{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:33:45Z","timestamp":1790375625961,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["8172030"],"award-info":[{"award-number":["8172030"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011395","name":"Major Science and Technology Program for Water Pollution Control and Treatment","doi-asserted-by":"publisher","award":["2017ZX07302"],"award-info":[{"award-number":["2017ZX07302"]}],"id":[{"id":"10.13039\/501100011395","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Project of China","award":["2018YFC0406502"],"award-info":[{"award-number":["2018YFC0406502"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.envpol.2018.11.024","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T10:33:05Z","timestamp":1542018785000},"page":"398-407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"special_numbering":"C","title":["A metagenomic analysis framework for characterization of antibiotic resistomes in river environment: Application to an urban river in Beijing"],"prefix":"10.1016","volume":"245","author":[{"given":"Haiyang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanguo","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2018.11.024_bib1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrmicro2312","article-title":"Call of the wild: antibiotic resistance genes in natural environments","volume":"8","author":"Allen","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"issue":"23","key":"10.1016\/j.envpol.2018.11.024_bib2","first-page":"1","article-title":"DeepARG: a deep learning approach for predicting antibiotic resistance genes from metagenomic data","volume":"6","author":"Arango-Argoty","year":"2018","journal-title":"Microbiome"},{"issue":"4","key":"10.1016\/j.envpol.2018.11.024_bib3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.tim.2006.02.006","article-title":"Co-selection of antibiotic and metal resistance","volume":"14","author":"Baker-Austin","year":"2006","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.envpol.2018.11.024_bib4","first-page":"361","article-title":"Gephi: an open source software for exploring and manipulating networks","volume":"8","author":"Bastian","year":"2009","journal-title":"Proc. Third Int. ICWSM Conf. (ICWSM)"},{"key":"10.1016\/j.envpol.2018.11.024_bib5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.envint.2015.10.015","article-title":"Concentrations of antibiotics predicted to select for resistant bacteria: proposed limits for environmental regulation","volume":"86","author":"Bengtsson-Palme","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2018.11.024_bib6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.tim.2007.05.004","article-title":"Integrons: mobilizable platforms that promote genetic diversity in bacteria","volume":"15","author":"Boucher","year":"2007","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.envpol.2018.11.024_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nmeth.3176","article-title":"Fast and sensitive protein alignment using DIAMOND","volume":"12","author":"Buchfink","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.envpol.2018.11.024_bib8","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.envint.2016.06.025","article-title":"Antibiotics in the aquatic environments: a review of the European scenario","volume":"94","author":"Carvalho","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2018.11.024_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.scitotenv.2015.01.025","article-title":"Contamination features and health risk of soil heavy metals in China","volume":"512\u2013523","author":"Chen","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2018.11.024_bib10","doi-asserted-by":"crossref","first-page":"D694","DOI":"10.1093\/nar\/gkv1239","article-title":"VFDB 2016: hierarchical and refined dataset for big data analysis-10 years on","volume":"44","author":"Chen","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2018.11.024_bib11","article-title":"Characterization of antibiotic resistance genes in the sediments of an urban river revealed by comparative metagenomics analysis","author":"Chen","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2018.11.024_bib12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jhazmat.2018.01.033","article-title":"Multimedia fate modeling and risk assessment of antibiotics in a water-scarce megacity","volume":"348","author":"Chen","year":"2018","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.envpol.2018.11.024_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.watres.2016.12.046","article-title":"Conjugative multi-resistant plasmids in Haihe River and their impacts on the abundance and spatial distribution of antibiotic resistance genes","volume":"111","author":"Dang","year":"2017","journal-title":"Water Res."},{"issue":"19","key":"10.1016\/j.envpol.2018.11.024_bib14","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"Edgar","year":"2010","journal-title":"Bioinformatics"},{"issue":"7","key":"10.1016\/j.envpol.2018.11.024_bib15","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.watres.2012.02.004","article-title":"Occurrence of sulfonamide and tetracycline-resistant bacteria and resistance genes in aquaculture environment","volume":"46","author":"Gao","year":"2012","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2018.11.024_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.envint.2017.09.013","article-title":"Integrating human and environmental health in antibiotic risk assessment: a critical analysis of protection goals, species sensitivity and antimicrobial resistance","volume":"109","author":"Gareth","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2018.11.024_bib17","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/ismej.2014.226","article-title":"Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution","volume":"9","author":"Gillings","year":"2015","journal-title":"ISME J."},{"key":"10.1016\/j.envpol.2018.11.024_bib18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.watres.2017.07.002","article-title":"Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements","volume":"123","author":"Guo","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2018.11.024_bib19","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2958.1995.tb02368.x","article-title":"Mobile gene cassettes and integrons: capture and spread of genes by site-specific recombination","volume":"15","author":"Hall","year":"1995","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.envpol.2018.11.024_bib20","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.envint.2016.03.023","article-title":"Discharge of swine wastes risks water quality and food safety: antibiotics and antibiotic resistance genes from swine sources to the receiving environments","volume":"92","author":"He","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2018.11.024_bib21","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1021\/es301912q","article-title":"Organic micropollutants in rivers downstream of the megacity Beijing: sources and mass fluxes in a large-scale wastewater irrigation system","volume":"46","author":"Heeb","year":"2012","journal-title":"Environ. Sci. Technol."},{"issue":"2151","key":"10.1016\/j.envpol.2018.11.024_bib22","first-page":"1","article-title":"Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota","volume":"4","author":"Hu","year":"2013","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.envpol.2018.11.024_bib23","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1101\/gr.120618.111","article-title":"Integrative analysis of environmental sequences using MEGAN4","volume":"21","author":"Huson","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.envpol.2018.11.024_bib24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jhazmat.2012.07.040","article-title":"Antibiotic resistance gene abundances associated with antibiotics and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai; China","volume":"235\u2013236","author":"Ji","year":"2012","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.envpol.2018.11.024_bib25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.watres.2017.07.061","article-title":"Fate of antibiotic resistance genes and their associations with bacterial community in livestock breeding wastewater and its receiving river water","volume":"124","author":"Jia","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2018.11.024_bib26","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.envpol.2018.11.024_bib27","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.tim.2017.09.005","article-title":"Antibiotic-resistance genes in WasteWater","volume":"26","author":"Karkman","year":"2018","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.envpol.2018.11.024_bib28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.envpol.2018.11.024_bib29","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S1473-3099(13)70318-9","article-title":"Antibiotic resistance - the need for global solutions","volume":"13","author":"Laxminarayan","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.envpol.2018.11.024_bib30","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.envpol.2017.12.001","article-title":"Metagenomic exploration reveals a marked change in the river resistome and mobilome after treated wastewater discharges","volume":"234","author":"Lekunberri","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2018.11.024_bib31","doi-asserted-by":"crossref","first-page":"D57","DOI":"10.1093\/nar\/gkp938","article-title":"ACLAME: a CLAssification of Mobile genetic Elements, update 2010","volume":"38","author":"Leplae","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2018.11.024_bib32","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1093\/bioinformatics\/btl158","article-title":"Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences","volume":"22","author":"Li","year":"2006","journal-title":"Bioinformatics"},{"issue":"11","key":"10.1016\/j.envpol.2018.11.024_bib33","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1038\/ismej.2015.59","article-title":"Metagenomic and network analysis reveal wide distribution and co-occurrence of environmental antibiotic resistance genes","volume":"9","author":"Li","year":"2015","journal-title":"ISME J."},{"key":"10.1016\/j.envpol.2018.11.024_bib34","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/bioinformatics\/btv033","article-title":"MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph","volume":"31","author":"Li","year":"2015","journal-title":"Bioinformatics"},{"issue":"93","key":"10.1016\/j.envpol.2018.11.024_bib35","first-page":"1","article-title":"Tracking antibiotic resistance gene pollution from different sources using machine-learning classification","volume":"6","author":"Li","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.envpol.2018.11.024_bib36","doi-asserted-by":"crossref","first-page":"7220","DOI":"10.1021\/es100233w","article-title":"Trends in antibiotic resistance genes occurrence in the Haihe River, China","volume":"44","author":"Luo","year":"2010","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.envpol.2018.11.024_bib37","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1021\/acs.est.5b03522","article-title":"Metagenomic assembly reveals hosts of antibiotic resistance genes and the shared resistome in pig, chicken and human feces","volume":"50","author":"Ma","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"154","key":"10.1016\/j.envpol.2018.11.024_bib38","first-page":"1","article-title":"Catalogue of antibiotic resistome and host-tracking in drinking water deciphered by a large scale survey","volume":"5","author":"Ma","year":"2017","journal-title":"Microbiome"},{"issue":"3","key":"10.1016\/j.envpol.2018.11.024_bib39","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1128\/MMBR.62.3.725-774.1998","article-title":"Insertion sequences","volume":"62","author":"Mahillon","year":"1998","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.envpol.2018.11.024_bib40","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1021\/es404280v","article-title":"Persistence of extracellular DNA in river sediment facilitates antibiotic resistance gene propagation","volume":"48","author":"Mao","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2018.11.024_bib41","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.watres.2017.07.060","article-title":"Untreated urban waste contaminates Indian river sediments with resistance genes to last resort antibiotics","volume":"124","author":"Marathe","year":"2017","journal-title":"Water Res."},{"issue":"5887","key":"10.1016\/j.envpol.2018.11.024_bib42","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1126\/science.1159483","article-title":"Antibiotics and antibiotic resistance genes in natural environments","volume":"321","author":"Mart\u00ednez","year":"2008","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.envpol.2018.11.024_bib43","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/bioinformatics\/btp105","article-title":"INTEGRALL: a database and search engine for integrons, integrases and gene cassettes","volume":"25","author":"Moura","year":"2009","journal-title":"Bioinformatics"},{"issue":"23","key":"10.1016\/j.envpol.2018.11.024_bib44","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1073\/pnas.0601602103","article-title":"Modularity and community structure in networks","volume":"103","author":"Newman","year":"2006","journal-title":"P.\u00a0Natl. Acad. Sci. USA."},{"key":"10.1016\/j.envpol.2018.11.024_bib45","doi-asserted-by":"crossref","first-page":"D737","DOI":"10.1093\/nar\/gkt1252","article-title":"BacMet: antibacterial biocide and metal resistance genes database","volume":"42","author":"Pal","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.envpol.2018.11.024_bib46","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1289\/ehp.1307009","article-title":"Metagenomic frameworks for monitoring antibiotic resistance in aquatic environments","volume":"122","author":"Port","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2018.11.024_bib47","doi-asserted-by":"crossref","first-page":"D231","DOI":"10.1093\/nar\/gkt1253","article-title":"eggNOG v4.0: nested orthology inference across 3686 organisms","volume":"42","author":"Powell","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2018.11.024_bib48","doi-asserted-by":"crossref","first-page":"11541","DOI":"10.1021\/es302657r","article-title":"Correlation between upstream human activities and riverine antibiotic resistance genes","volume":"46","author":"Pruden","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2018.11.024_bib49","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1289\/ehp.1206446","article-title":"Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment","volume":"121","author":"Pruden","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2018.11.024_bib50","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.envint.2017.10.016","article-title":"Review of antibiotic resistance in China and its environment","volume":"110","author":"Qiao","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2018.11.024_bib51","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.watres.2014.11.021","article-title":"Occurrence of antibiotics and antibiotic resistance genes in hospital and urban wastewaters and their impact on the receiving river","volume":"69","author":"Rodriguez-Mozaz","year":"2015","journal-title":"Water Res."},{"issue":"5","key":"10.1016\/j.envpol.2018.11.024_bib52","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1289\/ehp.11776","article-title":"Review of the occurrence of anti-infectives in contaminated wastewaters and natural and drinking waters","volume":"117","author":"Segura","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2018.11.024_bib53","doi-asserted-by":"crossref","first-page":"D32","DOI":"10.1093\/nar\/gkj014","article-title":"ISfinder: the reference centre for bacterial insertion sequences","volume":"34","author":"Siguier","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2018.11.024_bib54","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrmicro.2017.75","article-title":"Prediction of antibiotic resistance: time for a new preclinical paradigm?","volume":"15","author":"Sommer","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.envpol.2018.11.024_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2011.00203","article-title":"Acquired antibiotic resistance genes: an overview","volume":"2","author":"van Hoek","year":"2011","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2018.11.024_bib56","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1473-3099(12)70317-1","article-title":"The role of the natural environment in the emergence of antibiotic resistance in gramnegative bacteria","volume":"13","author":"Wellington","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.envpol.2018.11.024_bib57","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1126\/science.1243444","article-title":"Sources of antimicrobial resistance","volume":"341","author":"Woolhouse","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.envpol.2018.11.024_bib58","series-title":"Antimicrobial Resistance: 2014 Global Report on Surveillance","author":"World Health Organization","year":"2014"},{"issue":"34","key":"10.1016\/j.envpol.2018.11.024_bib59","first-page":"1","article-title":"Antibiotic-mediated changes in the fecal microbiome of broiler chickens define the incidence of antibiotic resistance genes","volume":"6","author":"Xiong","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.envpol.2018.11.024_bib60","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.envpol.2016.03.054","article-title":"Occurrence and distribution of antibiotics, antibiotic resistance genes in the urban rivers in Beijing, China","volume":"213","author":"Xu","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2018.11.024_bib61","doi-asserted-by":"crossref","first-page":"10197","DOI":"10.1021\/es4017365","article-title":"Exploring variation of antibiotic resistance genes in activated sludge over a four-year period through a metagenomic approach","volume":"47","author":"Yang","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"15","key":"10.1016\/j.envpol.2018.11.024_bib62","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1093\/bioinformatics\/btw136","article-title":"ARGs-OAP: online analysis pipeline for antibiotic resistance genes detection from metagenomic data using an integrated structured ARG-database","volume":"32","author":"Yang","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envpol.2018.11.024_bib63","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.1021\/acs.est.5b00729","article-title":"Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance","volume":"49","author":"Zhang","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2018.11.024_bib64","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.watres.2018.01.063","article-title":"Antibiotic resistome in landfill leachate from different cities of China deciphered by metagenomic analysis","volume":"134","author":"Zhao","year":"2018","journal-title":"Water Res."},{"issue":"12","key":"10.1016\/j.envpol.2018.11.024_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkq275","article-title":"Ab initio gene identification in metagenomic sequences","volume":"38","author":"Zhu","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"16270","key":"10.1016\/j.envpol.2018.11.024_bib66","first-page":"1","article-title":"Continental-scale pollution of estuaries with antibiotic resistance genes","volume":"2","author":"Zhu","year":"2017","journal-title":"Nat. Microbiol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749118341083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749118341083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T03:03:33Z","timestamp":1605409413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749118341083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":66,"alternative-id":["S0269749118341083"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2018.11.024","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A metagenomic analysis framework for characterization of antibiotic resistomes in river environment: Application to an urban river in Beijing","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2018.11.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}