{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T20:21:19Z","timestamp":1794082879732,"version":"4.8.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41561144007"],"award-info":[{"award-number":["41561144007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41877371"],"award-info":[{"award-number":["41877371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41977366"],"award-info":[{"award-number":["41977366"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42077388"],"award-info":[{"award-number":["42077388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFA0602004"],"award-info":[{"award-number":["2016YFA0602004"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.envpol.2021.117890","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T16:18:03Z","timestamp":1627748283000},"page":"117890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Transcriptomics changes and the candidate pathway in human macrophages induced by different PM2.5 extracts"],"prefix":"10.1016","volume":"289","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-8979","authenticated-orcid":false,"given":"Jing","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waner","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghua","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-8282","authenticated-orcid":false,"given":"Yingjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2021.117890_bib1","first-page":"1639","article-title":"Protein-protein interaction network analysis of salivary proteomic data in oral cancer cases","volume":"19","author":"Amiri Dash Atan","year":"2018","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.envpol.2021.117890_bib2","doi-asserted-by":"crossref","first-page":"C581","DOI":"10.1152\/ajpcell.00032.2013","article-title":"Requirement for active glycogen synthase kinase-3\u03b2 in TGF-\u03b21 upregulation of connective tissue growth factor (CCN2\/CTGF) levels in human gingival fibroblasts","volume":"305","author":"Bahammam","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.envpol.2021.117890_bib3","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrm3629","article-title":"Control of cell cycle transcription during G1 and S phases","volume":"14","author":"Bertoli","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2021.117890_bib4","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3109\/15563650.2014.923903","article-title":"Barium toxicity and the role of the potassium inward rectifier current","volume":"52","author":"Bhoelan","year":"2014","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.envpol.2021.117890_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mrgentox.2019.04.005","article-title":"Characterization of urban aerosol: seasonal variation of genotoxicity of the water-soluble portion of PM2.5 and PM1","volume":"841","author":"Bocchi","year":"2019","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envpol.2021.117890_bib6","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1289\/ehp.1103667","article-title":"Contrasts in oxidative potential and other particulate matter characteristics collected near major streets and background locations","volume":"120","author":"Boogaard","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2021.117890_bib7","doi-asserted-by":"crossref","first-page":"634\u2010642","DOI":"10.1016\/j.acvd.2017.05.003","article-title":"Cardiovascular effects of air pollution","volume":"110","author":"Bourdrel","year":"2017","journal-title":"Arch. Cardiovasc. Dis."},{"key":"10.1016\/j.envpol.2021.117890_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mrgentox.2019.01.009","article-title":"Investigation of spatial and temporal variation of particulate matter in vitro genotoxicity and cytotoxicity in relation to the elemental composition","volume":"842","author":"\u00c7akmak","year":"2019","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envpol.2021.117890_bib9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jes.2016.10.013","article-title":"Particulate matter (PM2.5) exposure season-dependently induces neuronal apoptosis and synaptic injuries","volume":"54","author":"Chen","year":"2017","journal-title":"J. Environ. Sci. (China)"},{"key":"10.1016\/j.envpol.2021.117890_bib10","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/S0140-6736(17)30505-6","article-title":"Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015","volume":"389","author":"Cohen","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.envpol.2021.117890_bib11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.etap.2019.04.006","article-title":"Different biological effects of PM2.5 from coal combustion, gasoline exhaust and urban ambient air relate to the PAH\/metal compositions","volume":"69","author":"Cui","year":"2019","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2021.117890_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12989-015-0087-3","article-title":"Cardiac effects of seasonal ambient particulate matter and ozone co-exposure in rats","volume":"12","author":"Farraj","year":"2015","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envpol.2021.117890_bib13","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/j.celrep.2017.05.031","article-title":"PLK1 activation in late G2 sets up commitment to mitosis","volume":"19","author":"Gheghiani","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.envpol.2021.117890_bib14","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/tox.22707","article-title":"PM2.5 exposure induces systemic inflammation and oxidative stress in an intracranial atherosclerosis rat model","volume":"34","author":"Guan","year":"2019","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envpol.2021.117890_bib15","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/S0140-6736(16)31597-5","article-title":"Impact of air pollution on the burden of chronic respiratory diseases in China: time for urgent action","volume":"388","author":"Guan","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.envpol.2021.117890_bib16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/em.20186","article-title":"Effect of chemical composition on the induction of DNA damage by urban airborne particulate matter","volume":"47","author":"Gutierrez\u2010Castillo","year":"2006","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.envpol.2021.117890_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature02555","article-title":"Evidence for dynamically organized modularity in the yeast protein-protein interaction network","volume":"430","author":"Han","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2021.117890_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1743-8977-2-4","article-title":"Cytokine release from alveolar macrophages exposed to ambient particulate matter: heterogeneity in relation to size, city and season","volume":"2","author":"Hetland","year":"2005","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envpol.2021.117890_bib19","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/tox.22236","article-title":"Integrative analysis of mRNA and microRNA expression of a human alveolar epithelial cell(A549) exposed to water and organic-soluble extract from particulate matter (PM)2.5","volume":"32","author":"Jeong","year":"2017","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envpol.2021.117890_bib20","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/tox.22591","article-title":"Effect of particulate matter 2.5 on gene expression profile and cell signaling in JEG-3 human placenta cells","volume":"33","author":"Kim","year":"2018","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envpol.2021.117890_bib21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.semcdb.2015.08.006","article-title":"The calcium-sensing receptor as a mediator of inflammation","volume":"49","author":"Klein","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.envpol.2021.117890_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/resp.12381","article-title":"Differential injurious effects of ambient and traffic-derived particulate matter on airway epithelial cells","volume":"20","author":"Kumar","year":"2015","journal-title":"Respirology"},{"key":"10.1016\/j.envpol.2021.117890_bib23","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3390\/ijerph13060579","article-title":"The effect of seasonal variations in airborne particulate matter on asthma-related airway inflammation in mice","volume":"13","author":"Kurai","year":"2016","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envpol.2021.117890_bib24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tiv.2018.02.002","article-title":"Transcriptional response to organic compounds from diverse gasoline and biogasoline fuel emissions in human lung cells","volume":"48","author":"Libalova","year":"2018","journal-title":"Toxicol. In. Vitro"},{"key":"10.1016\/j.envpol.2021.117890_bib25","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.3390\/ijms17111833","article-title":"Comparative analysis of toxic responses of organic extracts from diesel and selected alternative fuels engine emissions in human lung BEAS-2B cells","volume":"17","author":"Libalova","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2021.117890_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-981-10-5657-4_5","article-title":"Air pollution and mortality in China","volume":"1017","author":"Lin","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.envpol.2021.117890_bib27","doi-asserted-by":"crossref","first-page":"16195","DOI":"10.1007\/s11356-017-9265-1","article-title":"Seasonal variations and source apportionment of atmospheric PM2.5-bound polycyclic aromatic hydrocarbons in a mixed multi-function area of Hangzhou, China","volume":"24","author":"Lu","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2021.117890_bib28","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1289\/ehp.1409287","article-title":"TNF\u03b1 and IL-6 responses to particulate matter in vitro: variation according to PM size, season, and polycyclic aromatic hydrocarbon and soil content","volume":"124","author":"Manzano-Le\u00f3n","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2021.117890_bib29","first-page":"6021","article-title":"Nanoparticles of barium induce apoptosis in human phagocytes","volume":"10","author":"Mores","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.envpol.2021.117890_bib30","first-page":"dyaa211","article-title":"A directed acyclic graph for interactions","volume":"22","author":"Nilsson","year":"2020","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.envpol.2021.117890_bib31","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1080\/08958378.2018.1561769","article-title":"Involvement of PM2.5-bound protein and metals in PM2.5-induced allergic airway inflammation in mice","volume":"30","author":"Ogino","year":"2018","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.envpol.2021.117890_bib32","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.mrgentox.2011.04.003","article-title":"Organic extracts of urban air pollution particulate matter (PM2.5)-induced genotoxicity and oxidative stress in human lung bronchial epithelial cells (BEAS-2B cells)","volume":"723","author":"Oh","year":"2011","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.envpol.2021.117890_bib33","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/tox.22831","article-title":"Barium chloride dose-dependently induced heart and lung injury in Wistar rats","volume":"34","author":"Omole","year":"2019","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envpol.2021.117890_bib34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.scitotenv.2018.01.017","article-title":"Seasonal variations in fine particle composition from Beijing prompt oxidative stress response in mouse lung and liver","volume":"626","author":"Pardo","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.117890_bib35","doi-asserted-by":"crossref","first-page":"115961","DOI":"10.1016\/j.envpol.2020.115961","article-title":"microRNA-146a-5p negatively modulates PM2.5 caused inflammation in THP-1 cells via autophagy process","volume":"268","author":"Shang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.117890_bib36","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.biopha.2018.12.063","article-title":"CTGF-mediated ERK signaling pathway influences the inflammatory factors and intestinal flora in ulcerative colitis","volume":"111","author":"Song","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.envpol.2021.117890_bib37","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.toxlet.2011.02.005","article-title":"DNA adducts and oxidative DNA damage induced by organic extracts from PM2.5 in an acellular assay","volume":"202","author":"Topinka","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2021.117890_bib38","doi-asserted-by":"crossref","first-page":"138911","DOI":"10.1016\/j.scitotenv.2020.138911","article-title":"Seasonal variability of chemical composition and mutagenic effect of organic PM2.5 pollutants collected in the urban area of Wroc\u0142aw (Poland)","volume":"733","author":"Trusz","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.117890_bib39","doi-asserted-by":"crossref","first-page":"113984","DOI":"10.1016\/j.envpol.2020.113984","article-title":"Reactive oxygen species-mediated cellular genotoxic stress is involved in 1-nitropyrene-induced trophoblast cycle arrest and fetal growth restriction","volume":"260","author":"Wang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.117890_bib40","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.envpol.2012.10.009","article-title":"Pollution level, inhalation exposure and lung cancer risk of ambient atmospheric polycyclic aromatic hydrocarbons (PAHs) in Taiyuan, China","volume":"173","author":"Xia","year":"2013","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.117890_bib41","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.envint.2016.04.013","article-title":"Molecular mechanisms of dust-induced toxicity in human corneal epithelial cells: water and organic extract of office and house dust","volume":"92\u201393","author":"Xiang","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2021.117890_bib42","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.envpol.2018.02.086","article-title":"Effects on IL-1\u00df signaling activation induced by water and organic extracts of fine particulate matter (PM2.5) in vitro","volume":"237","author":"Xu","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.117890_bib43","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/j.scitotenv.2017.05.107","article-title":"Industrial PM2.5 cause pulmonary adverse effect through RhoA\/ROCK pathway","volume":"599\u2013600","author":"Yan","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.117890_bib44","doi-asserted-by":"crossref","first-page":"22408","DOI":"10.1007\/s11356-017-0430-3","article-title":"Oxidative stress and cell cycle arrest induced by short-term exposure to dustfall PM2.5 in A549 cells","volume":"25","author":"Yang","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2021.117890_bib45","doi-asserted-by":"crossref","first-page":"101161","DOI":"10.1016\/j.redox.2019.101161","article-title":"Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy","volume":"22","author":"Yue","year":"2019","journal-title":"Redox Biology"},{"key":"10.1016\/j.envpol.2021.117890_bib46","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1289\/ehp.0800108","article-title":"The effect of fine and coarse particulate air pollution on mortality: a national analysis","volume":"117","author":"Zanobetti","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2021.117890_bib47","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jpsychires.2018.09.020","article-title":"Voltage-gated calcium channel activity and complex related genes and schizophrenia: a systematic investigation based on Han Chinese population","volume":"106","author":"Zhang","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.envpol.2021.117890_bib48","first-page":"126","article-title":"A mechanism underlying hypertensive occurrence in the metabolic syndrome: cooperative effect of oxidative stress and calcium accumulation in vascular smooth muscle cells","volume":"46","author":"Zhang","year":"2014","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.envpol.2021.117890_bib49","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.envpol.2016.05.072","article-title":"Heavy metals bound to fine particulate matter from northern China induce season-dependent health risks: a study based on myocardial toxicity","volume":"216","author":"Zhang","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.117890_bib50","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.scitotenv.2016.07.073","article-title":"Response of aerosol composition to different emission scenarios in Beijing, China","volume":"571","author":"Zhang","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.117890_bib51","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.phrs.2007.07.004","article-title":"Effects of celecoxib on voltage-gated calcium channel currents in rat pheochromocytoma (PC12) cells","volume":"56","author":"Zhang","year":"2007","journal-title":"Pharmacol. Res."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974912101472X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974912101472X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T01:52:47Z","timestamp":1775181167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026974912101472X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":51,"alternative-id":["S026974912101472X"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2021.117890","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomics changes and the candidate pathway in human macrophages induced by different PM2.5 extracts","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2021.117890","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117890"}}