{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:27:48Z","timestamp":1793312868590,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970045"],"award-info":[{"award-number":["81970045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000044"],"award-info":[{"award-number":["82000044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000045"],"award-info":[{"award-number":["82000045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202102080045"],"award-info":[{"award-number":["202102080045"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["ZNSA-2020003"],"award-info":[{"award-number":["ZNSA-2020003"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["ZNSA-2020013"],"award-info":[{"award-number":["ZNSA-2020013"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2017BT01S155"],"award-info":[{"award-number":["2017BT01S155"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2019KTSCX139"],"award-info":[{"award-number":["2019KTSCX139"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2020B1111330001"],"award-info":[{"award-number":["2020B1111330001"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1304101"],"award-info":[{"award-number":["2016YFC1304101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013262","name":"State Key Laboratory of Respiratory Disease","doi-asserted-by":"publisher","award":["SKLRD-Z-202103"],"award-info":[{"award-number":["SKLRD-Z-202103"]}],"id":[{"id":"10.13039\/100013262","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.envpol.2021.118464","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T20:24:11Z","timestamp":1636316651000},"page":"118464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"special_numbering":"PB","title":["Biomass-related PM2.5 induces mitochondrial fragmentation and dysfunction in human airway epithelial cells"],"prefix":"10.1016","volume":"292","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4085-1374","authenticated-orcid":false,"given":"Mi","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haichao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhong","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiudi","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pixin","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.envpol.2021.118464_bib1","doi-asserted-by":"crossref","first-page":"L103","DOI":"10.1152\/ajplung.00320.2015","article-title":"Rejuvenating cellular respiration for optimizing respiratory function: targeting mitochondria","volume":"310","author":"Agrawal","year":"2016","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"1","key":"10.1016\/j.envpol.2021.118464_bib2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbcan.2018.05.005","article-title":"Mitochondria in cancer metabolism, an organelle whose time has come?","volume":"1870","author":"Anderson","year":"2018","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"issue":"9","key":"10.1016\/j.envpol.2021.118464_bib3","doi-asserted-by":"crossref","first-page":"L840","DOI":"10.1152\/ajplung.00155.2013","article-title":"Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle","volume":"306","author":"Aravamudan","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.envpol.2021.118464_bib4","doi-asserted-by":"crossref","first-page":"7808576","DOI":"10.1155\/2016\/7808576","article-title":"The role of mitochondria and oxidative\/antioxidative imbalance in pathobiology of chronic obstructive pulmonary disease","volume":"2016","author":"Bialas","year":"2016","journal-title":"Oxid Med Cell Longev"},{"issue":"8","key":"10.1016\/j.envpol.2021.118464_bib5","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3109\/02713683.2014.959607","article-title":"Mitochondria-targeted antioxidant peptide SS31 protects cultured human lens epithelial cells against oxidative stress","volume":"40","author":"Cai","year":"2014","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.envpol.2021.118464_bib6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.envpol.2021.118464_bib7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mito.2017.12.001","article-title":"Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases","volume":"41","author":"Dela Cruz","year":"2018","journal-title":"Mitochondrion"},{"issue":"8","key":"10.1016\/j.envpol.2021.118464_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/cells7080086","article-title":"Mitochondrial quality control in COPD and IPF","volume":"7","author":"Hara","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.envpol.2021.118464_bib9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1465-9921-14-97","article-title":"Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells","volume":"14","author":"Hoffmann","year":"2013","journal-title":"Respir. Res."},{"issue":"11","key":"10.1016\/j.envpol.2021.118464_bib10","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1164\/rccm.201205-0850OC","article-title":"Inflammatory and oxidative stress responses of healthy young adults to changes in air quality during the Beijing Olympics","volume":"186","author":"Huang","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.envpol.2021.118464_bib11","doi-asserted-by":"crossref","first-page":"11084","DOI":"10.1038\/s41598-017-11541-1","article-title":"Positive feedback of the amphiregulin-EGFR-ERK pathway mediates PM2.5 from wood smoke-induced MUC5AC expression in epithelial cells","volume":"7","author":"Huang","year":"2017","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.envpol.2021.118464_bib12","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3109\/10715762.2013.832831","article-title":"Oxidative potential of smoke from burning wood and mixed biomass fuels","volume":"47","author":"Kurmi","year":"2013","journal-title":"Free Radic. Res."},{"issue":"Pt B","key":"10.1016\/j.envpol.2021.118464_bib13","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.envpol.2018.09.062","article-title":"Air pollution-derived PM2.5 impairs mitochondrial function in healthy and chronic obstructive pulmonary diseased human bronchial epithelial cells","volume":"243","author":"Leclercq","year":"2018","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.envpol.2021.118464_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092782","article-title":"Combined therapy with SS31 and mitochondria mitigates myocardial ischemia-reperfusion injury in rats","volume":"19","author":"Lee","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"Pt B","key":"10.1016\/j.envpol.2021.118464_bib15","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.biocel.2016.07.026","article-title":"Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD","volume":"81","author":"Lerner","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.envpol.2021.118464_bib16","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.scitotenv.2017.05.006","article-title":"Multi-scale sustainability assessments for biomass-based and coal-based fuels in China","volume":"599\u2013600","author":"Man","year":"2017","journal-title":"Sci. Total Environ."},{"issue":"10","key":"10.1016\/j.envpol.2021.118464_bib17","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/jat.3828","article-title":"Mitochondrial dysfunction in endothelial cells induced by airborne fine particulate matter (<2.5 mum)","volume":"39","author":"Miao","year":"2019","journal-title":"J. Appl. Toxicol."},{"issue":"10","key":"10.1016\/j.envpol.2021.118464_bib18","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nrm3877","article-title":"Mitochondrial dynamics and inheritance during cell division, development and disease","volume":"15","author":"Mishra","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.envpol.2021.118464_bib19","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2217\/bmm-2016-0373","article-title":"Mitochondria in chronic obstructive pulmonary disease and lung cancer: where are we now?","volume":"11","author":"Nam","year":"2017","journal-title":"Biomarkers Med."},{"key":"10.1016\/j.envpol.2021.118464_bib20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.abb.2019.01.002","article-title":"Mitochondrial regulation of airway smooth muscle functions in health and pulmonary diseases","volume":"663","author":"Pan","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.envpol.2021.118464_bib21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.toxlet.2021.05.010","article-title":"Exposure to biomass smoke induces pulmonary Th17 cell differentiation by activating TLR2 on dendritic cells in a COPD rat model","volume":"348","author":"Pu","year":"2021","journal-title":"Toxicol. Lett."},{"issue":"Suppl. 4","key":"10.1016\/j.envpol.2021.118464_bib22","doi-asserted-by":"crossref","first-page":"S266","DOI":"10.1513\/AnnalsATS.201808-585MG","article-title":"Mitochondrial dysfunction as a pathogenic mediator of chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis","volume":"15","author":"Ryter","year":"2018","journal-title":"Ann Am Thorac Soc"},{"issue":"6","key":"10.1016\/j.envpol.2021.118464_bib23","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011072","article-title":"Mechanisms of mitochondrial fission and fusion","volume":"5","author":"van der Bliek","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"3","key":"10.1016\/j.envpol.2021.118464_bib24","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jaci.2015.01.046","article-title":"Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease","volume":"136","author":"Wiegman","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"issue":"9","key":"10.1016\/j.envpol.2021.118464_bib25","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1080\/15548627.2017.1338545","article-title":"BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming","volume":"13","author":"Xiang","year":"2017","journal-title":"Autophagy"},{"issue":"13","key":"10.1016\/j.envpol.2021.118464_bib26","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1007\/s00018-015-1863-9","article-title":"Mitochondrial fusion provides an 'initial metabolic complementation' controlled by mtDNA","volume":"72","author":"Yang","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.envpol.2021.118464_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12931-017-0702-y","article-title":"PM2.5 promotes human bronchial smooth muscle cell migration via the sonic hedgehog signaling pathway","volume":"19","author":"Ye","year":"2018","journal-title":"Respir. Res."},{"issue":"2","key":"10.1016\/j.envpol.2021.118464_bib28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000441299","article-title":"Mitochondrial regulation of inflammasome activation in chronic obstructive pulmonary disease","volume":"8","author":"Yoon","year":"2016","journal-title":"J Innate Immun"},{"issue":"5","key":"10.1016\/j.envpol.2021.118464_bib29","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3109\/15412555.2013.781579","article-title":"The association between BMI and COPD: the results of two population-based studies in Guangzhou, China","volume":"10","author":"Zhou","year":"2013","journal-title":"COPD"},{"issue":"3","key":"10.1016\/j.envpol.2021.118464_bib30","doi-asserted-by":"crossref","first-page":"e1001621","DOI":"10.1371\/journal.pmed.1001621","article-title":"Lung function and incidence of chronic obstructive pulmonary disease after improved cooking fuels and kitchen ventilation: a 9-year prospective cohort study","volume":"11","author":"Zhou","year":"2014","journal-title":"PLoS Med."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749121020467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749121020467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T18:12:12Z","timestamp":1762279932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749121020467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":30,"alternative-id":["S0269749121020467"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2021.118464","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomass-related PM2.5 induces mitochondrial fragmentation and dysfunction in human airway epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2021.118464","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"118464"}}