{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:15:36Z","timestamp":1783995336980,"version":"3.55.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31602123"],"award-info":[{"award-number":["31602123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772811"],"award-info":[{"award-number":["31772811"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31472253"],"award-info":[{"award-number":["31472253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20160736"],"award-info":[{"award-number":["BK20160736"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Higher Education Institutions (Jiangsu, China)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.envpol.2018.03.032","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T16:46:06Z","timestamp":1522514766000},"page":"656-662","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["PCV2 infection aggravates ochratoxin A-induced nephrotoxicity via autophagy involving p38 signaling pathway in\u00a0vivo and in\u00a0vitro"],"prefix":"10.1016","volume":"238","author":[{"given":"Fang","family":"Gan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingen","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehe","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2018.03.032_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0378-1135(94)00136-K","article-title":"Pathogenesis of porcine circovirus; experimental infections of colostrum deprived piglets and examination of pig foetal material","volume":"44","author":"Allan","year":"1995","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.envpol.2018.03.032_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.virusres.2007.06.024","article-title":"Phylogenetic characterization of porcine circovirus type 2 in PMWS and PDNS Korean pigs between 1999 and 2006","volume":"129","author":"An","year":"2007","journal-title":"Virus Res."},{"key":"10.1016\/j.envpol.2018.03.032_bib3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1080\/15548627.2016.1256932","article-title":"Autophagy and KRT8\/keratin 8 protect degeneration of retinal pigment epithelium under oxidative stress","volume":"13","author":"Baek","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.envpol.2018.03.032_bib4","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.16.3.497-516.2003","article-title":"Mycotoxins","volume":"16","author":"Bennett","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.envpol.2018.03.032_bib5","article-title":"Experimental direct and indirect prolonged ochratoxin A intoxication in swine","volume":"vol. 25","author":"Cabassi","year":"2005"},{"key":"10.1016\/j.envpol.2018.03.032_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/toxsci\/kfp090","article-title":"Ochratoxin A-mediated DNA and protein damage: roles of nitrosative and oxidative stresses","volume":"110","author":"Cavin","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.03.032_bib7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1179\/1351000213Y.0000000058","article-title":"Interaction of porcine circovirus type 2 replication with intracellular redox status in\u00a0vitro","volume":"18","author":"Chen","year":"2013","journal-title":"Redox Rep."},{"key":"10.1016\/j.envpol.2018.03.032_bib8","series-title":"Hygienical Standard for Feeds-Toleration of Ochratoxin A and Zearalenone in Feeds","author":"China","year":"2006"},{"key":"10.1016\/j.envpol.2018.03.032_bib9","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/jcb.25425","article-title":"Recombinant mitochondrial manganese containing superoxide dismutase protects against ochratoxin A-induced nephrotoxicity","volume":"117","author":"Ciarcia","year":"2016","journal-title":"J.\u00a0Cell Biochem."},{"issue":"L229","key":"10.1016\/j.envpol.2018.03.032_bib10","first-page":"7","article-title":"Commission recommendation 2006\/576\/EC August 17th 2006 on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding","volume":"49","author":"Commission","year":"2006","journal-title":"Off. J. Eur. Union"},{"key":"10.1016\/j.envpol.2018.03.032_bib11","first-page":"277","article-title":"Human ochratoxicosis","volume":"18","author":"Creppy","year":"1999","journal-title":"J.\u00a0Toxicol. Toxin Rev."},{"key":"10.1016\/j.envpol.2018.03.032_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119808","article-title":"Selenium alleviates porcine nephrotoxicity of ochratoxin a by improving selenoenzyme expression in\u00a0vitro","volume":"10","author":"Gan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2018.03.032_bib13","first-page":"33","article-title":"Ochratoxin A promotes porcine circovirus type 2 replication in\u00a0vitro and in\u00a0vivo","volume":"80C","author":"Gan","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envpol.2018.03.032_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.taap.2016.03.006","article-title":"Deoxynivalenol exposure induces autophagy\/apoptosis and epigenetic modification changes during porcine oocyte maturation","volume":"300","author":"Han","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2018.03.032_bib15","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.foodcont.2013.01.031","article-title":"Quantitative assessment of risk associated with dietary intake of mycotoxin ochratoxin A on the adult inhabitants in Shanghai city of PR China","volume":"32","author":"Han","year":"2013","journal-title":"Food Contr."},{"key":"10.1016\/j.envpol.2018.03.032_bib16","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1242\/jcs.01481","article-title":"MAP kinases and cell migration","volume":"117","author":"Huang","year":"2004","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.envpol.2018.03.032_bib17","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1128\/AEM.32.3.443-444.1976","article-title":"Degradation of ochratoxin A by a ruminant","volume":"32","author":"Hult","year":"1976","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.envpol.2018.03.032_bib18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.mce.2015.10.022","article-title":"Stimulatory effects of interleukin-1 beta on development of porcine uterine epithelial cell are mediated by activation of the ERK1\/2 MAPK cell signaling cascade","volume":"419","author":"Jeong","year":"2016","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.envpol.2018.03.032_bib19","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.envpol.2018.03.032_bib20","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1089\/ars.2015.6386","article-title":"NQO1 deficiency leads enhanced autophagy in cisplatin-induced acute kidney injury through the AMPK\/TSC2\/mTOR signaling pathway","volume":"24","author":"Kim","year":"2016","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.envpol.2018.03.032_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00204-011-0735-9","article-title":"A\u00a0potential role of calcium in apoptosis and aberrant chromatin forms in porcine kidney PK15 cells induced by individual and combined ochratoxin A and citrinin","volume":"86","author":"Klari\u0107","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2018.03.032_bib22","doi-asserted-by":"crossref","first-page":"37751","DOI":"10.1038\/srep37751","article-title":"Silymarin attenuates cigarette smoke extract-induced inflammation via simultaneous inhibition of autophagy and ERK\/p38 MAPK pathway in human bronchial epithelial cells","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2018.03.032_bib23","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.virol.2013.08.025","article-title":"Hsp70 positively regulates porcine circovirus type 2 replication in\u00a0vitro","volume":"447","author":"Liu","year":"2013","journal-title":"Virology"},{"key":"10.1016\/j.envpol.2018.03.032_bib24","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bbrc.2015.05.042","article-title":"Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK","volume":"463","author":"Liu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envpol.2018.03.032_bib25","doi-asserted-by":"crossref","first-page":"8253","DOI":"10.1073\/pnas.1118193109","article-title":"Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency","volume":"109","author":"McAfee","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envpol.2018.03.032_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/0300985812450726","article-title":"Current state of knowledge on porcine circovirus type 2-associated lesions","volume":"50","author":"Opriessnig","year":"2013","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.envpol.2018.03.032_bib27","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/104063870701900601","article-title":"Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies","volume":"19","author":"Opriessnig","year":"2007","journal-title":"J.\u00a0Vet. Diagn. Invest."},{"key":"10.1016\/j.envpol.2018.03.032_bib28","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.etp.2012.12.004","article-title":"Protective effect of lycopene against ochratoxin A induced renal oxidative stress and apoptosis in rats","volume":"65","author":"Palabiyik","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.envpol.2018.03.032_bib29","doi-asserted-by":"crossref","first-page":"16667","DOI":"10.1074\/jbc.M210998200","article-title":"Amino acids interfere with the ERK1\/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells","volume":"278","author":"Pattingre","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.envpol.2018.03.032_bib30","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.freeradbiomed.2015.11.006","article-title":"Glutathione-S-transferase omega 1 (GSTO1-1) acts as mediator of signaling pathways involved in aflatoxin B1-induced apoptosis-autophagy crosstalk in macrophages","volume":"89","author":"Paul","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envpol.2018.03.032_bib31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4161\/auto.26843","article-title":"Autophagy enhances the replication of classical swine fever virus in\u00a0vitro","volume":"10","author":"Pei","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.envpol.2018.03.032_bib32","first-page":"68","article-title":"Porcine dermatitis and nephropathy syndrome associated with porcine circovirus 2 infection in a Yorkshire pig","volume":"46","author":"Phaneuf","year":"2007","journal-title":"J.\u00a0Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.envpol.2018.03.032_bib33","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1128\/AEM.53.2.266-269.1987","article-title":"Penicillium viridicatum, Penicillium verrucosum, and production of ochratoxin A","volume":"53","author":"Pitt","year":"1987","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.envpol.2018.03.032_bib34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/vr.146.2.40","article-title":"Identification of porcine circovirus in tissues of pigs with porcine dermatitis and nephropathy syndrome","volume":"146","author":"Rosell","year":"2000","journal-title":"Vet. Rec."},{"key":"10.1016\/j.envpol.2018.03.032_bib35","doi-asserted-by":"crossref","DOI":"10.1136\/vr.132.2.47-b","article-title":"Dermatitis\/nephropathy syndrome of pigs","volume":"132","author":"Smith","year":"1993","journal-title":"Vet. Rec."},{"key":"10.1016\/j.envpol.2018.03.032_bib36","doi-asserted-by":"crossref","first-page":"C51","DOI":"10.1159\/000213081","article-title":"Fifty years of research in Balkan endemic nephropathy: where are we now?","volume":"112","author":"Stefanovic","year":"2009","journal-title":"Nephron Clin. Pract."},{"key":"10.1016\/j.envpol.2018.03.032_bib37","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1023\/A:1006433709685","article-title":"Experimental mycotoxic nephropathy in pigs provoked by a diet containing ochratoxin A and penicillic acid","volume":"25","author":"Stoev","year":"2001","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.envpol.2018.03.032_bib38","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.4161\/auto.21159","article-title":"Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication","volume":"8","author":"Sun","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.envpol.2018.03.032_bib39","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.freeradbiomed.2015.09.012","article-title":"Autophagy protects intestinal epithelial Cells against Deoxynivalenol toxicity by alleviating oxidative stress via IKK signaling pathway","volume":"89","author":"Tang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envpol.2018.03.032_bib40","doi-asserted-by":"crossref","first-page":"114","DOI":"10.5713\/ajas.2011.11104","article-title":"Isolation, screening and identification of Swine gut microbiota with ochratoxin a biodegradation ability","volume":"25","author":"Upadhaya","year":"2012","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"10.1016\/j.envpol.2018.03.032_bib41","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1089\/ars.2013.5363","article-title":"Autophagy in kidney health and disease","volume":"20","author":"Wang","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.envpol.2018.03.032_bib42","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijbiomac.2015.07.050","article-title":"Astragalus polysaccharides inhibits PCV2 replication by inhibiting oxidative stress and blocking NF-kappaB pathway","volume":"81","author":"Xue","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.envpol.2018.03.032_bib43","doi-asserted-by":"crossref","first-page":"37052","DOI":"10.1038\/srep37052","article-title":"Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways","volume":"6","author":"Yan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2018.03.032_bib44","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.bbrc.2012.12.083","article-title":"mir-30d Regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells","volume":"431","author":"Yang","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envpol.2018.03.032_bib45","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00204-015-1514-9","article-title":"Fumonisin B1 induces autophagic cell death via activation of ERN1-MAPK8\/9\/10 pathway in monkey kidney MARC-145 cells","volume":"90","author":"Yin","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2018.03.032_bib46","doi-asserted-by":"crossref","first-page":"33904","DOI":"10.1038\/srep33904","article-title":"Exposure to HT-2 toxin causes oxidative stress induced apoptosis\/autophagy in porcine oocytes","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2018.03.032_bib47","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.etp.2015.12.002","article-title":"Nephropathy and hepatopathy in weaned piglets provoked by natural ochratoxin A and involved mechanisms","volume":"68","author":"Zhang","year":"2016","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.envpol.2018.03.032_bib48","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.virusres.2011.11.012","article-title":"Porcine circovirus type 2 explores the autophagic machinery for replication in PK-15 cells","volume":"163","author":"Zhu","year":"2012","journal-title":"Virus Res."},{"key":"10.1016\/j.envpol.2018.03.032_bib49","doi-asserted-by":"crossref","first-page":"12003","DOI":"10.1128\/JVI.01434-12","article-title":"Porcine circovirus type 2 induces autophagy via the AMPK\/ERK\/TSC2\/mTOR signaling pathway in PK-15 cells","volume":"86","author":"Zhu","year":"2012","journal-title":"J.\u00a0Virol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749118301866?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749118301866?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T18:40:38Z","timestamp":1604083238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749118301866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":49,"alternative-id":["S0269749118301866"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2018.03.032","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PCV2 infection aggravates ochratoxin A-induced nephrotoxicity via autophagy involving p38 signaling pathway in\u00a0vivo and in\u00a0vitro","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2018.03.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}