{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:37:40Z","timestamp":1787647060773,"version":"build-2736575974"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31660726"],"award-info":[{"award-number":["31660726"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972754"],"award-info":[{"award-number":["31972754"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013151","name":"Scientific Research Foundation for Returned Scholars of Ministry of Education","doi-asserted-by":"publisher","award":["LC2017007"],"award-info":[{"award-number":["LC2017007"]}],"id":[{"id":"10.13039\/501100013151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.envpol.2019.113812","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T10:58:14Z","timestamp":1576666694000},"page":"113812","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":100,"special_numbering":"C","title":["Sulforaphane prevents chromium-induced lung injury in rats via activation of the Akt\/GSK-3\u03b2\/Fyn pathway"],"prefix":"10.1016","volume":"259","author":[{"given":"Yueying","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2019.113812_bib1","first-page":"184","article-title":"Evaluation of rhamnolipid (RL) as a biosurfactant for the removal of chromium from aqueous solutions by precipitate flotation","volume":"165","author":"Abyaneh","year":"2016","journal-title":"J.\u00a0Environ. Manag."},{"key":"10.1016\/j.envpol.2019.113812_bib2","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.3390\/ijms19071835","article-title":"DPIE [2-(1,2-diphenyl-1H-indol-3-yl)ethanamine] augments pro-inflammatory cytokine production in IL-1\u03b2-stimulated primary human oral cells","volume":"19","author":"Ahn","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2019.113812_bib3","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.scitotenv.2018.05.371","article-title":"Influence of different sludge compositions on understorey vegetation in an amended Pinus pinatser forest plantation","volume":"640","author":"Alaoui-Soss\u00e9","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2019.113812_bib4","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1007\/s12035-017-0798-6","article-title":"Natural dietary supplementation of anthocyanins via PI3K\/Akt\/Nrf2\/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse model of Alzheimer\u2019s disease","volume":"55","author":"Ali","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.envpol.2019.113812_bib5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s40495-014-0002-x","article-title":"Epigenetic regulation by sulforaphane: opportunities for breast and prostate cancer chemoprevention","volume":"1","author":"Atwell","year":"2015","journal-title":"Curr. Pharmacol. Rep."},{"key":"10.1016\/j.envpol.2019.113812_bib6","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ecoenv.2018.06.046","article-title":"Luteolin-mediated PI3K\/AKT\/Nrf2 signaling pathway ameliorates inorganic mercury-induced cardiac injury","volume":"161","author":"Baiyun","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2019.113812_bib7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.taap.2008.11.018","article-title":"Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium","volume":"235","author":"Beaver","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2019.113812_bib8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.neuropharm.2010.09.023","article-title":"Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage","volume":"60","author":"Bergstr\u00f6m","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.envpol.2019.113812_bib9","first-page":"E1119","article-title":"A\u00a0defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes","volume":"301","author":"Bitar","year":"2011","journal-title":"Am. J. Physiol. Endocrm."},{"key":"10.1016\/j.envpol.2019.113812_bib10","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1039\/C8FO00018B","article-title":"New highlights on the health-improving effects of sulforaphane","volume":"9","author":"Briones-Herrera","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.envpol.2019.113812_bib11","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1039\/C6FO00048G","article-title":"Modifications in nitric oxide and superoxide anion metabolism induced by fructose overload in rat heart are prevented by (\u2212)-epicatechin","volume":"7","author":"Calabr\u00f3","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.envpol.2019.113812_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12935-018-0559-2","article-title":"Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K\/AKT signaling in ovarian cancer","volume":"18","author":"Chan","year":"2018","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.envpol.2019.113812_bib13","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1021\/acs.est.5b05387","article-title":"Bisphenol analogues other than BPA: environmental occurrence, human exposure, and toxicity- a review","volume":"50","author":"Chen","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2019.113812_bib14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.intimp.2019.03.019","article-title":"Ethyl pyruvate protects against Salmonella intestinal infection in mice through down-regulation of pro-inflammatory factors and inhibition of TLR4\/MAPK pathway","volume":"71","author":"Dong","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.envpol.2019.113812_bib15","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.fct.2014.04.016","article-title":"Protective effect of curcumin against heavy metals-induced liver damage","volume":"69","author":"Garc\u00eda-Ni\u00f1o","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envpol.2019.113812_bib16","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/jnc.12038","article-title":"Neuroprotection by urate on 6-OHDA-lesioned rat model of Parkinson\u2019s disease: linking to Akt\/GSK3\u03b2 signaling pathway","volume":"123","author":"Gong","year":"2012","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.envpol.2019.113812_bib17","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1039\/C9FO01152H","article-title":"Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1\/Pgc-1\u03b1\/Nrf2 pathway","volume":"10","author":"Han","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.envpol.2019.113812_bib18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10787-008-7004-4","article-title":"Comparison of the preventive effect of vitamin C and E on hexavalent chromium induced pulmonary fibrosis in rat","volume":"16","author":"Hemmati","year":"2008","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.envpol.2019.113812_bib19","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1021\/tx100389r","article-title":"Modification of keap1 cysteine residues by sulforaphane","volume":"24","author":"Hu","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2019.113812_bib20","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1074\/jbc.M611336200","article-title":"GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2","volume":"282","author":"Jain","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.envpol.2019.113812_bib21","doi-asserted-by":"crossref","first-page":"8458","DOI":"10.1021\/jf070866p","article-title":"Antioxidative activity of amino acids on tissue oxidative stress in human intestinal epithelial cell model","volume":"55","author":"Katayama","year":"2007","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.envpol.2019.113812_bib22","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/mnfr.201500947","article-title":"Inflammation related responses of intestinal cells to plum and cabbage digesta with differential carotenoid and polyphenol profiles following simulated gastrointestinal digestion","volume":"60","author":"Kaulmann","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.envpol.2019.113812_bib23","doi-asserted-by":"crossref","first-page":"7864","DOI":"10.1021\/jf401575a","article-title":"Chromium uptake and consequences for metabolism and oxidative stress in chamomile plants","volume":"61","author":"Kov\u00e1\u010dik","year":"2013","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.envpol.2019.113812_bib24","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.envpol.2018.09.062","article-title":"Air pollution-derived PM2.5 impairs mitochondrial function in healthy and chronic obstructive pulmonary diseased human bronchial epithelial cells","volume":"243","author":"Leclercq","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2019.113812_bib25","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1111\/febs.12942","article-title":"Glycogen synthase kinase 3 beta in somites plays a role during the angiogenesis of zebrafish embryos","volume":"281","author":"Lee","year":"2014","journal-title":"FEBS J."},{"key":"10.1016\/j.envpol.2019.113812_bib26","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1002\/pmic.200701050","article-title":"Proteomic analysis of chromium cytotoxicity in cultured rat lung epithelial cells","volume":"8","author":"Lei","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.envpol.2019.113812_bib27","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.envpol.2019.02.097","article-title":"Multiple organ injury in male C57BL\/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China","volume":"248","author":"Li","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2019.113812_bib28","doi-asserted-by":"crossref","first-page":"110698","DOI":"10.1016\/j.jinorgbio.2019.110698","article-title":"Melatonin protects against chromium (VI)-induced cardiac injury via activating the AMPK\/Nrf2 pathway","volume":"197","author":"Li","year":"2019","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.envpol.2019.113812_bib29","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.chemosphere.2019.06.096","article-title":"Exploring the kidney hazard of exposure to mercuric chloride in mice: disorder of mitochondrial dynamics induces oxidative stress and results in apoptosis","volume":"234","author":"Li","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2019.113812_bib30","article-title":"Dietary luteolin protects against renal anemia in mice","author":"Li","year":"2020","journal-title":"J.\u00a0Funct. Foods"},{"key":"10.1016\/j.envpol.2019.113812_bib31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jnutbio.2017.09.025","article-title":"Grape seed procyanidin extract ameliorates lead-induced liver injury via miRNA153 and AKT\/GSK-3\u03b2\/Fyn-mediated Nrf2 activation","volume":"52","author":"Liu","year":"2018","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.envpol.2019.113812_bib32","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.fct.2018.02.003","article-title":"Protective effects of dietary luteolin against mercuric chloride-induced lung injury in mice: involvement of AKT\/Nrf2 and NF-\u03baB pathways","volume":"113","author":"Liu","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envpol.2019.113812_bib33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12951-019-0478-y","article-title":"Role of A2B adenosine receptor-dependent adenosine signaling in multi-walled carbon nanotube-triggered lung fibrosis in mice","volume":"17","author":"Liu","year":"2019","journal-title":"J.\u00a0Nanobiotechnol."},{"key":"10.1016\/j.envpol.2019.113812_bib34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.fct.2018.03.034","article-title":"Grape seed procyanidin extract protects against Pb-induced lung toxicity by activating the AMPK\/Nrf2\/p62 signaling axis","volume":"116","author":"Lu","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envpol.2019.113812_bib35","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1080\/15384101.2019.1669389","article-title":"1, 25 (OH)2D3 improves blood lipid metabolism, liver function, and atherosclerosis by constraining the TGF-\u03b2\/Smad signaling pathway in rats with hyperlipidemia","volume":"18","author":"Lu","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.envpol.2019.113812_bib36","first-page":"5399","article-title":"URI prevents potassium dichromate-induced oxidative stress and cell death in gastric cancer cells","volume":"8","author":"Luo","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.envpol.2019.113812_bib37","doi-asserted-by":"crossref","first-page":"135915","DOI":"10.1016\/j.scitotenv.2019.135915","article-title":"Imidacloprid-induced liver fibrosis in quails via activation of the TGF-\u03b21\/Smad pathway","volume":"705","author":"Lv","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2019.113812_bib38","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3389\/fphar.2016.00350","article-title":"Therapeutic potential and molecular mechanisms of gaertn in countering nephrotoxicity in rats induced by the chemotherapeutic agent cisplatin","volume":"7","author":"Malik","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.envpol.2019.113812_bib39","doi-asserted-by":"crossref","first-page":"e2888","DOI":"10.1371\/journal.pone.0002888","article-title":"Generation of breast cancer stem cells through epithelial-mesenchymal transition","volume":"3","author":"Morel","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2019.113812_bib40","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.freeradbiomed.2013.08.182","article-title":"Modulation of mitochondrial functions by the indirect antioxidant sulforaphane: a seemingly contradictory dual role and an integrative hypothesis","volume":"65","author":"Negrette-Guzm\u00e1n","year":"2013","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.envpol.2019.113812_bib41","doi-asserted-by":"crossref","first-page":"28821","DOI":"10.1074\/jbc.M111.255042","article-title":"Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression","volume":"286","author":"Niture","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.envpol.2019.113812_bib42","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/jcp.20710","article-title":"Chromium (VI) inhibits heme oxygenase-1 expression in\u00a0vivo and in arsenic-exposed human airway epithelial cells","volume":"209","author":"O\u2019Hara","year":"2006","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.envpol.2019.113812_bib43","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.envpol.2018.07.039","article-title":"Dioxin-like PCB 126 increases intestinal inflammation and disrupts gut microbiota and metabolic homeostasis","volume":"242","author":"Petriello","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2019.113812_bib44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.freeradbiomed.2015.11.009","article-title":"Dietary (\u2013)-epicatechin mitigates oxidative stress, NO metabolism alterations, and inflammation in renal cortex from fructose-fed rats","volume":"90","author":"Prince","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envpol.2019.113812_bib45","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1039\/C8FO02230E","article-title":"Dietary (\u2212)-epicatechin affects NF-\u03baB activation and NADPH oxidases in the kidney cortex of high-fructose-fed rats","volume":"10","author":"Prince","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.envpol.2019.113812_bib46","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.taap.2006.10.017","article-title":"In\u00a0vivo and in\u00a0vitro effects of chromium VI on anterior pituitary hormone release and cell viability","volume":"218","author":"Quinteros","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2019.113812_bib47","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.envpol.2019.113812_bib48","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s11224-017-0971-6","article-title":"Bidentate reagents form cyclic organic-Cr(VI) molecules for aiding in the removal of Cr(VI) from water: density functional theory and experimental results","volume":"28","author":"Regan","year":"2017","journal-title":"Struct. Chem."},{"key":"10.1016\/j.envpol.2019.113812_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168688","article-title":"Intranasal chromium induces acute brain and lung injuries in rats: assessment of different potential hazardous effects of environmental and occupational exposure to chromium and introduction of a novel pharmacological and toxicological animal model","volume":"11","author":"Salama","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2019.113812_bib50","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jnutbio.2014.12.008","article-title":"Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta\/Fyn\/Nrf2 signaling pathway","volume":"26","author":"Shang","year":"2015","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.envpol.2019.113812_bib51","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1002\/jcp.27473","article-title":"Pre-cold acclimation improves the immune function of trachea and resistance to cold stress in broilers","volume":"234","author":"Su","year":"2019","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.envpol.2019.113812_bib52","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2443.2010.01473.x","article-title":"Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution","volume":"16","author":"Taguchi","year":"2011","journal-title":"Genes Cells"},{"key":"10.1016\/j.envpol.2019.113812_bib53","doi-asserted-by":"crossref","first-page":"11017","DOI":"10.1021\/acs.est.8b02933","article-title":"Novel and traditional organophosphate esters in house dust from South China: association with hand wipes and exposure estimation","volume":"52","author":"Tan","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2019.113812_bib54","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jinorgbio.2017.11.010","article-title":"Dietary luteolin protects against HgCl2-induced renal injury via activation of Nrf2-mediated signaling in rat","volume":"179","author":"Tan","year":"2018","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.envpol.2019.113812_bib55","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3390\/nu11051185","article-title":"Sulforaphane prevents hepatic insulin resistance by blocking serine palmitoyltransferase 3-mediated ceramide biosynthesis","volume":"11","author":"Teng","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2019.113812_bib56","first-page":"383","article-title":"Bacterial chromate reductase, a potential enzyme for bioremediation of hexavalent chromium: a review","volume":"146","author":"Thatoi","year":"2014","journal-title":"J.\u00a0Environ. Manag."},{"key":"10.1016\/j.envpol.2019.113812_bib57","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/jcmm.12748","article-title":"Lipid peroxidation and apoptotic response in rat brain areas induced by long-term administration of nandrolone: the mutua l crosstalk between ROS and NF-\u03baB","volume":"20","author":"Turillazzi","year":"2016","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.envpol.2019.113812_bib58","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1080\/14786419.2017.1286485","article-title":"In\u00a0vitro assessment of the indirect antioxidant activity of sulforaphane in redox imbalance vanadium-induced","volume":"31","author":"Visalli","year":"2017","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.envpol.2019.113812_bib59","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1167\/iovs.07-1099","article-title":"Essential roles of the PI3 kinase\/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE","volume":"49","author":"Wang","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.envpol.2019.113812_bib60","article-title":"Kaempferide protects against myocardial ischemia\/reperfusion injury through activation of the PI3K\/Akt\/GSK-3\u03b2 pathway","volume":"5278218","author":"Wang","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.envpol.2019.113812_bib61","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3390\/toxins11070397","article-title":"Tannic acid induces the mitochondrial pathway of apoptosis and S phase arrest in porcine intestinal IPEC-J2 cells","volume":"11","author":"Wang","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.envpol.2019.113812_bib62","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.3389\/fphys.2018.01589","article-title":"Effects of acute cold stress after long-term cold stimulation on antioxidant status, heat shock proteins, inflammation and immune cytokines in broiler heart","volume":"9","author":"Wei","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.envpol.2019.113812_bib63","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.redox.2017.12.016","article-title":"Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt\/GSK-3\u03b2\/Fyn pathway","volume":"15","author":"Xin","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.envpol.2019.113812_bib64","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.7150\/thno.30658","article-title":"Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane","volume":"9","author":"Xu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.envpol.2019.113812_bib65","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1039\/C9FO01062A","article-title":"Lactobacillus acidophilus alleviates type 2 diabetes by regulating hepatic glucose, lipid metabolism and gut microbiota in mice","volume":"10","author":"Yan","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.envpol.2019.113812_bib66","doi-asserted-by":"crossref","first-page":"37157","DOI":"10.1038\/srep37157","article-title":"Regulation of Sirt1\/Nrf2\/TNF-\u03b1 signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep. UK"},{"key":"10.1016\/j.envpol.2019.113812_bib67","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s12011-016-0821-1","article-title":"Activation of the Nrf2 signaling pathway involving KLF9 plays a critical role in allicin resisting against arsenic trioxide-induced hepatotoxicity in rats","volume":"176","author":"Yang","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envpol.2019.113812_bib68","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.envpol.2018.02.035","article-title":"Dietary grape seed proanthocyanidin extract regulates metabolic disturbance in rat liver exposed to lead associated with PPAR\u03b1 signaling pathway","volume":"237","author":"Yang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2019.113812_bib69","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.scitotenv.2018.03.107","article-title":"Co-exposure of silica nanoparticles and methylmercury induced cardiac toxicity in\u00a0vitro and in\u00a0vivo","volume":"631","author":"Yang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2019.113812_bib70","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ecoenv.2019.03.093","article-title":"Bone marrow mesenchymal stem cells repair Cr(VI)-injured kidney by regulating mitochondria-mediated apoptosis and mitophagy mediated via the MAPK signaling pathway","volume":"176","author":"Yin","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2019.113812_bib71","article-title":"Diabetes-induced hepatic pathogenic damage, inflammation, oxidative stress, and insulin resistance was exacerbated in zinc deficient mouse model","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2019.113812_bib72","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1021\/es404934f","article-title":"Cell rescue by nanosequestration: reduced cytotoxicity of an environmental remediation residue, Mg(OH)2 nanoflake\/Cr (VI) adduct","volume":"48","author":"Zhang","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2019.113812_bib73","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1039\/C4RA11016A","article-title":"Study of chromium (VI) removal from aqueous solution using nitrogen-enriched activated carbon based bamboo processing residues","volume":"5","author":"Zhang","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.envpol.2019.113812_bib74","doi-asserted-by":"crossref","first-page":"1700016","DOI":"10.1002\/mnfr.201700016","article-title":"Effects of selenium on apoptosis and abnormal amino acid metabolism induced by excess fatty acid in isolated rat hepatocytes","volume":"61","author":"Zhang","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.envpol.2019.113812_bib75","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1021\/acs.jafc.7b05074","article-title":"Transcriptome analysis of hepatopancreas from the Cr(VI)-stimulated mantis shrimp (Oratosquilla oratoria) by illumina paired-end sequencing: assembly, annotation, and expression analysis","volume":"66","author":"Zhang","year":"2018","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.envpol.2019.113812_bib76","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.scitotenv.2017.11.169","article-title":"Roles and potential mechanisms of selenium in countering thyrotoxicity of DEHP","volume":"619","author":"Zhang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2019.113812_bib77","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1093\/jas\/skz209","article-title":"Effects of ORAI calcium release-activated calcium modulator 1 (ORAI1) on neutrophil activity in dairy cows with subclinical hypocalcemia","volume":"97","author":"Zhang","year":"2019","journal-title":"J.\u00a0Anim. Sci."},{"key":"10.1016\/j.envpol.2019.113812_bib78","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.toxlet.2019.04.007","article-title":"Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1\/HIF-1\u03b1 signaling pathway in rats","volume":"310","author":"Zhao","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2019.113812_bib79","doi-asserted-by":"crossref","first-page":"7359","DOI":"10.3168\/jds.2018-16015","article-title":"Fatty acid-induced endoplasmic reticulum stress promoted lipid accumulation in calf hepatocytes, and endoplasmic reticulum stress existed in the liver of severe fatty liver cows","volume":"102","author":"Zhu","year":"2019","journal-title":"J.\u00a0Dairy Sci."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749119343179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749119343179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:05:19Z","timestamp":1777539919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749119343179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":79,"alternative-id":["S0269749119343179"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2019.113812","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sulforaphane prevents chromium-induced lung injury in rats via activation of the Akt\/GSK-3\u03b2\/Fyn pathway","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2019.113812","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113812"}}