{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:21:11Z","timestamp":1775845271103,"version":"3.50.1"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["201600600010003"],"award-info":[{"award-number":["201600600010003"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.envpol.2021.116560","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T23:23:19Z","timestamp":1611444199000},"page":"116560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["4-Octylphenol induces developmental abnormalities and interferes the differentiation of neural crest cells in Xenopus laevis embryos"],"prefix":"10.1016","volume":"274","author":[{"given":"Yang","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8274-4115","authenticated-orcid":false,"given":"Ji Hyun","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-3709","authenticated-orcid":false,"given":"Myung Chan","family":"Gye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2021.116560_bib1","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1101\/gad.1171104","article-title":"Interactions between Sox9 and beta-catenin control chondrocyte differentiation","volume":"18","author":"Akiyama","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.envpol.2021.116560_bib2","series-title":"ASTM E 1439-1498 Standard Guide for Conducting the Frog Embryo Teratogenesis Assay-Xenopus (FETAX)","year":"2004"},{"key":"10.1016\/j.envpol.2021.116560_bib3","series-title":"Guidelines for Use of Live Amphibians and Reptiles in Field and Laboratory Research","year":"2004"},{"key":"10.1016\/j.envpol.2021.116560_bib4","first-page":"299","article-title":"Characterization of a cytosolic estrogen receptor and its up-regulation by 17 beta-estradiol and the xenoestrogen 4-tert-octylphenol in the liver of eelpout (Zoarces viviparus)","volume":"125","author":"Andreassen","year":"2000","journal-title":"Comp. Biochem. Physiol. C."},{"key":"10.1016\/j.envpol.2021.116560_bib5","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1016\/j.lfs.2003.09.066","article-title":"Nonylphenol enhances apoptosis induced by serum deprivation in PC12 cells","volume":"74","author":"Aoki","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.envpol.2021.116560_bib6","doi-asserted-by":"crossref","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.envpol.2021.116560_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.etap.2017.02.016","article-title":"Effects of octylphenol on the expression of StAR, CYP17 and CYP19 in testis of Rana chensinensis","volume":"51","author":"Bai","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2021.116560_bib8","series-title":"Isooctylphenol Subchronic Toxicological Experiments with Rats, 03\/16\/82","author":"Bayer","year":"2000"},{"key":"10.1016\/j.envpol.2021.116560_bib9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/humrep\/16.2.236","article-title":"Effect of 4-octylphenol on germ cell number in cultured human fetal gonads","volume":"16","author":"Bendsen","year":"2001","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.envpol.2021.116560_bib10","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1289\/ehp.5500","article-title":"Environmental estrogens alter early development in Xenopus laevis","volume":"111","author":"Bevan","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2021.116560_bib11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/8792","article-title":"Sox9 is required for cartilage formation","volume":"22","author":"Bi","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.envpol.2021.116560_bib12","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1016\/S0021-9258(18)32488-8","article-title":"A\u00a0study of the reactivity of HO2\/O2- with unsaturated fatty acids","volume":"258","author":"Bielski","year":"1983","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.envpol.2021.116560_bib13","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/0043-1354(94)00340-D","article-title":"Concentrations of alkylphenols in rivers and estuaries in England and Wales","volume":"29","author":"Blackburn","year":"1995","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2021.116560_bib14","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.1016\/j.scitotenv.2009.05.047","article-title":"Developmental toxicity, uptake and distribution of sodium chromate assayed by frog embryo teratogenesis assay-Xenopus (FETAX)","volume":"407","author":"Bosisio","year":"2009","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.116560_bib15","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/clinchem\/46.6.829","article-title":"HPLC analysis of lipidderived polyunsaturated fatty acid peroxidation products in oxidatively modified human plasma","volume":"46","author":"Browne","year":"2000","journal-title":"Clin. Chem."},{"key":"10.1016\/j.envpol.2021.116560_bib16","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/s41467-019-09010-6","article-title":"Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance","volume":"10","author":"Brock","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2021.116560_bib17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.envres.2018.01.028","article-title":"Endocrine disrupting chemicals in seminal plasma and couple fecundity","volume":"163","author":"Buck-Louis","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2021.116560_bib18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.scitotenv.2016.09.095","article-title":"Comparative study of diclofenac-induced embryotoxicity and teratogenesis in Xenopus laevis and Lithobates catesbeianus, using the frog embryo teratogenesis assay: Xenopus (FETAX)","volume":"1","author":"Cardoso-Cera","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.116560_bib19","series-title":"Letter from CHEM MFGS ASSN to U.S. EPA regarding submission of study protocols and additional comments on proposed voluntary testing program for octyphenol with attachments","year":"1983"},{"key":"10.1016\/j.envpol.2021.116560_bib20","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.chemosphere.2017.12.085","article-title":"Distribution and fate modeling of 4-nonylphenol, 4-t-octylphenol, and bisphenol A in the Yong river of China","volume":"195","author":"Cheng","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.116560_bib21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5114\/pdia.2013.33376","article-title":"Skin melanocytes: biology and development","volume":"30","author":"Cichorek","year":"2013","journal-title":"Postepy Dermatol. Alergol."},{"key":"10.1016\/j.envpol.2021.116560_bib22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1242\/dev.117.2.409","article-title":"The triple origin of skull in higher vertebrates: a study in quail-chick chimeras","volume":"117","author":"Couly","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.envpol.2021.116560_bib23","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1002\/etc.232","article-title":"Preexposure to ultraviolet B radiation and 4-tert-octylphenol affects the response of Rana pipiens tadpoles to 3,5,3\u2019-triiodothyronine","volume":"29","author":"Croteau","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2021.116560_bib24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an Endocrine Society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.envpol.2021.116560_bib25","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3390\/ijms17071144","article-title":"Signaling pathways in melanogenesis","volume":"17","author":"D\u2019Mello","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2021.116560_bib26","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.chemosphere.2014.10.082","article-title":"Seasonal and spatial distribution of 4-nonylphenol and 4-tert-octylphenol in the sediment of Kaohsiung Harbor, Taiwan","volume":"134","author":"Dong","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.116560_bib27","series-title":"Nonylphenol (NP) and Nonylphenal Ethoxylates (NPEs) Action Plan","year":"2010"},{"key":"10.1016\/j.envpol.2021.116560_bib28","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.yexcr.2010.02.042","article-title":"Cellular origin and developmental mechanisms during the formation of skin melanocytes","volume":"316","author":"Ernfors","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.envpol.2021.116560_bib29","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/cdd.2017.47","article-title":"Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease","volume":"24","author":"Fogarty","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.envpol.2021.116560_bib30","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00244-005-0217-2","article-title":"Comparative developmental toxicity of nickel to Gastrophryne carolinensis, Bufo terrestris, and Xenopus laevis","volume":"51","author":"Fort","year":"2006","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envpol.2021.116560_bib31","first-page":"412","article-title":"Biology of disease: free radicals and tissue injury","volume":"47","author":"Freeman","year":"1982","journal-title":"Lab. Invest."},{"key":"10.1016\/j.envpol.2021.116560_bib32","doi-asserted-by":"crossref","first-page":"12752","DOI":"10.1128\/JVI.02138-14","article-title":"The endoplasmic reticulum stress sensor IRE1\u03b1 protects cells from apoptosis induced by the coronavirus infectious bronchitis virus","volume":"88","author":"Fung","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.envpol.2021.116560_bib33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.aquatox.2014.07.019","article-title":"Nonmonotonic response of vitellogenin and estrogen receptor \u03b1 gene expression after octylphenol exposure of Cichlasoma dimerus (Perciformes, Cichlidae)","volume":"156","author":"Genovese","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2021.116560_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquatox.2012.02.005","article-title":"Time-course recovery of estrogen-responsive genes of a cichlid fish exposed to waterborne octylphenol","volume":"114\u2013115","author":"Genovese","year":"2012","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2021.116560_bib35","first-page":"2587","article-title":"Reproductive success and behavior of Japanese medaka (Oryzias latipes) exposed to 4-tert-octylphenol","volume":"18","author":"Gray","year":"2009","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envpol.2021.116560_bib36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1289\/ehp.99107385","article-title":"Serum vitellogenin levels and reproductive impairment of male Japanese medaka (Oryzias latipes) exposed to 4-tert-octylphenol","volume":"107","author":"Gronen","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2021.116560_bib37","doi-asserted-by":"crossref","first-page":"18304","DOI":"10.1038\/srep18304","article-title":"PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response","volume":"5","author":"Gupta","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2021.116560_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2190001","article-title":"Oxygen toxicity, oxygen radicals, transition metals and disease","volume":"219","author":"Halliwell","year":"1984","journal-title":"Biochem. J."},{"key":"10.1016\/j.envpol.2021.116560_bib39","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/jat.3330","article-title":"Development of the larval amphibian growth and development assay: effects of chronic 4-tert-octylphenol or 17\u03b2-trenbolone exposure in Xenopus laevis from embryo to juvenile","volume":"36","author":"Haselman","year":"2016","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.envpol.2021.116560_bib40","series-title":"Chemical Toxicity Test Report 1","first-page":"361","year":"1994"},{"key":"10.1016\/j.envpol.2021.116560_bib41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.etap.2006.07.004","article-title":"Multigenerational study of the hepatic effects exerted by the consumption of nonylphenol- and 4-octylphenol-contaminated drinking water in Sprague-Dawley rats","volume":"23","author":"Hern\u00e1ndez-Rodr\u00edguez","year":"2007","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2021.116560_bib42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jhazmat.2016.08.075","article-title":"Toxicity mechanisms and synergies of silver nanoparticles in 2,4-dichlorophenol degradation by Phanerochaete chrysosporium","volume":"321","author":"Huang","year":"2017","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.envpol.2021.116560_bib43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cub.2003.12.032","article-title":"Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae","volume":"14","author":"Jaklevic","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.envpol.2021.116560_bib44","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/jez.609","article-title":"Effects of exposure to the xenoestrogen octylphenol and subsequent transfer to clean water on liver and gonad ultrastructure during early development of Zoarces viviparus embryos","volume":"313","author":"Jespersen","year":"2010","journal-title":"J.\u00a0Exp. Zool. A. Ecol. Genet. Physiol."},{"key":"10.1016\/j.envpol.2021.116560_bib45","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/etc.5620150218","article-title":"Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals","volume":"15","author":"Jobling","year":"1996","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2021.116560_bib46","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1242\/dev.01429","article-title":"Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells","volume":"131","author":"Joseph","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.envpol.2021.116560_bib47","first-page":"105","article-title":"Effects of 4-tert-Octylphenol on the incubation of eggs in Japanese brown frogs (Rana japonica)","volume":"22","author":"Kawaguchi","year":"2008","journal-title":"In\u00a0Vivo"},{"key":"10.1016\/j.envpol.2021.116560_bib48","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1126\/science.6844926","article-title":"Neural crest cells contribute to normal aorticopulmonary septation","volume":"220","author":"Kirby","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.envpol.2021.116560_bib49","doi-asserted-by":"crossref","first-page":"80","DOI":"10.5004\/dwt.2010.1954","article-title":"Determination of nonylphenol ethoxylates in wastewater samples with SPME\/GC-MS","volume":"23","author":"Klontza","year":"2010","journal-title":"Desalin. Water Treat."},{"key":"10.1016\/j.envpol.2021.116560_bib50","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/eesa.2001.2123","article-title":"Decline in reproductive success, sex reversal, and developmental alterations in Japanese medaka (Oryzias latipes) after continuous exposure to octylphenol","volume":"51","author":"Kn\u00f6rr","year":"2002","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2021.116560_bib51","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/etc.5620210906","article-title":"Analysis of trace organic contaminants in sediment, pore water, and water samples from Onsan Bay, Korea: instrumental analysis and in\u00a0vitro gene expression assay","volume":"21","author":"Koh","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2021.116560_bib52","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1007\/s11270-014-2040-8","article-title":"Alkylphenols in surface sediments of the gulf of Gdansk (Baltic sea)","volume":"225","author":"Koniecko","year":"2014","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.envpol.2021.116560_bib53","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1242\/dev.105536","article-title":"A\u00a0pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation","volume":"142","author":"Kozhemyakina","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.envpol.2021.116560_bib54","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.etap.2008.08.009","article-title":"Mutual synergistic toxicity between environmental toxicants: a study of mercury chloride and 4-nonylphenol","volume":"27","author":"Lee","year":"2009","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2021.116560_bib55","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ecoenv.2016.02.013","article-title":"Octylphenol induced gene expression in testes of frog, Rana chensinensis","volume":"128","author":"Li","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2021.116560_bib56","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.trac.2007.10.011","article-title":"Laboratory intercomparison study for the analysis of nonylphenol and octylphenol in river water","volume":"27","author":"Loos","year":"2008","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.envpol.2021.116560_bib57","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0166-445X(03)00106-1","article-title":"Estrogenic effects in flounder Platichthys flesus orally exposed to 4-tert-octylphenol","volume":"64","author":"Madsen","year":"2003","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2021.116560_bib58","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1080\/17460441.2017.1367281","article-title":"Advances in the use of Xenopus for successful drug screening","volume":"12","author":"Maia","year":"2017","journal-title":"Expet Opin. Drug Discov."},{"key":"10.1016\/j.envpol.2021.116560_bib59","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1242\/dev.091751","article-title":"The neural crest","volume":"140","author":"Mayor","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.envpol.2021.116560_bib60","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-1-4939-7172-5_17","article-title":"FETAX assay for evaluation of developmental toxicity","volume":"1641","author":"Mouche","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.envpol.2021.116560_bib61","doi-asserted-by":"crossref","first-page":"30458","DOI":"10.3390\/ijms161226207","article-title":"Understanding melanocyte Stem cells for disease modeling and regenerative medicine applications","volume":"16","author":"Mull","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2021.116560_bib62","first-page":"295","article-title":"Lipid peroxidation and tissue damage","volume":"13","author":"Mylonas","year":"1999","journal-title":"Vivo"},{"key":"10.1016\/j.envpol.2021.116560_bib63","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0890-6238(01)00173-3","article-title":"Reproductive effects in male and female rats from neonatal exposure to p-octylphenol","volume":"15","author":"Nagao","year":"2001","journal-title":"Reprod. Toxicol. Nov."},{"key":"10.1016\/j.envpol.2021.116560_bib64","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.chemosphere.2011.01.061","article-title":"Acute effects of Fe2O3, TiO2, ZnO and CuO nanomaterials on Xenopus laevis","volume":"83","author":"Nations","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.116560_bib65","series-title":"Normal Table\u00a0of Xenopus laevis (Daudin)","author":"Nieuwkoop","year":"1967"},{"key":"10.1016\/j.envpol.2021.116560_bib66","series-title":"US National Institute for Occupational Safety and Health (NIOSH) RTECS Database","year":"2017"},{"key":"10.1016\/j.envpol.2021.116560_bib67","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1242\/dev.124.12.2377","article-title":"Melanocyte development in\u00a0vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor","volume":"124","author":"Opdecamp","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.envpol.2021.116560_bib68","first-page":"335","article-title":"The development of the neural crest in the human","volume":"211","author":"O\u2019Rahilly","year":"2007","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.envpol.2021.116560_bib69","series-title":"OECD SIDS Initial Assessment Profile","year":"2005"},{"key":"10.1016\/j.envpol.2021.116560_bib70","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.chemosphere.2010.08.039","article-title":"Effects of nonylphenol on early embryonic development, pigmentation and 3,5,3\u2019-triiodothyronine-induced metamorphosis in Xenopus laevis (Amphibia: Anura)","volume":"81","author":"Park","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.116560_bib71","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/etc.2519","article-title":"Developmental toxicity of treated municipal wastewater effluent on Xenopus laevis (Amphibia: Anura) embryos","volume":"33","author":"Park","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2021.116560_bib72","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.aquatox.2014.08.013","article-title":"Sensitization of vitellogenin gene expression by low doses of octylphenol is mediated by estrogen receptor autoregulation in the Xenopus laevis (Boulenger) male liver","volume":"156","author":"Park","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2021.116560_bib73","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.aquatox.2016.06.022","article-title":"Developmental and acute toxicity of cetylpyridinium chloride in Xenopus laevis (Amphibia: Anura)","volume":"177","author":"Park","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2021.116560_bib74","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1242\/dev.127.24.5367","article-title":"Ectopic Hoxa2 induction after neural crest migration results in homeosis of jaw elements in Xenopus","volume":"127","author":"Pasqualetti","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.envpol.2021.116560_bib75","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0166-445X(02)00107-8","article-title":"Estrogenic effect of dietary 4-tert-octylphenol in rainbow trout (Oncorhynchus mykiss)","volume":"62","author":"Pedersen","year":"2003","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2021.116560_bib76","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1242\/dev.01432","article-title":"Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila","volume":"131","author":"Perez-Garijo","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.envpol.2021.116560_bib77","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.aquatox.2011.02.019","article-title":"Effects of 4-tert-octylphenol on Xenopus tropicalis in a long-term exposure","volume":"103","author":"Porter","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2021.116560_bib79","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1039\/C0EM00204F","article-title":"Occurrence of estrogenic chemicals in South Korean surface waters and municipal wastewaters","volume":"13","author":"Ra","year":"2011","journal-title":"J.\u00a0Environ. Monit."},{"key":"10.1016\/j.envpol.2021.116560_bib80","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.cbpc.2009.05.012","article-title":"Exposure to waterborne 4-tert-octylphenol induces vitellogenin synthesis and disrupts testis morphology in the South American freshwater fish Cichlasoma dimerus (Teleostei, Perciformes)","volume":"150","author":"Rey-V\u00e1zquez","year":"2009","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2021.116560_bib81","series-title":"Experimental Embryology","author":"Rugh","year":"1962"},{"key":"10.1016\/j.envpol.2021.116560_bib82","first-page":"134","article-title":"Cranial muscles in amphibians: development, novelties and the role of cranial neural crest cells","volume":"222","author":"Schmidt","year":"2013","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.envpol.2021.116560_bib83","first-page":"226","article-title":"A\u00a0role for FoxN3 in the development of cranial cartilages and muscles in Xenopus laevis (Amphibia: Anura: Pipidae) with special emphasis on the novel rostral cartilages","volume":"218","author":"Schmidt","year":"2011","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.envpol.2021.116560_bib84","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1021\/tx700357u","article-title":"Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized products","volume":"21","author":"Schneider","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2021.116560_bib85","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/dvdy.21007","article-title":"FoxN3 is required for craniofacial and eye development of Xenopus laevis","volume":"236","author":"Schuff","year":"2007","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.envpol.2021.116560_bib86","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.chemosphere.2014.04.073","article-title":"Vitellogenin of the northern leopard frog (Rana pipiens): development of an ELISA assay and evaluation of induction after immersion in xenobiotic estrogens","volume":"112","author":"Selcer","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.116560_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.1993.1217","article-title":"Origins of neural crest cell diversity","volume":"159","author":"Selleck","year":"1993","journal-title":"Dev. Biol."},{"key":"10.1016\/j.envpol.2021.116560_bib88","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.13722","article-title":"The cell proliferation antigen Ki-67 organises heterochromatin","volume":"5","author":"Sobecki","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.envpol.2021.116560_bib90","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/S0043-1354(00)00445-0","article-title":"Evaluation of 4-nonylphenols and 4-tert-octylphenol contamination of fish in rivers by laboratory accumulation and excretion experiments","volume":"35","author":"Tsuda","year":"2001","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2021.116560_bib91","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1590\/S0365-05962013000100009","article-title":"Mechanisms regulating melanogenesis","volume":"88","author":"Videira","year":"2013","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.envpol.2021.116560_bib92","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1292\/jvms.66.635","article-title":"Study of migration of neural crest cells to adrenal medulla by three-dimensional reconstruction","volume":"66","author":"Yamamoto","year":"2004","journal-title":"J.\u00a0Vet. Med. Sci."},{"key":"10.1016\/j.envpol.2021.116560_bib93","first-page":"603","article-title":"Investigation and environmental risk assessment of nonylphenol, octylphenol and bisphenol A in sediments of Xiangjiang River, Zunyi","volume":"7","author":"Yang","year":"2019","journal-title":"J.\u00a0Environ. Health"},{"key":"10.1016\/j.envpol.2021.116560_bib94","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1038\/s41598-018-21725-y","article-title":"Nonylphenol aggravates non-alcoholic fatty liver disease in high sucrose-high fat diet-treated rats","volume":"8","author":"Yu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2021.116560_bib95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.scitotenv.2015.08.031","article-title":"Overuse or Underuse? An observation of pesticide use in China","volume":"538","author":"Zhang","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.116560_bib96","doi-asserted-by":"crossref","first-page":"25935","DOI":"10.1074\/jbc.R400008200","article-title":"Signaling the unfolded protein response from the endoplasmic reticulum","volume":"279","author":"Zhang","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.envpol.2021.116560_bib97","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12177-011-9075-5","article-title":"Endoplasmic reticulum stress and inflammation: mechanisms and implications in diabetic retinopathy","volume":"4","author":"Zhang","year":"2011","journal-title":"J.\u00a0Ocul. Biol. Dis. Infor."},{"key":"10.1016\/j.envpol.2021.116560_bib98","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0300-483X(02)00046-X","article-title":"Evaluation of acute hepatotoxic effects exerted by environmental estrogens nonylphenol and 4-octylphenol in immature male rats","volume":"175","author":"Zumbado","year":"2002","journal-title":"Toxicology"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974912100138X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974912100138X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T21:45:57Z","timestamp":1759441557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026974912100138X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":96,"alternative-id":["S026974912100138X"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2021.116560","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"4-Octylphenol induces developmental abnormalities and interferes the differentiation of neural crest cells in Xenopus laevis embryos","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2021.116560","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116560"}}