{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:54:53Z","timestamp":1791410093005,"version":"4.3.3"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.envpol.2021.116933","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T04:59:53Z","timestamp":1616043593000},"page":"116933","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Multiple bioanalytical methods reveal a thyroid-disrupting mechanism related to the membrane receptor integrin \u03b1v\u03b23"],"prefix":"10.1016","volume":"279","author":[{"given":"Dongdong","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2021.116933_bib1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.tiv.2019.01.015","article-title":"Evidences for involvement of estrogen receptor induced ERK1\/2 activation in ovarian cancer cell proliferation by cadmium chloride","volume":"56","author":"Ataei","year":"2019","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1016\/j.envpol.2021.116933_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.gendis.2018.12.001","article-title":"Forskolin and Phorbol 12-myristate 13-acetate modulates the expression pattern of AP-1 factors and cell cycle regulators in estrogen-responsive MCF-7 cells","volume":"6","author":"Babu","year":"2018","journal-title":"Genes Dis"},{"key":"10.1016\/j.envpol.2021.116933_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.molimm.2017.08.022","article-title":"Effect of lentivirus-mediated gene silencing, targeting toll-like receptor 2, on corneal allograft transplantation in rats","volume":"91","author":"Bai","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.envpol.2021.116933_bib4","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.scitotenv.2017.09.013","article-title":"Emergent contaminants: endocrine disruptors and their laccase-assisted degradation - a review","volume":"612","author":"Barrios-Estrada","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.116933_bib5","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1210\/en.2005-0102","article-title":"Integrin alphaVbeta3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and induction of angiogenesis","volume":"146","author":"Bergh","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2021.116933_bib6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mrrev.2012.03.001","article-title":"DEHP: genotoxicity and potential carcinogenic mechanisms-a review","volume":"751","author":"Caldwell","year":"2018","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envpol.2021.116933_bib7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ygcen.2003.12.003","article-title":"Rapid effects of 17beta-estradiol on cell signaling and function of Mytilus hemocytes","volume":"136","author":"Canesi","year":"2004","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.envpol.2021.116933_bib8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jsbmb.2013.09.010","article-title":"Estrogen receptor-mediated transcription involves the activation of multiple kinase pathways in neuroblastoma cells","volume":"139","author":"Clark","year":"2014","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.envpol.2021.116933_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.steroids.2006.11.008","article-title":"Molecular modeling of the thyroid hormone interactions with alpha v beta 3 integrin","volume":"72","author":"Cody","year":"2007","journal-title":"Steroids"},{"key":"10.1016\/j.envpol.2021.116933_bib10","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1158\/1541-7786.MCR-11-0187","article-title":"Thyroid hormone is a MAPK dependent growth factor for human myeloma cells acting via \u03b1v\u03b23 integrin","volume":"9","author":"Cohen","year":"2011","journal-title":"Mol. Canc. Res."},{"key":"10.1016\/j.envpol.2021.116933_bib11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jsbmb.2010.12.020","article-title":"Estrogenic effect of the MEK1 inhibitor PD98059 on endogenous estrogen receptor alpha and beta","volume":"124","author":"Cotrim","year":"2011","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.envpol.2021.116933_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bj3510095","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors","volume":"351","author":"Davies","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.envpol.2021.116933_bib68","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.yfrne.2007.09.003","article-title":"Mechanisms of nongenomic actions of thyroid hormone","volume":"29","author":"Davis","year":"2008","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.envpol.2021.116933_bib13","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1021\/es9037287","article-title":"Ecotoxicogenomics: bridging the gap between genes and populations","volume":"44","author":"Fedorenkova","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.116933_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2000.10.41","article-title":"Functions of thyroid hormone receptors in mice","volume":"10","author":"Forrest","year":"2000","journal-title":"Thyroid"},{"key":"10.1016\/j.envpol.2021.116933_bib15","doi-asserted-by":"crossref","first-page":"8537","DOI":"10.1038\/s41598-020-65250-3","article-title":"Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer","volume":"10","author":"Gagliardi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2021.116933_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.toxlet.2009.05.004","article-title":"Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions","volume":"189","author":"Ghisari","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2021.116933_bib17","doi-asserted-by":"crossref","first-page":"6106","DOI":"10.1016\/j.biomaterials.2014.04.031","article-title":"Targeting efficiency of RGD-modified nanocarriers with different ligand intervals in response to integrin alphavbeta3 clustering","volume":"35","author":"Guo","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.envpol.2021.116933_bib18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.etap.2004.06.003","article-title":"T-Screen as a tool to identify thyroid hormone receptor active compounds","volume":"19","author":"Gutleb","year":"2005","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2021.116933_bib19","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.fct.2018.07.030","article-title":"Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin alphavbeta3 and IGF-1R","volume":"120","author":"Ho","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envpol.2021.116933_bib20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.aquatox.2015.01.016","article-title":"Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos\/larvae, and in GH3 and FRTL-5 cell lines","volume":"160","author":"Kim","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2021.116933_bib21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.fct.2018.12.010","article-title":"Di-2-ethylhexylphthalate promotes thyroid cell proliferation and DNA damage through activating thyrotropin-receptor-mediated pathways in\u00a0vitro and in\u00a0vivo","volume":"124","author":"Kim","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envpol.2021.116933_bib23","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.chemosphere.2018.09.007","article-title":"DnBP-induced thyroid disrupting activities in GH3 cells via integrin \u03b1v\u03b23 and ERK1\/2 activation","volume":"212","author":"Kong","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.116933_bib24","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jhep.2010.04.028","article-title":"TRbeta is the critical thyroid hormone receptor isoform in T3-induced proliferation of hepatocytes and pancreatic acinar cells","volume":"53","author":"Kowalik","year":"2010","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.envpol.2021.116933_bib25","doi-asserted-by":"crossref","first-page":"8331","DOI":"10.3390\/s130708331","article-title":"Development of an enzyme-linked immunosorbent assay for dibutyl phthalate in liquor","volume":"13","author":"Kuang","year":"2013","journal-title":"Sensors"},{"key":"10.1016\/j.envpol.2021.116933_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/09540101003758962","article-title":"Development of determination of di-n-octyl phthalate (DOP) residue by an indirect enzyme-linked immunosorbent assay","volume":"21","author":"Kuang","year":"2010","journal-title":"Food Agric. Immunol."},{"key":"10.1016\/j.envpol.2021.116933_bib27","doi-asserted-by":"crossref","first-page":"127066","DOI":"10.1016\/j.chemosphere.2020.127066","article-title":"TDCPP mimics thyroid hormones associated with the activation of integrin \u03b1v\u03b23 and ERK1\/2","volume":"256","author":"Li","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.116933_bib28","doi-asserted-by":"crossref","first-page":"126034","DOI":"10.1016\/j.chemosphere.2020.126034","article-title":"Competitive binding assays for measuring the binding affinity of thyroid-disrupting chemicals for integrin \u03b1v\u03b23","volume":"249","author":"Li","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.116933_bib29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.chemosphere.2013.11.054","article-title":"A\u00a0yeast bioassay for direct measurement of thyroid hormone disrupting effects in water without sample extraction, concentration, or sterilization","volume":"100","author":"Li","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.116933_bib30","doi-asserted-by":"crossref","first-page":"6863","DOI":"10.1021\/es101254c","article-title":"Dibutyl phthalate contributes to the thyroid receptor antagonistic activity in drinking water processes","volume":"44","author":"Li","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.116933_bib31","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.taap.2014.03.027","article-title":"Coactivation of the PI3K\/Akt and ERK signaling pathways in PCB153-induced NF-\u03baB activation and caspase inhibition","volume":"277","author":"Liu","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2021.116933_bib32","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tiv.2017.12.006","article-title":"Fluorochloridone induces primary cultured Sertoli cells apoptosis: involvement of ROS and intracellular calcium ions-mediated ERK1\/2 activation","volume":"47","author":"Liu","year":"2018","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1016\/j.envpol.2021.116933_bib33","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.envpol.2016.03.005","article-title":"Probabilistic assessment of risks of diethylhexyl phthalate (DEHP) in surface waters of China on reproduction of fish","volume":"213","author":"Liu","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.116933_bib34","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/j.jes.2014.08.008","article-title":"Molecular characterization and developmental expression patterns of thyroid hormone receptors (TRs) and their responsiveness to TR agonist and antagonist in Rana nigromaculata","volume":"26","author":"Lou","year":"2014","journal-title":"J.\u00a0Environ. Sci. (China)"},{"key":"10.1016\/j.envpol.2021.116933_bib35","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/10937400903094091","article-title":"Reproductive and developmental toxicity of phthalates","volume":"12","author":"Lyche","year":"2009","journal-title":"J.\u00a0Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.envpol.2021.116933_bib36","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.tiv.2013.02.012","article-title":"Mechanism-based testing strategy using in\u00a0vitro approaches for identification of thyroid hormone disrupting chemicals","volume":"27","author":"Murk","year":"2013","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1016\/j.envpol.2021.116933_bib37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1043-2760(99)00232-5","article-title":"Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor","volume":"11","author":"Naor","year":"2000","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.envpol.2021.116933_bib38","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbrc.2009.03.061","article-title":"Possible involvement of mitogen-activated protein kinase phosphatase-1 (MKP-1) in thyrotropin-releasing hormone (TRH)-induced prolactin gene expression","volume":"382","author":"Oride","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envpol.2021.116933_bib39","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.chemosphere.2017.09.123","article-title":"Di(2-ethylhexyl) phthalate and diethyl phthalate disrupt lipid metabolism, reduce fecundity and shortens lifespan of Caenorhabditis elegans","volume":"190","author":"Pradhan","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.116933_bib40","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ejmech.2007.06.009","article-title":"Molecular modeling studies of phenoxypyrimidinyl imidazoles as p38 kinase inhibitors using QSAR and docking","volume":"43","author":"Ravindra","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.envpol.2021.116933_bib41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.phrs.2019.01.039","article-title":"Targeting ERK1\/2 protein-serine\/threonine kinases in human cancers","volume":"142","author":"Roskoski","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.envpol.2021.116933_bib42","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1210\/en.2013-1435","article-title":"The targeted inactivation of TRbeta gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production","volume":"155","author":"Selmi-Ruby","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2021.116933_bib43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.envint.2011.05.013","article-title":"Thyroid hormone disrupting activities associated with phthalate esters in water sources from Yangtze River Delta","volume":"42","author":"Shi","year":"2012","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2021.116933_bib44","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1210\/en.2003-0742","article-title":"Disparate effects of thyroid hormone on actions of epidermal growth factor and transforming growth factor-alpha are mediated by 3\u2019,5\u2019-cyclic adenosine 5\u2019-monophosphate-dependent protein kinase II","volume":"145","author":"Shih","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2021.116933_bib45","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1039\/C8SC00043C","article-title":"Isoform-selective activity-based profiling of ERK signaling","volume":"9","author":"Shin","year":"2018","journal-title":"Chem. Sci."},{"key":"10.1016\/j.envpol.2021.116933_bib46","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1038\/onc.2015.262","article-title":"The thyroid hormone-\u03b1v\u03b23 integrin axis in ovarian cancer: regulation of gene transcription and MAPK-dependent proliferation","volume":"35","author":"Shinderman-Maman","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.envpol.2021.116933_bib47","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.matbio.2013.09.002","article-title":"Cross-talk between estradiol receptor and EGFR\/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of proteoglycans","volume":"35","author":"Skandalis","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.envpol.2021.116933_bib48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/toxsci\/kfi330","article-title":"Detection of thyroid system-disrupting chemicals using in\u00a0vitro and in\u00a0vivo screening assays in Xenopus laevis","volume":"88","author":"Sugiyama","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2021.116933_bib49","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.abb.2017.04.003","article-title":"FBXO25 regulates MAPK signaling pathway through inhibition of ERK1\/2 phosphorylation","volume":"621","author":"Teixeira","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.envpol.2021.116933_bib50","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/1097-0274(200101)39:1<100::AID-AJIM10>3.0.CO;2-Q","article-title":"Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a Critical Review","volume":"39","author":"Tickner","year":"2001","journal-title":"Ind Med"},{"key":"10.1016\/j.envpol.2021.116933_bib51","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.chemosphere.2014.07.088","article-title":"Chlorpyrifos inhibits cell proliferation through ERK1\/2 phosphorylation in breast cancer cell lines","volume":"120","author":"Ventura","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.116933_bib52","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.steroids.2006.11.002","article-title":"Xenoestrogens are potent activators of nongenomic estrogenic responses","volume":"72","author":"Watson","year":"2007","journal-title":"Steroids"},{"key":"10.1016\/j.envpol.2021.116933_bib53","first-page":"41","article-title":"The other estrogen receptor in the plasma membrane: implications for the actions of environmental estrogens","volume":"137","author":"Watson","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2021.116933_bib54","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.phytol.2018.07.019","article-title":"6-Methoxy-5,6-dihydrochelerythrine suppresses PANC-1 cells by down-regulating the Ras\/Raf\/Mek\/Erk pathway","volume":"27","author":"Wu","year":"2018","journal-title":"Phytochem Lett"},{"key":"10.1016\/j.envpol.2021.116933_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ecoenv.2020.110605","article-title":"ITRAQ-based proteomics reveals the potential mechanism of fluoride-induced myocardial contraction function damage","volume":"197","author":"Xie","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2021.116933_bib57","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.scitotenv.2018.11.037","article-title":"Enantioselective thyroid disruption in zebrafish embryo-larvae via exposure to environmental concentrations of the chloroacetamide herbicide acetochlor","volume":"653","author":"Xu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.116933_bib58","article-title":"Nimodipine attenuates dibutyl phthalate-induced learning and memory impairment in kun ming mice: an in\u00a0vivo study based on bioinformatics analysis","author":"Yan","year":"2020","journal-title":"Environ Toxicol. Online."},{"key":"10.1016\/j.envpol.2021.116933_bib59","first-page":"1","article-title":"Di2-ethylhexyl phthalate disrupts thyroid hormone homeostasis through activating the Ras\/Akt\/TRHr pathway and inducing hepatic enzymes","volume":"7","author":"Ye","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2021.116933_bib60","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.mce.2005.11.030","article-title":"Thyroid hormone action at the cellular, genomic and target gene levels","volume":"246","author":"Yen","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envpol.2021.116933_bib61","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ecoenv.2018.07.066","article-title":"Di (2-ethylhexyl) phthalate-induced reproductive toxicity involved in dna damage-dependent oocyte apoptosis and oxidative stress in Caenorhabditis elegans","volume":"163","author":"Yin","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2021.116933_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2018.05.013","article-title":"Gestational di-(2-ethylhexyl) phthalate exposure causes fetal intrauterine growth restriction through disturbing placental thyroid hormone receptor signaling","volume":"294","author":"Yu","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2021.116933_bib63","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.cellsig.2017.07.008","article-title":"Hypoxia-induced suppression of c-Myc by HIF-2alpha in human pulmonary endothelial cells attenuates TFAM expression","volume":"38","author":"Zarrabi","year":"2017","journal-title":"Cell. Signal."},{"key":"10.1016\/j.envpol.2021.116933_bib64","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.envpol.2017.11.027","article-title":"Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in\u00a0vitro and in\u00a0vivo","volume":"237","author":"Zhang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.116933_bib65","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.etap.2017.09.006","article-title":"The role of PPAR alpha in perfluorooctanoic acid induced developmental cardiotoxicity and l-carnitine mediated protection-Results of in ovo gene silencing","volume":"56","author":"Zhao","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2021.116933_bib66","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.biopha.2017.12.029","article-title":"Resveratrol inhibits proliferation, migration and invasion via Akt and ERK1\/2 signaling pathways in renal cell carcinoma cells","volume":"98","author":"Zhao","year":"2018","journal-title":"Biomed. Pharmacother."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749121005157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749121005157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T22:00:29Z","timestamp":1759442429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749121005157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":65,"alternative-id":["S0269749121005157"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2021.116933","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple bioanalytical methods reveal a thyroid-disrupting mechanism related to the membrane receptor integrin \u03b1v\u03b23","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2021.116933","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116933"}}