{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:06:19Z","timestamp":1793271979543,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["201807010064"],"award-info":[{"award-number":["201807010064"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["31171074"],"award-info":[{"award-number":["31171074"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY20C110002"],"award-info":[{"award-number":["LY20C110002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008327","name":"Zhejiang University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31701028"],"award-info":[{"award-number":["31701028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.envpol.2021.117934","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T02:27:18Z","timestamp":1628476038000},"page":"117934","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Exposure to hexafluoropropylene oxide dimer acid (HFPO-DA) disturbs the gut barrier function and gut microbiota in mice"],"prefix":"10.1016","volume":"290","author":[{"given":"Xiaoxian","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luting","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruonan","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-3075","authenticated-orcid":false,"given":"Zhengwei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2021.117934_bib1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jcp.25435","article-title":"LPS induces hyper-permeability of intestinal epithelial cells","volume":"232","author":"Bein","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.envpol.2021.117934_bib2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12876-014-0189-7","article-title":"Intestinal permeability \u2013 a new target for disease prevention and therapy","volume":"14","author":"Bischoff","year":"2014","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.envpol.2021.117934_bib3","doi-asserted-by":"crossref","first-page":"27006","DOI":"10.1289\/EHP6233","article-title":"Evaluation of maternal, embryo, and placental effects in CD-1 mice following gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide dimer acid (HFPO-DA or GenX)","volume":"128","author":"Blake","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2021.117934_bib4","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.3389\/fmicb.2017.01765","article-title":"Next-generation beneficial microbes: the case of Akkermansia muciniphila","volume":"8","author":"Cani","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2021.117934_bib5","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.toxrep.2015.06.001","article-title":"Evaluation of chronic toxicity and carcinogenicity of ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate in Sprague\u2013Dawley rats","volume":"2","author":"Caverly Rae","year":"2015","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.envpol.2021.117934_bib6","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/0192623320905803","article-title":"Assessment of the mode of action underlying the effects of GenX in mouse liver and implications for assessing human health risks","volume":"48","author":"Chappell","year":"2020","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.envpol.2021.117934_bib7","doi-asserted-by":"crossref","first-page":"113817","DOI":"10.1016\/j.envpol.2019.113817","article-title":"Accumulation and phytotoxicity of perfluorooctanoic acid and 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate in Arabidopsis thaliana and Nicotiana benthamiana","volume":"259","author":"Chen","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.117934_bib8","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/j.gastro.2020.04.077","article-title":"Contribution of the intestinal microbiome and gut barrier to hepatic disorders","volume":"159","author":"Chopyk","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.envpol.2021.117934_bib9","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The impact of the gut microbiota on human health: an integrative view","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2021.117934_bib10","doi-asserted-by":"crossref","first-page":"114778","DOI":"10.1016\/j.envpol.2020.114778","article-title":"Adverse effects of in vitro GenX exposure on rat thyroid cell viability, DNA integrity and thyroid-related genes expression","volume":"264","author":"Coperchini","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.117934_bib11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fmicb.2011.00166","article-title":"Modulation of mucosal immune response, tolerance, and proliferation in mice colonized by the mucin-degrader Akkermansia muciniphila","volume":"2","author":"Derrien","year":"2011","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2021.117934_bib12","article-title":"Perfluoroalkyl substances are increased in patients with late-onset ulcerative colitis and induce intestinal barrier defects ex vivo in murine intestinal tissue","author":"Fart","year":"2020","journal-title":"MedRxiv"},{"key":"10.1016\/j.envpol.2021.117934_bib13","doi-asserted-by":"crossref","first-page":"112960","DOI":"10.1016\/j.envpol.2019.112960","article-title":"Bisphenol A increases intestinal permeability through disrupting intestinal barrier function in mice","volume":"254","author":"Feng","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.117934_bib14","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1021\/acs.est.9b07384","article-title":"Evidence of air dispersion: HFPO\u2013DA and PFOA in Ohio and West Virginia surface water and soil near a fluoropolymer production facility","volume":"54","author":"Galloway","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.117934_bib15","doi-asserted-by":"crossref","first-page":"105583","DOI":"10.1016\/j.envint.2020.105583","article-title":"Environmental contamination and human exposure to PFASs near a fluorochemical production plant: review of historic and current PFOA and GenX contamination in The Netherlands","volume":"137","author":"Gebbink","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2021.117934_bib16","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1136\/gut.2004.047092","article-title":"Increased gut permeability in Crohn's disease: is TNF the link?","volume":"53","author":"Gibson","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.envpol.2021.117934_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2018.01.011","article-title":"Comparing the toxic potency in vivo of long-chain perfluoroalkyl acids and fluorinated alternatives","volume":"113","author":"Gomis","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2021.117934_bib18","doi-asserted-by":"crossref","first-page":"105358","DOI":"10.1016\/j.envint.2019.105358","article-title":"Elevated levels of per- and polyfluoroalkyl substances in Cape Fear River Striped Bass (Morone saxatilis) are associated with biomarkers of altered immune and liver function","volume":"136","author":"Guillette","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2021.117934_bib19","doi-asserted-by":"crossref","first-page":"12672","DOI":"10.1073\/pnas.1904099116","article-title":"Ruminococcus gnavus<\/em>, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide","volume":"116","author":"Henke","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.envpol.2021.117934_bib20","doi-asserted-by":"crossref","first-page":"8386","DOI":"10.1021\/acs.est.5b01648","article-title":"Alternative and legacy perfluoroalkyl substances: differences between European and Chinese river\/estuary systems","volume":"49","author":"Heydebreck","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.117934_bib21","doi-asserted-by":"crossref","first-page":"9958","DOI":"10.1021\/acs.est.0c00228","article-title":"Transport of legacy perfluoroalkyl substances and the replacement compound HFPO-DA through the atlantic gateway to the arctic ocean\u2014is the arctic a sink or a source?","volume":"54","author":"Joerss","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.117934_bib22","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nri.2016.88","article-title":"Immunological aspects of intestinal mucus and mucins","volume":"16","author":"Johansson","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.envpol.2021.117934_bib23","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1007\/s00018-011-0822-3","article-title":"Composition and functional role of the mucus layers in the intestine","volume":"68","author":"Johansson","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.envpol.2021.117934_bib24","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.tim.2020.02.018","article-title":"Sutterella species, IgA-degrading bacteria in ulcerative colitis","volume":"28","author":"Kaakoush","year":"2020","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.envpol.2021.117934_bib25","doi-asserted-by":"crossref","first-page":"127504","DOI":"10.1016\/j.chemosphere.2020.127504","article-title":"Influences of hexafluoropropylene oxide (HFPO) homologues on soil microbial communities","volume":"259","author":"Ke","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.117934_bib26","doi-asserted-by":"crossref","first-page":"G803","DOI":"10.1152\/ajpgi.00069.2006","article-title":"Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells","volume":"291","author":"Khan","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.envpol.2021.117934_bib27","doi-asserted-by":"crossref","first-page":"77005","DOI":"10.1289\/EHP6837","article-title":"Measurement of novel, drinking water-associated PFAS in blood from adults and children in wilmington, North Carolina","volume":"128","author":"Kotlarz","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2021.117934_bib28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrgastro.2016.4","article-title":"Prevotella in the gut: choose carefully","volume":"13","author":"Ley","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.envpol.2021.117934_bib29","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1021\/acs.est.8b06978","article-title":"Adipogenic activity of oligomeric hexafluoropropylene oxide (perfluorooctanoic acid alternative) through peroxisome proliferator-activated receptor gamma pathway","volume":"53","author":"Li","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.117934_bib30","doi-asserted-by":"crossref","first-page":"105419","DOI":"10.1016\/j.envint.2019.105419","article-title":"Legacy per- and polyfluoroalkyl substances (PFASs) and alternatives (short-chain analogues, F-53B, GenX and FC-98) in residential soils of China: present implications of replacing legacy PFASs","volume":"135","author":"Li","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2021.117934_bib31","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1038\/s41598-019-40140-5","article-title":"Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice","volume":"9","author":"McGaughey","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2021.117934_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.envpol.2021.117934_bib34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.envpol.2019.05.103","article-title":"The effect of environmentally relevant emerging per- and polyfluoroalkyl substances on the growth and antioxidant response in marine Chlorella sp","volume":"252","author":"Niu","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.117934_bib35","doi-asserted-by":"crossref","first-page":"9553","DOI":"10.1021\/acs.est.7b02259","article-title":"First report on the occurrence and bioaccumulation of hexafluoropropylene oxide trimer acid: an emerging concern","volume":"51","author":"Pan","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.117934_bib36","doi-asserted-by":"crossref","first-page":"7621","DOI":"10.1021\/acs.est.8b00829","article-title":"Worldwide distribution of novel perfluoroether carboxylic and sulfonic acids in surface water","volume":"52","author":"Pan","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.117934_bib37","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.envpol.2019.07.021","article-title":"Subchronic exposure of environmentally relevant concentrations of F-53B in mice resulted in gut barrier dysfunction and colonic inflammation in a sex-independent manner","volume":"253","author":"Pan","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.117934_bib38","article-title":"Mucus barrier, mucins and gut microbiota: the expected slimy partners?","author":"Paone","year":"2020","journal-title":"Gut, gutjnl-2020-322260"},{"key":"10.1016\/j.envpol.2021.117934_bib39","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3390\/toxics8030064","article-title":"Effect of perfluorooctanoic acid on the epigenetic and tight junction genes of the mouse intestine","volume":"8","author":"Rashid","year":"2020","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2021.117934_bib40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/SHK.0b013e318257123a","article-title":"Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming","volume":"38","author":"Reino","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.envpol.2021.117934_bib41","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.3390\/ijms20081887","article-title":"Tumour necrosis factor Alpha in intestinal homeostasis and gut related diseases","volume":"20","author":"Ruder","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2021.117934_bib42","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.01202","article-title":"Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis","volume":"2","author":"Scher","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.envpol.2021.117934_bib43","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1152\/physrev.00045.2009","article-title":"Gut microbiota in health and disease","volume":"90","author":"Sekirov","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.envpol.2021.117934_bib44","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/19490976.2017.1349041","article-title":"Gut microbiome in multiple sclerosis: the players involved and the roles they play","volume":"8","author":"Shailesh","year":"2017","journal-title":"Gut Microb."},{"key":"10.1016\/j.envpol.2021.117934_bib45","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00204-017-2055-1","article-title":"Cytotoxicity of novel fluorinated alternatives to long-chain perfluoroalkyl substances to human liver cell line and their binding capacity to human liver fatty acid binding protein","volume":"92","author":"Sheng","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2021.117934_bib46","doi-asserted-by":"crossref","first-page":"13916","DOI":"10.1021\/acs.jafc.0c05834","article-title":"Exposure to perfluorooctanoic acid induces cognitive deficits via altering gut microbiota composition, impairing intestinal barrier integrity, and causing inflammation in gut and brain","volume":"68","author":"Shi","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.envpol.2021.117934_bib47","doi-asserted-by":"crossref","first-page":"9694","DOI":"10.1021\/acs.est.7b06657","article-title":"Emissions, transport, and fate of emerging per- and polyfluoroalkyl substances from One of the major fluoropolymer manufacturing facilities in China","volume":"52","author":"Song","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.117934_bib48","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1289\/ehp.1206449","article-title":"Ulcerative colitis and perfluorooctanoic acid (PFOA) in a highly exposed population of community residents and workers in the mid-Ohio valley","volume":"121","author":"Steenland","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2021.117934_bib49","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1021\/acs.estlett.6b00398","article-title":"Legacy and emerging perfluoroalkyl substances are important drinking water contaminants in the Cape Fear River watershed of North Carolina","volume":"3","author":"Sun","year":"2016","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.envpol.2021.117934_bib50","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.envpol.2018.12.065","article-title":"Hepatotoxicity of perfluorooctanoic acid and two emerging alternatives based on a 3D spheroid model","volume":"246","author":"Sun","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.117934_bib51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-\u03baB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envpol.2021.117934_bib53","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3389\/fcimb.2016.00179","article-title":"Tissue-associated bacterial alterations in rectal carcinoma patients revealed by 16S rRNA community profiling","volume":"6","author":"Thomas","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.envpol.2021.117934_bib54","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1210\/er.2014-1100","article-title":"TLR4 at the crossroads of nutrients, gut microbiota, and metabolic inflammation","volume":"36","author":"Velloso","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.envpol.2021.117934_bib55","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/2040-2392-4-42","article-title":"Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder","volume":"4","author":"Wang","year":"2013","journal-title":"Mol. Autism."},{"key":"10.1016\/j.envpol.2021.117934_bib56","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/jat.3376","article-title":"RNA-sequencing analysis reveals the hepatotoxic mechanism of perfluoroalkyl alternatives, HFPO2 and HFPO4, following exposure in mice","volume":"37","author":"Wang","year":"2017","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envpol.2021.117934_bib57","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1021\/acs.est.6b04806","article-title":"A never-ending story of per- and polyfluoroalkyl substances (PFASs)?","volume":"51","author":"Wang","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.117934_bib58","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.envint.2019.05.056","article-title":"Bioaccumulation in the gut and liver causes gut barrier dysfunction and hepatic metabolism disorder in mice after exposure to low doses of OBS","volume":"129","author":"Wang","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2021.117934_bib59","doi-asserted-by":"crossref","first-page":"129004","DOI":"10.1016\/j.chemosphere.2020.129004","article-title":"Perfluorooctanoic acid-induced liver injury is potentially associated with gut microbiota dysbiosis","volume":"266","author":"Wang","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.117934_bib60","doi-asserted-by":"crossref","first-page":"G171","DOI":"10.1152\/ajpgi.00048.2015","article-title":"Homeostasis of the gut barrier and potential biomarkers","volume":"312","author":"Wells","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.envpol.2021.117934_bib61","doi-asserted-by":"crossref","first-page":"103854","DOI":"10.1016\/j.jff.2020.103854","article-title":"Lactobacillus plantarum AR113 alleviates DSS-induced colitis by regulating the TLR4\/MyD88\/NF-\u03baB pathway and gut microbiota composition","volume":"67","author":"Xia","year":"2020","journal-title":"J. Funct. Foods"},{"issue":"1","key":"10.1016\/j.envpol.2021.117934_bib62","doi-asserted-by":"crossref","DOI":"10.14336\/AD.2021.0729","article-title":"Mammalian AKT, the emerging roles on mitochondrial function in diseases","volume":"13","author":"Xie","year":"2022","journal-title":"Aging Dis"},{"key":"10.1016\/j.envpol.2021.117934_bib63","doi-asserted-by":"crossref","first-page":"8371","DOI":"10.1021\/acs.est.9b01579","article-title":"Comparative in vitro and in vivo evaluation of the estrogenic effect of hexafluoropropylene oxide homologues","volume":"53","author":"Xin","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.117934_bib64","doi-asserted-by":"crossref","first-page":"141767","DOI":"10.1016\/j.scitotenv.2020.141767","article-title":"Legacy and emerging per- and polyfluoroalkyl substances (PFASs) in multi-media around a landfill in China: implications for the usage of PFASs alternatives","volume":"751","author":"Xu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.117934_bib65","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/cmi.12501","article-title":"The intestinal epithelium as guardian of gut barrier integrity","volume":"17","author":"Zhang","year":"2015","journal-title":"Cell Microbiol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749121015165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749121015165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T22:04:25Z","timestamp":1759442665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749121015165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":63,"alternative-id":["S0269749121015165"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2021.117934","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to hexafluoropropylene oxide dimer acid (HFPO-DA) disturbs the gut barrier function and gut microbiota in mice","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2021.117934","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117934"}}