{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:28:13Z","timestamp":1790972893416,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.envpol.2021.117096","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T23:22:15Z","timestamp":1617837735000},"page":"117096","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Moxidectin toxicity to zebrafish embryos: Bioaccumulation and biomarker responses"],"prefix":"10.1016","volume":"283","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8800-5436","authenticated-orcid":false,"given":"Marta Silva","family":"Muniz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Halbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor Cau\u00ea","family":"Alves Araruna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9819-0778","authenticated-orcid":false,"given":"Rafael Xavier","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Seiwert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Lechtenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Reemtsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5438-1919","authenticated-orcid":false,"given":"Davi","family":"Farias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2021.117096_bib1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3109\/15376516.2010.514962","article-title":"Effect of Piper betle on cardiac function, marker enzymes, and oxidative stress in isoproterenol-induced cardiotoxicity in rats","volume":"20","author":"Arya","year":"2010","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.envpol.2021.117096_bib2","doi-asserted-by":"crossref","first-page":"286A","DOI":"10.1021\/es032519b","article-title":"Are veterinary medicines causing environmental risks?","volume":"37","author":"Boxall","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.117096_bib3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cbpc.2016.02.007","article-title":"Metabolism of clofibric acid in zebrafish embryos (Danio rerio) as determined by liquid chromatography\u2013high resolution\u2013mass spectrometry","volume":"185\u2013186","author":"Brox","year":"2016","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2021.117096_bib4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00128-015-1656-8","article-title":"Acute toxicity and environmental risks of five veterinary pharmaceuticals for aquatic macroinvertebrates","volume":"96","author":"Bundschuh","year":"2016","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envpol.2021.117096_bib5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.aquatox.2012.10.008","article-title":"Toxicity of 15 veterinary pharmaceuticals in zebrafish (Danio rerio) embryos","volume":"126","author":"Carlsson","year":"2013","journal-title":"Aquat Toxicol Amst Neth"},{"key":"10.1016\/j.envpol.2021.117096_bib6","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.fsi.2019.11.066","article-title":"Effects of spinetoram on the developmental toxicity and immunotoxicity of zebrafish","volume":"96","author":"Cheng","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.envpol.2021.117096_bib7","series-title":"CRC Handbook of Methods for Oxygen Radical Research","article-title":"Catalase activity","author":"Claiborne","year":"1986"},{"key":"10.1016\/j.envpol.2021.117096_bib8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ecoenv.2018.08.015","article-title":"Chronic effects of carbamazepine on zebrafish: behavioral, reproductive and biochemical endpoints","volume":"164","author":"da Silva Santos","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2021.117096_bib9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jtherbio.2017.02.003","article-title":"Metabolic and cellular stress responses of catfish, Horabagrus brachysoma (G\u00fcnther) acclimated to increasing temperatures","volume":"65","author":"Dalvi","year":"2017","journal-title":"J.\u00a0Therm. Biol."},{"key":"10.1016\/j.envpol.2021.117096_bib10","doi-asserted-by":"crossref","first-page":"125914","DOI":"10.1016\/j.chemosphere.2020.125914","article-title":"Biochemical markers for prolongation of the acute stress of triclosan in the early life stages of four food fishes","volume":"247","author":"Dar","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.117096_bib11","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ecolind.2014.12.021","article-title":"RANKVET: a new ranking method for comparing and prioritizing the environmental risk of veterinary pharmaceuticals","volume":"52","author":"Di Nica","year":"2015","journal-title":"Ecol. Indicat."},{"key":"10.1016\/j.envpol.2021.117096_bib12","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10646-015-1607-5","article-title":"Effects of ivermectin on Danio rerio: a multiple endpoint approach: behaviour, weight and subcellular markers","volume":"25","author":"Domingues","year":"2016","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.envpol.2021.117096_bib13","first-page":"1165","article-title":"Pharmacogenetics: it\u2019s not just about ivermectin in collies","volume":"47","author":"Dowling","year":"2006","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.envpol.2021.117096_bib14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A\u00a0new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.envpol.2021.117096_bib15","series-title":"Referral: Moxidectin-Containing Veterinary Medicines Used in Cattle, Sheep and Horses","article-title":"Annex II: Scientific conclusions and grounds for amendment of the summaries of product characteristics, labelling and package leaflets","year":"2017"},{"key":"10.1016\/j.envpol.2021.117096_bib16","doi-asserted-by":"crossref","first-page":"11789","DOI":"10.1021\/acs.est.5b01034","article-title":"Identification and characterization of androgen-responsive genes in zebrafish embryos","volume":"49","author":"Fetter","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.117096_bib17","series-title":"Probit Analysis: A Statistical Treatment of the Sigmoid Response Curve","author":"Finney","year":"1952"},{"key":"10.1016\/j.envpol.2021.117096_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077548","article-title":"Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish","volume":"8","author":"Fleming","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.envpol.2021.117096_bib19","series-title":"Environmental Assessment \u2013 CYDECTIN Moxidectin 0.5% Pour-On for Cattle","year":"1997"},{"key":"10.1016\/j.envpol.2021.117096_bib20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ecoenv.2004.10.015","article-title":"Development of a zebrafish 4-day embryo-larval bioassay to assess toxicity of chemicals","volume":"63","author":"Fraysse","year":"2006","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2021.117096_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2885.2008.01007.x","article-title":"Brain penetration of ivermectin and selamectin in mdr1a,b P-glycoprotein- and bcrp- deficient knockout mice","volume":"32","author":"Geyer","year":"2009","journal-title":"J.\u00a0Vet. Pharmacol. Therapeut."},{"key":"10.1016\/j.envpol.2021.117096_bib22","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0076-6879(81)77053-8","article-title":"Assays for differentiation of glutathione S-transferases","volume":"77","author":"Habig","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.envpol.2021.117096_bib23","doi-asserted-by":"crossref","first-page":"10159","DOI":"10.1021\/acs.est.0c02068","article-title":"Yolk sac of zebrafish embryos as backpack for chemicals?","volume":"54","author":"Halbach","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.117096_bib24","series-title":"Summary of Product Characteristics: Tauramox 5 Mg\/ml Pour-On Solution for Cattle","year":"2019"},{"key":"10.1016\/j.envpol.2021.117096_bib25","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.smallrumres.2019.02.015","article-title":"Faecal excretion of moxidectin in lambs and its persistence in different environmental conditions","volume":"174","author":"Hentz","year":"2019","journal-title":"Small Rumin. Res."},{"key":"10.1016\/j.envpol.2021.117096_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.20278","article-title":"Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish","volume":"480","author":"Higashijima","year":"2004","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.envpol.2021.117096_bib27","series-title":"ISO 15088:2007 \u2014 Determination of the Acute Toxicity of Waste Water to Zebrafish Eggs (Danio rerio)","year":"2007"},{"key":"10.1016\/j.envpol.2021.117096_bib28","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1080\/1354750X.2019.1651902","article-title":"Glutathione reductase and catalase as potential biomarkers for synergistic intoxication of pesticides in fish","volume":"24","author":"Khare","year":"2019","journal-title":"Biomarkers"},{"key":"10.1016\/j.envpol.2021.117096_bib29","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1124\/dmd.109.030700","article-title":"Role of P-glycoprotein in the disposition of macrocyclic lactones: a comparison between ivermectin, eprinomectin, and moxidectin in mice","volume":"38","author":"Kiki-Mvouaka","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.envpol.2021.117096_bib30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1089\/zeb.2016.1392","article-title":"Zebrafish as a screening model for testing the permeability of blood\u2013brain barrier to small molecules","volume":"14","author":"Kim","year":"2017","journal-title":"Zebrafish"},{"key":"10.1016\/j.envpol.2021.117096_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.etap.2008.03.006","article-title":"Prioritizing veterinary pharmaceuticals for aquatic environment in Korea","volume":"26","author":"Kim","year":"2008","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2021.117096_bib32","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.chemosphere.2013.04.057","article-title":"Aquatic toxicity of four veterinary drugs commonly applied in fish farming and animal husbandry","volume":"92","author":"Ko\u0142odziejska","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.117096_bib33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1897\/IEAM_2008-002.1","article-title":"A\u00a0ranking of European veterinary medicines based on environmental risks","volume":"4","author":"Kools","year":"2008","journal-title":"Integrated Environ. Assess. Manag."},{"key":"10.1016\/j.envpol.2021.117096_bib34","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/etc.4068","article-title":"Differential uptake of and sensitivity to diphenhydramine in embryonic and larval zebrafish","volume":"37","author":"Kristofco","year":"2018","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2021.117096_bib35","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.2174\/138920112800399257","article-title":"A\u00a0review on the toxicity and non-target effects of macrocyclic lactones in terrestrial and aquatic environments","volume":"13","author":"Lumaret","year":"2012","journal-title":"Curr. Pharmaceut. Biotechnol."},{"key":"10.1016\/j.envpol.2021.117096_bib36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/(SICI)1096-9861(19980629)396:2<253::AID-CNE9>3.0.CO;2-#","article-title":"Sequence and expression of glutamic acid decarboxylase isoforms in the developing zebrafish","volume":"396","author":"Martin","year":"1998","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.envpol.2021.117096_bib37","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.aquatox.2015.06.011","article-title":"Differential sensitivity in embryonic stages of the zebrafish (Danio rerio): the role of toxicokinetics for stage-specific susceptibility for azinphos-methyl lethal effects","volume":"166","author":"Massei","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2021.117096_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001883","article-title":"Relative neurotoxicity of ivermectin and moxidectin in Mdr1ab (-\/-) mice and effects on mammalian GABA(A) channel activity","volume":"6","author":"M\u00e9nez","year":"2012","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.envpol.2021.117096_bib39","doi-asserted-by":"crossref","first-page":"135692","DOI":"10.1016\/j.scitotenv.2019.135692","article-title":"Concentration and environmental fate of ivermectin in floodplain wetlands: an ecosystem approach","volume":"706","author":"Mesa","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.117096_bib40","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00244-018-0539-5","article-title":"Effects of the antiparasitic drug moxidectin in cattle dung on zooplankton and benthic invertebrates and its accumulation in a water\u2013sediment system","volume":"75","author":"Mesa","year":"2018","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envpol.2021.117096_bib41","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ecoenv.2017.06.016","article-title":"Aquatic toxicity of ivermectin in cattle dung assessed using microcosms","volume":"144","author":"Mesa","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2021.117096_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196083","article-title":"Expression of the eight GABAA receptor \u03b1 subunits in the developing zebrafish central nervous system","volume":"13","author":"Monesson-Olson","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.envpol.2021.117096_bib43","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/cne.20824","article-title":"A\u00a0phylotypic stage in vertebrate brain development: GABA cell patterns in zebrafish compared with mouse","volume":"494","author":"Mueller","year":"2006","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.envpol.2021.117096_bib44","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s10646-013-1080-y","article-title":"Pesticide exposure impacts not only hatching of dormant eggs, but also hatchling survival and performance in the water flea Daphnia magna","volume":"22","author":"Navis","year":"2013","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.envpol.2021.117096_bib45","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1101\/gad.309823.117","article-title":"Bridging barriers: a comparative look at the blood\u2013brain barrier across organisms","volume":"32","author":"O\u2019Brown","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.envpol.2021.117096_bib46","series-title":"Test No. 236: Fish Embryo Acute Toxicity (FET) Test","year":"2013"},{"key":"10.1016\/j.envpol.2021.117096_bib47","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12302-019-0270-5","article-title":"Hypo- or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior changes","volume":"31","author":"Ogungbemi","year":"2019","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.envpol.2021.117096_bib48","doi-asserted-by":"crossref","first-page":"106918","DOI":"10.1016\/j.ntt.2020.106918","article-title":"Optimization of the spontaneous tail coiling test for fast assessment of neurotoxic effects in the zebrafish embryo using an automated workflow in KNIME\u00ae","volume":"81","author":"Ogungbemi","year":"2020","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.envpol.2021.117096_bib49","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cbpc.2016.04.004","article-title":"Multilevel assessment of ivermectin effects using different zebrafish life stages","volume":"187","author":"Oliveira","year":"2016","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2021.117096_bib50","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2210-8-16","article-title":"Pharmacokinetics and transcriptional effects of the anti-salmon lice drug emamectin benzoate in Atlantic salmon (Salmo salar L.)","volume":"8","author":"Olsvik","year":"2008","journal-title":"BMC Pharmacol."},{"key":"10.1016\/j.envpol.2021.117096_bib51","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1051\/limn:20054130161","article-title":"Agricultural impacts on Mediterranean wetlands: the effect of pesticides on survival and hatching rates in copepods","volume":"41","author":"Parra","year":"2005","journal-title":"Ann Limnol - Int J Limnol"},{"key":"10.1016\/j.envpol.2021.117096_bib52","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ijpddr.2012.04.001","article-title":"Moxidectin and the avermectins: consanguinity but not identity","volume":"2","author":"Prichard","year":"2012","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1016\/j.envpol.2021.117096_bib53","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.etap.2016.04.014","article-title":"Steroid androgen 17\u03b1-methyltestosterone induces malformations and biochemical alterations in zebrafish embryos","volume":"44","author":"Rivero-Wendt","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2021.117096_bib54","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/(SICI)1097-4695(199812)37:4<622::AID-NEU10>3.0.CO;2-S","article-title":"Time course of the development of motor behaviors in the zebrafish embryo","volume":"37","author":"Saint-Amant","year":"1998","journal-title":"J.\u00a0Neurobiol."},{"key":"10.1016\/j.envpol.2021.117096_bib55","series-title":"Fish Physiology","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-802728-8.00001-1","article-title":"The concept of stress in fish","author":"Schreck","year":"2016"},{"key":"10.1016\/j.envpol.2021.117096_bib56","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.chemosphere.2019.02.026","article-title":"Fish exposed to water contaminated with eprinomectin show inhibition of the activities of AChE and Na+\/K+-ATPase in the brain, and changes in natural behavior","volume":"223","author":"Serafini","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.117096_bib57","series-title":"Advances in Pharmacology","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S1054-3589(06)54010-4","article-title":"Structure, pharmacology, and function of GABAA receptor subtypes","author":"Sieghart","year":"2006"},{"key":"10.1016\/j.envpol.2021.117096_bib58","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.aquatox.2017.09.020","article-title":"Developmental toxicity and cardiac effects of butyl benzyl phthalate in zebrafish embryos","volume":"192","author":"Sun","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2021.117096_bib59","doi-asserted-by":"crossref","first-page":"137686","DOI":"10.1016\/j.scitotenv.2020.137686","article-title":"Environmental relevant concentrations of benzophenone-3 induced developmental neurotoxicity in zebrafish","volume":"721","author":"Tao","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.117096_bib60","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tox.2009.10.014","article-title":"Evaluation of the usefulness of biomarkers for cardiac and skeletal myotoxicity in rats","volume":"266","author":"Tonomura","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2021.117096_bib61","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1021\/acs.est.8b07188","article-title":"Toxicokinetics of perfluorinated alkyl acids influences their toxic potency in the zebrafish embryo (Danio rerio)","volume":"53","author":"Vogs","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.117096_bib62","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.chemosphere.2017.07.136","article-title":"Assessing the ecotoxicity of potentially neurotoxic substances \u2013 evaluation of a behavioural parameter in the embryogenesis of Danio rerio","volume":"186","author":"Weichert","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.117096_bib63","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.scitotenv.2018.06.338","article-title":"Exposure of Brazilian soil and groundwater to pollution by coccidiostats and antimicrobial agents used as growth promoters","volume":"644","author":"Yopas\u00e1-Arenas","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.117096_bib64","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.cub.2018.04.075","article-title":"Zebrafish differentially process color across visual space to match natural scenes","volume":"28","author":"Zimmermann","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.envpol.2021.117096_bib65","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.chemosphere.2013.10.091","article-title":"Analysis of anthelmintics in surface water by ultra high performance liquid chromatography coupled to quadrupole linear ion trap tandem mass spectrometry","volume":"99","author":"Zrn\u010di\u0107","year":"2014","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.envpol.2021.117096_bib66","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1021\/jf00038a028","article-title":"Absorption, tissue distribution, metabolism, and excretion of moxidectin in cattle","volume":"42","author":"Zulalian","year":"1994","journal-title":"J.\u00a0Agric. Food Chem"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749121006783?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749121006783?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T22:05:45Z","timestamp":1759442745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749121006783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":66,"alternative-id":["S0269749121006783"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2021.117096","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Moxidectin toxicity to zebrafish embryos: Bioaccumulation and biomarker responses","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2021.117096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117096"}}