{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:14:18Z","timestamp":1784031258174,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Health Research Institute of Taiwan","award":["NHRI EX95-9531PI"],"award-info":[{"award-number":["NHRI EX95-9531PI"]}]},{"name":"National Health Research Institute of Taiwan","award":["EX96-9531PI"],"award-info":[{"award-number":["EX96-9531PI"]}]},{"name":"National Health Research Institute of Taiwan","award":["EX97-9531PI"],"award-info":[{"award-number":["EX97-9531PI"]}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"crossref","award":["NSC 101-2314-B-002-184-NY3"],"award-info":[{"award-number":["NSC 101-2314-B-002-184-NY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"crossref","award":["NSC 99-2314-B-385-001-MY3"],"award-info":[{"award-number":["NSC 99-2314-B-385-001-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"crossref","award":["NSC 106-2314-B-385 -001"],"award-info":[{"award-number":["NSC 106-2314-B-385 -001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Environmental Medicine Collaboration Center of National Taiwan University Hospital, Taiwan","award":["NTUH 103-A123"],"award-info":[{"award-number":["NTUH 103-A123"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.envpol.2018.04.010","type":"journal-article","created":{"date-parts":[[2018,4,21]],"date-time":"2018-04-21T17:59:35Z","timestamp":1524333575000},"page":"493-498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Investigating the association between urinary levels of acrylonitrile metabolite N-acetyl-S-(2-cyanoethyl)-L-cysteine and the oxidative stress product 8-hydroxydeoxyguanosine in adolescents and young adults"],"prefix":"10.1016","volume":"239","author":[{"given":"Chien-Yu","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ling","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fung-Chang","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta-Chen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2018.04.010_bib1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1289\/ehp.7337","article-title":"Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements","volume":"113","author":"Barr","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2018.04.010_bib2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s40292-015-0114-3","article-title":"Hypertension in young people: epidemiology, diagnostic assessment and therapeutic approach","volume":"22","author":"Battistoni","year":"2015","journal-title":"High. Blood Press Cardiovasc Prev."},{"issue":"Suppl.\u00a02","key":"10.1016\/j.envpol.2018.04.010_bib3","first-page":"25","article-title":"Mortality of industrial workers exposed to acrylonitrile","volume":"24","author":"Blair","year":"1998","journal-title":"Scand. J. Work Environ. Health"},{"key":"10.1016\/j.envpol.2018.04.010_bib4","doi-asserted-by":"crossref","first-page":"6295","DOI":"10.1007\/s00216-016-9741-3","article-title":"Simultaneous, rapid, and sensitive quantification of 8-hydroxy-2'-deoxyguanosine and cotinine in human urine by on-line solid-phase extraction LC-MS\/MS: correlation with tobacco exposure biomarkers NNAL","volume":"408","author":"Chen","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.envpol.2018.04.010_bib5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.talanta.2014.09.029","article-title":"Fast and simple screening for the simultaneous analysis of seven metabolites derived from five volatile organic compounds in human urine using on-line solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry","volume":"132","author":"Chiang","year":"2015","journal-title":"Talanta"},{"key":"10.1016\/j.envpol.2018.04.010_bib6","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.yrtph.2008.09.004","article-title":"Acrylonitrile and cancer: a review of the epidemiology","volume":"52","author":"Cole","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2018.04.010_bib7","author":"Columbia University"},{"key":"10.1016\/j.envpol.2018.04.010_bib8","doi-asserted-by":"crossref","first-page":"6002","DOI":"10.3390\/ijms15046002","article-title":"Oxidative stress in cardiovascular disease","volume":"15","author":"Csanyi","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2018.04.010_bib9","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.toxlet.2014.09.009","article-title":"Acrylonitrile exposure in the general population following a major train accident in Belgium: a human biomonitoring study","volume":"231","author":"De Smedt","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2018.04.010_bib10","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/jbt.20237","article-title":"Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain","volume":"22","author":"El-Sayed el","year":"2008","journal-title":"J.\u00a0Biochem. Mol. Toxicol."},{"key":"10.1016\/j.envpol.2018.04.010_bib11","author":"EPA"},{"key":"10.1016\/j.envpol.2018.04.010_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.52.1.1","article-title":"Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?","volume":"52","author":"Evans","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.envpol.2018.04.010_bib13","article-title":"Biomarkers for the tobacco smoke-related exposure to acrylonitrile, CORESTA Meeting","author":"H.W","year":"2007","journal-title":"Smoke Science\/Product Technol."},{"key":"10.1016\/j.envpol.2018.04.010_bib14","first-page":"834","article-title":"2-Cyanoethylmercapturic acid (CEMA) in the urine as a possible indicator of exposure to acrylonitrile","volume":"44","author":"Jakubowski","year":"1987","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.envpol.2018.04.010_bib15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/toxsci\/46.2.333","article-title":"Induction of oxidative stress in rat brain by acrylonitrile (ACN)","volume":"46","author":"Jiang","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.04.010_bib16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijcard.2004.05.069","article-title":"Increased oxidative stress in children exposed to passive smoking","volume":"100","author":"Kosecik","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.envpol.2018.04.010_bib17","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1152\/ajpregu.00327.2006","article-title":"An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations","volume":"292","author":"Kregel","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.envpol.2018.04.010_bib18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1383-5742(99)00006-X","article-title":"Mutagenicity, carcinogenicity, and teratogenicity of acrylonitrile","volume":"436","author":"Leonard","year":"1999","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envpol.2018.04.010_bib19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.scitotenv.2015.04.020","article-title":"Co-exposure to polycyclic aromatic hydrocarbons, benzene and toluene and their dose-effects on oxidative stress damage in kindergarten-aged children in Guangzhou, China","volume":"524\u2013525","author":"Li","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2018.04.010_bib20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.envint.2016.04.006","article-title":"Positive association between concentration of phthalate metabolites in urine and microparticles in adolescents and young adults","volume":"92\u201393","author":"Lin","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2018.04.010_bib21","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/JOM.0000000000000369","article-title":"Mortality among chemical plant workers exposed to acrylonitrile: 2011 follow-up","volume":"57","author":"Marsh","year":"2015","journal-title":"J.\u00a0Occup. Environ. Med."},{"key":"10.1016\/j.envpol.2018.04.010_bib22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/1354750X.2010.533287","article-title":"Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption","volume":"16","author":"Minet","year":"2011","journal-title":"Biomarkers"},{"key":"10.1016\/j.envpol.2018.04.010_bib23","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1080\/10408440903052855","article-title":"Weight-of-the-evidence review of acrylonitrile reproductive and developmental toxicity studies","volume":"39","author":"Neal","year":"2009","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envpol.2018.04.010_bib24","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1289\/ehp.1509693","article-title":"Environmental chemicals in urine and blood: improving methods for creatinine and lipid adjustment","volume":"124","author":"O'Brien","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2018.04.010_bib25","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/toxsci\/kfp133","article-title":"Acrylonitrile-induced oxidative stress and oxidative DNA damage in male Sprague-Dawley rats","volume":"111","author":"Pu","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.04.010_bib26","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1002\/tox.22182","article-title":"Protective effects of antioxidants on acrylonitrile-induced oxidative stress in female F344 rats","volume":"31","author":"Pu","year":"2016","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envpol.2018.04.010_bib27","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/eurheartj\/ehi601","article-title":"Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigm","volume":"27","author":"Raupach","year":"2006","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.envpol.2018.04.010_bib28","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.neuint.2009.05.009","article-title":"Effects of acrylonitrile on antioxidant status of different brain regions in rats","volume":"55","author":"Rongzhu","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.envpol.2018.04.010_bib29","first-page":"19","article-title":"[Urinary 8-hydroxy-2'-deoxyguanosine: a biomarker of environmental oxidative stress?]","volume":"66","author":"Sajous","year":"2008","journal-title":"Ann. Biol. Clin. Paris."},{"key":"10.1016\/j.envpol.2018.04.010_bib30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.talanta.2012.06.074","article-title":"Accurate quantification of the mercapturic acids of acrylonitrile and its genotoxic metabolite cyanoethylene-epoxide in human urine by isotope-dilution LC-ESI\/MS\/MS","volume":"98","author":"Schettgen","year":"2012","journal-title":"Talanta"},{"key":"10.1016\/j.envpol.2018.04.010_bib31","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/jat.1535","article-title":"Acrylonitrile induced apoptosis via oxidative stress in neuroblastoma SH-SY5Y cell","volume":"30","author":"Watcharasit","year":"2010","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.envpol.2018.04.010_bib32","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1001\/jama.290.10.1345","article-title":"National surveillance for type 2 diabetes mellitus in Taiwanese children","volume":"290","author":"Wei","year":"2003","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"10.1016\/j.envpol.2018.04.010_bib33","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1161\/CIRCULATIONAHA.104.520650","article-title":"Tobacco smoke exposure is associated with the metabolic syndrome in adolescents","volume":"112","author":"Weitzman","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.envpol.2018.04.010_bib34","first-page":"43","article-title":"International agency for research on cancer","author":"WHO","year":"1999","journal-title":"Acrylonitrile. IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.envpol.2018.04.010_bib35","author":"WHO"},{"key":"10.1016\/j.envpol.2018.04.010_bib36","author":"WHO"},{"key":"10.1016\/j.envpol.2018.04.010_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cccn.2003.09.010","article-title":"Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics","volume":"339","author":"Wu","year":"2004","journal-title":"Clinica Chimica Acta; Int. J. Clin. Chem."},{"key":"10.1016\/j.envpol.2018.04.010_bib38","first-page":"44","article-title":"Effects of cigarette smoking and smoking cessation on plasma constituents and enzyme activities related to oxidative stress","volume":"13","author":"Zhou","year":"2000","journal-title":"Biomed. Environ. Sci."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749118302185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749118302185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T20:50:01Z","timestamp":1759438201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749118302185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":38,"alternative-id":["S0269749118302185"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2018.04.010","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the association between urinary levels of acrylonitrile metabolite N-acetyl-S-(2-cyanoethyl)-L-cysteine and the oxidative stress product 8-hydroxydeoxyguanosine in adolescents and young adults","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2018.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}