{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T22:44:24Z","timestamp":1759445064289,"version":"build-2065373602"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.envpol.2021.118226","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T19:01:48Z","timestamp":1632337308000},"page":"118226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Effect assessment of reclaimed waters and carbamazepine exposure on the thyroid axis of Xenopus laevis: Gene expression modifications"],"prefix":"10.1016","volume":"291","author":[{"given":"Jos\u00e9 Luis","family":"Mart\u00ednez-Guitarte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eulalia Mar\u00eda","family":"Beltr\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Gonz\u00e1lez-Doncel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Garc\u00eda-Hortig\u00fcela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2955-5846","authenticated-orcid":false,"given":"Mar\u00eda Victoria","family":"Pablos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2021.118226_bib1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1210\/me.2014-1349","article-title":"Deciphering the regulatory logic of an ancient, ultraconserved nuclear receptor enhancer module","volume":"29","author":"Bagamasbad","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.envpol.2021.118226_bib2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-1-4939-7902-8_8","article-title":"The deiodinase Trio and thyroid hormone signaling","volume":"1801","author":"Bianco","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.envpol.2021.118226_bib3","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1172\/JCI60047","article-title":"Mechanisms of thyroid hormone action","volume":"122","author":"Brent","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envpol.2021.118226_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.envpol.2012.01.038","article-title":"Occurrence and persistence of organic emerging contaminants and priority pollutants in five sewage treatment plants of Spain: two years pilot survey monitoring","volume":"164","author":"Bueno","year":"2012","journal-title":"Environ. Poll."},{"key":"10.1016\/j.envpol.2021.118226_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms18122583","article-title":"Thyroid disrupting chemicals","volume":"18","author":"Calsolaro","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2021.118226_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ygcen.2010.06.001","article-title":"The hypothalamus-pituitary-thyroid axis in teleosts and amphibians: endocrine disruption and its consequences to natural populations","volume":"170","author":"Carr","year":"2011","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.envpol.2021.118226_bib7","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.watres.2003.10.058","article-title":"Carbamazepine as a possible anthropogenic marker in the aquatic environment: investigations on the behaviour of Carbamazepine in wastewater treatment and during groundwater infiltration","volume":"38","author":"Clara","year":"2004","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2021.118226_bib8","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/j.1365-2826.2010.02047.x","article-title":"Regulation of thyroid hormone-, oestrogen- and androgen-related genes by triiodothyronine in the brain of Silurana tropicalis","volume":"22","author":"Duarte-Guterman","year":"2010","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.envpol.2021.118226_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.emcon.2016.12.004","article-title":"Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment","volume":"3","author":"Ebele","year":"2017","journal-title":"Emerg. Contam."},{"year":"2012","series-title":"Towards Efficient Use of Water Resources in Europe","key":"10.1016\/j.envpol.2021.118226_bib10"},{"year":"2019","series-title":"European Union Strategic Approach to Pharmaceuticals in the Environment","key":"10.1016\/j.envpol.2021.118226_bib11"},{"key":"10.1016\/j.envpol.2021.118226_bib12","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1016\/j.scitotenv.2010.03.036","article-title":"The risk associated with wastewater reuse and xenobiotics in the agroecological environment","volume":"409","author":"Fatta-Kasinos","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.118226_bib13","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.scitotenv.2009.10.009","article-title":"Occurrence of pharmaceutically active compounds in surface waters of the Henares-Jarama-Tajo river system (Madrid, Spain) and a potential risk characterization","volume":"408","author":"Fern\u00e1ndez","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.118226_bib14","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1210\/en.2002-220126","article-title":"The transcription factor basic transcription element-binding protein 1 is a direct thyroid hormone response gene in the frog Xenopus laevis","volume":"143","author":"Furlow","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2021.118226_bib15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.tem.2006.01.007","article-title":"A developmental switch induced by thyroid hormone: Xenopus laevis metamorphosis","volume":"17","author":"Furlow","year":"2006","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.envpol.2021.118226_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.iswcr.2015.03.002","article-title":"Emerging pollutants in the environment: a challenge for water resource management","volume":"3","author":"Geissen","year":"2015","journal-title":"Int. Soil Water Conserv. Res."},{"key":"10.1016\/j.envpol.2021.118226_bib17","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1007\/s11356-013-1636-7","article-title":"Endocrine disruptors compounds, pharmaceuticals and personal care products in urban wastewater: implications for agricultural reuse and their removal by adsorption process","volume":"20","author":"Grassi","year":"2013","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2021.118226_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/w10020107","article-title":"Carbamazepine as a possible anthropogenic marker in water: occurrences, toxicological effects, regulations and removal by wastewater treatment technologies","volume":"10","author":"Hai","year":"2018","journal-title":"Water"},{"key":"10.1016\/j.envpol.2021.118226_bib19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.aquatox.2007.02.013","article-title":"Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay. Part 1: effects on the brain","volume":"82","author":"Helbing","year":"2007","journal-title":"Aquat. Toxicol. (Amst.)"},{"key":"10.1016\/j.envpol.2021.118226_bib20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.aquatox.2007.02.014","article-title":"Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay. Part 2: effects on the tail and hindlimb","volume":"82","author":"Helbing","year":"2007","journal-title":"Aquat. Toxicol. (Amst.)"},{"key":"10.1016\/j.envpol.2021.118226_bib21","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1442-200X.2007.02456.x","article-title":"Thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate","volume":"49","author":"Hirfanoglu","year":"2007","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.envpol.2021.118226_bib22","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s11269-006-9111-6","article-title":"Challenge to manage the risk of water scarcity and climatic change in the Mediterranean","volume":"21","author":"Iglesias","year":"2007","journal-title":"Water Resour. Manag."},{"key":"10.1016\/j.envpol.2021.118226_bib23","doi-asserted-by":"crossref","DOI":"10.1007\/s10661-018-6745-9","article-title":"Screening and quantification of emerging contaminants in Periyar River, Kerala (India) by using high-resolution mass spectrometry (LC-Q-ToF-MS)","volume":"190","author":"Khalid","year":"2018","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.envpol.2021.118226_bib24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000497141","article-title":"The colorful diversity of thyroid hormone metabolites","volume":"8","author":"K\u00f6hrle","year":"2019","journal-title":"Eur Thyroid J"},{"key":"10.1016\/j.envpol.2021.118226_bib25","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1021\/es011055j","article-title":"Pharmaceutical, hormones and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance","volume":"36","author":"Kolpin","year":"2002","journal-title":"Environ. Sci. Technicol."},{"key":"10.1016\/j.envpol.2021.118226_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134140","article-title":"Disruptive effects of two organotin pesticides on the thyroid signaling pathway in Xenopus laevis during metamorphosis","volume":"697","author":"Li","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.118226_bib27","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.scitotenv.2006.03.021","article-title":"Occurrence and reductions of pharmaceuticals and personal care products and estrogens by municipal wastewater treatment plants in Ontario, Canada","volume":"367","author":"Lishman","year":"2006","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.118226_bib28","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/toxsci\/kfab029","article-title":"Thyroid disrupting chemicals in mixture Perturb thymocyte differentiation in Xenopus laevis tadpoles","volume":"181","author":"McGuire","year":"2021","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2021.118226_bib29","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1021\/es050261e","article-title":"Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plant","volume":"39","author":"Miao","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.118226_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2166\/wst.2008.823","article-title":"Removal efficiency of pharmaceuticals and personal care products with varying wastewater treatment processes and operating conditions - conception of a database and first results","volume":"57","author":"Mi\u00e8ge","year":"2008","journal-title":"Water Sci. Technol."},{"year":"2011","series-title":"Carbamazepine in Drinking Water","key":"10.1016\/j.envpol.2021.118226_bib31"},{"key":"10.1016\/j.envpol.2021.118226_bib32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-1-4939-7902-8_15","article-title":"Evaluating thyroid disrupting chemicals in Vivo using Xenopus laevis","volume":"1801","author":"Mughal","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.envpol.2021.118226_bib33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/physrev.00030.2013","article-title":"Thyroid hormone regulation of metabolism","volume":"94","author":"Mullur","year":"2014","journal-title":"Physiol. Rev."},{"year":"1994","series-title":"Normal Tables of Xenopus laevis (Daudin)","author":"Nieuwkoop","key":"10.1016\/j.envpol.2021.118226_bib34"},{"key":"10.1016\/j.envpol.2021.118226_bib35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.yebeh.2018.11.003","article-title":"Lipid and thyroid hormone levels in children with epilepsy treated with levetiracetam or carbamazepine: a prospective observational study","volume":"90","author":"Nishiyama","year":"2019","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.envpol.2021.118226_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/JME-18-0081","article-title":"Thyroid function disruptors: from nature to chemicals","volume":"62","author":"Oliveira","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.envpol.2021.118226_bib37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1677\/joe.1.06606","article-title":"Expression of sodium-iodide symporter mRNA in the thyroid gland of Xenopus laevis tadpoles: developmental expression, effects of antithyroidal compounds, and regulation by TSH","volume":"190","author":"Opitz","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.envpol.2021.118226_bib38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mce.2008.08.020","article-title":"Perchlorate and ethylenethiourea induce different histological and molecular alterations in a non-mammalian vertebrate model of thyroid goitrogenesis","volume":"298","author":"Opitz","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envpol.2021.118226_bib39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ygcen.2010.04.013","article-title":"Developmental regulation of gene expression in the thyroid gland of Xenopus laevis tadpoles","volume":"168","author":"Opitz","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"year":"2009","series-title":"Test N\u00ba 231: Apmhibian Metamorphosis Assay","key":"10.1016\/j.envpol.2021.118226_bib40"},{"key":"10.1016\/j.envpol.2021.118226_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138023","article-title":"Effect assessment of reclaimed water and carbamazepine exposure on the thyroid axis of Xenopus laevis: apical and histological effects","volume":"723","author":"Pablos","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.118226_bib55","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.scitotenv.2018.05.349","article-title":"Sublethal and chronic effects of reclaimed water on aquatic organisms. Looking for relationships between physico-chemical characterisation and toxic effects","volume":"640-641","author":"Pablos","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.118226_bib42","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3109\/10408444.2010.494250","article-title":"Screening chemicals for thyroid-disrupting activity: a critical comparison of mammalian and amphibian models","volume":"40","author":"Pickford","year":"2010","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envpol.2021.118226_bib43","first-page":"1581","article-title":"Carbamazepine concentrations in natural waters and wastewater treatment plant samples","volume":"76","author":"Sajwan","year":"2014","journal-title":"Organohalogen Compd."},{"key":"10.1016\/j.envpol.2021.118226_bib44","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.mce.2017.07.038","article-title":"Frontiers in endocrine disruption: impacts of organotin on the hypothalamus-pituitary-thyroid axis","volume":"460","author":"Santos-Silva","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envpol.2021.118226_bib45","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ygcen.2011.12.036","article-title":"Thyroid hormone-dependent development in Xenopus laevis: a sensitive screen of thyroid hormone signaling disruption by municipal wastewater treatment plant effluent","volume":"176","author":"Searcy","year":"2012","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.envpol.2021.118226_bib46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1600-0404.2007.00883.x","article-title":"Carbamazepine and risk of hypothyroidism: a prospective study","volume":"116","author":"Simko","year":"2007","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.envpol.2021.118226_bib47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ydbio.2017.01.003","article-title":"The thyroid hormone nuclear receptors and the Wnt\/\u03b2-catenin pathway: an intriguing liaison","volume":"422","author":"Skah","year":"2017","journal-title":"Dev. Biol."},{"key":"10.1016\/j.envpol.2021.118226_bib48","article-title":"Contaminant and environmental influences on thyroid hormone action in Amphibian metamorphosis","volume":"10","author":"Thambirajah","year":"2019","journal-title":"Front. Endocrinol."},{"year":"2002","series-title":"Revised Draft Detailed Review Paper for Amphibian Metamorphosis Assay","author":"Touart","key":"10.1016\/j.envpol.2021.118226_bib49"},{"year":"2020","series-title":"Department of Economic and Social Affairs Sustainable Development. The 17 Goals","key":"10.1016\/j.envpol.2021.118226_bib50"},{"key":"10.1016\/j.envpol.2021.118226_bib51","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1007\/s11356-013-1637-6","article-title":"Is the evaluation of \u201ctraditional\u201d physicochemical parameters sufficient to explain the potential toxicity of the treated wastewater at sewage treatment plants?","volume":"20","author":"Vasquez","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2021.118226_bib52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1530\/JME-12-0068","article-title":"Thyroid hormone and the central control of homeostasis","volume":"26","author":"Warner","year":"2012","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.envpol.2021.118226_bib53","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.etap.2016.11.002","article-title":"Dietary exposure to polybrominated diphenyl ether 47 (BDE-47) inhibits development and alters thyroid hormone-related gene expression in the brain of Xenopus laevis tadpoles","volume":"48","author":"Yost","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2021.118226_bib54","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.aquatox.2005.09.003","article-title":"Evaluation of gene expression endpoints in the context of a Xenopus laevis metamorphosis-based bioassay to detect thyroid hormone disruptors","volume":"76","author":"Zhang","year":"2006","journal-title":"Aquat. Toxicol. (Amst.)"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974912101808X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974912101808X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T22:22:06Z","timestamp":1759443726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026974912101808X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":55,"alternative-id":["S026974912101808X"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2021.118226","relation":{},"ISSN":["0269-7491"],"issn-type":[{"type":"print","value":"0269-7491"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect assessment of reclaimed waters and carbamazepine exposure on the thyroid axis of Xenopus laevis: Gene expression modifications","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2021.118226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118226"}}