{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:03:34Z","timestamp":1781777014187,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.envpol.2019.113021","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T15:48:10Z","timestamp":1565020090000},"page":"113021","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"PA","title":["Neutrophil extracellular traps promote cadmium chloride-induced lung injury in mice"],"prefix":"10.1016","volume":"254","author":[{"given":"Chaoqun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengkai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2019.113021_bib1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jbspin.2016.05.013","article-title":"NETosis: at the crossroads of rheumatoid arthritis, lupus, and vasculitis","volume":"84","author":"Berthelot","year":"2017","journal-title":"Jt. Bone Spine"},{"key":"10.1016\/j.envpol.2019.113021_bib2","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1038\/s41598-017-02611-5","article-title":"Protective effect of low dose intra-articular cadmium on inflammation and joint destruction in arthritis","volume":"7","author":"Bonaventura","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2019.113021_bib3","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1159\/000489829","article-title":"Neutrophil extracellular traps in the second decade","volume":"10","author":"Brinkmann","year":"2018","journal-title":"J.\u00a0Innate Immun."},{"key":"10.1016\/j.envpol.2019.113021_bib4","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.envpol.2019.113021_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12389","article-title":"Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome","volume":"62","author":"Cao","year":"2017","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.envpol.2019.113021_bib6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jhazmat.2019.01.054","article-title":"Hydrogen sulfide exposure triggers chicken trachea inflammatory injury through oxidative stress-mediated FOS\/IL8 signaling","volume":"368","author":"Chen","year":"2019","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.envpol.2019.113021_bib7","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1007\/s00018-016-2195-0","article-title":"Matters of life and death. How neutrophils die or survive along NET release and is \u201cNETosis\u201d\u00a0= necroptosis?","volume":"73","author":"Desai","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.envpol.2019.113021_bib8","doi-asserted-by":"crossref","first-page":"25356","DOI":"10.1007\/s11356-016-7603-3","article-title":"Mitigation of cadmium-induced lung injury by Nigella sativa oil","volume":"23","author":"El-Ebiary","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2019.113021_bib9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.toxlet.2005.07.001","article-title":"In\u00a0vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride","volume":"160","author":"Fotakis","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2019.113021_bib10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1745-6673-1-22","article-title":"The toxicity of cadmium and resulting hazards for human health","volume":"1","author":"Godt","year":"2006","journal-title":"J.\u00a0Occup. Med. Toxicol."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.envpol.2019.113021_bib11","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1111\/jth.12977","article-title":"Extracellular DNA and histones: double-edged swords in immunothrombosis","volume":"13","author":"Gould","year":"2015","journal-title":"J.\u00a0Thromb. Haemost."},{"key":"10.1016\/j.envpol.2019.113021_bib12","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00204-015-1484-y","article-title":"Ethylmercury and Hg2+ induce the formation of neutrophil extracellular traps (NETs) by human neutrophil granulocytes","volume":"90","author":"Haase","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2019.113021_bib13","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1007\/s00204-016-1661-7","article-title":"Acute exposure to cadmium induces prolonged neutrophilia along with delayed induction of granulocyte colony-stimulating factor in the livers of mice","volume":"90","author":"Horiguchi","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2019.113021_bib14","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2147\/COPD.S152028","article-title":"Cadmium nanoparticles citrullinate cytokeratins within lung epithelial cells: cadmium as a potential cause of citrullination in chronic obstructive pulmonary disease","volume":"13","author":"Hutchinson","year":"2018","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"10.1016\/j.envpol.2019.113021_bib15","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/jat.3286","article-title":"Evaluation of kidney injury biomarkers in rat amniotic fluid after gestational exposure to cadmium","volume":"36","author":"Jacobo-Estrada","year":"2016","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.envpol.2019.113021_bib16","first-page":"767","article-title":"Guarea kunthiana bark extract enhances the antimicrobial activities of human and bovine neutrophils","volume":"11","author":"Jerjomiceva","year":"2016","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.envpol.2019.113021_bib17","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1107\/S0907444912028776","article-title":"Pattern prediction and coordination geometry analysis from cadmium-binding proteins: a computational approach","volume":"68","author":"Jesu Jaya Sudan","year":"2012","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.envpol.2019.113021_bib18","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1126\/science.aam8897","article-title":"Host DNases prevent vascular occlusion by neutrophil extracellular traps","volume":"358","author":"Jimenez-Alcazar","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.envpol.2019.113021_bib19","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1136\/annrheumdis-2014-205365","article-title":"Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL\/lpr mice","volume":"74","author":"Knight","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.envpol.2019.113021_bib20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.envpol.2019.113021_bib21","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fimmu.2016.00461","article-title":"A\u00a0critical reappraisal of neutrophil extracellular traps and NETosis mimics based on differential requirements for protein citrullination","volume":"7","author":"Konig","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2019.113021_bib22","doi-asserted-by":"crossref","first-page":"730","DOI":"10.4103\/0366-6999.201608","article-title":"Role of neutrophil extracellular traps in asthma and chronic obstructive pulmonary disease","volume":"130","author":"Liu","year":"2017","journal-title":"Chin. Med. J. (Engl)"},{"key":"10.1016\/j.envpol.2019.113021_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/5584_2015_117","article-title":"Neutrophils: the role of oxidative and nitrosative stress in health and disease","volume":"857","author":"Manda-Handzlik","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.envpol.2019.113021_bib24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.dci.2015.05.007","article-title":"NADPH oxidase, MPO, NE, ERK1\/2, p38 MAPK and Ca2+ influx are essential for Cryptosporidium parvum-induced NET formation","volume":"52","author":"Munoz-Caro","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.envpol.2019.113021_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13567-015-0155-6","article-title":"Eimeria bovis-triggered neutrophil extracellular trap formation is CD11b-, ERK 1\/2-, p38 MAP kinase- and SOCE-dependent","volume":"46","author":"Munoz-Caro","year":"2015","journal-title":"Vet. Res."},{"key":"10.1016\/j.envpol.2019.113021_bib26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10123-018-0003-4","article-title":"Isolation of toxic metal-tolerant bacteria from soil and examination of their bioaugmentation potentiality by pot studies in cadmium- and lead-contaminated soil","volume":"21","author":"Nath","year":"2018","journal-title":"Int. Microbiol."},{"key":"10.1016\/j.envpol.2019.113021_bib27","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ni.2921","article-title":"Neutrophils at work","volume":"15","author":"Nauseef","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.envpol.2019.113021_bib28","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1136\/thoraxjnl-2016-209887","article-title":"Neutrophil extracellular traps induced by cigarette smoke activate plasmacytoid dendritic cells","volume":"72","author":"Qiu","year":"2017","journal-title":"Thorax"},{"key":"10.1016\/j.envpol.2019.113021_bib29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1080\/10715762.2017.1416112","article-title":"NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells","volume":"52","author":"Sakai","year":"2018","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.envpol.2019.113021_bib30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/exd.12599","article-title":"The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity","volume":"24","author":"Stephan","year":"2015","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.envpol.2019.113021_bib31","first-page":"1005","article-title":"Extracellular cadmium in the bronchoalveolar space of long-term tobacco smokers with and without COPD and its association with inflammation","volume":"11","author":"Sundblad","year":"2016","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"10.1016\/j.envpol.2019.113021_bib32","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.envres.2018.01.008","article-title":"Cadmium and atherosclerosis: a review of toxicological mechanisms and a meta-analysis of epidemiologic studies","volume":"162","author":"Tinkov","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2019.113021_bib33","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.envpol.2018.08.070","article-title":"Atrazine hinders PMA-induced neutrophil extracellular traps in carp via the promotion of apoptosis and inhibition of ROS burst, autophagy and glycolysis","volume":"243","author":"Wang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2019.113021_bib34","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.intimp.2015.07.009","article-title":"Renoprotective mechanisms of morin in cisplatin-induced kidney injury","volume":"28","author":"Wei","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.envpol.2019.113021_bib35","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3389\/fimmu.2016.00436","article-title":"Canine neutrophil extracellular traps release induced by the apicomplexan parasite Neospora caninum in\u00a0vitro","volume":"7","author":"Wei","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2019.113021_bib36","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3389\/fimmu.2019.01003","article-title":"Effects of neutrophil extracellular traps on bovine mammary epithelial cells in\u00a0vitro","volume":"10","author":"Wei","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2019.113021_bib37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.chemosphere.2017.12.175","article-title":"The formation of canine neutrophil extracellular traps induced by sodium arsenic in polymorphonuclear neutrophils","volume":"196","author":"Wei","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2019.113021_bib38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.chemosphere.2018.05.184","article-title":"Nickel (II) nitrate hexahydrate triggered canine neutrophil extracellular traps release in\u00a0vitro","volume":"208","author":"Wei","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2019.113021_bib39","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1172\/JCI83873","article-title":"Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation","volume":"126","author":"Yost","year":"2016","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.envpol.2019.113021_bib40","first-page":"1763589","article-title":"Chlorpyrifos suppresses neutrophil extracellular traps in carp by promoting necroptosis and inhibiting respiratory burst caused by the PKC\/MAPK pathway","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid. Med. Cell Longev."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749119317774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749119317774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T21:11:47Z","timestamp":1759439507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749119317774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":40,"alternative-id":["S0269749119317774"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2019.113021","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil extracellular traps promote cadmium chloride-induced lung injury in mice","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2019.113021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113021"}}