{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:39:45Z","timestamp":1790552385776,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"am","delay-in-days":670,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007546","name":"Anses","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007546","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012952","name":"Universit\u00e9 Grenoble Alpes","doi-asserted-by":"publisher","award":["ANR-15-IDEX-02"],"award-info":[{"award-number":["ANR-15-IDEX-02"]}],"id":[{"id":"10.13039\/100012952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"CNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004617","name":"Institut national des sciences de l&apos;Univers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010115","name":"R\u00e9gion Auvergne-Rh\u00f4ne-Alpes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010115","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004562","name":"Minist\u00e8re de l&apos;Education Nationale, de l&apos;Enseignement Superieur et de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.envpol.2021.118418","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T06:35:25Z","timestamp":1635748525000},"page":"118418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"PB","title":["Exposure to a mixture of benzo[a]pyrene and triclosan induces multi-and transgenerational metabolic disorders associated with decreased female investment in reproduction in Silurana (Xenopus) tropicalis"],"prefix":"10.1016","volume":"292","author":[{"given":"Marie","family":"Usal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Veyrenc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-2362","authenticated-orcid":false,"given":"Marie","family":"Darracq--Ghitalla-Ciock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Regnault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Sroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Fini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Raveton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0248-0602","authenticated-orcid":false,"given":"St\u00e9phane","family":"Reynaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2021.118418_bib1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mce.2014.08.011","article-title":"Dioxin induction of transgenerational inheritance of disease in zebrafish","volume":"398","author":"Baker","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envpol.2021.118418_bib2","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.chemosphere.2013.07.057","article-title":"Pharmaceuticals and personal care products found in the Great Lakes above concentrations of environmental concern","volume":"93","author":"Blair","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.118418_bib3","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.scitotenv.2018.03.363","article-title":"Endocrine disruptors in breeding ponds and reproductive health of toads in agricultural, urban and natural landscapes","volume":"634","author":"Bokony","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.118418_bib4","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envpol.2021.118418_bib5","doi-asserted-by":"crossref","first-page":"13496","DOI":"10.1038\/ncomms13496","article-title":"Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic beta-cells","volume":"7","author":"Brereton","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2021.118418_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1400253","article-title":"Accelerated modern human-induced species losses: entering the sixth mass extinction","volume":"1","author":"Ceballos","year":"2015","journal-title":"Science advances"},{"key":"10.1016\/j.envpol.2021.118418_bib7","article-title":"Changes in hepatic metabolic profile during the evolution of STZ-induced diabetic rats via an (1)H NMR-based metabonomic investigation","volume":"39","author":"Chen","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.envpol.2021.118418_bib8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.aquatox.2015.01.013","article-title":"Chronic effects of clofibric acid in zebrafish (Danio rerio): a multigenerational study","volume":"160","author":"Coimbra","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2021.118418_bib9","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.6156","article-title":"Direct and indirect parental exposure to endocrine disruptors and elevated temperature influences gene expression across generations in a euryhaline model fish","volume":"7","author":"DeCourten","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.envpol.2021.118418_bib10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s004240050489","article-title":"Independent responsiveness of frog liver low-density lipoprotein receptor and HMGCoA reductase to estrogen treatment","volume":"435","author":"Di Croce","year":"1997","journal-title":"Pflueg. Arch. Eur. J. Physiol."},{"key":"10.1016\/j.envpol.2021.118418_bib11","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/j.peptides.2010.07.020","article-title":"Insulin-induced gene: a new regulator in lipid metabolism","volume":"31","author":"Dong","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.envpol.2021.118418_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ygcen.2014.03.015","article-title":"Mechanisms of crosstalk between endocrine systems: regulation of sex steroid hormone synthesis and action by thyroid hormones","volume":"203","author":"Duarte-Guterman","year":"2014","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.envpol.2021.118418_bib13","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1053\/j.gastro.2003.10.065","article-title":"Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma","volume":"126","author":"El-Serag","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.envpol.2021.118418_bib14","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1111\/j.1420-9101.2012.02570.x","article-title":"Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and nonparallel physiological divergence","volume":"25","author":"Evans","year":"2012","journal-title":"J. Evol. Biol."},{"key":"10.1016\/j.envpol.2021.118418_bib15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/09687688.2012.729094","article-title":"Linking epigenetics to lipid metabolism: focus on histone deacetylases","volume":"29","author":"Ferrari","year":"2012","journal-title":"Mol. Membr. Biol."},{"key":"10.1016\/j.envpol.2021.118418_bib16","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/icb\/16.4.725","article-title":"Life history patterns of storage and utilization of lipids for energy in amphibians","volume":"16","author":"Fitzpatrick","year":"1976","journal-title":"Am. Zool."},{"key":"10.1016\/j.envpol.2021.118418_bib17","series-title":"USGS Numbered Series","article-title":"Occurrence of pharmaceuticals and other organic wastewater constituents in selected streams in northern Arkansas, 2004","author":"Galloway","year":"2005"},{"key":"10.1016\/j.envpol.2021.118418_bib18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/onc.2015.92","article-title":"The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia","volume":"35","author":"Giotopoulos","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.envpol.2021.118418_bib19","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1111\/mec.13808","article-title":"Rapid transcriptional acclimation following transgenerational exposure of oysters to ocean acidification","volume":"25","author":"Goncalves","year":"2016","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.envpol.2021.118418_bib20","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1210\/me.2002-0246","article-title":"Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha","volume":"17","author":"Goodwin","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.envpol.2021.118418_bib21","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/419895a","article-title":"Herbicides: feminization of male frogs in the wild","volume":"419","author":"Hayes","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2021.118418_bib22","doi-asserted-by":"crossref","first-page":"5476","DOI":"10.1073\/pnas.082121499","article-title":"Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses","volume":"99","author":"Hayes","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.envpol.2021.118418_bib23","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1242\/jeb.040865","article-title":"The cause of global amphibian declines: a developmental endocrinologist's perspective","volume":"213","author":"Hayes","year":"2010","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.envpol.2021.118418_bib24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jsbmb.2011.03.015","article-title":"Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes","volume":"127","author":"Hayes","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.envpol.2021.118418_bib25","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2009.03.016","article-title":"Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein","volume":"137","author":"He","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2021.118418_bib26","series-title":"Guidelines for Canadian Drinking Water Quality: Guideline Technical Document \u2014 Benzo[a]pyrene. Water and Air Quality Bureau, Healthy Environments and Consumer Safety Branch","year":"2016"},{"key":"10.1016\/j.envpol.2021.118418_bib27","first-page":"108685","article-title":"Transgenerational disrupting impacts of atrazine in zebrafish: beneficial effects of dietary spirulina. Comparative biochemistry and physiology","volume":"230","author":"Hedayatirad","year":"2020","journal-title":"Toxicology & pharmacology : CB (Curr. Biol.)"},{"key":"10.1016\/j.envpol.2021.118418_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2021.118418_bib29","doi-asserted-by":"crossref","first-page":"E876","DOI":"10.1152\/ajpendo.00118.2004","article-title":"Regulation of adiponectin receptor gene expression in diabetic mice","volume":"288","author":"Inukai","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.envpol.2021.118418_bib30","doi-asserted-by":"crossref","first-page":"9900","DOI":"10.1073\/pnas.152098899","article-title":"Synergism between trematode infection and pesticide exposure: a link to amphibian limb deformities in nature?","volume":"99","author":"Kiesecker","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.envpol.2021.118418_bib31","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1194\/jlr.M700330-JLR200","article-title":"Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine","volume":"48","author":"Kim","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.envpol.2021.118418_bib32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.envpol.2021.118418_bib33","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.aquatox.2011.02.003","article-title":"Early life progestin exposure causes arrested oocyte development, oviductal agenesis and sterility in adult Xenopus tropicalis frogs","volume":"103","author":"Kvarnryd","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2021.118418_bib34","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1289\/ehp.0901418","article-title":"Low levels of the herbicide atrazine alter sex ratios and reduce metamorphic success in Rana pipiens tadpoles raised in outdoor mesocosms","volume":"118","author":"Langlois","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2021.118418_bib35","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ygcen.2009.11.004","article-title":"Fadrozole and finasteride exposures modulate sex steroid- and thyroid hormone-related gene expression in Silurana (Xenopus) tropicalis early larval development","volume":"166","author":"Langlois","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.envpol.2021.118418_bib36","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00442-003-1390-5","article-title":"Growth or reproduction? Resource allocation by female frogs Rana temporaria","volume":"137","author":"Lardner","year":"2003","journal-title":"Oecologia"},{"key":"10.1016\/j.envpol.2021.118418_bib37","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1021\/es0114254","article-title":"Occurrence and environmental behavior of the bactericide triclosan and its methyl derivative in surface waters and in wastewater","volume":"36","author":"Lindstrom","year":"2002","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2021.118418_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2020.00471","article-title":"Early life exposure to environmentally relevant levels of endocrine disruptors drive multigenerational and transgenerational epigenetic changes in a fish model","volume":"7","author":"Major","year":"2020","journal-title":"Frontiers in Marine Science"},{"key":"10.1016\/j.envpol.2021.118418_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-8784-9_1","article-title":"Husbandry, general care, and transportation of Xenopus laevis and Xenopus tropicalis","volume":"1865","author":"McNamara","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.envpol.2021.118418_bib40","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s10646-014-1414-4","article-title":"Relationship between biomarkers and endocrine-disrupting compounds in wild Girardnichthys viviparus from two lakes with different degrees of pollution","volume":"24","author":"Olivares-Rubio","year":"2015","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.envpol.2021.118418_bib41","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s10646-011-0658-5","article-title":"Agricultural intensity in ovo affects growth, metamorphic development and sexual differentiation in the common toad (Bufo bufo)","volume":"20","author":"Orton","year":"2011","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.envpol.2021.118418_bib42","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1890\/ES13-00388.1","article-title":"Biological carryover effects: linking common concepts and mechanisms in ecology and evolution","volume":"5","author":"O'Connor","year":"2014","journal-title":"Ecosphere"},{"key":"10.1016\/j.envpol.2021.118418_bib43","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/icb\/icj028","article-title":"Larval experience and latent effects--metamorphosis is not a new beginning","volume":"46","author":"Pechenik","year":"2006","journal-title":"Integr. Comp. Biol."},{"key":"10.1016\/j.envpol.2021.118418_bib44","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/em.22311","article-title":"The role of environmental exposures and the epigenome in health and disease","volume":"61","author":"Perera","year":"2020","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.envpol.2021.118418_bib45","author":"Petersen"},{"key":"10.1016\/j.envpol.2021.118418_bib46","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.aquatox.2006.07.004","article-title":"Persistent sex-reversal and oviducal agenesis in adult Xenopus (Silurana) tropicalis frogs following larval exposure to the environmental pollutant ethynylestradiol","volume":"79","author":"Pettersson","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2021.118418_bib47","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1186\/1471-2164-15-666","article-title":"Impaired liver function in Xenopus tropicalis exposed to benzo[a]pyrene: transcriptomic and metabolic evidence","volume":"15","author":"Regnault","year":"2014","journal-title":"BMC Genom."},{"key":"10.1016\/j.envpol.2021.118418_bib48","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.chemosphere.2016.04.047","article-title":"Metabolic and immune impairments induced by the endocrine disruptors benzo[a]pyrene and triclosan in Xenopus tropicalis","volume":"155","author":"Regnault","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2021.118418_bib49","doi-asserted-by":"crossref","first-page":"E4416","DOI":"10.1073\/pnas.1721267115","article-title":"Unexpected metabolic disorders induced by endocrine disruptors in Xenopus tropicalis provide new lead for understanding amphibian decline","volume":"115","author":"Regnault","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.envpol.2021.118418_bib50","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.bbadis.2009.04.003","article-title":"OXPHOS gene expression and control in mitochondrial disorders","volume":"1792","author":"Reinecke","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.envpol.2021.118418_bib51","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1096\/fj.05-3993fje","article-title":"PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle","volume":"19","author":"Southgate","year":"2005","journal-title":"Faseb. J. : official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.envpol.2021.118418_bib52","doi-asserted-by":"crossref","first-page":"141940","DOI":"10.1016\/j.scitotenv.2020.141940","article-title":"Developmental reproductive toxicity and endocrine activity of propiconazole in the Xenopus tropicalis model","volume":"753","author":"Svanholm","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.118418_bib53","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.fsi.2009.04.008","article-title":"Role of maternally derived immunity in fish","volume":"27","author":"Swain","year":"2009","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.envpol.2021.118418_bib54","doi-asserted-by":"crossref","first-page":"15539","DOI":"10.3748\/wjg.v20.i42.15539","article-title":"Histopathology of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"20","author":"Takahashi","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.envpol.2021.118418_bib55","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/hep.25571","article-title":"Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner","volume":"55","author":"Tanos","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.envpol.2021.118418_bib56","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00031723","article-title":"On polynuclear aromatic hydrocarbons contamination levels in the ecosystem of Lake Peipsi in the 1970s-1980s","volume":"338","author":"Trapido","year":"1996","journal-title":"Hydrobiologia"},{"key":"10.1016\/j.envpol.2021.118418_bib57","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.envpol.2021.118418_bib58","doi-asserted-by":"crossref","first-page":"110861","DOI":"10.1016\/j.mce.2020.110861","article-title":"Agrochemicals disrupt multiple endocrine axes in amphibians","volume":"513","author":"Trudeau","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envpol.2021.118418_bib59","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.scitotenv.2019.06.386","article-title":"Concomitant exposure to benzo[a]pyrene and triclosan at environmentally relevant concentrations induces metabolic syndrome with multigenerational consequences in Silurana (Xenopus) tropicalis","volume":"689","author":"Usal","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2021.118418_bib60","doi-asserted-by":"crossref","first-page":"116109","DOI":"10.1016\/j.envpol.2020.116109","article-title":"Transgenerational metabolic disorders and reproduction defects induced by benzo[a]pyrene in Xenopus tropicalis","volume":"269","author":"Usal","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.118418_bib61","series-title":"Federal Register. Office of the Federal Register","article-title":"Endocrine disruptor screening program; second list of chemicals for tier 1 screening","year":"2010"},{"key":"10.1016\/j.envpol.2021.118418_bib62","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.envpol.2021.118418_bib63","doi-asserted-by":"crossref","first-page":"E12435","DOI":"10.1073\/pnas.1811695115","article-title":"Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish Danio rerio","volume":"115","author":"Vera-Chang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.envpol.2021.118418_bib64","doi-asserted-by":"crossref","first-page":"14968","DOI":"10.1074\/jbc.273.24.14968","article-title":"Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase","volume":"273","author":"Wagle","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 1","key":"10.1016\/j.envpol.2021.118418_bib65","doi-asserted-by":"crossref","first-page":"11466","DOI":"10.1073\/pnas.0801921105","article-title":"Colloquium paper: are we in the midst of the sixth mass extinction? A view from the world of amphibians","volume":"105","author":"Wake","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.envpol.2021.118418_bib66","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.envpol.2015.07.001","article-title":"Reproductive endocrine-disrupting effects of triclosan: population exposure, present evidence and potential mechanisms","volume":"206","author":"Wang","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2021.118418_bib67","series-title":"Reviews of Environmental Contamination and Toxicology","author":"Whitacre","year":"2010"},{"key":"10.1016\/j.envpol.2021.118418_bib68","article-title":"Polynuclear aromatic hydrocarbons in Drinking-water. Background document for development of WHO., Guidelines for drinking-water quality","volume":"vol. 2","author":"Who","year":"2003"},{"key":"10.1016\/j.envpol.2021.118418_bib69","series-title":"State of the Science of Endocrine Disrupting Chemicals in: Bergman","year":"2012"},{"key":"10.1016\/j.envpol.2021.118418_bib70","first-page":"155","article-title":"Cholesterol, corneal lipidosis, and xanthomatosis in amphibians. The veterinary clinics of North America","volume":"6","author":"Wright","year":"2003","journal-title":"Exotic animal practice"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749121020005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749121020005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:10:38Z","timestamp":1777540238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749121020005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":70,"alternative-id":["S0269749121020005"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2021.118418","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to a mixture of benzo[a]pyrene and triclosan induces multi-and transgenerational metabolic disorders associated with decreased female investment in reproduction in Silurana (Xenopus) tropicalis","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2021.118418","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118418"}}