{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:50:53Z","timestamp":1777866653092,"version":"3.51.4"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004387","name":"Ningbo University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004387","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703189"],"award-info":[{"award-number":["81703189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602940"],"award-info":[{"award-number":["81602940"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["2018A610237"],"award-info":[{"award-number":["2018A610237"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["2017A610267"],"award-info":[{"award-number":["2017A610267"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.envpol.2019.113266","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T08:25:01Z","timestamp":1568795101000},"page":"113266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"P2","title":["Air pollution and placental mitochondrial DNA copy number: Mechanistic insights and epidemiological challenges"],"prefix":"10.1016","volume":"255","author":[{"given":"Zhen","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihang","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinshun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2019.113266_bib1","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.placenta.2015.08.005","article-title":"Hemangioblastic foci in human first trimester placenta: distribution and gestational profile","volume":"36","author":"Aplin","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.envpol.2019.113266_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1126\/science.aal0219","article-title":"Gene-environment interplay","volume":"354","author":"Berg","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.envpol.2019.113266_bib3","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.envres.2015.09.006","article-title":"Sex-specific differences in fetal growth in newborns exposed prenatally to traffic-related air pollution in the PELAGIE mother-child cohort (Brittany, France)","volume":"142","author":"Bertin","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2019.113266_bib4","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1096\/fj.12-210989","article-title":"Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner","volume":"26","author":"Bolton","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.envpol.2019.113266_bib5","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/humupd\/dmy030","article-title":"Placental formation in early pregnancy: how is the centre of the placenta made?","volume":"24","author":"Boss","year":"2018","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.envpol.2019.113266_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.envint.2017.12.020","article-title":"Prenatal particulate matter exposure and mitochondrial dysfunction at the maternal-fetal interface: effect modification by maternal lifetime trauma and child sex","volume":"112","author":"Brunst","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2019.113266_bib7","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.rbmo.2018.02.007","article-title":"The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights","volume":"36","author":"Cecchino","year":"2018","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.envpol.2019.113266_bib8","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.scitotenv.2018.11.088","article-title":"Estimation of personal exposure to fine particles (PM2.5) of ambient origin for healthy adults in Hong Kong","volume":"654","author":"Chen","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2019.113266_bib9","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.scitotenv.2018.02.049","article-title":"Determinants of personal exposure to fine particulate matter (PM2.5) in adult subjects in Hong Kong","volume":"628\u2013629","author":"Chen","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2019.113266_bib10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.envint.2015.11.010","article-title":"Prenatal particulate air pollution and neurodevelopment in urban children: examining sensitive windows and sex-specific associations","volume":"87","author":"Chiu","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2019.113266_bib11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.envres.2017.05.018","article-title":"Prenatal ambient air pollution exposure, infant growth and placental mitochondrial DNA content in the INMA birth cohort","volume":"157","author":"Clemente","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2019.113266_bib12","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1289\/ehp.1408981","article-title":"Prenatal ambient air pollution, placental mitochondrial DNA content, and birth weight in the INMA (Spain) and ENVIRONAGE (Belgium) birth cohorts","volume":"124","author":"Clemente","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2019.113266_bib13","doi-asserted-by":"crossref","first-page":"D698","DOI":"10.1093\/nar\/gkw1066","article-title":"HmtDB 2016: data update, a better performing query system and human mitochondrial DNA haplogroup predictor","volume":"45","author":"Clima","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2019.113266_bib14","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.annepidem.2015.08.005","article-title":"Role of infant sex in the association between air pollution and preterm birth","volume":"25","author":"Cossi","year":"2015","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.envpol.2019.113266_bib15","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.envpol.2018.09.065","article-title":"PM2.5 exposure during pregnancy induces hypermethylation of estrogen receptor promoter region in rat uterus and declines offspring birth weights","volume":"243","author":"Dang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2019.113266_bib16","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1289\/ehp.1002785","article-title":"Ambient air pollution and birth weight in full-term infants in Atlanta, 1994-2004","volume":"119","author":"Darrow","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2019.113266_bib17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature17948","article-title":"Self-organization of the in\u00a0vitro attached human embryo","volume":"533","author":"Deglincerti","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2019.113266_bib18","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.fertnstert.2015.05.022","article-title":"Mitochondrial DNA content as a viability score in human euploid embryos: less is better","volume":"104","author":"Diez-Juan","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.envpol.2019.113266_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005241","article-title":"Altered levels of mitochondrial DNA are associated with female age, aneuploidy, and provide an independent measure of embryonic implantation potential","volume":"11","author":"Fragouli","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.envpol.2019.113266_bib20","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/mrd.22042","article-title":"The importance of mitochondrial metabolic activity and mitochondrial DNA replication during oocyte maturation in\u00a0vitro on oocyte quality and subsequent embryo developmental competence","volume":"79","author":"Ge","year":"2012","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.envpol.2019.113266_bib21","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.envres.2007.03.009","article-title":"Does the effect of air pollution on pregnancy outcomes differ by gender? A systematic review","volume":"105","author":"Ghosh","year":"2007","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2019.113266_bib22","doi-asserted-by":"crossref","first-page":"16080","DOI":"10.1038\/nrdp.2016.80","article-title":"Mitochondrial diseases","volume":"2","author":"Gorman","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.envpol.2019.113266_bib23","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1021\/cr040463d","article-title":"DNA polymerase gamma in mitochondrial DNA replication and repair","volume":"106","author":"Graziewicz","year":"2006","journal-title":"Chem. Rev."},{"key":"10.1016\/j.envpol.2019.113266_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12940-016-0095-2","article-title":"Mitochondrial oxidative DNA damage and exposure to particulate air pollution in mother-newborn pairs","volume":"15","author":"Grevendonk","year":"2016","journal-title":"Environ. Health"},{"key":"10.1016\/j.envpol.2019.113266_bib25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev-biochem-060815-014402","article-title":"Maintenance and expression of mammalian mitochondrial DNA","volume":"85","author":"Gustafsson","year":"2016","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.envpol.2019.113266_bib26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.tcb.2018.11.004","article-title":"The cellular mitochondrial genome landscape in disease","volume":"29","author":"Hahn","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.envpol.2019.113266_bib27","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s10815-017-0886-6","article-title":"Quantitative and qualitative changes of mitochondria in human preimplantation embryos","volume":"34","author":"Hashimoto","year":"2017","journal-title":"J.\u00a0Assist. Reprod. Genet."},{"issue":"Suppl.\u00a02","key":"10.1016\/j.envpol.2019.113266_bib28","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1038\/sj.jes.7500627","article-title":"Characterization of PM2.5, gaseous pollutants, and meteorological interactions in the context of time-series health effects models","volume":"17","author":"Ito","year":"2007","journal-title":"J.\u00a0Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envpol.2019.113266_bib29","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1080\/15592294.2015.1048412","article-title":"Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: an ENVIRONAGE birth cohort study","volume":"10","author":"Janssen","year":"2015","journal-title":"Epigenetics"},{"key":"10.1016\/j.envpol.2019.113266_bib30","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1289\/ehp.1104458","article-title":"Placental mitochondrial DNA content and particulate air pollution during in utero life","volume":"120","author":"Janssen","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2019.113266_bib31","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cmet.2017.07.003","article-title":"Increased total mtDNA copy number cures male infertility despite unaltered mtDNA mutation load","volume":"26","author":"Jiang","year":"2017","journal-title":"Cell Metabol."},{"key":"10.1016\/j.envpol.2019.113266_bib32","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.atmosenv.2012.06.039","article-title":"Size, source and chemical composition as determinants of toxicity attributable to ambient particulate matter","volume":"60","author":"Kelly","year":"2012","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.envpol.2019.113266_bib33","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.bbabio.2015.05.015","article-title":"Mitochondrial DNA mutations in neurodegeneration","volume":"1847","author":"Keogh","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.envpol.2019.113266_bib34","doi-asserted-by":"crossref","first-page":"48627","DOI":"10.1074\/jbc.M306981200","article-title":"TWINKLE Has 5\u2019 -> 3\u2019 DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein","volume":"278","author":"Korhonen","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.envpol.2019.113266_bib35","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/ng.2501","article-title":"Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease","volume":"45","author":"Kornblum","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.envpol.2019.113266_bib36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/ajerev\/mxp003","article-title":"What causes racial disparities in very preterm birth? A biosocial perspective","volume":"31","author":"Kramer","year":"2009","journal-title":"Epidemiol. Rev."},{"key":"10.1016\/j.envpol.2019.113266_bib37","doi-asserted-by":"crossref","first-page":"13534","DOI":"10.1073\/pnas.1109263108","article-title":"Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA","volume":"108","author":"Kukat","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envpol.2019.113266_bib38","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.envres.2014.10.035","article-title":"Associations between prenatal traffic-related air pollution exposure and birth weight: modification by sex and maternal pre-pregnancy body mass index","volume":"137","author":"Lakshmanan","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2019.113266_bib39","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0140-6736(14)60496-7","article-title":"Every Newborn: progress, priorities, and potential beyond survival","volume":"384","author":"Lawn","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.envpol.2019.113266_bib40","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1016\/j.jaci.2017.07.017","article-title":"Prenatal fine particulate exposure and early childhood asthma: effect of maternal stress and fetal sex","volume":"141","author":"Lee","year":"2018","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.envpol.2019.113266_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.34","article-title":"Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny","volume":"6","author":"Lee","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.envpol.2019.113266_bib42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/nyas.12873","article-title":"The control of mitochondrial DNA replication during development and tumorigenesis","volume":"1350","author":"Lee","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.envpol.2019.113266_bib43","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1262\/jrd.2012-145","article-title":"Effects of exposure to nanoparticle-rich diesel exhaust on pregnancy in rats","volume":"59","author":"Li","year":"2013","journal-title":"J.\u00a0Reprod. Dev."},{"key":"10.1016\/j.envpol.2019.113266_bib44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1289\/ehp.6000","article-title":"Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage","volume":"111","author":"Li","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2019.113266_bib45","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.envpol.2019.03.076","article-title":"Association of ambient air pollutants and birth weight in Ningbo, 2015\u20132017","volume":"249","author":"Li","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2019.113266_bib46","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/bs.ctdb.2017.10.012","article-title":"The mitochondria and the regulation of cell fitness during early mammalian development","volume":"128","author":"Lima","year":"2018","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.envpol.2019.113266_bib47","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41422-018-0066-y","article-title":"Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta","volume":"28","author":"Liu","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.envpol.2019.113266_bib48","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.12659\/MSM.897808","article-title":"Effect of fine particulate matter (PM2.5) on rat placenta pathology and perinatal outcomes","volume":"22","author":"Liu","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.envpol.2019.113266_bib49","doi-asserted-by":"crossref","first-page":"13039","DOI":"10.1073\/pnas.1810946115","article-title":"Biparental inheritance of mitochondrial DNA in humans","volume":"115","author":"Luo","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envpol.2019.113266_bib50","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.envres.2018.03.025","article-title":"Air pollution and the fetal origin of disease: a systematic review of the molecular signatures of air pollution exposure in human placenta","volume":"166","author":"Luyten","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2019.113266_bib51","doi-asserted-by":"crossref","first-page":"7303","DOI":"10.1038\/ncomms8303","article-title":"The exonuclease activity of DNA polymerase \u03b3 is required for ligation during mitochondrial DNA replication","volume":"6","author":"Macao","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2019.113266_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199772","article-title":"Air pollution during pregnancy and placental adaptation in the levels of global DNA methylation","volume":"13","author":"Maghbooli","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2019.113266_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2011.06.067","article-title":"Mitochondrial DNA as a non-invasive biomarker: accurate quantification using real time quantitative PCR without co-amplification of pseudogenes and dilution bias","volume":"412","author":"Malik","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envpol.2019.113266_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/kft102","article-title":"Mitochondria as a target of environmental toxicants","volume":"134","author":"Meyer","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2019.113266_bib55","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1159\/000492901","article-title":"Particulate matter exposure during perinatal life results in impaired glucose metabolism in adult male rat offspring","volume":"49","author":"Miranda","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.envpol.2019.113266_bib56","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0168-9525(01)02238-7","article-title":"What regulates mitochondrial DNA copy number in animal cells?","volume":"17","author":"Moraes","year":"2001","journal-title":"Trends Genet."},{"key":"10.1016\/j.envpol.2019.113266_bib57","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12989-019-0289-1","article-title":"In utero exposure to ultrafine particles promotes placental stress-induced programming of renin-angiotensin system-related elements in the offspring results in altered blood pressure in adult mice","volume":"16","author":"Morales-Rubio","year":"2019","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envpol.2019.113266_bib58","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0074-7696(05)23004-8","article-title":"Morphodynamics of the follicular-luteal complex during early ovarian development and reproductive life","volume":"223","author":"Motta","year":"2003","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.envpol.2019.113266_bib59","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature19096","article-title":"A\u00a0developmental coordinate of pluripotency among mice, monkeys and humans","volume":"537","author":"Nakamura","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2019.113266_bib60","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev-biochem-011116-110824","article-title":"Mitochondrial gene expression: a playground of evolutionary tinkering","volume":"85","author":"Neupert","year":"2016","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.envpol.2019.113266_bib61","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.molcel.2017.11.033","article-title":"Topoisomerase 3\u03b1 is required for decatenation and segregation of human mtDNA","volume":"69","author":"Nicholls","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.envpol.2019.113266_bib62","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1101\/gr.207597.116","article-title":"Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface","volume":"27","author":"Pavli\u010dev","year":"2017","journal-title":"Genome Res."},{"key":"10.1016\/j.envpol.2019.113266_bib63","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1002\/sim.1296","article-title":"Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: current practice and problems","volume":"21","author":"Pocock","year":"2002","journal-title":"Stat. Med."},{"key":"10.1016\/j.envpol.2019.113266_bib64","doi-asserted-by":"crossref","first-page":"13068","DOI":"10.1074\/jbc.M117.791392","article-title":"The human mitochondrial single-stranded DNA-binding protein displays distinct kinetics and thermodynamics of DNA binding and exchange","volume":"292","author":"Qian","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.envpol.2019.113266_bib65","first-page":"93","article-title":"Replication stress in mitochondria","volume":"808","author":"Ricchetti","year":"2018","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envpol.2019.113266_bib66","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.envres.2019.03.003","article-title":"Association between prenatal particulate air pollution exposure and telomere length in cord blood: effect modification by fetal sex","volume":"172","author":"Rosa","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2019.113266_bib67","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.tox.2017.06.012","article-title":"Mitochondria and mitochondrial DNA as relevant targets for environmental contaminants","volume":"391","author":"Roubicek","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2019.113266_bib68","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/aje\/kww007","article-title":"Placental nitrosative stress and exposure to ambient air pollution during gestation: a population study","volume":"184","author":"Saenen","year":"2016","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envpol.2019.113266_bib69","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/aje\/kwx332","article-title":"Early-pregnancy plasma concentrations of perfluoroalkyl substances and birth outcomes in project viva: confounded by pregnancy hemodynamics?","volume":"187","author":"Sagiv","year":"2018","journal-title":"Am. J. Epidemiol."},{"issue":"Suppl.\u00a02","key":"10.1016\/j.envpol.2019.113266_bib70","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/humrep\/15.suppl_2.148","article-title":"Mitochondrial morphology during preimplantational human embryogenesis","volume":"15","author":"Sathananthan","year":"2000","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.envpol.2019.113266_bib71","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/aje\/kwt268","article-title":"Ambient fine particulate matter, nitrogen dioxide, and term birth weight in New York, New York","volume":"179","author":"Savitz","year":"2014","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envpol.2019.113266_bib72","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/aje\/kwx333","article-title":"Invited commentary: exposure biomarkers indicate more than just exposure","volume":"187","author":"Savitz","year":"2018","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envpol.2019.113266_bib73","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.atmosenv.2012.09.053","article-title":"Personal, indoor and outdoor air pollution levels among pregnant women","volume":"64","author":"Schembari","year":"2013","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.envpol.2019.113266_bib74","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12861-015-0094-5","article-title":"The developmental basis of mesenchymal stem\/stromal cells (MSCs)","volume":"15","author":"Sheng","year":"2015","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.envpol.2019.113266_bib75","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0070-2153(06)77004-1","article-title":"Mitochondrial DNA and the mammalian oocyte","volume":"77","author":"Shoubridge","year":"2007","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.envpol.2019.113266_bib76","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.semcdb.2016.01.028","article-title":"Mitochondrial DNA copy number and replication in reprogramming and differentiation","volume":"52","author":"St. John","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.envpol.2019.113266_bib77","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ajog.2017.12.009","article-title":"Spontaneous preterm birth: advances toward the discovery of genetic predisposition","volume":"218","author":"Strauss","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.envpol.2019.113266_bib78","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13072-018-0223-z","article-title":"Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours","volume":"11","author":"Sun","year":"2018","journal-title":"Epigenet. Chromatin"},{"key":"10.1016\/j.envpol.2019.113266_bib79","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/jes.2017.11","article-title":"Development of a modeling approach to estimate indoor-to-outdoor sulfur ratios and predict indoor PM2.5 and black carbon concentrations for Eastern Massachusetts households","volume":"28","author":"Tang","year":"2018","journal-title":"J.\u00a0Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envpol.2019.113266_bib80","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1681\/ASN.2015060661","article-title":"Association between mitochondrial DNA copy number in peripheral blood and incident CKD in the atherosclerosis risk in communities study","volume":"27","author":"Tin","year":"2016","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.envpol.2019.113266_bib81","first-page":"954","article-title":"Levels of trophectoderm mitochondrial DNA do not predict the reproductive potential of sibling embryos","volume":"32","author":"Treff","year":"2017","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.envpol.2019.113266_bib82","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1093\/nar\/gkw468","article-title":"MGME1 processes flaps into ligatable nicks in concert with DNA polymerase \u03b3 during mtDNA replication","volume":"44","author":"Uhler","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2019.113266_bib83","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1289\/ehp.1204918","article-title":"Air pollution exposure and markers of placental growth and function: the generation R study","volume":"120","author":"van den Hooven","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2019.113266_bib84","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2019.113266_bib85","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.fertnstert.2016.09.028","article-title":"Accurate quantitation of mitochondrial DNA reveals uniform levels in human blastocysts irrespective of ploidy, age, or implantation potential","volume":"107","author":"Victor","year":"2017","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.envpol.2019.113266_bib86","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12651","article-title":"Mitochondrial dysfunction and ovarian aging","volume":"77","author":"Wang","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.envpol.2019.113266_bib87","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.fertnstert.2017.10.007","article-title":"Mitochondrial DNA quantity as a biomarker for blastocyst implantation potential","volume":"108","author":"Wells","year":"2017","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.envpol.2019.113266_bib88","series-title":"Ambient Air Pollution: Pollutants","author":"WHO","year":"2019"},{"key":"10.1016\/j.envpol.2019.113266_bib89","series-title":"Facts Sheets: Ambient (Outdoor) Air Quality and Health","author":"WHO","year":"2018"},{"key":"10.1016\/j.envpol.2019.113266_bib90","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1080\/10473289.2000.10464164","article-title":"Estimating separately personal exposure to ambient and nonambient particulate matter for epidemiology and risk assessment: why and how","volume":"50","author":"Wilson","year":"2000","journal-title":"J.\u00a0Air Waste Manag. Assoc."},{"key":"10.1016\/j.envpol.2019.113266_bib91","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1289\/EHP256","article-title":"Placental pathology associated with household air pollution in a cohort of pregnant women from dar es salaam, Tanzania","volume":"125","author":"Wylie","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2019.113266_bib92","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/jb\/mvy058","article-title":"An overview of mammalian mitochondrial DNA replication mechanisms","volume":"164","author":"Yasukawa","year":"2018","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.envpol.2019.113266_bib93","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ajog.2013.10.001","article-title":"The contribution of genetic and environmental factors to the duration of pregnancy","volume":"210","author":"York","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.envpol.2019.113266_bib94","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.gde.2016.03.005","article-title":"Human mitochondrial DNA replication machinery and disease","volume":"38","author":"Young","year":"2016","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.envpol.2019.113266_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206003","article-title":"Association between mitochondrial DNA copy number and cardiovascular disease: current evidence based on a systematic review and meta-analysis","volume":"13","author":"Yue","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2019.113266_bib96","doi-asserted-by":"crossref","first-page":"10608","DOI":"10.1073\/pnas.191321998","article-title":"Human mitochondrial topoisomerase I","volume":"98","author":"Zhang","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envpol.2019.113266_bib97","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.envint.2018.03.037","article-title":"Sources of particulate matter in China: insights from source apportionment studies published in 1987-2017","volume":"115","author":"Zhu","year":"2018","journal-title":"Environ. Int."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974911932278X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974911932278X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:04:27Z","timestamp":1777539867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026974911932278X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":97,"alternative-id":["S026974911932278X"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2019.113266","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Air pollution and placental mitochondrial DNA copy number: Mechanistic insights and epidemiological challenges","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2019.113266","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113266"}}