{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:49:50Z","timestamp":1792122590972,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI15C0810"],"award-info":[{"award-number":["HI15C0810"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI17C0929"],"award-info":[{"award-number":["HI17C0929"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.envpol.2018.09.092","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:12:48Z","timestamp":1537488768000},"page":"1263-1273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"PB","title":["Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K\/AKT and MAPK pathways"],"prefix":"10.1016","volume":"243","author":[{"given":"Changwon","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whasun","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuller W.","family":"Bazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwonhwa","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2018.09.092_bib1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.taap.2015.10.005","article-title":"Toxicological responses of environmental mixtures: environmental metal mixtures display synergistic induction of metal-responsive and oxidative stress genes in placental cells","volume":"289","author":"Adebambo","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2018.09.092_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091558","article-title":"ER stress-mediated signaling: action potential and Ca(2+) as key players","volume":"17","author":"Bahar","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2018.09.092_bib3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/toxsci\/kfl043","article-title":"Estrogen-like response to p-nonylphenol in human first trimester placenta and BeWo choriocarcinoma cells","volume":"93","author":"Bechi","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.09.092_bib4","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.tiv.2013.01.013","article-title":"Toxicity assessment on trophoblast cells for some environment polluting chemicals and 17beta-estradiol","volume":"27","author":"Bechi","year":"2013","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.envpol.2018.09.092_bib5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s002449900322","article-title":"Effects of xenoestrogenic environmental pollutants on the proliferation of a human breast cancer cell line (MCF-7)","volume":"34","author":"Blom","year":"1998","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envpol.2018.09.092_bib6","doi-asserted-by":"crossref","first-page":"20140070","DOI":"10.1098\/rstb.2014.0070","article-title":"The role of invasive trophoblast in implantation and placentation of primates","volume":"370","author":"Carter","year":"2015","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.envpol.2018.09.092_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18040771","article-title":"Endoplasmic reticulum stress and oxidative stress: a vicious nexus implicated in bowel disease pathophysiology","volume":"18","author":"Chong","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2018.09.092_bib8","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1210\/en.2004-1272","article-title":"Estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the ultraviolet filter 4-methylbenzylidene camphor","volume":"146","author":"Durrer","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2018.09.092_bib9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/00365510500375230","article-title":"Oxidative stress and inflammation in pregnancy","volume":"66","author":"Fialova","year":"2006","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.envpol.2018.09.092_bib10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/15287390590895054","article-title":"Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks","volume":"68","author":"Gomez","year":"2005","journal-title":"J.\u00a0Toxicol. Environ. Health"},{"key":"10.1016\/j.envpol.2018.09.092_bib11","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1289\/ehp.10983","article-title":"Region-specific growth effects in the developing rat prostate following fetal exposure to estrogenic ultraviolet filters","volume":"116","author":"Hofkamp","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2018.09.092_bib12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jchromb.2013.08.006","volume":"936","author":"Jimenez-Diaz","year":"2013","journal-title":"J\u00a0Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.envpol.2018.09.092_bib13","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nrd2755","article-title":"Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities","volume":"7","author":"Kim","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.envpol.2018.09.092_bib14","doi-asserted-by":"crossref","first-page":"R121","DOI":"10.1530\/REP-14-0072","article-title":"Transcriptional regulators of the trophoblast lineage in mammals with hemochorial placentation","volume":"148","author":"Knott","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.envpol.2018.09.092_bib15","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1365-2605.2012.01280.x","article-title":"Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters","volume":"35","author":"Krause","year":"2012","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.envpol.2018.09.092_bib16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.taap.2006.07.014","article-title":"Estrogenic activity of UV filter mixtures","volume":"217","author":"Kunz","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2018.09.092_bib17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mce.2017.07.016","article-title":"Bisphenol A affects trophoblast invasion by inhibiting CXCL8 expression in decidual stromal cells","volume":"470","author":"Li","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envpol.2018.09.092_bib18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/jcp.25423","article-title":"Chrysophanol induces apoptosis of choriocarcinoma through regulation of ROS and the AKT and ERK1\/2 pathways","volume":"232","author":"Lim","year":"2017","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.envpol.2018.09.092_bib19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.tiv.2005.01.004","article-title":"Estrogenic activity of 37 components of commercial sunscreen lotions evaluated by in\u00a0vitro assays","volume":"19","author":"Morohoshi","year":"2005","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.envpol.2018.09.092_bib20","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11154-016-9326-7","article-title":"Polycystic ovary syndrome (PCOS) and endocrine disrupting chemicals (EDCs)","volume":"16","author":"Palioura","year":"2015","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.envpol.2018.09.092_bib21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.chemosphere.2013.10.053","article-title":"Ecotoxicological evaluation of four UV filters using marine organisms from different trophic levels Isochrysis galbana, Mytilus galloprovincialis, Paracentrotus lividus, and Siriella armata","volume":"104","author":"Paredes","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2018.09.092_bib22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1478-811X-9-19","article-title":"Calcium signaling around mitochondria associated membranes (MAMs)","volume":"9","author":"Patergnani","year":"2011","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.envpol.2018.09.092_bib23","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1210\/en.2007-1282","article-title":"Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling","volume":"149","author":"Prast","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2018.09.092_bib24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jchromb.2003.12.022","article-title":"Liquid chromatographic assay for common sunscreen agents: application to in\u00a0vivo assessment of skin penetration and systemic absorption in human volunteers","volume":"803","author":"Sarveiya","year":"2004","journal-title":"J\u00a0Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.envpol.2018.09.092_bib25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1289\/ehp.01109239","article-title":"In\u00a0vitro and in\u00a0vivo estrogenicity of UV screens","volume":"109","author":"Schlumpf","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2018.09.092_bib26","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.chemosphere.2010.09.079","article-title":"Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: correlation of UV filters with use of cosmetics","volume":"81","author":"Schlumpf","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2018.09.092_bib27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/toxsci\/kfi035","article-title":"Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays","volume":"83","author":"Schreurs","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2018.09.092_bib28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.watres.2016.05.067","article-title":"Transformation of avobenzone in conditions of aquatic chlorination and UV-irradiation","volume":"101","author":"Trebse","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2018.09.092_bib29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.freeradbiomed.2011.04.019","article-title":"ROS-activated p38 MAPK\/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation","volume":"51","author":"Wang","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envpol.2018.09.092_bib30","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/icb.2010.95","article-title":"Expression of chemokine decoy receptors and their ligands at the porcine maternal-fetal interface","volume":"89","author":"Wessels","year":"2011","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.envpol.2018.09.092_bib31","doi-asserted-by":"crossref","first-page":"e1976","DOI":"10.1038\/cddis.2015.331","article-title":"Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress","volume":"6","author":"Xu","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.envpol.2018.09.092_bib32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.taap.2017.12.009","article-title":"Decanoic acid suppresses proliferation and invasiveness of human trophoblast cells by disrupting mitochondrial function","volume":"339","author":"Yang","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2018.09.092_bib33","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.fct.2017.09.049","article-title":"Propyl gallate induces cell death and inhibits invasion of human trophoblasts by blocking the AKT and mitogen-activated protein kinase pathways","volume":"109","author":"Yang","year":"2017","journal-title":"Food Chem. Toxicol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749118309990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749118309990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T20:51:51Z","timestamp":1759438311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749118309990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":33,"alternative-id":["S0269749118309990"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2018.09.092","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K\/AKT and MAPK pathways","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2018.09.092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}