{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:25:49Z","timestamp":1793042749116,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/EBB-EBI\/111699\/2009"],"award-info":[{"award-number":["PTDC\/EBB-EBI\/111699\/2009"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/86939\/2012"],"award-info":[{"award-number":["SFRH\/BD\/86939\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006111","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior","doi-asserted-by":"publisher","award":["PEst FCOMP-01-0124-FEDER-022718"],"award-info":[{"award-number":["PEst FCOMP-01-0124-FEDER-022718"]}],"id":[{"id":"10.13039\/501100006111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006111","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior","doi-asserted-by":"publisher","award":["PEst-OE\/SAU\/UI4040\/2014"],"award-info":[{"award-number":["PEst-OE\/SAU\/UI4040\/2014"]}],"id":[{"id":"10.13039\/501100006111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006111","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior","doi-asserted-by":"publisher","award":["PEst-OE\/EQB\/LA0016\/2011"],"award-info":[{"award-number":["PEst-OE\/EQB\/LA0016\/2011"]}],"id":[{"id":"10.13039\/501100006111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["UID\/QUI\/50006\/2019"],"award-info":[{"award-number":["UID\/QUI\/50006\/2019"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.envpol.2020.113927","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T23:28:24Z","timestamp":1578612504000},"page":"113927","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"special_numbering":"C","title":["Quantification of fluoroquinolones in wastewaters by liquid chromatography-tandem mass spectrometry"],"prefix":"10.1016","volume":"259","author":[{"given":"Alexandra S.","family":"Maia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Pa\u00edga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Delerue-Matos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula M.L.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elizabeth","family":"Tiritan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2020.113927_bib2","first-page":"265","volume":"vol. 34","author":"Al-Omar","year":"2009"},{"key":"10.1016\/j.envpol.2020.113927_bib3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.scitotenv.2015.12.157","article-title":"Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents","volume":"548\u2013549","author":"Azuma","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2020.113927_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.chroma.2012.09.046","article-title":"Advantages of electronic circular dichroism detection for the stereochemical analysis and characterization of drugs and natural products by liquid chromatography","volume":"1269","author":"Bertucci","year":"2012","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.envpol.2020.113927_bib5","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.scitotenv.2017.08.279","article-title":"Occurrence, distribution and environmental risk of pharmaceutically active compounds (PhACs) in coastal and ocean waters from the Gulf of Cadiz (SW Spain)","volume":"612","author":"Biel-Maeso","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2020.113927_bib6","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jhazmat.2016.08.022","article-title":"Occurrence and fate of amisulpride, sulpiride, and lamotrigine in municipal wastewater treatment plants with biological treatment and ozonation","volume":"320","author":"Bollmann","year":"2016","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.envpol.2020.113927_bib7","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.envint.2016.06.025","article-title":"Antibiotics in the aquatic environments: a review of the European scenario","volume":"94","author":"Carvalho","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2020.113927_bib8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.chemosphere.2018.05.005","article-title":"Enantioselective fractionation of fluoroquinolones in the aqueous environment using chiral liquid chromatography coupled with tandem mass spectrometry","volume":"206","author":"Castrignan\u00f2","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2020.113927_bib9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.watres.2017.07.004","article-title":"The potential implications of reclaimed wastewater reuse for irrigation on the agricultural environment: the knowns and unknowns of the fate of antibiotics and antibiotic resistant bacteria and resistance genes \u2013 a review","volume":"123","author":"Christou","year":"2017","journal-title":"Water Res."},{"issue":"17","key":"10.1016\/j.envpol.2020.113927_bib10","doi-asserted-by":"crossref","first-page":"14717","DOI":"10.1007\/s11356-017-9012-7","article-title":"Occurrence and behaviour of pharmaceutical compounds in a Portuguese wastewater treatment plant: removal efficiency through conventional treatment processes","volume":"24","author":"de Jesus Gaffney","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2020.113927_bib73","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.microc.2012.09.002","article-title":"Simultaneous determination of 13 quinolone antibiotic derivatives in wastewater samples using solid\u2013phase extraction and ultra performance liquid chromatography\u2013tandem mass spectrometry","volume":"106","author":"Dorival\u2013Garc\u00eda","year":"2012","journal-title":"Microchem. J."},{"issue":"1","key":"10.1016\/j.envpol.2020.113927_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.emcon.2016.12.004","article-title":"Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment","volume":"3","author":"Ebele","year":"2017","journal-title":"Emerg. Contam."},{"key":"10.1016\/j.envpol.2020.113927_bib12","series-title":"Antimicrobial Consumption. Annual Epidemiological Report for 2016","year":"2018"},{"key":"10.1016\/j.envpol.2020.113927_bib13","series-title":"Antimicrobial Consumption. Annual Epidemiological Report for 2017","year":"2018"},{"key":"10.1016\/j.envpol.2020.113927_bib14","first-page":"8","article-title":"2002\/657\/EC: Commission Decision of 12 August 2002 implementing Council Directive 96\/23\/EC concerning the performance of analytical methods and the interpretation of results. 2002\/657\/EC. European Commission","volume":"221","year":"2002","journal-title":"Off. J. Eur. Commun."},{"key":"10.1016\/j.envpol.2020.113927_bib15","series-title":"Guideline on Bioanalytical Method Validation (EMEA\/CHMP\/EWP\/192217\/2009)","year":"2011"},{"key":"10.1016\/j.envpol.2020.113927_bib16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jhazmat.2018.07.092","article-title":"Human and veterinary antibiotics during composting of sludge or manure: global perspectives on persistence, degradation, and resistance genes","volume":"359","author":"Ezzariai","year":"2018","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.envpol.2020.113927_bib17","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.ecoleng.2016.06.093","article-title":"Comparison of the removal efficiencies of selected pharmaceuticals in wastewater treatment plants in the region of Murcia, Spain","volume":"95","author":"Fern\u00e1ndez-L\u00f3pez","year":"2016","journal-title":"Ecol. Eng."},{"issue":"1","key":"10.1016\/j.envpol.2020.113927_bib18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.chemosphere.2012.02.017","article-title":"Occurrence of pharmaceuticals in a municipal wastewater treatment plant: mass balance and removal processes","volume":"88","author":"Gao","year":"2012","journal-title":"Chemosphere"},{"issue":"17","key":"10.1016\/j.envpol.2020.113927_bib19","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1021\/es0256212","article-title":"Environmental exposure and risk assessment of fluoroquinolone antibacterial agents in wastewater and river water of the Glatt Valley Watershed, Switzerland","volume":"36","author":"Golet","year":"2002","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"10.1016\/j.envpol.2020.113927_bib20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/clen.201300989","article-title":"Antibiotic pollution in the environment: a review","volume":"43","author":"Gothwal","year":"2015","journal-title":"Clean. - Soil, Air, Water"},{"key":"10.1016\/j.envpol.2020.113927_bib21","article-title":"Sources, behaviour and health risks of antimicrobial resistance genes in wastewaters: a hotspot reservoir","author":"Gwenzi","year":"2018","journal-title":"J.\u00a0Environ. Chem. Eng."},{"issue":"1","key":"10.1016\/j.envpol.2020.113927_bib22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0378-4274(02)00041-3","article-title":"Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data","volume":"131","author":"Heberer","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2020.113927_bib23","series-title":"Validation of Analytical Procedures: Text and Methodology Q2 (R1)","year":"2005"},{"key":"10.1016\/j.envpol.2020.113927_bib24","first-page":"265","volume":"vol. 1","author":"Jacoby","year":"2017"},{"issue":"11","key":"10.1016\/j.envpol.2020.113927_bib25","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1002\/etc.3552","article-title":"Implications of fluoroquinolone contamination for the aquatic environment - a review","volume":"35","author":"Janecko","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"issue":"7","key":"10.1016\/j.envpol.2020.113927_bib26","doi-asserted-by":"crossref","first-page":"578","DOI":"10.4236\/aim.2018.87038","article-title":"Analysis of trends in resistance to fluoroquinolones and extended spectrum beta-lactams among Salmonella typhi isolates obtained from patients at four outpatient clinics in Nairobi county, Kenya","volume":"8","author":"Kavai","year":"2018","journal-title":"Adv. Microbiol."},{"key":"10.1016\/j.envpol.2020.113927_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijfoodmicro.2018.05.001","article-title":"Emerging high-level ciprofloxacin resistance and molecular basis of resistance in Salmonella enterica from humans, food and animals","volume":"280","author":"Kuang","year":"2018","journal-title":"Int. J. Food Microbiol."},{"issue":"4","key":"10.1016\/j.envpol.2020.113927_bib28","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chemosphere.2008.11.086","article-title":"Antibiotics in the aquatic environment--a review--part I","volume":"75","author":"K\u00fcmmerer","year":"2009","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.envpol.2020.113927_bib29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.chemosphere.2008.12.006","article-title":"Antibiotics in the aquatic environment--a review--part II","volume":"75","author":"K\u00fcmmerer","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2020.113927_bib30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-environ-052809-161223","article-title":"Pharmaceuticals in the environment","volume":"35","author":"K\u00fcmmerer","year":"2010","journal-title":"Annu. Rev. Environ. Resour."},{"issue":"6399","key":"10.1016\/j.envpol.2020.113927_bib31","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1126\/science.aau2405","article-title":"A\u00a0path to clean water","volume":"361","author":"K\u00fcmmerer","year":"2018","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.envpol.2020.113927_bib32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.chnaes.2018.01.006","article-title":"Progress of research on the toxicology of antibiotic pollution in aquatic organisms","volume":"38","author":"Liu","year":"2018","journal-title":"Acta Ecol. Sin."},{"issue":"42","key":"10.1016\/j.envpol.2020.113927_bib33","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.1016\/j.chroma.2009.08.060","article-title":"Pharmaceutical trace analysis in aqueous environmental matrices by liquid chromatography-ion trap tandem mass spectrometry","volume":"1216","author":"Madureira","year":"2009","journal-title":"J.\u00a0Chromatogr. A"},{"issue":"22","key":"10.1016\/j.envpol.2020.113927_bib34","doi-asserted-by":"crossref","first-page":"5513","DOI":"10.1016\/j.scitotenv.2010.07.069","article-title":"Spatiotemporal distribution of pharmaceuticals in the Douro River estuary (Portugal)","volume":"408","author":"Madureira","year":"2010","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.envpol.2020.113927_bib35","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/chromsci\/48.3.176","article-title":"Development and optimization of a HPLC-DAD method for the determination of diverse pharmaceuticals in estuarine surface waters","volume":"48","author":"Madureira","year":"2010","journal-title":"J.\u00a0Chromatogr. Sci."},{"issue":"13","key":"10.1016\/j.envpol.2020.113927_bib36","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1021\/ac020361s","article-title":"Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC- MS\/MS","volume":"75","author":"Matuszewski","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envpol.2020.113927_bib37","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.envpol.2017.09.009","article-title":"Antimicrobial activity of pharmaceutical cocktails in sewage treatment plant effluent \u2013 an experimental and predictive approach to mixture risk assessment","volume":"231","author":"Menz","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2020.113927_bib38","first-page":"446","article-title":"Occurrence and fate of most prescribed antibiotics in different water environments of Tehran, Iran","volume":"vols. 619\u2013620","author":"Mirzaei","year":"2018"},{"key":"10.1016\/j.envpol.2020.113927_bib39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.chemosphere.2018.12.187","article-title":"Antibiotics in urban wastewater and rivers of Tehran, Iran: consumption, mass load, occurrence, and ecological risk","volume":"221","author":"Mirzaei","year":"2019","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.envpol.2020.113927_bib40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1358\/dot.2000.36.4.570201","article-title":"Pharmacokinetics and metabolism of moxifloxacin","volume":"36","author":"Moise","year":"2000","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.envpol.2020.113927_bib41","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jhazmat.2016.04.058","article-title":"Lessons learned from more than two decades of research on emerging contaminants in the environment","volume":"316","author":"Noguera-Oviedo","year":"2016","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.envpol.2020.113927_bib42","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jpba.2016.12.013","article-title":"Development of a multi-residue method for the determination of human and veterinary pharmaceuticals and some of their metabolites in aqueous environmental matrices by SPE-UHPLC\u2013MS\/MS","volume":"135","author":"Pa\u00edga","year":"2017","journal-title":"J.\u00a0Pharm. Biomed. Anal."},{"issue":"9","key":"10.1016\/j.envpol.2020.113927_bib43","first-page":"R1321","article-title":"Considerations on the aquaculture development and on the use of veterinary drugs: special issue for fluoroquinolones\u2014a review","volume":"78","author":"Pilco","year":"2013","journal-title":"J.\u00a0Food Sci."},{"key":"10.1016\/j.envpol.2020.113927_bib44","article-title":"On the contribution of reclaimed wastewater irrigation to the potential exposure of humans to antibiotics, antibiotic resistant bacteria and antibiotic resistance genes \u2013 NEREUS COST Action ES1403 position paper","author":"Pi\u00f1a","year":"2018","journal-title":"J.\u00a0Environ. Chem. Eng."},{"key":"10.1016\/j.envpol.2020.113927_bib46","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.chemosphere.2017.10.092","article-title":"Fluoroquinolones (FQs) in the environment: a review on their abundance, sorption and toxicity in soil","volume":"191","author":"Riaz","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2020.113927_bib47","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.chroma.2014.06.099","article-title":"Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry","volume":"1363","author":"Ribeiro","year":"2014","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.envpol.2020.113927_bib48","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.chemosphere.2013.09.118","article-title":"Enantioselective quantification of fluoxetine and norfluoxetine by HPLC in wastewater effluents","volume":"95","author":"Ribeiro","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2020.113927_bib49","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.watres.2014.11.021","article-title":"Occurrence of antibiotics and antibiotic resistance genes in hospital and urban wastewaters and their impact on the receiving river","volume":"69","author":"Rodriguez-Mozaz","year":"2015","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2020.113927_bib50","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.scitotenv.2013.04.077","article-title":"Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: identification of ecologically relevant pharmaceuticals","volume":"461\u2013462","author":"Santos","year":"2013","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.envpol.2020.113927_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2006.03.026","article-title":"A\u00a0global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment","volume":"65","author":"Sarmah","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2020.113927_bib52","series-title":"Responsible Use of Antibiotics in Aquaculture","author":"Serrano","year":"2005"},{"issue":"8","key":"10.1016\/j.envpol.2020.113927_bib53","article-title":"Trends in fluoroquinolone resistance in Campylobacter","volume":"4","author":"Sproston","year":"2018","journal-title":"Microb. Genom."},{"key":"10.1016\/j.envpol.2020.113927_bib54","first-page":"131","article-title":"Fluoroquinolone antibiotics in the environment","volume":"vol. 191","author":"Sukul","year":"2007"},{"key":"10.1016\/j.envpol.2020.113927_bib55","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jhazmat.2013.11.056","article-title":"Seasonal variation in the occurrence and removal of pharmaceuticals and personal care products in a wastewater treatment plant in Xiamen, China","volume":"277","author":"Sun","year":"2014","journal-title":"J.\u00a0Hazard Mater."},{"issue":"4","key":"10.1016\/j.envpol.2020.113927_bib56","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.clinbiochem.2004.11.007","article-title":"Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography\u2013electrospray\u2013tandem mass spectrometry","volume":"38","author":"Taylor","year":"2005","journal-title":"Clin. Biochem."},{"issue":"11","key":"10.1016\/j.envpol.2020.113927_bib57","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1016\/S0043-1354(98)00099-2","article-title":"Occurrence of drugs in German sewage treatment plants and rivers1Dedicated to Professor Dr. Klaus Haberer on the occasion of his 70th birthday.1","volume":"32","author":"Ternes","year":"1998","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2020.113927_bib58","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.scitotenv.2019.07.092","article-title":"Occurrence and risk assessment of multiple classes of antibiotics in urban canals and lakes in Hanoi, Vietnam","volume":"692","author":"Tran","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"8","key":"10.1016\/j.envpol.2020.113927_bib60","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S1473-3099(14)70780-7","article-title":"Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data","volume":"14","author":"Van Boeckel","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.envpol.2020.113927_bib61","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.scitotenv.2014.08.075","article-title":"Fluoroquinolone antibiotics: an emerging class of environmental micropollutants","volume":"500\u2013501","author":"Van Doorslaer","year":"2014","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.envpol.2020.113927_bib62","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.watres.2006.12.017","article-title":"Elimination of pharmaceuticals in sewage treatment plants in Finland","volume":"41","author":"Vieno","year":"2007","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2020.113927_bib63","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.scitotenv.2014.06.082","article-title":"Development of sensitive and reliable LC-MS\/MS methods for the determination of three fluoroquinolones in water and fish tissue samples and preliminary environmental risk assessment of their presence in two rivers in northern Poland","volume":"493","author":"Wagil","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2020.113927_bib64","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.scitotenv.2018.07.415","article-title":"The occurrence, distribution and degradation of antibiotics by ionizing radiation: an overview","volume":"646","author":"Wang","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2020.113927_bib65","series-title":"The Occurrence of Antibiotics in an Urban Watershed: from Wastewater to Drinking Water","author":"Watkinson","year":"2009"},{"issue":"46","key":"10.1016\/j.envpol.2020.113927_bib66","doi-asserted-by":"crossref","first-page":"30401","DOI":"10.2807\/1560-7917.ES.2016.21.46.30399","article-title":"ECDC publishes 2015 surveillance data on antimicrobial resistance and antimicrobial consumption in Europe","volume":"21","author":"Weist","year":"2016","journal-title":"Euro Surveill."},{"issue":"D1","key":"10.1016\/j.envpol.2020.113927_bib67","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: a major update to the DrugBank database for 2018","volume":"46","author":"Wishart","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.envpol.2020.113927_bib68","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/tox.22087","article-title":"Toxicity assessment of combined fluoroquinolone and tetracycline exposure in zebrafish (Danio rerio)","volume":"31","author":"Yuna","year":"2016","journal-title":"Environ. Toxicol."},{"issue":"1","key":"10.1016\/j.envpol.2020.113927_bib69","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s00128-017-2107-5","article-title":"Occurrence, distribution and ecological risks of fluoroquinolone antibiotics in the Dongjiang river and the Beijiang river, pearl river Delta, south China","volume":"99","author":"Zhang","year":"2017","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"19","key":"10.1016\/j.envpol.2020.113927_bib70","doi-asserted-by":"crossref","first-page":"16478","DOI":"10.1007\/s11356-017-9296-7","article-title":"Occurrence, removal, and risk assessment of antibiotics in 12 wastewater treatment plants from Dalian, China","volume":"24","author":"Zhang","year":"2017","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.envpol.2020.113927_bib71","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.scitotenv.2018.05.230","article-title":"Occurrence, fate and mass loadings of antibiotics in two swine wastewater treatment systems","volume":"639","author":"Zhang","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"8","key":"10.1016\/j.envpol.2020.113927_bib72","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/clen.201100731","article-title":"Partitioning of fluoroquinolones on wastewater sludge","volume":"41","author":"Zhou","year":"2013","journal-title":"Clean. - Soil, Air, Water"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749119322833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749119322833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:45:07Z","timestamp":1778543107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749119322833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":70,"alternative-id":["S0269749119322833"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2020.113927","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantification of fluoroquinolones in wastewaters by liquid chromatography-tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2020.113927","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113927"}}