{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:31:49Z","timestamp":1792794709797,"version":"4.5.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["ZD 2020C005"],"award-info":[{"award-number":["ZD 2020C005"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2572021AW04"],"award-info":[{"award-number":["2572021AW04"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.envpol.2022.119449","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T02:24:28Z","timestamp":1652063068000},"page":"119449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":196,"special_numbering":"C","title":["Polystyrene microplastics up-regulates liver glutamine and glutamate synthesis and promotes autophagy-dependent ferroptosis and apoptosis in the cerebellum through the liver-brain axis"],"prefix":"10.1016","volume":"307","author":[{"given":"Kai","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yachen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.envpol.2022.119449_bib1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.tips.2017.02.005","article-title":"Ferroptosis inhibition: mechanisms and opportunities","volume":"38","author":"Angeli","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"issue":"4493","key":"10.1016\/j.envpol.2022.119449_bib2","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/1761126a0","article-title":"Role of glutamine in urea synthesis","volume":"176","author":"Bach","year":"1956","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.envpol.2022.119449_bib3","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.bbrc.2018.12.039","article-title":"Lipid storage and lipophagy regulates ferroptosis","volume":"508","author":"Bai","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.envpol.2022.119449_bib4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4161\/gmic.28684","article-title":"The role of microbiota in hepatic encephalopathy","volume":"5","author":"Bajaj","year":"2014","journal-title":"Gut Microb."},{"key":"10.1016\/j.envpol.2022.119449_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138707","article-title":"Zebrafish: an emerging model to study microplastic and nanoplastic toxicity","volume":"728","author":"Bhagat","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119449_bib6","doi-asserted-by":"crossref","first-page":"149674","DOI":"10.1016\/j.scitotenv.2021.149674","article-title":"Organochlorine pesticides, polycyclic aromatic hydrocarbons, metals and metalloids in microplastics found in regurgitated pellets of black vulture from Campeche, Mexico","volume":"801","author":"Borges-Ram\u00edrez","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119449_bib7","doi-asserted-by":"crossref","first-page":"142808","DOI":"10.1016\/j.scitotenv.2020.142808","article-title":"Breeding seabirds as vectors of microplastics from sea to land: evidence from colonies in Arctic Canada","volume":"764","author":"Bourdages","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119449_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.113978","article-title":"High density polyethylene (HDPE) microplastics impair development and swimming activity of Pacific oyster D-larvae, Crassostrea gigas, depending on particle size","volume":"260","author":"Bringer","year":"2020","journal-title":"Environ. Pollut."},{"issue":"11","key":"10.1016\/j.envpol.2022.119449_bib9","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1139\/cjfas-2018-0388","article-title":"Microplastics in the diet of nestling double-crested cormorants (Phalacrocorax auritus), an obligate piscivore in a freshwater ecosystem","volume":"76","author":"Brookson","year":"2019","journal-title":"Can. J. Fish. Aquat. Sci."},{"key":"10.1016\/j.envpol.2022.119449_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114633","article-title":"Microplastic accumulation in the gastrointestinal tracts in birds of prey in central Florida, USA","volume":"264","author":"Carlin","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2022.119449_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152681","article-title":"Long-term exposure to polyethylene microplastics and glyphosate interferes with the behavior, intestinal microbial homeostasis, and metabolites of the common carp (Cyprinus carpio L.)","volume":"814","author":"Chen","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.envpol.2022.119449_bib12","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3892\/or.2015.3712","article-title":"Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-gamma-lyase function","volume":"33","author":"Chen","year":"2015","journal-title":"Oncol. Rep."},{"issue":"9","key":"10.1016\/j.envpol.2022.119449_bib13","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.envpol.2022.119449_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.marenvres.2019.104838","article-title":"Evaluation of microplastic toxicity in accordance with different sizes and exposure times in the marine copepod Tigriopus japonicus","volume":"153","author":"Choi","year":"2020","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.envpol.2022.119449_bib15","doi-asserted-by":"crossref","first-page":"134317","DOI":"10.1016\/j.chemosphere.2022.134317","article-title":"Long-term exposure of the Mediterranean mussels, Mytilus galloprovincialis to polyethylene terephthalate microfibers: implication for reproductive and neurotoxic effects","volume":"299","author":"Choi","year":"2022","journal-title":"Chemosphere"},{"issue":"5","key":"10.1016\/j.envpol.2022.119449_bib16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41556-019-0305-6","article-title":"ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway","volume":"21","author":"Chu","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"11","key":"10.1016\/j.envpol.2022.119449_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/nu10111564","article-title":"Glutamine: metabolism and immune function, supplementation and clinical translation","volume":"10","author":"Cruzat","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2022.119449_bib18","series-title":"An Introduction to Glutamine Metabolism: Glutamine: Biochemistry, Physiology, and Clinical Applications","author":"Cruzat","year":"2017"},{"key":"10.1016\/j.envpol.2022.119449_bib19","first-page":"764","article-title":"Dibutyl phthalate-induced oxidative stress, inflammation and apoptosis in grass carp hepatocytes and the therapeutic use of taxifolin","author":"Cui","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119449_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jhazmat.2020.122693","article-title":"Toxicological effects of nano- and micro-polystyrene plastics on red tilapia: are larger plastic particles more harmless?","volume":"396","author":"Ding","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2022.119449_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.nbd.2016.05.011","article-title":"Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC","volume":"94","author":"Do Van","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.envpol.2022.119449_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.marpolbul.2019.04.030","article-title":"Microplastics and the gut microbiome: how chronically exposed species may suffer from gut dysbiosis","volume":"143","author":"Fackelmann","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.envpol.2022.119449_bib23","first-page":"9638797","article-title":"Cognitive changes and brain volume reduction in patients with nonalcoholic fatty liver disease","volume":"2018","author":"Filipovi\u0107","year":"2018","journal-title":"Canad. J. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.envpol.2022.119449_bib24","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and transferrin regulate ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.envpol.2022.119449_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127110","article-title":"Epigenetic regulator BRD4 is involved in cadmium-induced acute kidney injury via contributing to lysosomal dysfunction, autophagy blockade and oxidative stress","volume":"423","author":"Gong","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2022.119449_bib26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.watres.2020.115623","article-title":"Microplastics entering northwestern Lake Ontario are diverse and linked to urban sources","volume":"174","author":"Grbic","year":"2020","journal-title":"Water Res."},{"issue":"11","key":"10.1016\/j.envpol.2022.119449_bib27","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1016\/j.bbagen.2017.07.015","article-title":"Expression and characterization of the ferritin binding domain of Nuclear Receptor Coactivator-4 (NCOA4)","volume":"1861","author":"Gryzik","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"4","key":"10.1016\/j.envpol.2022.119449_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biology5040037","article-title":"How glutamate is managed by the blood\u2013brain barrier","volume":"5","author":"Hawkins","year":"2016","journal-title":"Biology"},{"issue":"3","key":"10.1016\/j.envpol.2022.119449_bib29","doi-asserted-by":"crossref","first-page":"867S","DOI":"10.3945\/ajcn.2009.27462BB","article-title":"The blood-brain barrier and glutamate","volume":"90","author":"Hawkins","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.envpol.2022.119449_bib30","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.scitotenv.2017.01.190","article-title":"Microplastics in freshwater and terrestrial environments: evaluating the current understanding to identify the knowledge gaps and future research priorities","volume":"586","author":"Horton","year":"2017","journal-title":"Sci. Total Environ."},{"issue":"8","key":"10.1016\/j.envpol.2022.119449_bib31","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.envpol.2022.119449_bib32","doi-asserted-by":"crossref","first-page":"138929","DOI":"10.1016\/j.scitotenv.2020.138929","article-title":"Exposure to microplastics impairs digestive performance, stimulates immune response and induces microbiota dysbiosis in the gut of juvenile guppy (Poecilia reticulata)","volume":"733","author":"Huang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119449_bib33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neulet.2018.02.004","article-title":"Why do so many genetic insults lead to Purkinje Cell degeneration and spinocerebellar ataxia?","volume":"688","author":"Huang","year":"2019","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.envpol.2022.119449_bib34","first-page":"352","article-title":"The direct contribution of astrocytes and microglia to the pathogenesis of hepatic encephalopathy","volume":"7","author":"Jaeger","year":"2019","journal-title":"Journal of Clinical and Translational Hepatology"},{"issue":"7545","key":"10.1016\/j.envpol.2022.119449_bib35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.envpol.2022.119449_bib36","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2022.119449_bib37","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.scitotenv.2018.08.353","article-title":"Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice","volume":"649","author":"Jin","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.envpol.2022.119449_bib38","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s12311-010-0182-9","article-title":"Deranged calcium signaling in Purkinje cells and pathogenesis in spinocerebellar ataxia 2 (SCA2) and other ataxias","volume":"11","author":"Kasumu","year":"2012","journal-title":"Cerebellum"},{"issue":"17","key":"10.1016\/j.envpol.2022.119449_bib39","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1089\/ars.2017.7176","article-title":"The roles of NRF2 in modulating cellular iron homeostasis","volume":"29","author":"Kerins","year":"2018","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.envpol.2022.119449_bib40","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.biopha.2018.11.030","article-title":"Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway","volume":"109","author":"Kong","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.envpol.2022.119449_bib41","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.neuron.2015.03.010","article-title":"Circuit mechanisms underlying motor memory formation in the cerebellum","volume":"86","author":"Lee","year":"2015","journal-title":"Neuron"},{"issue":"15","key":"10.1016\/j.envpol.2022.119449_bib42","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1039\/C8AN00599K","article-title":"Partial least squares-discriminant analysis (PLS-DA) for classification of high-dimensional (HD) data: a review of contemporary practice strategies and knowledge gaps","volume":"143","author":"Lee","year":"2018","journal-title":"Analyst"},{"issue":"9\u201310","key":"10.1016\/j.envpol.2022.119449_bib43","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s10495-020-01627-z","article-title":"BAX-dependent mitochondrial pathway mediates the crosstalk between ferroptosis and apoptosis","volume":"25","author":"Lee","year":"2020","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.envpol.2022.119449_bib44","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-021-02745-1","article-title":"Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2\/HO-1 pathway","volume":"19","author":"Li","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.envpol.2022.119449_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134296","article-title":"Hydrogen sulfide exposure induces apoptosis and necroptosis through lncRNA3037\/miR-15a\/BCL2-A20 signaling in broiler trachea","volume":"699","author":"Li","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119449_bib46","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.envpol.2020.114721","article-title":"Are we underestimating microplastic abundance in the marine environment? A comparison of microplastic capture with nets of different mesh-size","volume":"265","author":"Lindeque","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2022.119449_bib47","doi-asserted-by":"crossref","first-page":"107038","DOI":"10.1016\/j.envint.2021.107038","article-title":"Glyphosate damages blood-testis barrier via NOX1-triggered oxidative stress in rats: long-term exposure as a potential risk for male reproductive health","volume":"159","author":"Liu","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2022.119449_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.107038","article-title":"Glyphosate damages blood-testis barrier via NOX1-triggered oxidative stress in rats: long-term exposure as a potential risk for male reproductive health","volume":"159","author":"Liu","year":"2022","journal-title":"Environ. Int."},{"issue":"1\u20132","key":"10.1016\/j.envpol.2022.119449_bib49","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41417-020-0182-y","article-title":"Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death","volume":"28","author":"Liu","year":"2021","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.envpol.2022.119449_bib50","first-page":"1","article-title":"Melatonin suppresses ferroptosis induced by high glucose via activation of the Nrf2\/HO-1 signaling pathway in type 2 diabetic osteoporosis","volume":"2020","author":"Ma","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.envpol.2022.119449_bib51","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1021\/es5053655","article-title":"Altered behavior, physiology, and metabolism in fish exposed to polystyrene nanoparticles","volume":"49","author":"Mattsson","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119449_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10813-0","article-title":"Brain damage and behavioural disorders in fish induced by plastic nanoparticles delivered through the food chain","volume":"7","author":"Mattsson","year":"2017","journal-title":"Sci. Rep."},{"issue":"16","key":"10.1016\/j.envpol.2022.119449_bib53","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1113\/JP271897","article-title":"Cellular and circuit mechanisms underlying spinocerebellar ataxias","volume":"594","author":"Meera","year":"2016","journal-title":"J. Physiol.-Lond."},{"key":"10.1016\/j.envpol.2022.119449_bib54","series-title":"Activation of Pyroptosis and Ferroptosis Is Involved in the Hepatotoxicity Induced by Polystyrene Microplastics in Mice","first-page":"132944","author":"Mu","year":"2021"},{"issue":"8","key":"10.1016\/j.envpol.2022.119449_bib55","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/apt.12925","article-title":"Review article: depression and the use of antidepressants in patients with chronic liver disease or liver transplantation","volume":"40","author":"Mullish","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.envpol.2022.119449_bib56","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.abb.2006.08.005","article-title":"Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion","volume":"454","author":"Osburn","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.envpol.2022.119449_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112518","article-title":"Neuroprotective effects of Dendropanax morbifera leaves on glutamate-induced oxidative cell death in HT22 mouse hippocampal neuronal cells","volume":"251","author":"Park","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.envpol.2022.119449_bib58","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/bib\/bby128","article-title":"miR plus Pathway: the integration and visualization of miRNA and KEGG pathways","volume":"21","author":"Pian","year":"2020","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.envpol.2022.119449_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125476","article-title":"Studying microplastics: lessons from evaluated literature on animal model organisms and experimental approaches","volume":"414","author":"Prokic","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2022.119449_bib60","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.scitotenv.2019.02.184","article-title":"Is plastic ingestion in birds as toxic as we think? Insights from a plastic feeding experiment","volume":"665","author":"Roman","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.envpol.2022.119449_bib61","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.jhep.2020.07.013","article-title":"Hepatic encephalopathy: novel insights into classification, pathophysiology and therapy","volume":"73","author":"Rose","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.envpol.2022.119449_bib62","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1042\/BST20130237","article-title":"Astrocyte glutamine synthetase: pivotal in health and disease","volume":"41","author":"Rose","year":"2013","journal-title":"Biochem. Soc. Trans."},{"issue":"4","key":"10.1016\/j.envpol.2022.119449_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041410","article-title":"Nanoplastics cause neurobehavioral impairments, reproductive and oxidative damages, and biomarker responses in Zebrafish: throwing up alarms of wide spread health risk of exposure","volume":"21","author":"Sarasamma","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"47","key":"10.1016\/j.envpol.2022.119449_bib64","doi-asserted-by":"crossref","first-page":"44765","DOI":"10.1074\/jbc.M208704200","article-title":"Electrophile response element-mediated induction of the cystine\/glutamate exchange transporter gene expression","volume":"277","author":"Sasaki","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2022.119449_bib65","volume":"vol. 12","author":"Schwarzfischer","year":"2022"},{"issue":"12","key":"10.1016\/j.envpol.2022.119449_bib66","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1212\/WNL.0000000000002498","article-title":"Nonalcoholic fatty liver disease is associated with cognitive function in adults","volume":"86","author":"Seo","year":"2016","journal-title":"Neurology"},{"issue":"7443","key":"10.1016\/j.envpol.2022.119449_bib67","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature12040","article-title":"Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway","volume":"496","author":"Son","year":"2013","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.envpol.2022.119449_bib68","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.cub.2018.05.094","article-title":"AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system X-c(-) activity","volume":"28","author":"Song","year":"2018","journal-title":"Curr. Biol."},{"issue":"6","key":"10.1016\/j.envpol.2022.119449_bib69","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","article-title":"Emerging mechanisms and disease relevance of ferroptosis","volume":"30","author":"Stockwell","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.envpol.2022.119449_bib70","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2018.09.008","article-title":"Iron catalysis of lipid peroxidation in ferroptosis: regulated enzymatic or random free radical reaction?","volume":"133","author":"Stoyanovsky","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envpol.2022.119449_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125581","article-title":"Environmentally relevant concentrations of microplastics influence the locomotor activity of aquatic biota","volume":"414","author":"Sun","year":"2021","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.envpol.2022.119449_bib72","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.28251","article-title":"Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells","volume":"63","author":"Sun","year":"2016","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.envpol.2022.119449_bib73","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S1665-2681(19)32153-2","article-title":"Brain edema in acute liver failure. A window to the pathogenesis of hepatic encephalopathy","volume":"2","author":"Vaquero","year":"2003","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.envpol.2022.119449_bib74","doi-asserted-by":"crossref","first-page":"102255","DOI":"10.1016\/j.redox.2022.102255","article-title":"Selenoprotein K protects skeletal muscle from damage and is required for satellite cells-mediated myogenic differentiation","volume":"50","author":"Wang","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.envpol.2022.119449_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121626","article-title":"Ammonia regulates chicken tracheal cell necroptosis via the LncRNA-107053293\/MiR-148a-3p\/FAF1 axis","volume":"386","author":"Wang","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2022.119449_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116597","article-title":"Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene","volume":"274","author":"Wang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2022.119449_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111473","article-title":"Zinc offers splenic protection through suppressing PERK\/IRE1-driven apoptosis pathway in common carp (Cyprinus carpio) under arsenic stress","volume":"208","author":"Wang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2022.119449_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109870","article-title":"Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation","volume":"78","author":"Wang","year":"2021","journal-title":"Cell. Signal."},{"issue":"5","key":"10.1016\/j.envpol.2022.119449_bib79","doi-asserted-by":"crossref","DOI":"10.1289\/EHP7612","article-title":"The kidney-related effects of polystyrene microplastics on human kidney proximal tubular epithelial cells HK-2 and male C57BL\/6 mice","volume":"129","author":"Wang","year":"2021","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.envpol.2022.119449_bib80","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ymthe.2020.09.024","article-title":"Q nuclear long non-coding RNA LINC00618 accelerates ferroptosis in a manner dependent upon apoptosis","volume":"29","author":"Wang","year":"2021","journal-title":"Mol. Ther."},{"issue":"6","key":"10.1016\/j.envpol.2022.119449_bib81","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.jhep.2016.07.046","article-title":"Cerebrospinal fluid metabolomics highlights dysregulation of energy metabolism in overt hepatic encephalopathy","volume":"65","author":"Weiss","year":"2016","journal-title":"J. Hepatol."},{"issue":"38","key":"10.1016\/j.envpol.2022.119449_bib82","doi-asserted-by":"crossref","first-page":"11899","DOI":"10.1073\/pnas.1502108112","article-title":"Threat of plastic pollution to seabirds is global, pervasive, and increasing","volume":"112","author":"Wilcox","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.envpol.2022.119449_bib83","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.envint.2019.105411","article-title":"Atmospheric microplastic deposition in an urban environment and an evaluation of transport","volume":"136","author":"Wright","year":"2020","journal-title":"Environ. Int."},{"issue":"8","key":"10.1016\/j.envpol.2022.119449_bib84","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1111\/jcmm.14511","article-title":"Molecular mechanisms of ferroptosis and its role in cancer therapy","volume":"23","author":"Xu","year":"2019","journal-title":"J. Cell Mol. Med."},{"issue":"2","key":"10.1016\/j.envpol.2022.119449_bib85","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00253-019-10257-8","article-title":"Targeting PI3K\/AKT\/mTOR-mediated autophagy for tumor therapy","volume":"104","author":"Xu","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.envpol.2022.119449_bib86","doi-asserted-by":"crossref","first-page":"107844","DOI":"10.1016\/j.intimp.2021.107844","article-title":"Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2\/ARE\/NF-\u03baB signal pathway","volume":"98","author":"Yan","year":"2021","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.envpol.2022.119449_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122058","article-title":"Toxicity comparison of nano-sized and micron-sized microplastics to Goldfish Carassius auratus Larvae","volume":"388","author":"Yang","year":"2020","journal-title":"J. Hazard Mater."},{"issue":"14","key":"10.1016\/j.envpol.2022.119449_bib88","doi-asserted-by":"crossref","first-page":"5933","DOI":"10.1128\/MCB.25.14.5933-5946.2005","article-title":"Nrf 1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappa B and AP-1","volume":"25","author":"Yang","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2022.119449_bib89","doi-asserted-by":"crossref","first-page":"146546","DOI":"10.1016\/j.scitotenv.2021.146546","article-title":"Microplastics in soil: a review on methods, occurrence, sources, and potential risk","volume":"780","author":"Yang","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"1\u20132","key":"10.1016\/j.envpol.2022.119449_bib90","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2022.119449_bib91","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.chemosphere.2019.125627","article-title":"Freshwater microplastics pollution: detecting and visualizing emerging trends based on Citespace II","volume":"245","author":"Yao","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2022.119449_bib92","first-page":"774","article-title":"A comparative review of microplastics and nanoplastics: toxicity hazards on digestive, reproductive and nervous system","author":"Yin","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119449_bib93","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.aquatox.2018.04.015","article-title":"Accumulation of polystyrene microplastics in juvenile Eriocheir sinensis and oxidative stress effects in the liver","volume":"200","author":"Yu","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2022.119449_bib94","doi-asserted-by":"crossref","first-page":"143054","DOI":"10.1016\/j.scitotenv.2020.143054","article-title":"Environmentally relevant concentration of cypermethrin or\/and sulfamethoxazole induce neurotoxicity of grass carp: involvement of blood-brain barrier, oxidative stress and apoptosis","volume":"762","author":"Zhao","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"9","key":"10.1016\/j.envpol.2022.119449_bib95","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1021\/acs.est.1c00515","article-title":"ROS-induced hepatotoxicity under cypermethrin: involvement of the crosstalk between nrf2\/keap1 and NF-kappa B\/i kappa B-alpha pathways regulated by proteasome","volume":"55","author":"Zhao","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119449_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.150252","article-title":"Microplastic-induced apoptosis and metabolism responses in marine Dinoflagellate, Karenia mikimotoi","volume":"804","author":"Zhao","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.envpol.2022.119449_bib97","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cell.2015.10.067","article-title":"Establishment and dysfunction of the blood-brain barrier","volume":"163","author":"Zhao","year":"2015","journal-title":"Cell"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749122006637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749122006637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T22:27:13Z","timestamp":1759444033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749122006637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":97,"alternative-id":["S0269749122006637"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2022.119449","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polystyrene microplastics up-regulates liver glutamine and glutamate synthesis and promotes autophagy-dependent ferroptosis and apoptosis in the cerebellum through the liver-brain axis","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2022.119449","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119449"}}