{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:44:32Z","timestamp":1786988672718,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["C26340037"],"award-info":[{"award-number":["C26340037"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Health and Labour Science Research Grants, Research on Risk of Chemical Substance, Ministry of Health, Labour and Welfare, Japan","doi-asserted-by":"publisher","award":["H25-Toxical-003"],"award-info":[{"award-number":["H25-Toxical-003"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.envpol.2017.04.088","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T16:26:49Z","timestamp":1496161609000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["4-Nitrophenol (PNP) inhibits the expression of estrogen receptor \u03b2 and disrupts steroidogenesis during the ovarian development in female rats"],"prefix":"10.1016","volume":"229","author":[{"given":"Haolin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Taya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Nagaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-4678","authenticated-orcid":false,"given":"Gen","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2017.04.088_bib1","doi-asserted-by":"crossref","first-page":"10930","DOI":"10.1007\/s11356-015-4245-9","article-title":"Suppressive effects of long-term exposure to P-nitrophenol on gonadal development, hormonal profile with disruption of tissue integrity, and activation of caspase-3 in male Japanese quail (Coturnix japonica)","volume":"22","author":"Ahmed","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2017.04.088_bib2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/mrd.22070","article-title":"Parabens inhibit the early phase of folliculogenesis and steroidogenesis in the ovaries of neonatal rats","volume":"79","author":"Ahn","year":"2012","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.envpol.2017.04.088_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.rbmo.2014.03.002","article-title":"Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development","volume":"29","author":"Al-Gubory","year":"2014","journal-title":"Reprod. Biomed. online"},{"key":"10.1016\/j.envpol.2017.04.088_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bmb\/ldg019","article-title":"Environmental pollution and the global burden of disease","volume":"68","author":"Briggs","year":"2003","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.envpol.2017.04.088_bib5","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S0140-6736(02)11274-8","article-title":"Air pollution and health","volume":"360","author":"Brunekreef","year":"2002","journal-title":"Lancet (London, Engl."},{"key":"10.1016\/j.envpol.2017.04.088_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1095\/biolreprod66.1.77","article-title":"A\u00a0role for the androgen receptor in follicular atresia of estrogen receptor beta knockout mouse ovary","volume":"66","author":"Cheng","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.envpol.2017.04.088_bib7","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1210\/en.2005-0213","article-title":"Estrogen receptor-beta is critical to granulosa cell differentiation and the ovulatory response to gonadotropins","volume":"146","author":"Couse","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2017.04.088_bib8","first-page":"4277","article-title":"Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes","volume":"127","author":"Dupont","year":"2000","journal-title":"Dev. Camb. Engl."},{"key":"10.1016\/j.envpol.2017.04.088_bib9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.anireprosci.2012.04.001","article-title":"Prenatal and neonatal flutamide administration increases proliferation and reduces apoptosis in large antral follicles of adult pigs","volume":"132","author":"Durlej","year":"2012","journal-title":"Animal Reprod. Sci."},{"key":"10.1016\/j.envpol.2017.04.088_bib10","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1210\/er.2009-0012","article-title":"The mammalian ovary from genesis to revelation","volume":"30","author":"Edson","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.envpol.2017.04.088_bib11","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1289\/ehp.0901257","article-title":"Neonatal exposure to bisphenol a and reproductive and endocrine alterations resembling the polycystic ovarian syndrome in adult rats","volume":"118","author":"Fernandez","year":"2010","journal-title":"Environ. health Perspect."},{"key":"10.1016\/j.envpol.2017.04.088_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.taap.2015.02.010","article-title":"Di(2-ethylhexyl) phthalate inhibits antral follicle growth, induces atresia, and inhibits steroid hormone production in cultured mouse antral follicles","volume":"284","author":"Hannon","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2017.04.088_bib13","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1095\/biolreprod65.6.1623","article-title":"Regulation of follicle-stimulating hormone secretion by estradiol and dimeric inhibins in the infantile female rat","volume":"65","author":"Herath","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.envpol.2017.04.088_bib14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/dvdy.1162","article-title":"Neonatal estrogen exposure inhibits steroidogenesis in the developing rat ovary","volume":"221","author":"Ikeda","year":"2001","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.envpol.2017.04.088_bib15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.yrtph.2006.04.002","article-title":"Changes in estrogen receptors alpha and beta expression in the brain of mice exposed prenatally to bisphenol A","volume":"47","author":"Kawai","year":"2007","journal-title":"Regul. Toxicol. Pharmacol. RTP"},{"key":"10.1016\/j.envpol.2017.04.088_bib16","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.chemosphere.2005.05.038","article-title":"Degradation mechanism and the toxicity assessment in TiO2 photocatalysis and photolysis of parathion","volume":"62","author":"Kim","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2017.04.088_bib17","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1210\/en.2006-1083","article-title":"Neonatal exposure to estrogens suppresses activin expression and signaling in the mouse ovary","volume":"148","author":"Kipp","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2017.04.088_bib18","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.rbmo.2013.02.005","article-title":"Endocrine-disrupting chemicals and male reproductive health","volume":"26","author":"Knez","year":"2013","journal-title":"Reprod. Biomed. online"},{"key":"10.1016\/j.envpol.2017.04.088_bib19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2131\/jts.26.299","article-title":"Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats","volume":"26","author":"Koizumi","year":"2001","journal-title":"J.\u00a0Toxicol. Sci."},{"key":"10.1016\/j.envpol.2017.04.088_bib20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-4939-0820-2_4","article-title":"Impacts of endocrine disrupting chemicals on reproduction in wildlife","volume":"753","author":"Kumar","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.envpol.2017.04.088_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.113.116244","article-title":"Engineered nanomaterials: an emerging class of novel endocrine disruptors","volume":"91","author":"Larson","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.envpol.2017.04.088_bib22","doi-asserted-by":"crossref","first-page":"12426","DOI":"10.3390\/ijerph121012426","article-title":"Exposure to endocrine disruptors and nuclear receptors gene expression in infertile and fertile men from Italian areas with different environmental features","volume":"12","author":"La Rocca","year":"2015","journal-title":"Int. J. Environ. Res. public health"},{"key":"10.1016\/j.envpol.2017.04.088_bib23","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1210\/en.2008-1774","article-title":"Theca-specific estrogen receptor-alpha knockout mice lose fertility prematurely","volume":"150","author":"Lee","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2017.04.088_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2006.06.010","article-title":"Estrogenic and anti-androgenic activities of 4-nitrophenol in diesel exhaust particles","volume":"217","author":"Li","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2017.04.088_bib25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/jat.3332","article-title":"4-Nitrophenol exposure alters the AhR signaling pathway and related gene expression in the rat liver","volume":"37","author":"Li","year":"2017","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.envpol.2017.04.088_bib26","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s12020-009-9192-0","article-title":"4-Nitrophenol isolated from diesel exhaust particles disrupts regulation of reproductive hormones in immature male rats","volume":"36","author":"Li","year":"2009","journal-title":"Endocrine"},{"key":"10.1016\/j.envpol.2017.04.088_bib27","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/toxsci\/kfp207","volume":"112","author":"Mathews","year":"2009","journal-title":"Off. J. Soc. Toxicol."},{"key":"10.1016\/j.envpol.2017.04.088_bib28","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1002\/ar.22765","article-title":"Supplementation with quercetin attenuates 4-nitrophenol-induced testicular toxicity in adult male mice","volume":"296","author":"Mi","year":"2013","journal-title":"Anat. Rec. (Hoboken, N.J. 2007)"},{"key":"10.1016\/j.envpol.2017.04.088_bib29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1262\/jrd.09-074N","article-title":"Protective effect of quercetin on the reproductive toxicity of 4-nitrophenol in diesel exhaust particles on male embryonic chickens","volume":"56","author":"Mi","year":"2010","journal-title":"J.\u00a0Reprod. Dev."},{"key":"10.1016\/j.envpol.2017.04.088_bib30","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1210\/en.2012-1045","article-title":"Arcuate kisspeptin\/neurokinin B\/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight","volume":"153","author":"Mittelman-Smith","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2017.04.088_bib31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s11356-008-0006-3","article-title":"Improvement of an efficient separation method for chemicals in diesel exhaust particles: analysis for nitrophenols","volume":"15","author":"Noya","year":"2008","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2017.04.088_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.reprotox.2014.03.001","article-title":"Neonatal exposure to 17alpha-ethynyl estradiol affects ovarian gene expression and disrupts reproductive cycles in female rats","volume":"46","author":"Nozawa","year":"2014","journal-title":"Reprod. Toxicol. (Elmsford, N.Y.)"},{"key":"10.1016\/j.envpol.2017.04.088_bib33","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1210\/er.2003-0030","article-title":"Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones","volume":"25","author":"Payne","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.envpol.2017.04.088_bib34","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s11356-014-3468-5","article-title":"Environmental chemicals mediated the effect of old housing on adult health problems: US NHANES, 2009-2010","volume":"22","author":"Shiue","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2017.04.088_bib35","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0006-2952(95)02093-4","article-title":"Role of the steroidogenic acute regulatory protein (StAR) in steroidogenesis","volume":"51","author":"Stocco","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.envpol.2017.04.088_bib36","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1248\/bpb.27.835","article-title":"Estrogenic and anti-androgenic activity of nitrophenols in diesel exhaust particles (DEP)","volume":"27","author":"Taneda","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.envpol.2017.04.088_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.envpol.2016.05.040","article-title":"Effects of 4-nitrophenol on expression of the ER-alpha and AhR signaling pathway-associated genes in the small intestine of rats","volume":"216","author":"Tang","year":"2016","journal-title":"Environ. Pollut. (Barking, Essex 1987)"},{"key":"10.1016\/j.envpol.2017.04.088_bib38","doi-asserted-by":"crossref","first-page":"e99423","DOI":"10.1371\/journal.pone.0099423","article-title":"Effects of 5\u03b1-Dihydrotestosterone and 17\u03b2-estradiol on the mouse ovarian follicle development and oocyte maturation","volume":"9","author":"Tarumi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2017.04.088_bib39","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.chemosphere.2005.10.012","article-title":"Microbial and kinetic characterization of pure and mixed cultures aerobically degrading 4-nitrophenol","volume":"63","author":"Tomei","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2017.04.088_bib40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/biolreprod\/78.s1.199a","article-title":"Fetal and neonatal exposure to endocrine disruptor Methoxychlor impairs adult ovarian function","volume":"78","author":"Uzumcu","year":"2008","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.envpol.2017.04.088_bib41","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1210\/en.2005-0630","article-title":"To beta or not to beta: estrogen receptors and ovarian function","volume":"146","author":"Woodruff","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2017.04.088_bib42","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/em.21776","article-title":"Diethylhexyl phthalate exposure impairs follicular development and affects oocyte maturation in the mouse","volume":"54","author":"Zhang","year":"2013","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.envpol.2017.04.088_bib43","doi-asserted-by":"crossref","first-page":"13035","DOI":"10.1007\/s11356-016-6470-2","article-title":"4-Nitrophenol induces activation of Nrf2 antioxidant pathway and apoptosis of the germ cells in rat testes","volume":"23","author":"Zhang","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2017.04.088_bib44","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.toxlet.2013.09.011","article-title":"4-Nitrophenol induces Leydig cells hyperplasia, which may contribute to the differential modulation of the androgen receptor and estrogen receptor-alpha and -beta expression in male rat testes","volume":"223","author":"Zhang","year":"2013","journal-title":"Toxicol. Lett."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974911631956X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974911631956X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T05:29:39Z","timestamp":1535779779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026974911631956X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":44,"alternative-id":["S026974911631956X"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2017.04.088","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"4-Nitrophenol (PNP) inhibits the expression of estrogen receptor \u03b2 and disrupts steroidogenesis during the ovarian development in female rats","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2017.04.088","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}