{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:04:52Z","timestamp":1792569892870,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Government of Japan Ministry of Education Culture Sports Science and Technology","doi-asserted-by":"publisher","award":["19K05924"],"award-info":[{"award-number":["19K05924"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004721","name":"University of Tokyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002770","name":"Cabinet Office, Government of Japan","doi-asserted-by":"publisher","award":["1905"],"award-info":[{"award-number":["1905"]}],"id":[{"id":"10.13039\/501100002770","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.envpol.2022.119555","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T02:35:29Z","timestamp":1653878129000},"page":"119555","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Presence of nano-sized mercury-containing particles in seafoods, and an estimate of dietary exposure"],"prefix":"10.1016","volume":"307","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6240-2078","authenticated-orcid":false,"given":"Yoshinari","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumitsu","family":"Ogra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2022.119555_bib1","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1897\/06-359R.1","article-title":"Evaluating mercury biomagnification in fish from a tropical marine environment using stable isotopes (\u03b413C and \u03b415N)","volume":"26","author":"Al-Reasi","year":"2007","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2022.119555_bib2","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.1021\/es040367u","article-title":"Chemical forms of mercury and cadmium accumulated in marine mammals and seabirds as determined by XAFS analysis","volume":"38","author":"Arai","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119555_bib3","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.envpol.2008.05.020","article-title":"Trace elements and stable isotopes (\u03b413C and \u03b415N) in shallow and deep-water organisms from the East China Sea","volume":"156","author":"Asante","year":"2008","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2022.119555_bib4","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.1038\/s41598-019-43825-z","article-title":"High-precision isotopic analysis sheds new light on mercury metabolism in long-finned pilot whales (Globicephala melas)","volume":"9","author":"Bolea-Fernandez","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2022.119555_bib5","doi-asserted-by":"crossref","first-page":"19964","DOI":"10.1039\/C5RA26268B","article-title":"Precise determination of the nanoparticle concentration and ligand density of engineered water-soluble HgSe fluorescent nanoparticles","volume":"6","author":"Bouzas-Ramos","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.envpol.2022.119555_bib7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0025-326X(02)00095-4","article-title":"Mercury, organic-mercury and selenium in small cetaceans in Taiwanese waters","volume":"45","author":"Chen","year":"2002","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.envpol.2022.119555_bib8","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMra022471","article-title":"The toxicology of mercury \u2014 current exposures and clinical manifestations","volume":"349","author":"Clarkson","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envpol.2022.119555_bib9","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.scitotenv.2012.11.046","article-title":"What are the toxicological effects of mercury in arctic biota?","volume":"443","author":"Dietz","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119555_bib10","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.2903\/j.efsa.2015.3982","article-title":"Statement on the benefits of fish\/seafood consumption compared to the risks of methylmercury in fish\/seafood","volume":"13","year":"2015","journal-title":"EFSA J."},{"key":"10.1016\/j.envpol.2022.119555_bib11","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1021\/es050215e","article-title":"Total mercury, methyl mercury, and selenium levels in the red meat of small cetaceans sold for human consumption in Japan","volume":"39","author":"Endo","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119555_bib14","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1021\/tx000050h","article-title":"Structural basis of the antagonism between inorganic mercury and selenium in mammals","volume":"13","author":"Gailer","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2022.119555_bib15","doi-asserted-by":"crossref","first-page":"34361","DOI":"10.1038\/srep34361","article-title":"In vivo formation of natural HgSe nanoparticles in the liver and brain of pilot whales","volume":"6","author":"Gajdosechova","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2022.119555_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.trac.2017.12.005","article-title":"The role of selenium in mercury toxicity \u2013 current analytical techniques and future trends in analysis of selenium and mercury interactions in biological matrices","volume":"104","author":"Gajdosechova","year":"2018","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.envpol.2022.119555_bib17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/0192623310390705","article-title":"Nanotoxicology\u2014a pathologist's perspective","volume":"39","author":"Hubbs","year":"2011","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.envpol.2022.119555_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/15555270903404651","article-title":"An XAFS investigation of mercury and selenium in beluga whale tissues","volume":"4","author":"Huggins","year":"2009","journal-title":"Environ. Bioindic."},{"key":"10.1016\/j.envpol.2022.119555_bib19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s00244-004-3188-9","article-title":"Detoxification mechanism of heavy metals in marine mammals and seabirds: interaction of selenium with mercury, silver, copper, zinc, and cadmium in liver","volume":"47","author":"Ikemoto","year":"2004","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envpol.2022.119555_bib20","first-page":"1109","article-title":"Mercury and selenium levels in striped dolphins caught off the Pacific coast of Japan","volume":"48","author":"Itano","year":"1984","journal-title":"Agr. Biol. Chem. Tokyo"},{"key":"10.1016\/j.envpol.2022.119555_bib22","doi-asserted-by":"crossref","first-page":"127759","DOI":"10.1016\/j.jhazmat.2021.127759","article-title":"Identification of mercury-containing nanoparticles in the liver and muscle of cetaceans","volume":"424","author":"Ji","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2022.119555_bib23","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1897\/08-375.1","article-title":"Mercury-selenium compounds and their toxicological significance: toward a molecular understanding of the mercury-selenium antagonism","volume":"28","author":"Khan","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2022.119555_bib24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0269-7491(96)00110-8","article-title":"Specific accumulation of mercury and selenium in seabirds","volume":"94","author":"Kim","year":"1996","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2022.119555_bib25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/245385a0","article-title":"Mercury-selenium correlations in marine mammals","volume":"245","author":"Koeman","year":"1973","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2022.119555_bib26","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1021\/cn1000765","article-title":"The chemical nature of mercury in human brain following poisoning or environmental exposure","volume":"1","author":"Korbas","year":"2010","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.envpol.2022.119555_bib27","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.matpr.2020.05.761","article-title":"Mercury selenide nanoparticles induced toxicity on LDL, VLDL and cholesterol-HDL ratio of Rattus norvegicus","volume":"31","author":"Kumar","year":"2020","journal-title":"Mater. Today Proc."},{"key":"10.1016\/j.envpol.2022.119555_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042162","article-title":"Mercury-selenium relationships in liver of Guiana dolphin: the possible role of kupffer cells in the detoxification process by tiemannite formation","volume":"7","author":"Lailson-Brito","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2022.119555_bib29","first-page":"154557","article-title":"Understanding the risks of mercury sulfide nanoparticles in the environment: formation, presence, and environmental behaviors","volume":"829","author":"Lei","year":"2022","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.envpol.2022.119555_bib30","doi-asserted-by":"crossref","first-page":"125688","DOI":"10.1016\/j.chemosphere.2019.125688","article-title":"A critical review about neurotoxic effects in marine mammals of mercury and other trace elements","volume":"246","author":"L\u00f3pez-Berenguer","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2022.119555_bib31","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1039\/c5mt00145e","article-title":"Interaction of mercury and selenium in the larval stage zebrafish vertebrate model","volume":"7","author":"MacDonald","year":"2015","journal-title":"Metallomics"},{"key":"10.1016\/j.envpol.2022.119555_bib32","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1021\/acs.est.0c06269","article-title":"In vivo formation of HgSe nanoparticles and Hg\u2013tetraselenolate complex from methylmercury in seabirds\u2014implications for the Hg\u2013Se antagonism","volume":"55","author":"Manceau","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119555_bib33","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/acs.estlett.1c00217","article-title":"Chemical forms of mercury in blue Marlin Billfish: implications for human exposure","volume":"8","author":"Manceau","year":"2021","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.envpol.2022.119555_bib34","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.earscirev.2009.06.002","article-title":"Mercury methylation dynamics in estuarine and coastal marine environments \u2014 a critical review","volume":"96","author":"Merritt","year":"2009","journal-title":"Earth Sci. Rev."},{"key":"10.1016\/j.envpol.2022.119555_bib35","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1039\/C9JA00206E","article-title":"A critical review of single particle inductively coupled plasma mass spectrometry \u2013 a step towards an ideal method for nanomaterial characterization","volume":"35","author":"Mozhayeva","year":"2020","journal-title":"J. Anal. Atomic Spectrom."},{"key":"10.1016\/j.envpol.2022.119555_bib36","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1039\/c0mt00106f","article-title":"The presence of mercury selenide in various tissues of the striped dolphin: evidence from \u03bc-XRF-XRD and XAFS analyses","volume":"3","author":"Nakazawa","year":"2011","journal-title":"Metallomics"},{"key":"10.1016\/j.envpol.2022.119555_bib37","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.2116\/analsci.18P255","article-title":"A method for methylmercury and inorganic mercury in biological samples using high performance liquid chromatography\u2013inductively coupled plasma mass spectrometry","volume":"34","author":"Narukawa","year":"2018","journal-title":"Anal. Sci."},{"key":"10.1016\/j.envpol.2022.119555_bib38","doi-asserted-by":"crossref","first-page":"11551","DOI":"10.1021\/es501369b","article-title":"Molecular and neurochemical biomarkers in arctic beluga whales (Delphinapterus leucas) were correlated to brain mercury and selenium concentrations","volume":"48","author":"Ostertag","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119555_bib39","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1021\/ac201952t","article-title":"Determining transport efficiency for the purpose of counting and sizing nanoparticles via single particle inductively coupled plasma mass spectrometry","volume":"83","author":"Pace","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envpol.2022.119555_bib40","doi-asserted-by":"crossref","first-page":"127922","DOI":"10.1016\/j.jhazmat.2021.127922","article-title":"New insights into the biomineralization of mercury selenide nanoparticles through stable isotope analysis in giant petrel tissues","volume":"425","author":"Queipo-Abad","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2022.119555_bib41","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/wnan.24","article-title":"Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots","volume":"1","author":"Riviere","year":"2009","journal-title":"WIREs Nanomed. Nanobiotech."},{"key":"10.1016\/j.envpol.2022.119555_bib42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.envres.2015.09.010","article-title":"Mercury speciation and selenium in toothed-whale muscles","volume":"143","author":"Sakamoto","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2022.119555_bib43","series-title":"Proceedings of the the World Congress on New Technologies","article-title":"Mercury selenide nanoparticles induced immunological alterations in male Wistar rat","author":"Saxena","year":"2015"},{"key":"10.1016\/j.envpol.2022.119555_bib44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev.environ.051308.084314","article-title":"Global biogeochemical cycling of mercury: a review","volume":"34","author":"Selin","year":"2009","journal-title":"Annu. Rev. Environ. Resour."},{"key":"10.1016\/j.envpol.2022.119555_bib45","doi-asserted-by":"crossref","first-page":"12733","DOI":"10.1021\/acs.analchem.1c02769","article-title":"Development of mercury analysis by nanoSIMS for the localization of mercury\u2013selenium particles in whale liver","volume":"93","author":"Subirana","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envpol.2022.119555_bib46","doi-asserted-by":"crossref","first-page":"147","DOI":"10.5702\/massspec.S19-33","article-title":"Development of data analysis software for nanoparticle measurement by ICP-mass spectrometry","volume":"67","author":"Suzuki","year":"2019","journal-title":"J. Mass Spectrom. Soc. Jpn."},{"key":"10.1016\/j.envpol.2022.119555_bib47","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jtemb.2012.02.004","article-title":"The toxicology of mercury and its compounds","volume":"26","author":"Syversen","year":"2012","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.envpol.2022.119555_bib48","doi-asserted-by":"crossref","first-page":"112867","DOI":"10.1016\/j.ecoenv.2021.112867","article-title":"Distributions of mercury and selenium in rats ingesting mercury selenide nanoparticles","volume":"226","author":"Takahashi","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"12","key":"10.1016\/j.envpol.2022.119555_bib49","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1021\/acs.chemrestox.1c00231","article-title":"Formation mechanism and toxicological significance of biogenic mercury selenide nanoparticles in human hepatoma HepG2 cells","volume":"34","author":"Tanaka","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2022.119555_bib50","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/1758-2229.12829","article-title":"Widespread microbial mercury methylation genes in the global ocean","volume":"12","author":"Villar","year":"2020","journal-title":"Environ. Microbiol. Rep."},{"key":"10.1016\/j.envpol.2022.119555_bib51","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF00200996","article-title":"Change in the level of tissue selenium after a single administration of mercuric chloride in mice","volume":"51","author":"Watanabe","year":"1993","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envpol.2022.119555_bib52","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00244-001-0055-9","article-title":"Accumulation of heavy metals in Caspian seals (Phoca caspica)","volume":"43","author":"Watanabe","year":"2002","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envpol.2022.119555_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14252\/foodsafetyfscj.D-20-00018","article-title":"Probabilistic estimation of dietary intake of methylmercury from fish in Japan","volume":"9","author":"Watanabe","year":"2021","journal-title":"Food. Saf."},{"key":"10.1016\/j.envpol.2022.119555_bib54","series-title":"Mercury and Health (Fact Sheet No. 361)","year":"2017"},{"key":"10.1016\/j.envpol.2022.119555_bib55","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/j.1539-6924.2009.01268.x","article-title":"An exposure assessment of methyl mercury via fish consumption for the Japanese population","volume":"29","author":"Zhang","year":"2009","journal-title":"Risk Anal."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749122007692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749122007692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:11:27Z","timestamp":1778631087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749122007692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":51,"alternative-id":["S0269749122007692"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2022.119555","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Presence of nano-sized mercury-containing particles in seafoods, and an estimate of dietary exposure","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2022.119555","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119555"}}