{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:42:27Z","timestamp":1791362547959,"version":"4.3.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.envpol.2021.118075","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T05:27:22Z","timestamp":1630387642000},"page":"118075","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Safety of composts consisting of hydrothermally treated penicillin fermentation residue: Degradation products, antibiotic resistance genes and bacterial diversity"],"prefix":"10.1016","volume":"290","author":[{"given":"Jianjun","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liujie","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Huhetaoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6554-885X","authenticated-orcid":false,"given":"Dongze","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2021.118075_bib1","first-page":"1","article-title":"Megasphaera elsdeniiLactate degradation pattern shifts in rumen acidosis models","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2021.118075_bib2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.wasman.2019.07.031","article-title":"Degradation of antibiotics and antibiotic resistance genes in erythromycin fermentation residues using radiation coupled with peroxymonosulfate oxidation","volume":"96","author":"Chu","year":"2019","journal-title":"Waste Manag."},{"key":"10.1016\/j.envpol.2021.118075_bib3","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41589-018-0052-1","article-title":"Shared strategies for \u03b2-lactam catabolism in the soil microbiome","volume":"14","author":"Crofts","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.envpol.2021.118075_bib4","doi-asserted-by":"crossref","first-page":"135215","DOI":"10.1016\/j.scitotenv.2019.135215","article-title":"Appraisal of lignocellusoic biomass degrading potential of three earthworm species using vermireactor mediated with spent mushroom substrate: compost quality, crystallinity, and microbial community structural analysis","volume":"716","author":"Devi","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.118075_bib5","first-page":"238","article-title":"Measurement of trace levels of antibiotics in river water using on-line enrichment and triple-quadrupole LC\u2013MS\/MS","volume":"85","author":"Dinh","year":"2011","journal-title":"Talanta"},{"key":"10.1016\/j.envpol.2021.118075_bib6","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: highly accurate OTU sequences from microbial amplicon reads","volume":"10","author":"Edgar","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.envpol.2021.118075_bib7","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.wasman.2017.06.036","article-title":"Evaluation of the antibiotics effects on the physical and chemical parameters during the co-composting of sewage sludge with palm wastes in a bioreactor","volume":"68","author":"Ezzariai","year":"2017","journal-title":"Waste Manag."},{"key":"10.1016\/j.envpol.2021.118075_bib8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/329162a0","article-title":"Antibacterial agents specifically inhibiting lipopolysaccharide synthesis","volume":"329","author":"Goldman","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2021.118075_bib9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.wasman.2020.02.008","article-title":"Alkaline-thermally treated penicillin V mycelial residue amendment improved the soil properties without triggering antibiotic resistance","volume":"105","author":"Gong","year":"2020","journal-title":"Waste Manag."},{"key":"10.1016\/j.envpol.2021.118075_bib10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.biortech.2018.01.040","article-title":"Modelling for reactor-style aerobic composting based on coupling theory of mass-heat-momentum transport and Contois equation","volume":"253","author":"He","year":"2018","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.envpol.2021.118075_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4491\/eer.2020.001","article-title":"Succession of microbial community in anaerobic digestion of dairy manure induced by manure-derived biochar","volume":"26","author":"Jang","year":"2020","journal-title":"Environ. Eng. Res."},{"key":"10.1016\/j.envpol.2021.118075_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-12004-3","article-title":"Affected energy metabolism under manganese stress governs cellular toxicity","volume":"7","author":"Kaur","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2021.118075_bib13","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences","volume":"31","author":"Langille","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.envpol.2021.118075_bib14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.watres.2007.07.016","article-title":"Determination of penicillin G and its degradation products in a penicillin production wastewater treatment plant and the receiving river","volume":"42","author":"Li","year":"2008","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2021.118075_bib15","series-title":"Organic Chemistry of Drug Degradation","author":"Li","year":"2012"},{"key":"10.1016\/j.envpol.2021.118075_bib16","doi-asserted-by":"crossref","first-page":"122456","DOI":"10.1016\/j.biortech.2019.122456","article-title":"Lactobacillus plantarum improves the efficiency of sheep manure composting and the quality of the final product","volume":"297","author":"Li","year":"2020","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.envpol.2021.118075_bib17","doi-asserted-by":"crossref","first-page":"105203","DOI":"10.1016\/j.envint.2019.105203","article-title":"Efficient reduction of antibiotic residues and associated resistance genes in tylosin antibiotic fermentation waste using hyperthermophilic composting","volume":"133","author":"Liao","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2021.118075_bib18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.biortech.2015.03.124","article-title":"Biodiversity and succession of mycobiota associated to agricultural lignocellulosic waste-based composting","volume":"187","author":"L\u00f3pez-Gonz\u00e1lez","year":"2015","journal-title":"Bioresour. Technol."},{"issue":"80","key":"10.1016\/j.envpol.2021.118075_bib19","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1126\/science.aaf4507","article-title":"Decoupling function and taxonomy in the global ocean microbiome","volume":"353","author":"Louca","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.envpol.2021.118075_bib20","doi-asserted-by":"crossref","first-page":"122883","DOI":"10.1016\/j.biortech.2020.122883","article-title":"Metabolic function, trophic mode, organics degradation ability and influence factor of bacterial and fungal communities in chicken manure composting","volume":"302","author":"Mao","year":"2020","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.envpol.2021.118075_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/1065657X.1996.10701852","article-title":"The use of bacillus licheniformis ha1 to accelerate composting of organic wastes","volume":"4","author":"Nakasaki","year":"1996","journal-title":"Compost Sci. Util."},{"key":"10.1016\/j.envpol.2021.118075_bib22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1134\/S0003683819030104","article-title":"Composition of a microbial community at different stages of composting and the prospects for compost production from municipal organic waste (Review)","volume":"55","author":"Nozhevnikova","year":"2019","journal-title":"Appl. Biochem. Microbiol."},{"key":"10.1016\/j.envpol.2021.118075_bib23","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jtusci.2014.04.010","article-title":"Production, optimization and partial purification of protease from Bacillus subtilis","volume":"9","author":"Pant","year":"2015","journal-title":"J. Taibah Univ. Sci."},{"key":"10.1016\/j.envpol.2021.118075_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fbioe.2019.00110","article-title":"Microbial proteases applications","volume":"7","author":"Razzaq","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.envpol.2021.118075_bib25","first-page":"13","article-title":"Biodegradation of antibiotics: the new resistance determinants \u2013 part II","volume":"54","author":"Reis","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.envpol.2021.118075_bib45","doi-asserted-by":"crossref","first-page":"111984","DOI":"10.1016\/j.jenvman.2021.111984","article-title":"Effects of added thermally treated penicillin fermentation residues on the quality and safety of composts","volume":"238","author":"Ren","year":"2021","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.envpol.2021.118075_bib26","doi-asserted-by":"crossref","first-page":"122550","DOI":"10.1016\/j.biortech.2019.122550","article-title":"Assessment of bacterial and fungal communities in a full-scale thermophilic sewage sludge composting pile under a semipermeable cover","volume":"298","author":"Robledo-Mah\u00f3n","year":"2020","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.envpol.2021.118075_bib27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.wasman.2017.08.012","article-title":"Compost supplementation with nutrients and microorganisms in composting process","volume":"69","author":"S\u00e1nchez","year":"2017","journal-title":"Waste Manag."},{"key":"10.1016\/j.envpol.2021.118075_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jenvman.2018.11.050","article-title":"Degradation of antibiotics and antibiotic resistance genes in fermentation residues by ionizing radiation: a new insight into a sustainable management of antibiotic fermentative residuals","volume":"232","author":"Shen","year":"2019","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.envpol.2021.118075_bib29","doi-asserted-by":"crossref","first-page":"124048","DOI":"10.1016\/j.biortech.2020.124048","article-title":"Behaviors and related mechanisms of Zn resistance and antibiotic resistance genes during co-composting of erythromycin manufacturing wastes and pig manure","volume":"318","author":"Sun","year":"2020","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.envpol.2021.118075_bib30","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1016\/j.biortech.2006.09.021","article-title":"NH3, N2O and CH4 emissions during passively aerated composting of straw-rich pig manure","volume":"98","author":"Szanto","year":"2007","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.envpol.2021.118075_bib31","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.scitotenv.2018.04.288","article-title":"Assessing the safety of thermally processed penicillin mycelial dreg following the soil application: organic matter's maturation and antibiotic resistance genes","volume":"636","author":"Wang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.118075_bib32","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jhazmat.2018.08.032","article-title":"Succession of organics metabolic function of bacterial community in swine manure composting","volume":"360","author":"Wang","year":"2018","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2021.118075_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13068-016-0440-2","article-title":"Metagenomic analysis of microbial consortia enriched from compost: new insights into the role of Actinobacteria in lignocellulose decomposition","volume":"9","author":"Wang","year":"2016","journal-title":"Biotechnol. Biofuels"},{"key":"10.1016\/j.envpol.2021.118075_bib34","doi-asserted-by":"crossref","first-page":"113956","DOI":"10.1016\/j.envpol.2020.113956","article-title":"Risk of penicillin fermentation dreg: increase of antibiotic resistance genes after soil discharge","volume":"259","author":"Wang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.118075_bib35","article-title":"BugBase predicts organism-level microbiome phenotypes","volume":"5","author":"Ward","year":"2017","journal-title":"bioRxiv"},{"key":"10.1016\/j.envpol.2021.118075_bib36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.biortech.2018.08.079","article-title":"How does manganese dioxide affect humus formation during bio-composting of chicken manure and corn straw?","volume":"269","author":"Wu","year":"2018","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.envpol.2021.118075_bib37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.biortech.2016.01.004","article-title":"Maturity and security assessment of pilot-scale aerobic co-composting of penicillin fermentation dregs (PFDs) with sewage sludge","volume":"204","author":"Yang","year":"2016","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.envpol.2021.118075_bib38","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.scitotenv.2018.08.212","article-title":"Compost-bulking agents reduce the reservoir of antibiotics and antibiotic resistance genes in manures by modifying bacterial microbiota","volume":"649","author":"Zhang","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.118075_bib39","first-page":"1","article-title":"Lignocellulose utilization and bacterial communities of millet straw based mushroom (Agaricus bisporus) production","volume":"9","author":"Zhang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2021.118075_bib40","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jhazmat.2018.06.052","article-title":"Contributions of the microbial community and environmental variables to antibiotic resistance genes during co-composting with swine manure and cotton stalks","volume":"358","author":"Zhang","year":"2018","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2021.118075_bib41","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.biortech.2017.12.051","article-title":"The effects of bio-available copper on macrolide antibiotic resistance genes and mobile elements during tylosin fermentation dregs co-composting","volume":"251","author":"Zhang","year":"2018","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.envpol.2021.118075_bib42","first-page":"1","article-title":"Enhanced growth and activities of the dominant functional microbiota of chicken manure composts in the presence of maize straw","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2021.118075_bib43","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1007\/s11356-015-5357-y","article-title":"Effectiveness of bulking agents for co-composting penicillin mycelial dreg (PMD) and sewage sludge in pilot-scale system","volume":"23","author":"Zhang","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2021.118075_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biortech.2015.12.040","article-title":"Dynamic changes of the dominant functioning microbial community in the compost of a 90-m3 aerobic solid state fermentor revealed by integrated meta-omics","volume":"203","author":"Zhang","year":"2016","journal-title":"Bioresour. Technol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749121016572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749121016572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T22:16:27Z","timestamp":1759443387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749121016572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":45,"alternative-id":["S0269749121016572"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2021.118075","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety of composts consisting of hydrothermally treated penicillin fermentation residue: Degradation products, antibiotic resistance genes and bacterial diversity","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2021.118075","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118075"}}