{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:52:04Z","timestamp":1783097524516,"version":"3.54.6"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001381","name":"Singapore National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Water Technologies Strategic Research Programme"},{"name":"Environment and Water Industry Programme Office (EWI)","award":["1102-IRIS-12-02"],"award-info":[{"award-number":["1102-IRIS-12-02"]}]},{"name":"Singapore Ministry of Education","award":["R-302-000-051-133"],"award-info":[{"award-number":["R-302-000-051-133"]}]},{"name":"Singapore-Peking-Oxford Research Enterprise","award":["COY-15-EWI-RCFSA\/N197-1"],"award-info":[{"award-number":["COY-15-EWI-RCFSA\/N197-1"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.envpol.2018.11.009","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T03:23:42Z","timestamp":1541215422000},"page":"282-289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["The potential impact of naturally produced antibiotics, environmental factors, and anthropogenic pressure on the occurrence of erm genes in urban soils"],"prefix":"10.1016","volume":"245","author":[{"given":"Xinzhu","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1252-2626","authenticated-orcid":false,"given":"Zhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2018.11.009_bib1","series-title":"Heavy Metals in Soils","author":"Alloway","year":"1995"},{"key":"10.1016\/j.envpol.2018.11.009_bib2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.tim.2006.02.006","article-title":"Co-selection of antibiotic and metal resistance","volume":"14","author":"Baker-Austin","year":"2006","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.envpol.2018.11.009_bib3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1146\/annurev.mi.42.100188.002555","article-title":"Genetics of Streptomyces fradiae and tylosin biosynthesis","volume":"42","author":"Baltz","year":"1988","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.envpol.2018.11.009_bib4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1128\/AEM.01649-08","article-title":"Quantitative PCR monitoring of antibiotic resistance genes and bacterial pathogens in three European artificial groundwater recharge systems","volume":"75","author":"B\u00f6ckelmann","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.envpol.2018.11.009_bib5","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1128\/AAC.00652-07","article-title":"Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom","author":"Byrne-Bailey","year":"2009","journal-title":"Antimicrob. Agents"},{"key":"10.1016\/j.envpol.2018.11.009_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1177\/104063871102300102","article-title":"Selection of a cutoff value for real-time polymerase chain reaction results to fit a diagnostic purpose: analytical and epidemiologic approaches","volume":"23","author":"Caraguel","year":"2011","journal-title":"J.\u00a0Vet. Diagn. Invest."},{"key":"10.1016\/j.envpol.2018.11.009_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1897\/04-657R.1","article-title":"Dissipation kinetics and mobility of chlortetracycline, tylosin, and monensin in an agricultural soil in Northumberland County, Ontario, Canada","volume":"25","author":"Carlson","year":"2006","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2018.11.009_bib8","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1002\/j.1460-2075.1985.tb03866.x","article-title":"Resistance, regulatory and production genes for the antibiotic methylenomycin are clustered","volume":"4","author":"Chater","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.envpol.2018.11.009_bib9","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1126\/science.1120800","article-title":"Sampling the antibiotic resistome","volume":"311","author":"D'Costa","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.envpol.2018.11.009_bib10","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1128\/AEM.70.2.1051-1058.2004","article-title":"Spatial variation in frequency and intensity of antibiotic interactions among Streptomycetes from prairie soil","volume":"70","author":"Davelos","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.envpol.2018.11.009_bib11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/MMBR.00016-10","article-title":"Origins and evolution of antibiotic resistance","volume":"74","author":"Davies","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.envpol.2018.11.009_bib12","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.mib.2007.08.009","article-title":"Expanding the soil antibiotic resistome: exploring environmental diversity","volume":"10","author":"D'Costa","year":"2007","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.envpol.2018.11.009_bib13","first-page":"481","article-title":"The persistence of fecal-borne antibiotics in soil","volume":"77","author":"Gavalchin","year":"1994","journal-title":"J.\u00a0AOAC Int."},{"key":"10.1016\/j.envpol.2018.11.009_bib14","doi-asserted-by":"crossref","DOI":"10.3201\/eid1907.120871","article-title":"Influence of humans on evolution and mobilization of environmental antibiotic resistome","volume":"19","author":"Gaze","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.envpol.2018.11.009_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2007.04.002","article-title":"Quantitation of rabbit cytokine mRNA by real-time RT-PCR","volume":"38","author":"Godornes","year":"2007","journal-title":"Cytokine"},{"key":"10.1016\/j.envpol.2018.11.009_bib16","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1021\/es102473z","article-title":"Antibiotic resistance gene abundances associated with waste discharges to the Almendares River near Havana, Cuba","volume":"45","author":"Graham","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2018.11.009_bib17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.envpol.2015.12.033","article-title":"Impacts of reclaimed water irrigation on soil antibiotic resistome in urban parks of Victoria, Australia","volume":"211","author":"Han","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2018.11.009_bib18","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1128\/AAC.46.5.1410-1416.2002","article-title":"tcrB, a gene conferring transferable copper resistance in Enterococcus faecium: occurrence, transferability, and linkage to macrolide and glycopeptide resistance","volume":"46","author":"Hasman","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.envpol.2018.11.009_bib19","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1128\/aem.53.10.2338-2342.1987","article-title":"Frequency of antibiotic and heavy metal resistance, pigmentation, and plasmids in bacteria of the marine air-water interface","volume":"53","author":"Hermansson","year":"1987","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.envpol.2018.11.009_bib20","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1016\/j.soilbio.2008.03.014","article-title":"Fate of sulfadiazine administered to pigs and its quantitative effect on the dynamics of bacterial resistance genes in manure and manured soil","volume":"40","author":"Heuer","year":"2008","journal-title":"Soil Biol. Biochem."},{"key":"10.1016\/j.envpol.2018.11.009_bib21","series-title":"Ion Chromatography in Environmental Analysis","first-page":"2779","author":"Jackson","year":"2000"},{"key":"10.1016\/j.envpol.2018.11.009_bib22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0160-4120(02)00076-4","article-title":"Presence of erm genes among macrolide-resistant Gram-positive bacteria isolated from Danish farm soil","volume":"28","author":"Jensen","year":"2002","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2018.11.009_bib23","doi-asserted-by":"crossref","first-page":"12081","DOI":"10.1021\/es4026358","article-title":"Fate and transport of antimicrobials and antimicrobial resistance genes in soil and runoff following land application of swine manure slurry","volume":"47","author":"Joy","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2018.11.009_bib24","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1021\/es901221x","article-title":"Evidence of increasing antibiotic resistance gene abundances in archived soils since 1940","volume":"44","author":"Knapp","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2018.11.009_bib25","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.envpol.2009.12.020","article-title":"Differential fate of erythromycin and beta-lactam resistance genes from swine lagoon waste under different aquatic conditions","volume":"158","author":"Knapp","year":"2010","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2018.11.009_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027300","article-title":"Antibiotic resistance gene abundances correlate with metal and geochemical conditions in archived Scottish soils","volume":"6","author":"Knapp","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.envpol.2018.11.009_bib27","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00248-009-9610-0","article-title":"Molecular ecology of macrolide\u2013lincosamide\u2013streptogramin B methylases in waste lagoons and subsurface waters associated with swine production","volume":"59","author":"Koike","year":"2010","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.envpol.2018.11.009_bib28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mimet.2014.08.010","article-title":"Quantification of polyketide synthase genes in tropical urban soils using real-time PCR","volume":"106","author":"Le","year":"2014","journal-title":"J.\u00a0Microbiol. Methods"},{"key":"10.1016\/j.envpol.2018.11.009_bib29","series-title":"Guide to Laboratory Etablishment for Pant Nutrient Analysis","author":"Motsara","year":"2008"},{"key":"10.1016\/j.envpol.2018.11.009_bib30","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1021\/es204665b","article-title":"Impact of treated wastewater irrigation on antibiotic resistance in agricultural soils","volume":"46","author":"Negreanu","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2018.11.009_bib31","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1039\/np9920900447","article-title":"Biosynthesis of polyketide metabolites","volume":"9","author":"O'Hagan","year":"1992","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.envpol.2018.11.009_bib32","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3923\/biotech.2008.660.668","article-title":"Phylogenetic analysis of type I and type II polyketide synthase from tropical forest soil","volume":"7","author":"Pang","year":"2008","journal-title":"Biotechnology"},{"key":"10.1016\/j.envpol.2018.11.009_bib33","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1574-6941.2011.01122.x","article-title":"Polyketide synthase pathways identified from a metagenomic library are derived from soil Acidobacteria","volume":"78","author":"Parsley","year":"2011","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.envpol.2018.11.009_bib34","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1462-2920.2006.01190.x","article-title":"Distribution of specific tetracycline and erythromycin resistance genes in environmental samples assessed by macroarray detection","volume":"9","author":"Patterson","year":"2007","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.envpol.2018.11.009_bib35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fmicb.2013.00138","article-title":"The antibiotic resistance \u201cmobilome\u201d: searching for the link between environment and clinic","volume":"4","author":"Perry","year":"2013","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2018.11.009_bib36","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1128\/AAC.05766-11","article-title":"Influence of soil use on prevalence of tetracycline, streptomycin, and erythromycin resistance and associated resistance genes","volume":"56","author":"Popowska","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.envpol.2018.11.009_bib37","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1128\/AEM.00102-12","article-title":"Natural product biosynthetic gene diversity in geographically distinct soil microbiomes","volume":"78","author":"Reddy","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.envpol.2018.11.009_bib38","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1574-6968.2008.01145.x","article-title":"Update on macrolide\u2013lincosamide\u2013streptogramin, ketolide, and oxazolidinone resistance genes","volume":"282","author":"Roberts","year":"2008","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.envpol.2018.11.009_bib39","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.envpol.2005.10.049","article-title":"Persistence of antibiotics such as macrolides, tiamulin and salinomycin in soil","volume":"143","author":"Schl\u00fcsener","year":"2006","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2018.11.009_bib40","series-title":"Soil Sampling and Methods of Analysis","author":"Schoenau","year":"2008"},{"key":"10.1016\/j.envpol.2018.11.009_bib41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2217\/fmb.11.135","article-title":"Insights into antibiotic resistance through metagenomic approaches","volume":"7","author":"Schmieder","year":"2012","journal-title":"Future Microbiol."},{"key":"10.1016\/j.envpol.2018.11.009_bib42","doi-asserted-by":"crossref","first-page":"9716","DOI":"10.1021\/es302020s","article-title":"Prevalence of clinically relevant antibiotic resistance genes in surface water samples collected from Germany and Australia","volume":"46","author":"Stoll","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2018.11.009_bib43","series-title":"Inductively Coupled Plasma - Atomic Emission Spectroscopy (ICP-AES)","author":"USEPA","year":"2007"},{"key":"10.1016\/j.envpol.2018.11.009_bib44","series-title":"Method 3051A Microwave Assisted Acid Digestion of Sediments, Sludges, Soils, and Oils","author":"USEPA","year":"2007"},{"key":"10.1016\/j.envpol.2018.11.009_bib45","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1128\/AEM.71.5.2232-2238.2005","article-title":"Identification of unique type II polyketide synthase genes in soil","volume":"71","author":"Wawrik","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.envpol.2018.11.009_bib46","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1128\/AEM.02611-06","article-title":"Biogeography of actinomycete communities and type II polyketide synthase genes in soils collected in New Jersey and Central Asia","volume":"73","author":"Wawrik","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.envpol.2018.11.009_bib47","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1128\/jb.172.5.2372-2383.1990","article-title":"Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea","volume":"172","author":"Weber","year":"1990","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.envpol.2018.11.009_bib48","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/ismej.2008.8","article-title":"Influence of industrial contamination on mobile genetic elements: class 1 integron abundance and gene cassette structure in aquatic bacterial communities","volume":"2","author":"Wright","year":"2008","journal-title":"ISME J."},{"key":"10.1016\/j.envpol.2018.11.009_bib49","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.1007\/s00216-015-9074-7","article-title":"Improved detection of multiple environmental antibiotics through an optimized sample extraction strategy in liquid chromatography-mass spectrometry analysis","volume":"407","author":"Yi","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.envpol.2018.11.009_bib50","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.envpol.2016.08.081","article-title":"Occurrence of antibiotic resistance genes in landfill leachate treatment plant and its effluent-receiving soil and surface water","volume":"218","author":"Zhang","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2018.11.009_bib51","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1073\/pnas.1222743110","article-title":"Diverse and abundant antibiotic resistance genes in Chinese swine farms","volume":"110","author":"Zhu","year":"2013","journal-title":"P.\u00a0Natl. Acad. Sci. USA"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749118321420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749118321420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T20:52:59Z","timestamp":1759438379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749118321420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":51,"alternative-id":["S0269749118321420"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2018.11.009","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potential impact of naturally produced antibiotics, environmental factors, and anthropogenic pressure on the occurrence of erm genes in urban soils","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2018.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}