{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:03:22Z","timestamp":1768295002388,"version":"3.49.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Tom Yawkey Wildlife Center Heritage Preserve"},{"DOI":"10.13039\/100010242","name":"South Carolina Department of Natural Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.envpol.2017.07.065","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T06:01:14Z","timestamp":1502344874000},"page":"1050-1061","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["AHR and CYP1A expression link historical contamination events to modern day developmental effects in the American alligator"],"prefix":"10.1016","volume":"230","author":[{"given":"Matthew D.","family":"Hale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Galligan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Rainwater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon C.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip M.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis J.","family":"Guillette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin B.","family":"Parrott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2017.07.065_bib1","doi-asserted-by":"crossref","first-page":"34989","DOI":"10.1038\/srep34989","article-title":"Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver","volume":"6","author":"Amenya","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2017.07.065_bib2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/aja.1002040204","article-title":"Developmental expression of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL\/6N mouse embryo","volume":"204","author":"Abbott","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.envpol.2017.07.065_bib3","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.tiv.2009.06.021","article-title":"Mechanisms of p,p\u2019-DDE-induced apoptosis in human peripheral mononuclear cells","volume":"23","author":"Alegria-Torres","year":"2009","journal-title":"Toxicol. Vitro"},{"issue":"3","key":"10.1016\/j.envpol.2017.07.065_bib4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1615\/CritRevEukarGeneExpr.v18.i3.20","article-title":"The aryl hydrocarbon nreceptor complex and the control of gene expression","volume":"18","author":"Beischlag","year":"2008","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.envpol.2017.07.065_bib5","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.etp.2012.07.006","article-title":"p,p\u2019-DDE, a DDT metabolite, induces proinflammatory molecules in human peripheral blood mononuclear cells \u201cin\u00a0vitro\u201d","volume":"65","author":"Cardenas-Gonzalez","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.envpol.2017.07.065_bib6","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1093\/bioinformatics\/bti473","article-title":"MatInspector and beyond: promoter analysis based on transcription factor binding sites","volume":"21","author":"Cartharius","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envpol.2017.07.065_bib7","series-title":"Activation of the NFkB Pathway Enhances AhR Expression in Intestinal Caco-2 Cells","author":"Champion","year":"2013"},{"issue":"1","key":"10.1016\/j.envpol.2017.07.065_bib8","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.envpol.2017.07.065_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0269-7491(01)00284-6","article-title":"Polychlorinated biphenyl occurrence in American alligators (Alligator mississippiensis) from Louisiana and South Carolina","volume":"118","author":"Cobb","year":"2002","journal-title":"Environ. Pollut."},{"issue":"7","key":"10.1016\/j.envpol.2017.07.065_bib10","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1002\/etc.5620160719","article-title":"Polychlorinated biphenyls in eggs and chorioallantoic membranes of American alligators (Alligator mississippiensis) from coastal South Carolina","volume":"16","author":"Cobb","year":"1997","journal-title":"Environ. Toxicol. Chem."},{"issue":"4","key":"10.1016\/j.envpol.2017.07.065_bib11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/jez.10189","article-title":"Microsatellite DNA analyses support an east-west phylogeographic split of American alligator populations","volume":"294","author":"Davis","year":"2002","journal-title":"J.\u00a0Exp. Zool."},{"key":"10.1016\/j.envpol.2017.07.065_bib12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/zoo.10039","article-title":"Carotenoids, vitamin A, and vitamin E concentrations during egg development in panther chameleons (Furcifer pardalis)","volume":"21","author":"Dierenfeld","year":"2002","journal-title":"Zoo. Biol."},{"key":"10.1016\/j.envpol.2017.07.065_bib13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.pharmtox.43.100901.135828","article-title":"Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals","volume":"43","author":"Denison","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.envpol.2017.07.065_bib14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0006-2952(99)00110-0","article-title":"Tissue- and cell-type specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localized in situ hybridization","volume":"58","author":"Dey","year":"1999","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.envpol.2017.07.065_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/(SICI)1099-0461(1999)13:1<17::AID-JBT3>3.0.CO;2-6","article-title":"Liver microsomal cytochromes P450-dependent alkoxyphenoxazone O-dealkylation in\u00a0vitro by alligator and rat: activities, inhibition, substrate preference, and discrimination factors","volume":"13","author":"Ertl","year":"1999","journal-title":"J.\u00a0Biochem. Mol. Toxicol."},{"issue":"9","key":"10.1016\/j.envpol.2017.07.065_bib16","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0006-2952(98)00003-3","article-title":"Induction time course of cytochromes P450 by phenobarbital and 3-methylcholanthrene pretreatment in liver microsomes of Alligator mississippiensis","volume":"55","author":"Ertl","year":"1998","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.envpol.2017.07.065_bib17","first-page":"691","article-title":"Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites","volume":"26","author":"Fernandez","year":"2005","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.envpol.2017.07.065_bib18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bbrc.2005.08.162","article-title":"Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes","volume":"338","author":"Fujii-Kuriyama","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envpol.2017.07.065_bib19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2050-3385-2-8","article-title":"Home range and movements of American alligators (Alligator mississippiensis) in an estuary habitat","volume":"2","author":"Fujisaki","year":"2014","journal-title":"Anim. Biotelemetry"},{"issue":"1","key":"10.1016\/j.envpol.2017.07.065_bib20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1006\/abbi.1999.1425","article-title":"Molecular cloning and sequence analysis of cDNAs coding for 3-methylcholanthrene-inducible cytochromes P450 in Xenopus laevis liver","volume":"371","author":"Fujita","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.envpol.2017.07.065_bib21","first-page":"329","article-title":"Reproductive biology and embryology of the crocodilians","volume":"14","author":"Ferguson","year":"1985","journal-title":"Biol. Reptilia"},{"issue":"3","key":"10.1016\/j.envpol.2017.07.065_bib22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3109\/1547691X.2014.960108","article-title":"DDE and PCB 153 independently induce aryl hydrocarbon receptor (AhR) expression in peripheral blood mononuclear cells","volume":"12","author":"Gaspar-Ramirez","year":"2015","journal-title":"J.\u00a0Immunotoxicol."},{"issue":"51","key":"10.1016\/j.envpol.2017.07.065_bib23","doi-asserted-by":"crossref","first-page":"33054","DOI":"10.1074\/jbc.271.51.33054","article-title":"Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"271","author":"Gilday","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.envpol.2017.07.065_bib24","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1007\/s00239-005-0134-z","article-title":"A\u00a0revised evolutionary history of the CYP1A subfamily: gene duplication, gene conversion, and positive selection","volume":"62","author":"Goldstone","year":"2006","journal-title":"J.\u00a0Mol. Evol."},{"issue":"12","key":"10.1016\/j.envpol.2017.07.065_bib25","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1093\/molbev\/msm200","article-title":"Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family","volume":"24","author":"Goldstone","year":"2007","journal-title":"Mol. Biol. Evol."},{"issue":"8","key":"10.1016\/j.envpol.2017.07.065_bib26","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1289\/ehp.94102680","article-title":"Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida","volume":"102","author":"Guillette","year":"1994","journal-title":"Environ. Health Perspect."},{"issue":"Suppl.\u00a04","key":"10.1016\/j.envpol.2017.07.065_bib27","first-page":"31","article-title":"Gonadal steroidogenesis in\u00a0vitro from juvenile alligators obtained from contaminated or control lakes","volume":"103","author":"Guillette","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2017.07.065_bib28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1006\/gcen.1996.0005","article-title":"Reduction in penis size and plasma testosterone concentrations in juvenile alligators living in a contaminated environment","volume":"101","author":"Guillette","year":"1996","journal-title":"General Comp. Endocrinol."},{"key":"10.1016\/j.envpol.2017.07.065_bib29","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/PL00006617","article-title":"Serum concentrations of various environmental contaminants and their relationship to sex steroid concentrations and phallus size in juvenile American alligators","volume":"36","author":"Guillette","year":"1999","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envpol.2017.07.065_bib30","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.abb.2004.09.031","article-title":"Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor","volume":"433","author":"Hankinson","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.envpol.2017.07.065_bib31","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.bcp.2013.07.004","article-title":"The emerging roles of AhR in physiology and immunity","volume":"86","author":"Hao","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.envpol.2017.07.065_bib32","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/toxsci\/kfh030","article-title":"DNA adduct formation in precision-cut rat liver and lung slices exposed to Benzo[a]pyrene","volume":"77","author":"Harrigan","year":"2004","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.envpol.2017.07.065_bib33","first-page":"617","article-title":"Differential expression, induction, and stability of CYP1A4 and CYP1A5 mRNA in chicken and herring gull embryo hepatocytes","volume":"145","author":"Head","year":"2007","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.envpol.2017.07.065_bib34","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00397615","article-title":"Contaminants in American alligator eggs from Lake Apopka, lake Griffin, and Lake Okeechobee, Florida","volume":"16","author":"Heinz","year":"1991","journal-title":"Environ. Monit. Assess."},{"issue":"10","key":"10.1016\/j.envpol.2017.07.065_bib35","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.3109\/00498258909043171","article-title":"The hepatic microsomal mixed-function oxygenase (MFO) system of Alligator mississippiensis: induction by 3-methylcolanthrene (MC)","volume":"19","author":"Jewell","year":"1989","journal-title":"Xenobiotica"},{"issue":"19","key":"10.1016\/j.envpol.2017.07.065_bib36","doi-asserted-by":"crossref","first-page":"13519","DOI":"10.1074\/jbc.274.19.13519","article-title":"Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (aryl hydrocarbon) receptor","volume":"274","author":"Kazlauskas","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.envpol.2017.07.065_bib37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/BJ20050713","article-title":"AHR1B, a new functional aryl hydrocarbon receptor in zebrafish: tandem arrangement of ahr1b and ahr2 genes","volume":"392","author":"Karchner","year":"2005","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.envpol.2017.07.065_bib38","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/toxsci\/kfl001","article-title":"Cytochrome P450 1A4 and 1A5 in Common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds","volume":"92","author":"Kubota","year":"2006","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.envpol.2017.07.065_bib39","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/toxsci\/kfu240","article-title":"Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish","volume":"143","author":"Kubota","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2017.07.065_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2008.09.007","article-title":"Dioxin activation of CYP1A5 promoter\/enhancer regions from two avian species, common cormorant (Phalacrocorax carbo) and chicken (Gallus gallus): association with aryl hydrocarbon receptor 1 and 2 isoforms","volume":"234","author":"Lee","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"7","key":"10.1016\/j.envpol.2017.07.065_bib41","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1124\/dmd.107.015826","article-title":"CYP1A induction and human risk assessment: an evolving tale of in\u00a0vitro and in\u00a0vivo studies","volume":"35","author":"Ma","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.envpol.2017.07.065_bib42","series-title":"A\u00a0Novel Cytoplasmic Protein that Interacts with the Ah Receptor, Contains Tetratricopeptide Repeat Motifs, and Augments the Transcriptional Response to 2,3,7,8-tetrachlorodibenzo-p-dioxin","author":"Ma","year":"1997"},{"key":"10.1016\/j.envpol.2017.07.065_bib43","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1530\/REP-15-0155","article-title":"Incubation history prior to the canonical thermosensitive period determines sex in the American alligator","volume":"150","author":"McCoy","year":"2015","journal-title":"Reproduction"},{"issue":"10","key":"10.1016\/j.envpol.2017.07.065_bib44","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1897\/02-495","article-title":"Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories","volume":"22","author":"Meyer","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2017.07.065_bib45","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ygcen.2011.11.018","article-title":"Gonadotropin-induced changes in oviducal mRNA expression levels of sex steroid hormone receptors and activin-related signaling factors in the alligator","volume":"175","author":"Moore","year":"2012","journal-title":"General Comp. Endocrinol."},{"key":"10.1016\/j.envpol.2017.07.065_bib46","first-page":"218","article-title":"Altered sex hormone concentrations and gonadal mRNA expression levels of activin signaling factors in hatchling alligators from a contaminated Florida lake","volume":"313A","author":"Moore","year":"2010","journal-title":"J.\u00a0Exp. Zool."},{"key":"10.1016\/j.envpol.2017.07.065_bib47","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.mce.2011.10.020","article-title":"Gene-environment interactions: the potential role of contaminants in somatic growth and the development of the reproductive system of the American alligator","volume":"354","author":"Moore","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"issue":"10","key":"10.1016\/j.envpol.2017.07.065_bib48","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.1073\/pnas.1037886100","article-title":"Distinct response to dioxin in an aryhydrocarbon receptor (AHR)-humanized mouse","volume":"100","author":"Moriguchi","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envpol.2017.07.065_bib49","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/1365-2656.12306","article-title":"Size, sex, and individual-level behavior drive intrapopulation variation in cross-ecosystem foraging of a top predator","volume":"84","author":"Nifong","year":"2015","journal-title":"J.\u00a0Animal Ecol."},{"issue":"4","key":"10.1016\/j.envpol.2017.07.065_bib50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1379\/1466-1268(1996)001<0237:APOMCI>2.3.CO;2","article-title":"A\u00a0pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor","volume":"1","author":"Nair","year":"1996","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.envpol.2017.07.065_bib51","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.bcp.2008.10.026","article-title":"Conserved genomic structure of the Cyp1a1 and Cyp1a2 loci and their dioxin responsive elements cluster","volume":"77","author":"Nukaya","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.envpol.2017.07.065_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2016.05.002","article-title":"2016. Molecular cloning and characterization of the aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocators in the American alligator","author":"Oka","year":"2016","journal-title":"General Comp. Endocrinol."},{"issue":"1","key":"10.1016\/j.envpol.2017.07.065_bib53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/toxsci\/kfr032","article-title":"Aryl hydrocarbon receptor ligands of widely different toxic equivalency patterns induce similar histone marks in target gene chromatin","volume":"121","author":"Ovesen","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"12","key":"10.1016\/j.envpol.2017.07.065_bib54","article-title":"Differential incubation temperatures result in dimorphic DNA methylation patterning of the SOX9 and aromatase promoters in gonads of alligator (Alligator mississippiensis) embryos","volume":"90","author":"Parrott","year":"2014","journal-title":"Biol. Reprod."},{"issue":"27","key":"10.1016\/j.envpol.2017.07.065_bib55","doi-asserted-by":"crossref","first-page":"13802","DOI":"10.1016\/S0021-9258(18)68314-0","article-title":"Association of the Ah receptor with the 90-kDa heat shock protein","volume":"263","author":"Perdew","year":"1988","journal-title":"J.\u00a0Biol. Chem."},{"issue":"16","key":"10.1016\/j.envpol.2017.07.065_bib56","doi-asserted-by":"crossref","first-page":"4936","DOI":"10.1016\/S0021-9258(17)33205-2","article-title":"Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol","volume":"251","author":"Poland","year":"1976","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.envpol.2017.07.065_bib57","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1021\/es0628194","article-title":"Parental exposure to pesticides and poor clutch viability in American alligators","volume":"41","author":"Rauschenberger","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2017.07.065_bib58","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2148-14-6","article-title":"Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats","volume":"14","author":"Reitzel","year":"2014","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.envpol.2017.07.065_bib59","series-title":"Diet and Condition of American alligator (Alligator mississippiensis) in Three Central Florida Lakes [dissertation]","author":"Rice","year":"2004"},{"issue":"5","key":"10.1016\/j.envpol.2017.07.065_bib60","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1016\/S0021-9258(17)41874-6","article-title":"Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver","volume":"269","author":"Rifkind","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.envpol.2017.07.065_bib61","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0048-9697(99)00500-8","article-title":"Cytochrome P4501A (CYP1A) in teleostean fishes. A review of immunohistochemical studies","volume":"247","author":"Sarasquete","year":"2000","journal-title":"Sci. Total Environ."},{"issue":"9\u201310","key":"10.1016\/j.envpol.2017.07.065_bib62","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.bbaexp.2007.07.002","article-title":"HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated transactivation","volume":"1769","author":"Schnekenburger","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.envpol.2017.07.065_bib63","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.1016\/S0021-9258(19)50499-9","article-title":"Protein-DNA interactions at a dioxin-responsive enhancer: mutational analysis of the DNA-binding site for the liganded Ah receptor","volume":"267","author":"Shen","year":"1992","journal-title":"J.\u00a0Biol. Chem."},{"issue":"1","key":"10.1016\/j.envpol.2017.07.065_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1349-7006.2004.tb03162.x","article-title":"Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1","volume":"95","author":"Shimada","year":"2004","journal-title":"Cancer Sci."},{"key":"10.1016\/j.envpol.2017.07.065_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0041-008X(02)00035-2","article-title":"Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL\/6J mice of arylhydrocarbon receptor gene","volume":"187","author":"Shimada","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2017.07.065_bib66","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.taap.2014.10.017","article-title":"Analysis of the AHR gene proximal promoter GGGGC-repeat polymorphism in lung, breast, and colon cancer","volume":"282","author":"Spink","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2017.07.065_bib67","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.2144\/00286ir01","article-title":"The Sequence Manipulation Suite: JavaScript programs for analyzing and formatting protein and DNA sequences","volume":"28","author":"Stothard","year":"2000","journal-title":"Biotechniques"},{"key":"10.1016\/j.envpol.2017.07.065_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2141\/jpsa.38.1","article-title":"Carotenoids in avian nutrition and embryonic development","volume":"38","author":"Surai","year":"2001","journal-title":"J.\u00a0Poult. Sci."},{"key":"10.1016\/j.envpol.2017.07.065_bib69","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1095-6433(98)10150-2","article-title":"Changes in fatty acid profiles and in protein, ion, and energy contents of eggs of the Murray short-necked turtle, Emydura macquarii (Chelonia, Pleurodira) during development","volume":"122","author":"Thompson","year":"1999","journal-title":"Comp. Biochem. Physiol. Part A"},{"key":"10.1016\/j.envpol.2017.07.065_bib70","series-title":"Hazardous Waste Site Descriptions National Priorities List. EPA HW-8.1","author":"US EPA","year":"1983"},{"key":"10.1016\/j.envpol.2017.07.065_bib71","series-title":"Preliminary Data Summary for the Pulp, Paper, and Paperboard Point Source Category. EPA 440\/1-89-025","author":"US EPA","year":"1989"},{"key":"10.1016\/j.envpol.2017.07.065_bib72","series-title":"Bioaccumulation of Selected Pollutants in Fish (Vol. II). EPA 506\/6\u201390\/001b","author":"US EPA","year":"1990"},{"key":"10.1016\/j.envpol.2017.07.065_bib73","series-title":"Dioxin Contamination in Sampit River, Winyah Bay System, Georgetown County, South Carolina. FWS 90-4-060","author":"US FWS","year":"1991"},{"key":"10.1016\/j.envpol.2017.07.065_bib74","first-page":"305","article-title":"Molecular characterization and developmental expression of the aryl hydrocarbon receptor from the chick embryo","volume":"126","author":"Walker","year":"2000","journal-title":"Comp. Biochem. Physiol., Part C"},{"issue":"4","key":"10.1016\/j.envpol.2017.07.065_bib75","first-page":"2504","article-title":"Ligand-dependent recruitment of the Arnt coregulatory determines DNA recognition by the dioxin receptor","volume":"13","author":"Whitelaw","year":"1993","journal-title":"Mol. Cell. Biol."},{"issue":"4","key":"10.1016\/j.envpol.2017.07.065_bib76","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1643\/CH-16-430","article-title":"Determinate growth and reproductive lifespan in the American alligator (Alligator mississippiensis): evidence from long-term recaptures","volume":"104","author":"Wilkinson","year":"2016","journal-title":"Copeia"},{"key":"10.1016\/j.envpol.2017.07.065_bib77","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.1197296","article-title":"Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River","volume":"331","author":"Wirgin","year":"2011","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.envpol.2017.07.065_bib78","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.4049\/jimmunol.1402044","article-title":"Linking the aryl hydrocarbon receptor with altered DNA methylation patterns and developmentally induced aberrant antiviral CD8+ T cell responses","volume":"194","author":"Winans","year":"2015","journal-title":"J.\u00a0Immunol."},{"issue":"6","key":"10.1016\/j.envpol.2017.07.065_bib79","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/S1734-1140(11)70710-1","article-title":"Effects of two isomers of DDT and their metabolite DDE on CYP1A1 and AhR function in human placental cells","volume":"63","author":"W\u00f3jtowicz","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.envpol.2017.07.065_bib80","series-title":"Wildlife Ecotoxicology: Forensic Approaches","first-page":"153","article-title":"Abnormal alligators and organochlorine pesticides in lake Apopka, Florida","author":"Woodward","year":"2011"},{"issue":"9","key":"10.1016\/j.envpol.2017.07.065_bib81","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1002\/etc.5620160906","article-title":"Cytochrome P4501A immunoassay in freshwater turtles and exposure to PCBs and environmental pollutants","volume":"16","author":"Yawetz","year":"1997","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2017.07.065_bib82","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1021\/tx0502645","article-title":"Mutagenic activity of 4-hydrocyestradiol, but not 2-hydroxyestradiol, in BB rat2 embryonic cells, and the mutational spectrum of 4-hydroxyestradiol. 2006","volume":"19","author":"Zhao","year":"2006","journal-title":"Chem. Res. Toxicol."}],"updated-by":[{"DOI":"10.1016\/j.envpol.2018.06.041","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000}}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749117314203?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749117314203?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T20:41:09Z","timestamp":1759437669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749117314203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":82,"alternative-id":["S0269749117314203"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2017.07.065","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AHR and CYP1A expression link historical contamination events to modern day developmental effects in the American alligator","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2017.07.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}