animal manure","volume":"34","author":"Kumar","year":"2005","journal-title":"J.\u00a0Environ. Qual."},{"key":"10.1016\/j.envpol.2016.12.017_bib74","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/jac\/dkh325","article-title":"Resistance in the environment","volume":"54","author":"K\u00fcmmerer","year":"2004","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.envpol.2016.12.017_bib75","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.chemosphere.2008.12.006","article-title":"Antibiotics in the aquatic environment\u2013a review\u2013part II","volume":"75","author":"K\u00fcmmerer","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2016.12.017_bib76","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1021\/ic00290a022","article-title":"Metal ion-tetracycline interactions in biological fluids. 9. Circular dichroism spectra of calcium and magnesium complexes with tetracycline, oxytetracycline, doxycycline, and chlortetracycline and discussion of their binding modes","volume":"27","author":"Lambs","year":"1988","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib77","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1021\/jm060289g","article-title":"Structural changes and binding characteristics of the tetracycline-repressor binding site on induction","volume":"49","author":"Lanig","year":"2006","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib78","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1021\/ja00407a045","article-title":"Binding of manganese (II) by tetracycline. Carbon-13 NMR spin-lattice relaxation study","volume":"103","author":"Lee","year":"1981","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.envpol.2016.12.017_bib79","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/jac\/49.1.25","article-title":"Factors impacting on the problem of antibiotic resistance","volume":"49","author":"Levy","year":"2002","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.envpol.2016.12.017_bib80","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1128\/AAC.38.8.1732","article-title":"Role of efflux pump (s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin","volume":"38","author":"Li","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.envpol.2016.12.017_bib81","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1021\/ac010514w","article-title":"Analysis of trace levels of sulfonamide and tetracycline antimicrobials in groundwater and surface water using solid-phase extraction and liquid chromatography\/mass spectrometry","volume":"73","author":"Lindsey","year":"2001","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib82","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.envpol.2008.12.021","article-title":"Effects of six selected antibiotics on plant growth and soil microbial and enzymatic activities","volume":"157","author":"Liu","year":"2009","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2016.12.017_bib83","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jhazmat.2014.08.022","article-title":"Interaction of veterinary antibiotic tetracyclines and copper on their fates in water and water hyacinth (Eichhornia crassipes)","volume":"280","author":"Lu","year":"2014","journal-title":"J.\u00a0Hazard. Mater."},{"key":"10.1016\/j.envpol.2016.12.017_bib84","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.2134\/jeq2005.0014","article-title":"Oxytetracycline sorption to organic matter by metal-bridging","volume":"34","author":"MacKay","year":"2005","journal-title":"J.\u00a0Environ. Qual."},{"key":"10.1016\/j.envpol.2016.12.017_bib85","first-page":"153","article-title":"Phytoremediation potential of Cicer arietinum for tetracycline","volume":"5","author":"Makhijani","year":"2014","journal-title":"Int. J. Gen. Eng. Biotechnol."},{"key":"10.1016\/j.envpol.2016.12.017_bib86","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00214-010-0881-9","article-title":"Interaction of chemically modified tetracyclines with catalytic Zn (II) ion in matrix metalloproteinase: evidence for metal coordination sites","volume":"128","author":"Marcial","year":"2011","journal-title":"Theor. Chem. Acc."},{"key":"10.1016\/j.envpol.2016.12.017_bib87","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0301-4622(79)85019-X","article-title":"Equilibrium and kinetic studies on the interaction of tetracyclines with calcium and magnesium","volume":"10","author":"Martin","year":"1979","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib88","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1128\/AAC.24.4.544","article-title":"Susceptible Escherichia coli cells can actively excrete tetracyclines","volume":"24","author":"McMurry","year":"1983","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.envpol.2016.12.017_bib89","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2165\/00003495-197611010-00004","article-title":"Interactions with the absorption of tetracyclines","volume":"11","author":"Neuvonen","year":"1976","journal-title":"Drugs"},{"key":"10.1016\/j.envpol.2016.12.017_bib90","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0168-6445(03)00048-2","article-title":"Efflux-mediated heavy metal resistance in prokaryotes","volume":"27","author":"Nies","year":"2003","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.envpol.2016.12.017_bib91","doi-asserted-by":"crossref","first-page":"5853","DOI":"10.1128\/jb.178.20.5853-5859.1996","article-title":"Multidrug efflux pumps of gram-negative bacteria","volume":"178","author":"Nikaido","year":"1996","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.envpol.2016.12.017_bib92","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1128\/AAC.37.7.1393","article-title":"Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples","volume":"37","author":"Nikaido","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.envpol.2016.12.017_bib93","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0731-7085(96)01734-7","article-title":"Equilibrium studies on tetracycline\u2014metal ion systems","volume":"14","author":"Nov\u00e1k-P\u00e9kli","year":"1996","journal-title":"J.\u00a0Pharm. Biomed. Anal."},{"key":"10.1016\/j.envpol.2016.12.017_bib94","doi-asserted-by":"crossref","first-page":"S244","DOI":"10.1093\/clinids\/9.Supplement_3.S244","article-title":"Resistance of bacteria to antibacterial agents: report of Task Force 2","volume":"9","author":"O'Brien","year":"1987","journal-title":"Rev. Infect. Dis."},{"key":"10.1016\/j.envpol.2016.12.017_bib95","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1128\/jb.178.1.306-308.1996","article-title":"AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants","volume":"178","author":"Okusu","year":"1996","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.envpol.2016.12.017_bib96","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1021\/bi9816610","article-title":"Tetracycline-chelated Mg2+ ion initiates helix unwinding in Tet repressor induction","volume":"38","author":"Orth","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.envpol.2016.12.017_bib97","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/73324","article-title":"Structural basis of gene regulation by the tetracycline inducible Tet repressor\u2013operator system","volume":"7","author":"Orth","year":"2000","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.envpol.2016.12.017_bib98","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.trac.2007.02.007","article-title":"Analysis of tetracycline antibiotics in soil: advances in extraction, clean-up, and quantification","volume":"26","author":"O'Connor","year":"2007","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib99","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00775-008-0395-2","article-title":"Specific binding of divalent metal ions to tetracycline and to the Tet repressor\/tetracycline complex","volume":"13","author":"Palm","year":"2008","journal-title":"JBIC J. Biol. Inorg. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib100","series-title":"Textbook of Microbiology & Immunology","author":"Parija","year":"2014"},{"key":"10.1016\/j.envpol.2016.12.017_bib101","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.clay.2007.08.003","article-title":"Tetracycline adsorption on montmorillonite: pH and ionic strength effects","volume":"40","author":"Parolo","year":"2008","journal-title":"Appl. Clay Sci."},{"key":"10.1016\/j.envpol.2016.12.017_bib102","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.clay.2010.05.005","article-title":"Antimicrobial properties of tetracycline and minocycline-montmorillonites","volume":"49","author":"Parolo","year":"2010","journal-title":"Appl. Clay Sci."},{"key":"10.1016\/j.envpol.2016.12.017_bib103","unstructured":"Periodic Table\u00a0of Elements. http:\/\/environmentalchemistry.com\/yogi\/periodic\/."},{"key":"10.1016\/j.envpol.2016.12.017_bib104","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1351\/PAC-CON-09-10-22","article-title":"Hydrated metal ions in aqueous solution: how regular are their structures?","volume":"82","author":"Persson","year":"2010","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib105","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/jac\/dkg483","article-title":"Does the use of antibiotics in food animals pose a risk to human health? A critical review of published data","volume":"53","author":"Phillips","year":"2004","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.envpol.2016.12.017_bib106","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1021\/es062316y","article-title":"Sorption of tetracycline and chlortetracycline on K-and Ca-saturated soil clays, humic substances, and clay-humic complexes","volume":"41","author":"Pils","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2016.12.017_bib107","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/emboj\/20.8.1829","article-title":"Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3","volume":"20","author":"Pioletti","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.envpol.2016.12.017_bib108","first-page":"ciw323","article-title":"Antibiotic stewardship programs in US acute care hospitals: findings from the 2014 National Healthcare Safety Network (NHSN) Annual Hospital Survey","author":"Pollack","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.envpol.2016.12.017_bib109","first-page":"1596","article-title":"A\u00a0persistent antibiotic partitioning and co-relation with metals in wastewater treatment plant\u2014chlortetracycline","volume":"2","author":"Puicharla","year":"2014","journal-title":"J.\u00a0Environ. Chem. Eng."},{"key":"10.1016\/j.envpol.2016.12.017_bib110","article-title":"Removal processes of antibiotics in waters and wastewaters: crucial link to physical-chemical properties and degradation","volume":"19","author":"Pulicharla","year":"2015","journal-title":"J.\u00a0Hazard. Toxic Radioact. Waste"},{"key":"10.1016\/j.envpol.2016.12.017_bib111","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.scitotenv.2015.05.140","article-title":"Toxicity of chlortetracycline and its metal complexes to model microorganisms in wastewater sludge","volume":"532","author":"Pulicharla","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2016.12.017_bib112","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ultsonch.2016.05.042","article-title":"Degradation of chlortetracycline in wastewater sludge by ultrasonication, Fenton oxidation, and ferro-sonication","volume":"34","author":"Pulicharla","year":"2017","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.envpol.2016.12.017_bib113","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1016\/j.watres.2004.03.017","article-title":"Potentiometric determination of acid dissociation constants (pK a) for human and veterinary antibiotics","volume":"38","author":"Qiang","year":"2004","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2016.12.017_bib114","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.3168\/jds.S0022-0302(06)72598-X","article-title":"Assessment and promotion of judicious antibiotic use on dairy farms in Washington State","volume":"89","author":"Raymond","year":"2006","journal-title":"J.\u00a0Dairy Sci."},{"key":"10.1016\/j.envpol.2016.12.017_bib115","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jphotochem.2006.04.007","article-title":"Degradation and inactivation of tetracycline by TiO2 photocatalysis","volume":"184","author":"Reyes","year":"2006","journal-title":"J.\u00a0Photochem. Photobiol. A Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib116","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.femsle.2005.02.034","article-title":"Update on acquired tetracycline resistance genes","volume":"245","author":"Roberts","year":"2005","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.envpol.2016.12.017_bib117","series-title":"Influence of MnO2 on the Transformation of Oxy-and Chlortetracycline in Pond Water","first-page":"45","author":"Rubert","year":"2009"},{"key":"10.1016\/j.envpol.2016.12.017_bib118","first-page":"939","article-title":"Determination of protonation constants of some tetracycline antibiotics by potentiometry and lc methods in water and acetonitrile-water binary mixtures","volume":"20","author":"\u015eanli","year":"2009","journal-title":"J.\u00a0Braz. Chem. Soc."},{"key":"10.1016\/j.envpol.2016.12.017_bib119","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.chemosphere.2006.03.026","article-title":"A\u00a0global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment","volume":"65","author":"Sarmah","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2016.12.017_bib120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1039\/b005722n","article-title":"Spectroscopic investigation of complexation between various tetracyclines and Mg2+ or Ca2+","volume":"3","author":"Schmitt","year":"2000","journal-title":"PhysChemComm"},{"key":"10.1016\/j.envpol.2016.12.017_bib121","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s002030050339","article-title":"Tetracyclines: antibiotic action, uptake, and resistance mechanisms","volume":"165","author":"Schnappinger","year":"1996","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.envpol.2016.12.017_bib122","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/zph.12191","article-title":"Antimicrobials in animal agriculture: parables and policy","volume":"62","author":"Scott","year":"2015","journal-title":"Zoonoses Public health"},{"key":"10.1016\/j.envpol.2016.12.017_bib123","first-page":"1","article-title":"Tetracycline uptake and metabolism by vetiver grass (Chrysopogon zizanioides L. Nash)","author":"Sengupta","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2016.12.017_bib124","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0920-5861(98)00027-3","article-title":"Liquid phase oxidation at metal ions and complexes in constrained environments","volume":"41","author":"Sheldon","year":"1998","journal-title":"Catal. Today"},{"key":"10.1016\/j.envpol.2016.12.017_bib125","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jhazmat.2011.04.048","article-title":"Sorption and biodegradation of tetracycline by nitrifying granules and the toxicity of tetracycline on granules","volume":"191","author":"Shi","year":"2011","journal-title":"J.\u00a0Hazard. Mater."},{"key":"10.1016\/j.envpol.2016.12.017_bib126","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/817365","article-title":"Spectral characterization and 3D molecular modeling studies of metal complexes involving the O, N-donor environment of quinazoline-4 (3H)-one Schiff base and their biological studies","volume":"2014","author":"Siddappa","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.envpol.2016.12.017_bib127","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1021\/ic101791r","article-title":"Two new ternary complexes of copper (II) with tetracycline or doxycycline and 1, 10-phenanthroline and their potential as antitumoral: cytotoxicity and DNA cleavage","volume":"50","author":"Silva","year":"2011","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib128","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/jps.2600660829","article-title":"Rate and proposed mechanism of anhydrotetracycline epimerization in acid solution","volume":"66","author":"Sokoloski","year":"1977","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.envpol.2016.12.017_bib129","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2113\/gselements.1.4.193","article-title":"Toxic metals in the environment: the role of surfaces","volume":"1","author":"Sparks","year":"2005","journal-title":"Elements"},{"key":"10.1016\/j.envpol.2016.12.017_bib130","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1002\/etc.248","article-title":"Tetracycline sorption to coal and soil humic acids: an examination of humic structural heterogeneity","volume":"29","author":"Sun","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib131","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0022-2836(86)90437-7","article-title":"Kinetic and equilibrium characterization of the tet repressor-tetracycline complex by fluorescence measurements: evidence for divalent metal ion requirement and energy transfer","volume":"187","author":"Takahashi","year":"1986","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.envpol.2016.12.017_bib132","first-page":"327","article-title":"Thermodynamic parameters and kinetic stability of manganese (II) complexes with some antibiotics: a polarographic approach","volume":"20","author":"Tantuvay","year":"2004","journal-title":"Bull. Electrochem."},{"key":"10.1016\/j.envpol.2016.12.017_bib133","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1081\/PDT-100100534","article-title":"The effects of pH and PEG 400\u2013water cosolvents on oxytetracycline\u2013magnesium complex formation and stability","volume":"5","author":"Tongaree","year":"2000","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.envpol.2016.12.017_bib134","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1128\/JB.184.8.2131-2140.2002","article-title":"Mutations in the 16S rRNA genes of Helicobacter pylori mediate resistance to tetracycline","volume":"184","author":"Trieber","year":"2002","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.envpol.2016.12.017_bib135","series-title":"Phytoremediation of Heavy Metal Contaminated Soils and Water Using Vetiver Grass, Environmental Bioengineering","first-page":"233","author":"Truong","year":"2010"},{"key":"10.1016\/j.envpol.2016.12.017_bib136","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/jac\/dkg493","article-title":"Antibiotic use in animals\u2014prejudices, perceptions and realities","volume":"53","author":"Turnidge","year":"2004","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.envpol.2016.12.017_bib137","doi-asserted-by":"crossref","first-page":"11153","DOI":"10.3390\/molecules180911153","article-title":"Metal complexes of quinolone antibiotics and their applications: an update","volume":"18","author":"Uivarosi","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.envpol.2016.12.017_bib138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2011.00203","article-title":"Acquired antibiotic resistance genes: an overview","volume":"2","author":"Van Hoek","year":"2011","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2016.12.017_bib139","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1016\/j.biortech.2009.03.068","article-title":"Pathogens and antibiotic residues in animal manures and hygienic and ecological risks related to subsequent land application","volume":"100","author":"Venglovsky","year":"2009","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.envpol.2016.12.017_bib140","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.chemosphere.2010.04.066","article-title":"Simultaneous adsorption and desorption of cadmium and tetracycline on cinnamon soil","volume":"80","author":"Wan","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2016.12.017_bib141","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1631\/jzus.A1400108","article-title":"Effects of Cu (II) and Ni (II) ions on adsorption of tetracycline to functionalized carbon nanotubes","volume":"15","author":"Wang","year":"2014","journal-title":"J.\u00a0Zhejiang Univ. Sci. A"},{"key":"10.1016\/j.envpol.2016.12.017_bib142","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1021\/acs.est.5b03696","article-title":"Transformation of tetracycline antibiotics and Fe (II) and Fe (III) species induced by their complexation","volume":"50","author":"Wang","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2016.12.017_bib143","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.chemosphere.2014.09.098","article-title":"Oxidation of tetracycline antibiotics induced by Fe (III) ions without light irradiation","volume":"119","author":"Wang","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2016.12.017_bib144","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.chemosphere.2015.04.070","article-title":"Simultaneous removal of tetracycline hydrochloride and As (III) using poorly-crystalline manganese dioxide","volume":"136","author":"Wang","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2016.12.017_bib145","doi-asserted-by":"crossref","first-page":"7236","DOI":"10.1021\/es060337m","article-title":"Water hardness as a photochemical parameter: tetracycline photolysis as a function of calcium concentration, magnesium concentration, and pH","volume":"40","author":"Werner","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2016.12.017_bib146","doi-asserted-by":"crossref","first-page":"9323","DOI":"10.1021\/jp9824050","article-title":"The complexation of tetracycline and anhydrotetracycline with Mg2+ and Ca2+: a spectroscopic study","volume":"102","author":"Wessels","year":"1998","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.envpol.2016.12.017_bib147","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0022-2836(71)90255-5","article-title":"Role of magnesium in the binding of tetracycline to Escherichia coli ribosomes","volume":"58","author":"White","year":"1971","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.envpol.2016.12.017_bib148","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1128\/AAC.45.11.3046-3055.2001","article-title":"Single ribosomal protein mutations in antibiotic-resistant bacteria analyzed by mass spectrometry","volume":"45","author":"Wilcox","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.envpol.2016.12.017_bib149","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02987711","article-title":"Use of veterinary drugs in intensive animal production","volume":"1","author":"Winckler","year":"2001","journal-title":"J.\u00a0Soils Sediments"},{"key":"10.1016\/j.envpol.2016.12.017_bib150","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1139\/L10-100","article-title":"Tetracycline degradation by ozonation, and evaluation of biodegradability and toxicity of ozonation byproducts","volume":"37","author":"Wu","year":"2010","journal-title":"Can. J. Civ. Eng."},{"key":"10.1016\/j.envpol.2016.12.017_bib151","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1021\/jm030417q","article-title":"Multivalent antibiotics via metal complexes: potent divalent vancomycins against vancomycin-resistant enterococci","volume":"46","author":"Xing","year":"2003","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib152","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1016\/S0021-9258(19)34044-X","article-title":"Transport of divalent cations with tetracycline as mediated by the transposon Tn10-encoded tetracycline resistance protein","volume":"265","author":"Yamaguchi","year":"1990","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.envpol.2016.12.017_bib153","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jtemb.2005.02.007","article-title":"Molecular mechanisms of heavy metal hyperaccumulation and phytoremediation","volume":"18","author":"Yang","year":"2005","journal-title":"J.\u00a0Trace Elem. Med. Biol."},{"key":"10.1016\/j.envpol.2016.12.017_bib154","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.scitotenv.2008.03.036","article-title":"Historical records of heavy metal accumulation in sediments and the relationship with agricultural intensification in the Yangtze\u2013Huaihe region, China","volume":"399","author":"Zhang","year":"2008","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2016.12.017_bib155","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1021\/es5003428","article-title":"Role of tetracycline speciation in the bioavailability to Escherichia coli for uptake and expression of antibiotic resistance","volume":"48","author":"Zhang","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2016.12.017_bib156","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.colsurfa.2015.02.018","article-title":"Removal of tetracycline antibiotics from aqueous solution by amino-Fe (III) functionalized SBA15","volume":"471","author":"Zhang","year":"2015","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.envpol.2016.12.017_bib157","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.chemosphere.2015.07.014","article-title":"Preparation of amino-Fe(III) functionalized mesoporous silica for synergistic adsorption of tetracycline and copper","volume":"138","author":"Zhang","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2016.12.017_bib158","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jcis.2011.05.051","article-title":"Adsorption of tetracycline onto goethite in the presence of metal cations and humic substances","volume":"361","author":"Zhao","year":"2011","journal-title":"J.\u00a0Colloid Interface Sci."},{"key":"10.1016\/j.envpol.2016.12.017_bib159","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s10646-011-0665-6","article-title":"Tetracycline adsorption on kaolinite: pH, metal cations and humic acid effects","volume":"20","author":"Zhao","year":"2011","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.envpol.2016.12.017_bib160","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.envpol.2013.05.043","article-title":"Interactions of tetracycline with Cd (II) Cu (II) and Pb (II) and their cosorption behavior in soils","volume":"180","author":"Zhao","year":"2013","journal-title":"Environ. Pollut."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749116308028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749116308028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T20:39:43Z","timestamp":1759437583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749116308028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":159,"alternative-id":["S0269749116308028"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2016.12.017","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tetracyclines metal complexation: Significance and fate of mutual existence in the environment","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2016.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}