{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:28:36Z","timestamp":1793449716640,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010211","name":"Jilin Provincial Department of Education","doi-asserted-by":"publisher","award":["JJKH20190714KJ"],"award-info":[{"award-number":["JJKH20190714KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Science and Technology Development Project of Jilin Province","doi-asserted-by":"publisher","award":["20180101309JC"],"award-info":[{"award-number":["20180101309JC"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51678189"],"award-info":[{"award-number":["51678189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.envpol.2020.113956","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T17:24:18Z","timestamp":1578677058000},"page":"113956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Risk of penicillin fermentation dreg: Increase of antibiotic resistance genes after soil discharge"],"prefix":"10.1016","volume":"259","author":[{"given":"Bing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianquan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guomin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houhe","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.envpol.2020.113956_bib1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.watres.2015.01.036","article-title":"Removal of bacterial contaminants and antibiotic resistance genes by conventional wastewater treatment processes in Saudi Arabia: is the treated wastewater safe to reuse for agricultural irrigation?","volume":"73","author":"Al-Jassim","year":"2015","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.envpol.2020.113956_bib2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00284-015-0952-1","article-title":"Detection of multiple resistances, biofilm formation and conjugative transfer of Bacillus cereus from contaminated soils","volume":"72","author":"Anjum","year":"2016","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.envpol.2020.113956_bib3","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.scitotenv.2017.09.012","article-title":"Towards the understanding of antibiotic occurrence and transport in groundwater: findings from the Baix Fluvi\u00e0 alluvial aquifer (NE Catalonia, Spain)","volume":"612","author":"Boy-Roura","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"5759","key":"10.1016\/j.envpol.2020.113956_bib4","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1126\/science.1120800","article-title":"Sampling the antibiotic resistome","volume":"311","author":"D\u2019Costa","year":"2006","journal-title":"Science"},{"issue":"7502","key":"10.1016\/j.envpol.2020.113956_bib5","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature13377","article-title":"Bacterial phylogeny structures soil resistomes across habitats","volume":"509","author":"Forsberg","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2020.113956_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2017.09.004","article-title":"Distribution of species and antimicrobial resistance among enterococci isolated from the fecal microbiota of captive blue-fronted parrot ( Amazona aestiva ) in Rio de Janeiro, Brazil","author":"Freitas","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2020.113956_bib7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.scitotenv.2018.02.122","article-title":"Diverse and abundant antibiotic resistance genes from mariculture sites of China\u2019s coastline","volume":"630","author":"Gao","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"8","key":"10.1016\/j.envpol.2020.113956_bib8","first-page":"1253","article-title":"Impacts of anthropogenic activity on the ecology of class 1 integrons and integron-associated genes in the environment","volume":"5","author":"Gaze","year":"2011","journal-title":"Impacts Anthropogenic Act. Ecol."},{"issue":"1","key":"10.1016\/j.envpol.2020.113956_bib9","first-page":"52","article-title":"Phenotypic and molecular identification of extended-spectrum b-lactamase (ESBL) TEM and SHV produced by clinical isolates Escherichia coli and Klebsiella spp. in hospitals","volume":"59","author":"Gonz\u00e1lez Mesa","year":"2007","journal-title":"Rev. Cuba. Med. Trop."},{"issue":"3","key":"10.1016\/j.envpol.2020.113956_bib10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.mib.2011.04.009","article-title":"Antibiotic resistance gene spread due to manure application on agricultural fields","volume":"14","author":"Heuer","year":"2011","journal-title":"Curr. Opin. Microbiol."},{"issue":"9","key":"10.1016\/j.envpol.2020.113956_bib11","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.tim.2014.05.005","article-title":"Fate and effects of veterinary antibiotics in soil","volume":"22","author":"Jechalke","year":"2014","journal-title":"Trends Microbiol."},{"issue":"12","key":"10.1016\/j.envpol.2020.113956_bib12","doi-asserted-by":"crossref","first-page":"9075","DOI":"10.1007\/s11356-013-1924-2","article-title":"Occurrence and sources of antibiotics and their metabolites in river water, WWTPs, and swine wastewater in Jiulongjiang River basin, south China","volume":"20","author":"Jiang","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2020.113956_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.chemosphere.2017.12.176","article-title":"Effects of direct current on Klebsiella spp. viability and corresponding resistance gene expression in simulative bio-electrochemical reactors","volume":"196","author":"Li","year":"2017","journal-title":"Chemosphere"},{"issue":"AUG","key":"10.1016\/j.envpol.2020.113956_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cej.2015.01.041","article-title":"Hydrothermal treatment of antibiotic mycelial dreg: more understanding from fuel characteristics","volume":"273","author":"Ma","year":"2015","journal-title":"Chem. Eng. J."},{"issue":"6","key":"10.1016\/j.envpol.2020.113956_bib15","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/jac\/dkm336","article-title":"Detailed structure of integrons and transposons carried by large conjugative plasmids responsible for multidrug resistance in diverse genomic types of Salmonella enterica serovar Brandenburg","volume":"60","author":"Martinez","year":"2007","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.envpol.2020.113956_bib16","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.watres.2017.01.010","article-title":"Removal of antibiotic resistance genes from wastewater treatment plant effluent by coagulation","volume":"111","author":"Na","year":"2017","journal-title":"Water Res."},{"issue":"5","key":"10.1016\/j.envpol.2020.113956_bib17","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1128\/JCM.43.5.2291-2302.2005","article-title":"Microarray-based detection of 90 antibiotic resistance genes of gram-positive bacteria","volume":"43","author":"Perreten","year":"2005","journal-title":"J.\u00a0Clin. Microbiol."},{"issue":"3","key":"10.1016\/j.envpol.2020.113956_bib18","first-page":"701","article-title":"Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against \u03b2-lactam antibiotics","volume":"70","author":"R\u00e9gis","year":"2014","journal-title":"J.\u00a0Antimicrob. Chemother."},{"issue":"15","key":"10.1016\/j.envpol.2020.113956_bib19","doi-asserted-by":"crossref","first-page":"8b","DOI":"10.1021\/acs.est.8b01888","article-title":"Photocatalytic reactive ultrafiltration membrane for removal of antibiotic resistant bacteria and antibiotic resistance genes from wastewater effluent","volume":"52","author":"Ren","year":"2018","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.envpol.2020.113956_bib20","first-page":"329","article-title":"Antibiotic resistance of Vibrio species isolated from Sparus aurata reared in Italian mariculture","volume":"37","author":"Scarano","year":"2014","journal-title":"New Microbiol."},{"issue":"4","key":"10.1016\/j.envpol.2020.113956_bib21","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.biortech.2012.03.045","article-title":"Fate of tetracycline, sulfonamide and fluoroquinolone resistance genes and the changes in bacterial diversity during composting of swine manure","volume":"126","author":"Selvam","year":"2012","journal-title":"Bioresour. Technol."},{"issue":"2","key":"10.1016\/j.envpol.2020.113956_bib22","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ijmm.2014.12.015","article-title":"Self-resistance mechanisms of actinomycetes producing lipid II-targeting antibiotics","volume":"305","author":"Stegmann","year":"2015","journal-title":"Int. J. Med. Microbiol."},{"issue":"12","key":"10.1016\/j.envpol.2020.113956_bib23","doi-asserted-by":"crossref","first-page":"7356","DOI":"10.1021\/acs.est.5b01012","article-title":"Antibiotic resistome and its association with bacterial communities during sewage sludge composting","volume":"49","author":"Su","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2020.113956_bib24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.procbio.2019.01.004","article-title":"New insights into the rapid formation of initial membrane fouling after in-situ cleaning in a membrane bioreactor","volume":"78","author":"Sun","year":"2019","journal-title":"Process Biochem."},{"issue":"5","key":"10.1016\/j.envpol.2020.113956_bib25","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1111\/1462-2920.12421","article-title":"Antimicrobial resistance and antimicrobial resistance genes in marine bacteria from salmon aquaculture and non-aquaculture sites","volume":"16","author":"Syed","year":"2014","journal-title":"Environ. Microbiol."},{"issue":"16","key":"10.1016\/j.envpol.2020.113956_bib26","doi-asserted-by":"crossref","first-page":"9079","DOI":"10.1021\/es502615e","article-title":"High throughput profiling of antibiotic resistance genes in urban park soils with reclaimed water irrigation","volume":"48","author":"Wang","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"5","key":"10.1016\/j.envpol.2020.113956_bib27","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1111\/1462-2920.12578","article-title":"Functional characterization and phylogenetic analysis of acquired and intrinsic macrolide phosphotransferases in the Bacillus cereus group","volume":"17","author":"Wang","year":"2015","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.envpol.2020.113956_bib28","first-page":"1","article-title":"Assessing the stability in dry mycelial fertilizer of Penicillium chrysogenum as soil amendment via fluorescence excitation-emission matrix spectra: organic matter\u2019s transformation and maturity","author":"Wang","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2020.113956_bib29","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.scitotenv.2018.04.288","article-title":"Assessing the safety of thermally processed penicillin mycelial dreg following the soil application: organic matter\u2019s maturation and antibiotic resistance genes","volume":"636","author":"Wang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2020.113956_bib30","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.scitotenv.2018.05.213","article-title":"Identification of a bacteriophage from an environmental multidrug-resistant E. coli isolate and its function in horizontal transfer of ARGs","volume":"639","author":"Wang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2020.113956_bib31","doi-asserted-by":"crossref","first-page":"113392","DOI":"10.1016\/j.envpol.2019.113392","article-title":"Dosage effects of lincomycin mycelial residues on lincomycin resistance genes and soil microbial communities","volume":"256","author":"Wang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2020.113956_bib32","first-page":"S485289576","article-title":"Impacts of biochar on the environmental risk of antibiotic resistance genes and mobile genetic elements during anaerobic digestion of cattle farm wastewater","volume":"256","author":"Wei","year":"2018","journal-title":"Bioresour. Technol."},{"issue":"22","key":"10.1016\/j.envpol.2020.113956_bib33","first-page":"683","article-title":"Corrigendum: antibacterial activities of bacteriocins: application in foods and pharmaceuticals","volume":"5","author":"Yang","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2020.113956_bib34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.biortech.2016.01.004","article-title":"Maturity and security assessment of pilot-scale aerobic co-composting of penicillin fermentation dregs (PFDs) with sewage sludge","volume":"204","author":"Yang","year":"2016","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.envpol.2020.113956_bib35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.biortech.2015.05.014","article-title":"Anaerobic digestion of antibiotic residue in combination with hydrothermal pretreatment for biogas","volume":"192","author":"Zhang","year":"2015","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.envpol.2020.113956_bib36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cej.2016.04.020","article-title":"Assessing the stability in composting of penicillin mycelial dreg via parallel factor (PARAFAC) analysis of fluorescence excitation\u2013emission matrix (EEM)","volume":"299","author":"Zhang","year":"2016","journal-title":"Chem. Eng. J."},{"issue":"1","key":"10.1016\/j.envpol.2020.113956_bib37","first-page":"7b","article-title":"Cell-free DNA: a neglected source for antibiotic resistance genes spreading from WWTPs","volume":"52","author":"Zhang","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.envpol.2020.113956_bib38","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s40168-018-0516-2","article-title":"Conserved phylogenetic distribution and limited antibiotic resistance of class 1 integrons revealed by assessing the bacterial genome and plasmid collection","volume":"6","author":"Zhang","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.envpol.2020.113956_bib39","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bej.2019.04.016","article-title":"Fate of NaClO and membrane foulants during in-situ cleaning of membrane bioreactors: combined effect on thermodynamic properties of sludge","volume":"147","author":"Zhang","year":"2019","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.envpol.2020.113956_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.scitotenv.2017.08.072","article-title":"Antibiotic resistome promotion in drinking water during biological activated carbon treatment: is it influenced by quorum sensing?","volume":"612","author":"Zheng","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"9","key":"10.1016\/j.envpol.2020.113956_bib41","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1073\/pnas.1222743110","article-title":"Diverse and abundant antibiotic resistance genes in Chinese swine farms","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"2","key":"10.1016\/j.envpol.2020.113956_bib42","first-page":"139","article-title":"Comparison of definitions of the lag phase and the exponential phase in bacterial growth","volume":"72","author":"Zwietering","year":"2010","journal-title":"J.\u00a0Appl. Microbiol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749119353370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749119353370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T21:27:13Z","timestamp":1759440433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749119353370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":42,"alternative-id":["S0269749119353370"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2020.113956","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk of penicillin fermentation dreg: Increase of antibiotic resistance genes after soil discharge","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2020.113956","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113956"}}