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A."},{"key":"10.1016\/j.envpol.2021.116706_bib76","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ecoenv.2012.03.016","article-title":"Toxicological responses of halophyte Suaeda salsa to mercury under environmentally relevant salinity Ecotoxicol","volume":"85","author":"Wu","year":"2012","journal-title":"Environ Saf"},{"key":"10.1016\/j.envpol.2021.116706_bib77","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03191","article-title":"The metal transporter ZIP13 supplies iron to the secretory pathway in Drosophila melanogaster","volume":"3","author":"Xiao","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.envpol.2021.116706_bib78","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.marpolbul.2016.07.049","article-title":"An integrative biomarker approach was used to assess the environmental stress on the north coast of the Shandong Peninsula using native oysters, Crassostrea gigas","volume":"112","author":"Xie","year":"2016","journal-title":"Mar. 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