{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:20Z","timestamp":1792785860434,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T00:00:00Z","timestamp":1552608000000},"content-version":"am","delay-in-days":287,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["P503\/12\/G147"],"award-info":[{"award-number":["P503\/12\/G147"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["16-17085S"],"award-info":[{"award-number":["16-17085S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004240","name":"Czech Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004240","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007059","name":"Palack\u00fd University in Olomouc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007059","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Czech Ministry of Agriculture","award":["RO 0517"],"award-info":[{"award-number":["RO 0517"]}],"id":[{"id":"https:\/\/ror.org\/049wftm75","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.envpol.2018.02.067","type":"journal-article","created":{"date-parts":[[2018,3,18]],"date-time":"2018-03-18T15:32:26Z","timestamp":1521387146000},"page":"473-486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"special_numbering":"C","title":["In\u00a0vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion"],"prefix":"10.1016","volume":"237","author":[{"given":"Kate\u0159ina","family":"P\u011bn\u010d\u00edkov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Svr\u017ekov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Strap\u00e1\u010dov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Ne\u010da","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iveta","family":"Barto\u0148kov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zden\u011bk","family":"Dvo\u0159\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"H\u00fd\u017e\u010falov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Pivni\u010dka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"P\u00e1lkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-927X","authenticated-orcid":false,"given":"Hans-Joachim","family":"Lehmler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueshu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Vondr\u00e1\u010dek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6870-6542","authenticated-orcid":false,"given":"Miroslav","family":"Machala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2018.02.067_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.taap.2012.05.016","article-title":"Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner","volume":"263","author":"Al-Salman","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2018.02.067_bib2","doi-asserted-by":"crossref","first-page":"14478","DOI":"10.1007\/s11356-014-2985-6","article-title":"Polychlorinated biphenyl contamination of paints containing polycyclic- and Naphthol AS-type pigments","volume":"22","author":"Anezaki","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2018.02.067_bib3","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1124\/dmd.109.030197","article-title":"Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells","volume":"38","author":"Anth\u00e9rieu","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.envpol.2018.02.067_bib4","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1021\/acs.chemrestox.6b00170","article-title":"Profiling of vitamin D metabolic intermediates toward VDR using novel stable gene reporter cell lines IZ-VDRE and IZ-CYP24","volume":"29","author":"Barto\u0148kov\u00e1","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2018.02.067_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121316","article-title":"Novel stably transfected human reporter cell line AIZ-AR as a tool for an assessment of human androgen receptor transcriptional activity","volume":"10","author":"Barto\u0148kov\u00e1","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2018.02.067_bib6","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00216-011-5162-5","article-title":"Recombinant cell bioassays for the detection of (gluco)corticosteroids and endocrine-disrupting potencies of several environmental PCB contaminants","volume":"401","author":"Bovee","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.envpol.2018.02.067_bib7","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1007\/s11356-015-4819-6","article-title":"Pure non-dioxin-like PCB congeners suppress induction of AhR-dependent endpoints in rat liver cells","volume":"23","author":"Brenerov\u00e1","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2018.02.067_bib8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1515\/reveh-2014-0074","article-title":"Exposure to and health effects of volatile PCBs","volume":"30","author":"Carpenter","year":"2015","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.envpol.2018.02.067_bib9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.freeradbiomed.2010.03.012","article-title":"Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle","volume":"49","author":"Chaudhuri","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envpol.2018.02.067_bib10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/sj.bjp.0703573","article-title":"Investigation into the involvement of phospholipases A(2) and MAP kinases in modulation of AA release and cell growth in A549 cells","volume":"131","author":"Choudhury","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.envpol.2018.02.067_bib11","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.envint.2010.05.011","article-title":"PCB congener specific oxidative stress response by microarray analysis using human liver cell line","volume":"36","author":"De","year":"2010","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2018.02.067_bib12","doi-asserted-by":"crossref","DOI":"10.1007\/s11356-017-9694-x","article-title":"Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs)","author":"Dhakal","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2018.02.067_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.taap.2009.07.016","article-title":"Hydroxylated polychlorinated biphenyls increase reactive oxygen species formation and induce cell death in cultured cerebellar granule cells","volume":"240","author":"Dreiem","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2018.02.067_bib14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.chemosphere.2011.06.027","article-title":"Polychlorinated biphenyls (PCBs) in indoor air and in serum among older residents of upper Hudson River communities","volume":"85","author":"Fitzgerald","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2018.02.067_bib15","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0045-6535(99)00353-7","article-title":"PCB-blood levels in teachers, working in PCB-contaminated schools","volume":"40","author":"Gabrio","year":"2000","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2018.02.067_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.taap.2013.05.034","article-title":"Role of the nuclear xenobiotic receptors CAR and PXR in induction of cytochromes P450 by non-dioxinlike polychlorinated biphenyls in cultured rat hepatocytes","volume":"272","author":"G\u00e4hrs","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2018.02.067_bib17","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1210\/er.2015-1010","article-title":"EDC-2: the endocrine Society's second scientific statement on endocrine-disrupting chemicals","volume":"36","author":"Gore","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.envpol.2018.02.067_bib18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.taap.2003.12.003","article-title":"Differential action of polycyclic aromatic hydrocarbons on endogenous estrogen-responsive genes and on a transfected estrogen-responsive reporter in MCF-7 cells","volume":"196","author":"Gozgit","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2018.02.067_bib19","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/S0140-6736(06)69665-7","article-title":"Developmental neurotoxicity of industrial chemicals","volume":"368","author":"Grandjean","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.envpol.2018.02.067_bib20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/10408444.2014.999365","article-title":"Metabolism and metabolites of polychlorinated biphenyls","volume":"45","author":"Grimm","year":"2015","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envpol.2018.02.067_bib21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/toxsci\/kfr043","article-title":"In\u00a0vitro toxicity profiling of ultrapure non-dioxin-like polychlorinated biphenyl congeners and their relative toxic contribution to PCB mixtures in humans","volume":"121","author":"Hamers","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.02.067_bib22","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1289\/ehp.6912","article-title":"An unrecognized source of PCB contamination in schools and other buildings","volume":"112","author":"Herrick","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2018.02.067_bib23","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1021\/es902413k","article-title":"Inadvertent polychlorinated biphenyls in commercial paint pigments","volume":"44","author":"Hu","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2018.02.067_bib24","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1021\/es3049114","article-title":"Elimination of inhaled 3,3'-dichlorobiphenyl and the formation of the 4-hydroxylated metabolite","volume":"47","author":"Hu","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2018.02.067_bib25","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1021\/acs.jafc.5b01519","article-title":"Development and characterization of a human reporter cell line for the assessment of thyroid receptor transcriptional activity: a case of organotin endocrine disruptors","volume":"63","author":"Ill\u00e9s","year":"2015","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.envpol.2018.02.067_bib26","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1021\/es062218c","article-title":"Concentrations and chiral signatures of polychlorinated biphenyls in outdoor and indoor air and soil in a major U.K. conurbation","volume":"41","author":"Jamshidi","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2018.02.067_bib27","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.tiv.2015.07.021","article-title":"Detection and measurement of the agonistic activities of PCBs and mono-hydroxylated PCBs to the constitutive androstane receptor using a recombinant yeast assay","volume":"29","author":"Kamata","year":"2015","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.envpol.2018.02.067_bib28","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1080\/10408440600845304","article-title":"Carcinogenicity of \"non-dioxinlike\" polychlorinated biphenyls","volume":"36","author":"Knerr","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envpol.2018.02.067_bib29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/toxsci\/68.2.451","article-title":"Differential effects of polybrominated diphenyl ethers and polychlorinated biphenyls on [3H]arachidonic acid release in rat cerebellar granule neurons","volume":"68","author":"Kodavanti","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.02.067_bib30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cbi.2005.06.003","article-title":"CAR and PXR: xenosensors of endocrine disrupters?","volume":"155","author":"Kretschmer","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envpol.2018.02.067_bib31","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ejmech.2016.05.064","article-title":"Pleiotropic effects of gold(I) mixed-ligand complexes of 9-deazahypoxanthine on transcriptional activity of receptors for steroid hormones, nuclear receptors and xenoreceptors in human hepatocytes and cell lines","volume":"121","author":"Kube\u0161ov\u00e1","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.envpol.2018.02.067_bib32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1470-2045(13)70104-9","article-title":"Carcinogenicity of polychlorinated biphenyls and polybrominated biphenyls","volume":"14","author":"Lauby-Secretan","year":"2013","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.envpol.2018.02.067_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/toxsci\/48.1.55","article-title":"Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line","volume":"48","author":"Legler","year":"1999","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.02.067_bib34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1289\/ehp.1408564","article-title":"Evaluating health risks from inhaled polychlorinated biphenyls: research needs for addressing uncertainty","volume":"123","author":"Lehmann","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2018.02.067_bib35","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/tx030034v","article-title":"Toxicity of hydroxylated and quinoid PCB metabolites: inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells","volume":"17","author":"Machala","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2018.02.067_bib36","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/toxsci\/kfg209","article-title":"Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action","volume":"76","author":"Machala","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.02.067_bib37","doi-asserted-by":"crossref","DOI":"10.1021\/acs.est.7b01910","article-title":"Airborne PCBs and OH-PCBs inside and outside urban and rural U.S. Schools","volume":"51","author":"Marek","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2018.02.067_bib38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.tiv.2017.03.014","article-title":"Differentiating true androgen receptor inhibition from cytotoxicity-mediated reduction of reporter-gene transactivation in vitro","volume":"45","author":"Marin-Kuan","year":"2017","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.envpol.2018.02.067_bib39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1021\/mp700103m","article-title":"Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response","volume":"5","author":"Moreau","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.envpol.2018.02.067_bib40","doi-asserted-by":"crossref","first-page":"10133","DOI":"10.1021\/es2029334","article-title":"Novel stably transfected gene reporter human hepatoma cell line for assessment of aryl hydrocarbon receptor transcriptional activity: construction and characterization","volume":"45","author":"Novotn\u00e1","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2018.02.067_bib41","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.ejps.2012.10.003","article-title":"Construction and characterization of a reporter gene cell line for assessment of human glucocorticoid receptor activation","volume":"47","author":"Novotn\u00e1","year":"2012","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.envpol.2018.02.067_bib42","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/toxsci\/kfr032","article-title":"Aryl hydrocarbon receptor ligands of widely different toxic equivalency factors induce similar histone marks in target gene chromatin","volume":"121","author":"Ovesen","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.02.067_bib43","doi-asserted-by":"crossref","DOI":"10.1007\/s11356-017-0683-x","article-title":"Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in\u00a0vitro","author":"P\u011bn\u010d\u00edkov\u00e1","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2018.02.067_bib44","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1021\/tx050196m","article-title":"Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1)","volume":"19","author":"Pessah","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2018.02.067_bib45","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1289\/ehp.7745","article-title":"Impact of polychlorinated biphenyls contamination on estrogenic activity in human male serum","volume":"113","author":"Pl\u00ed\u0161kov\u00e1","year":"2005","journal-title":"Environ. Health Perspect."},{"issue":"Suppl.\u00a06","key":"10.1016\/j.envpol.2018.02.067_bib46","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1289\/ehp.02110s6925","article-title":"Problems for risk assessment of endocrine-active estrogenic compounds","volume":"110","author":"Safe","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2018.02.067_bib47","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/tx034036r","article-title":"Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action","volume":"16","author":"Safe","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2018.02.067_bib48","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/toxsci\/kfx100","article-title":"Detection of 3,3'-dichlorobiphenyl in human maternal plasma and its effects on axonal and dendritic growth in primary rat neurons","volume":"158","author":"Sethi","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.02.067_bib49","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.yrtph.2007.03.005","article-title":"Development of a neurotoxic equivalence scheme of relative potency for assessing the risk of PCB mixtures","volume":"48","author":"Simon","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2018.02.067_bib50","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jsbmb.2010.06.010","article-title":"Superinduction of estrogen receptor mediated gene expression in luciferase based reporter gene assays is mediated by a post-transcriptional mechanism","volume":"122","author":"Sotoca","year":"2010","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.envpol.2018.02.067_bib51","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/toxsci\/kfn202","article-title":"The 2,2',4,4',5,5'-hexachlorobiphenyl-enhanced degradation of connexin 43 involves both proteasomal and lysosomal activities","volume":"107","author":"\u0160ime\u010dkov\u00e1","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.02.067_bib52","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1289\/ehp.6560","article-title":"Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR)","volume":"112","author":"Tabb","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2018.02.067_bib53","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.envpol.2017.04.059","article-title":"Effects of unintentional PCBs in pigments and chemical products on transcriptional activity via aryl hydrocarbon and nuclear hormone receptors","volume":"227","author":"Takeuchi","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2018.02.067_bib54","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.tox.2011.08.001","article-title":"Characterization of steroid hormone receptor activities in 100 hydroxylated polychlorinated biphenyls, including congeners identified in humans","volume":"289","author":"Takeuchi","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2018.02.067_bib55","first-page":"52","article-title":"Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls","volume":"104","author":"Tithof","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2018.02.067_bib56","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1021\/tx200049x","article-title":"Toxic effects of methylated benzo[a]pyrenes in rat liver stem-like cells","volume":"24","author":"Trilecov\u00e1","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2018.02.067_bib57","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jnutbio.2016.09.006","article-title":"Activation of autophagy and PPARgamma protect colon cancer cells against apoptosis induced by interactive effects of butyrate and DHA in a cell type-dependent manner: the role of cell differentiation","volume":"39","author":"Tylichov\u00e1","year":"2017","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.envpol.2018.02.067_bib58","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tox.2008.02.002","article-title":"Non-dioxin-like polychlorinated biphenyls induce a release of arachidonic acid in liver epithelial cells: a partial role of cytosolic phospholipase A(2) and extracellular signal-regulated kinases 1\/2 signalling","volume":"247","author":"Umannov\u00e1","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2018.02.067_bib59","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/toxsci\/kfl055","article-title":"The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds","volume":"93","author":"Van den Berg","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.02.067_bib60","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/toxsci\/kfv250","article-title":"Polychlorinated biphenyl-xenobiotic nuclear receptor interactions regulate energy metabolism, behavior, and inflammation in non-alcoholic-steatohepatitis","volume":"149","author":"Wahlang","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.02.067_bib61","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.envpol.2014.03.001","article-title":"Characterization of estrogen receptor alpha activities in polychlorinated biphenyls by in\u00a0vitro dual-luciferase reporter gene assay","volume":"189","author":"Zhang","year":"2014","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2018.02.067_bib62","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/toxsci\/kft186","article-title":"A\u00a0new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11)","volume":"136","author":"Zhu","year":"2013","journal-title":"Toxicol. Sci."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749118301222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749118301222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T20:41:59Z","timestamp":1759437719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749118301222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":62,"alternative-id":["S0269749118301222"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2018.02.067","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In\u00a0vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2018.02.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}