{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:46:00Z","timestamp":1788432360806,"version":"build-2803163510"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["11G1821N"],"award-info":[{"award-number":["11G1821N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1264022N"],"award-info":[{"award-number":["1264022N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["2641\\u20135211"],"award-info":[{"award-number":["2641\\u20135211"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002913","name":"Vlaamse Overheid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["829047"],"award-info":[{"award-number":["829047"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["BEFPI\/2021\/025"],"award-info":[{"award-number":["BEFPI\/2021\/025"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.envpol.2022.119972","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T19:15:23Z","timestamp":1660850123000},"page":"119972","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Comprehensive investigation of persistent and mobile chemicals and per- and polyfluoroalkyl substances in urine of flemish adolescents using a suspect screening approach"],"prefix":"10.1016","volume":"312","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9677-4937","authenticated-orcid":false,"given":"Da-Hye","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8802-3295","authenticated-orcid":false,"given":"Yunsun","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Belova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6643-4907","authenticated-orcid":false,"given":"Maarten","family":"Roggeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7795-4289","authenticated-orcid":false,"given":"Sandra F.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-2653","authenticated-orcid":false,"given":"Giulia","family":"Poma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Remy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5262-5665","authenticated-orcid":false,"given":"Veerle J.","family":"Verheyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greet","family":"Schoeters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.N.","family":"van Nuijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0527-1136","authenticated-orcid":false,"given":"Adrian","family":"Covaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2022.119972_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11419-021-00588-5","article-title":"Ethyl glucuronide and ethyl sulfate: a review of their roles in forensic toxicology analysis of alcohol postmortem","volume":"40","author":"Alsayed","year":"2022","journal-title":"Forensic Toxicol."},{"key":"10.1016\/j.envpol.2022.119972_bib2","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.scitotenv.2015.09.126","article-title":"Estimation of alcohol consumption during \u201cFallas\u201d festivity in the wastewater of Valencia city (Spain) using ethyl sulfate as a biomarker","volume":"541","author":"Andr\u00e9s-Costa","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119972_bib3","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1039\/C7EM00158D","article-title":"Ranking REACH registered neutral, ionizable and ionic organic chemicals based on their aquatic persistency and mobility","volume":"19","author":"Arp","year":"2017","journal-title":"Environ. Sci. Process. Impacts"},{"key":"10.1016\/j.envpol.2022.119972_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116724","article-title":"Biomarkers of phthalates and alternative plasticizers in the Flemish Environment and Health Study (FLEHS IV): time trends and exposure assessment","volume":"276","author":"Bastiaensen","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2022.119972_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106368","article-title":"Exposure levels, determinants and risk assessment of organophosphate flame retardants and plasticizers in adolescents (14\u201315 years) from the Flemish Environment and Health Study","volume":"147","author":"Bastiaensen","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2022.119972_bib6","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1016\/j.scitotenv.2011.07.015","article-title":"Occurrence and removal of antibiotics, hormones and several other pharmaceuticals in wastewater treatment plants of the largest industrial city of Korea","volume":"409","author":"Behera","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119972_bib7","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1021\/es990855f","article-title":"Concentrations and mass fluxes of chloroacetic acids and trifluoroacetic acid in rain and natural waters in Switzerland","volume":"34","author":"Berg","year":"2000","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119972_bib8","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.chemosphere.2012.03.030","article-title":"Stability considerations of aspartame in the direct analysis of artificial sweeteners in water samples using high-performance liquid chromatography\u2013tandem mass spectrometry (HPLC\u2013MS\/MS)","volume":"88","author":"Berset","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2022.119972_bib9","doi-asserted-by":"crossref","first-page":"11093","DOI":"10.1021\/acs.est.9b02211","article-title":"Ultra-short-chain perfluoroalkyl acids including trifluoromethane sulfonic acid in water connected to known and suspected point sources in Sweden","volume":"53","author":"Bj\u00f6rnsdotter","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119972_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.chroma.2017.12.023","article-title":"Utilization of large volume zwitterionic hydrophilic interaction liquid chromatography for the analysis of polar pharmaceuticals in aqueous environmental samples: benefits and limitations","volume":"1535","author":"Boulard","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.envpol.2022.119972_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2021.113849","article-title":"Combined chemical exposure using exposure loads on human biomonitoring data of the 4th Flemish Environment and Health Study (FLEHS-4)","volume":"238","author":"Buekers","year":"2021","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envpol.2022.119972_bib12","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1021\/es1031272","article-title":"Saccharin and other artificial sweeteners in soils: estimated inputs from agriculture and households, degradation, and leaching to groundwater","volume":"45","author":"Buerge","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119972_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.130683","article-title":"Identification of chemicals of emerging concern in urine of Flemish adolescents using a new suspect screening workflow for LC-QTOF-MS","volume":"280","author":"Caballero-Casero","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2022.119972_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105048","article-title":"Legacy and alternative per- and polyfluoroalkyl substances in the U.S. general population: paired serum-urine data from the 2013\u20132014 National Health and Nutrition Examination Survey","volume":"131","author":"Calafat","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2022.119972_bib14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.5021\/ad.2017.29.2.180","article-title":"Knowledge and behavior regarding cosmetics in Koreans visiting dermatology clinics","volume":"29","author":"Cho","year":"2017","journal-title":"Ann. Dermatol."},{"key":"10.1016\/j.envpol.2022.119972_bib93","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.talanta.2015.06.038","article-title":"Development of an analytical method for the targeted screening and multi-residue quantification of environmental contaminants in urine by liquid chromatography coupled to high resolution mass spectrometry for evaluation of human exposures","volume":"146","author":"Cort\u00e9jade","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.envpol.2022.119972_bib15","first-page":"1","article-title":"Continuous synthesis of triacetonamine over cation-exchange resin","volume":"26","author":"Du","year":"2014","journal-title":"Asian J. Chem."},{"key":"10.1016\/j.envpol.2022.119972_bib17","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.envint.2008.09.003","article-title":"Non-invasive matrices in human biomonitoring: a review","volume":"35","author":"Esteban","year":"2009","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2022.119972_bib18","doi-asserted-by":"crossref","DOI":"10.1289\/EHP5843","article-title":"Evaluation of developmental toxicity, developmental neurotoxicity, and tissue dose in zebrafish exposed to GenX and other PFAS","volume":"128","author":"Gaballah","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2022.119972_bib19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.chroma.2012.11.081","article-title":"A novel solid-phase extraction for the concentration of sweeteners in water and analysis by ion-pair liquid chromatography\u2013triple quadrupole mass spectrometry","volume":"1274","author":"Gan","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.envpol.2022.119972_bib20","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.1016\/j.chroma.2011.09.003","article-title":"Use of an accurate-mass database for the systematic identification of transformation products of organic contaminants in wastewater effluents","volume":"1218","author":"P\u00e9rez-Parada","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.envpol.2022.119972_bib21","series-title":"Percutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products","first-page":"83","article-title":"Determination of the unconjugated forms of benzophenone-3 and benzophenone-4 in urine by solid-phase extraction coupled to a liquid chromatographic system with UV\/Vis detection by using automated sequential injection analysis","author":"Gonz\u00e1lez","year":"2014"},{"key":"10.1016\/j.envpol.2022.119972_bib22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yrtph.2010.09.008","article-title":"Toxicological evaluation of ammonium 4,8-dioxa-3H-perfluorononanoate, a new emulsifier to replace ammonium perfluorooctanoate in fluoropolymer manufacturing","volume":"59","author":"Gordon","year":"2011","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2022.119972_bib23","doi-asserted-by":"crossref","first-page":"945","DOI":"10.15288\/jsad.2017.78.945","article-title":"Utility of commercial ethyl glucuronide (EtG) and ethyl sulfate (EtS) testing for detection of lighter drinking among women of childbearing years","volume":"78","author":"Graham","year":"2017","journal-title":"J. Stud. Alcohol Drugs"},{"key":"10.1016\/j.envpol.2022.119972_bib24","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.chroma.2012.05.084","volume":"1248","author":"Gros","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.envpol.2022.119972_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.121339","article-title":"Recent advances in non-targeted screening analysis using liquid chromatography - high resolution mass spectrometry to explore new biomarkers for human exposure","volume":"219","author":"Guo","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.envpol.2022.119972_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110567","article-title":"Determinants of exposure levels of bisphenols in flemish adolescents","volume":"193","author":"Gys","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2022.119972_bib27","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0378-4347(96)00527-0","article-title":"Determination of the halothane metabolites trifluoroacetic acid and bromide in plasma and urine by ion chromatography","volume":"692","author":"Hankins","year":"1997","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.envpol.2022.119972_bib28","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1373\/clinchem.2004.031252","article-title":"Mass spectrometric identification of ethyl sulfate as an ethanol metabolite in humans","volume":"50","author":"Helander","year":"2004","journal-title":"Clin. Chem."},{"key":"10.1016\/j.envpol.2022.119972_bib29","doi-asserted-by":"crossref","first-page":"7326","DOI":"10.1007\/s11356-018-1731-x","article-title":"Robust trace analysis of polar (C2-C8) perfluorinated carboxylic acids by liquid chromatography-tandem mass spectrometry: method development and application to surface water, groundwater and drinking water","volume":"26","author":"Janda","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2022.119972_bib30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0731-7085(03)00573-9","article-title":"The quantification of paracetamol, paracetamol glucuronide and paracetamol sulphate in plasma and urine using a single high-performance liquid chromatography assay","volume":"34","author":"Jensen","year":"2004","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.envpol.2022.119972_bib31","doi-asserted-by":"crossref","first-page":"11651","DOI":"10.1021\/acs.est.0c04281","article-title":"The need to adopt an international PMT strategy to protect drinking water resources","volume":"54","author":"Jin","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119972_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envres.2016.04.036","article-title":"Urinary benzophenone concentrations and their association with demographic factors in a South Korean population","volume":"149","author":"Kang","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2022.119972_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s0054080020161","article-title":"Salivary excretion of trifluoroacetic acid (TFAA) after halothane anesthesia","volume":"2","author":"Kawahara","year":"1988","journal-title":"J. Anesth."},{"key":"10.1016\/j.envpol.2022.119972_bib34","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.scitotenv.2011.01.010","article-title":"Pharmaceuticals, hormones and bisphenol A in untreated source and finished drinking water in Ontario, Canada \u2014 occurrence and treatment efficiency","volume":"409","author":"Kleywegt","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119972_bib35","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1007\/s00216-020-02542-7","article-title":"Persistent and mobile organic compounds\u2014an environmental challenge","volume":"412","author":"Knepper","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.envpol.2022.119972_bib36","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s40257-014-0106-4","article-title":"The influence of age and gender in knowledge, behaviors and attitudes towards sun protection: a cross-sectional survey of Australian outpatient clinic attendees","volume":"16","author":"Lee","year":"2015","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.envpol.2022.119972_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116219","article-title":"Perfluoroalkyl substances in the urine and hair of preschool children, airborne particles in kindergartens, and drinking water in Hong Kong","volume":"270","author":"Li","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2022.119972_bib38","doi-asserted-by":"crossref","first-page":"7954","DOI":"10.1021\/es2011622","article-title":"Polyfluorinated compounds: past, present, and future","volume":"45","author":"Lindstrom","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119972_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2019.02.021","article-title":"High-resolution mass spectrometry (HRMS) methods for nontarget discovery and characterization of poly- and per-fluoroalkyl substances (PFASs) in environmental and human samples","volume":"121","author":"Liu","year":"2019","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.envpol.2022.119972_bib40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jfluchem.2013.09.004","article-title":"Trifluoroacetic acid: uses and recent applications in organic synthesis","volume":"156","author":"L\u00f3pez","year":"2013","journal-title":"J. Fluor. Chem."},{"key":"10.1016\/j.envpol.2022.119972_bib41","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0015-6264(73)90006-0","article-title":"The excretion and metabolism of saccharin in man. I. Methods of investigation and preliminary results","volume":"11","author":"McChesney","year":"1973","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envpol.2022.119972_bib42","article-title":"Prevalence and predictors of the use of sunscreen amongst medical students: a multi-center cross-sectional study","volume":"11","author":"Memon","year":"2019","journal-title":"Cureus"},{"key":"10.1016\/j.envpol.2022.119972_bib92","article-title":"Wide-scope screening of polar contaminants of concern in water: A critical review of liquid chromatography-high resolution mass spectrometry-based strategies","volume":"28","author":"Menger","year":"2020","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.envpol.2022.119972_bib43","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jchromb.2013.02.023","article-title":"Rapid determination of N-acetyl-4-aminophenol (paracetamol) in urine by tandem mass spectrometry coupled with on-line clean-up by two dimensional turbulent flow\/reversed phase liquid chromatography","volume":"925","author":"Modick","year":"2013","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.envpol.2022.119972_bib44","doi-asserted-by":"crossref","first-page":"R105","DOI":"10.1530\/REP-13-0527","article-title":"Ubiquitous presence of paracetamol in human urine: sources and implications","volume":"147","author":"Modick","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.envpol.2022.119972_bib45","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.1021\/acs.est.6b05135","article-title":"Screening for polar chemicals in water by trifunctional mixed-mode liquid chromatography-high resolution mass spectrometry","volume":"51","author":"Montes","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119972_bib46","doi-asserted-by":"crossref","first-page":"5176","DOI":"10.1021\/acs.analchem.8b05792","article-title":"Determination of persistent and mobile organic contaminants (PMOCs) in water by mixed-mode liquid chromatography-tandem mass spectrometry","volume":"91","author":"Montes","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envpol.2022.119972_bib47","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00414-010-0511-z","article-title":"Ethyl glucuronide and ethyl sulfate in urine after consumption of various beverages and foods-misleading results?","volume":"124","author":"Musshoff","year":"2010","journal-title":"Int. J. Leg. Med."},{"key":"10.1016\/j.envpol.2022.119972_bib48","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.chroma.2012.07.073","article-title":"Determination of artificial sweeteners in water samples by solid-phase extraction and liquid chromatography\u2013tandem mass spectrometry","volume":"1256","author":"Ord\u00f3\u00f1ez","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.envpol.2022.119972_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2020.122337","article-title":"Determination, occurrence, and treatment of saccharin in water: a review","volume":"270","author":"Pang","year":"2020","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.envpol.2022.119972_bib50","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1021\/es802216n","article-title":"A first global production, emission, and environmental inventory for perfluorooctane sulfonate","volume":"43","author":"Paul","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119972_bib51","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/jssc.200600269","article-title":"Pharmaceutical determination in surface and wastewaters using high-performance liquid chromatography-(electrospray)-mass spectrometry","volume":"30","author":"Pedrouzo","year":"2007","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.envpol.2022.119972_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105545","article-title":"Suspect and non-targeted screening of chemicals of emerging concern for human biomonitoring, environmental health studies and support to risk assessment: From promises to challenges and harmonisation issues","volume":"139","author":"Pourchet","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2022.119972_bib52","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1021\/es060528p","article-title":"Consequences of treated water recycling as regards pharmaceuticals and drugs in surface and ground waters of a medium-sized Mediterranean catchment","volume":"40","author":"Rabiet","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119972_bib53","doi-asserted-by":"crossref","first-page":"10308","DOI":"10.1021\/acs.est.6b03338","article-title":"Mind the gap: persistent and mobile organic compounds\u2014water contaminants that slip through","volume":"50","author":"Reemtsma","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119972_bib54","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/anatox\/35.5.264","article-title":"Ethyl glucuronide, ethyl sulfate, and ethanol in urine after intensive exposure to high ethanol content mouthwash","volume":"35","author":"Reisfield","year":"2011","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.envpol.2022.119972_bib55","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2217\/17455057.5.1.79","article-title":"Gender differences and pain medication","volume":"5","author":"Richardson","year":"2009","journal-title":"Women's Health"},{"key":"10.1016\/j.envpol.2022.119972_bib56","series-title":"Comprehensive Suspect Screening for the Identification of Contaminants of Emerging Concern in Urine of Flemish Adolescents by Liquid Chromatography High-Resolution Mass Spectrometry","author":"Roggeman","year":"2022"},{"key":"10.1016\/j.envpol.2022.119972_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12302-019-0286-x","article-title":"Persistent, mobile and toxic substances in the environment: a spotlight on current research and regulatory activities","volume":"32","author":"R\u00fcdel","year":"2020","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.envpol.2022.119972_bib58","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.toxrep.2017.05.006","article-title":"Neurotoxic effect of active ingredients in sunscreen products, a contemporary review","volume":"4","author":"Ruszkiewicz","year":"2017","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.envpol.2022.119972_bib59","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jchromb.2013.04.032","article-title":"Development of a simple analytical method for the simultaneous determination of paracetamol, paracetamol-glucuronide and p-aminophenol in river water","volume":"930","author":"Santos","year":"2013","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.envpol.2022.119972_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2022.113972","article-title":"Internal exposure of flemish teenagers to environmental pollutants: results of the flemish environment and health study 2016\u20132020 (FLEHS IV)","volume":"242","author":"Schoeters","year":"2022","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envpol.2022.119972_bib61","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1007\/s00216-020-02722-5","article-title":"A rapid method for quantification of persistent and mobile organic substances in water using supercritical fluid chromatography coupled to high-resolution mass spectrometry","volume":"412","author":"Schulze","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.envpol.2022.119972_bib96","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.scitotenv.2017.12.305","article-title":"Using REACH registration data to rank the environmental emission potential of persistent and mobile organic chemicals","volume":"625","author":"Schulze","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119972_bib62","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.watres.2019.01.008","article-title":"Occurrence of emerging persistent and mobile organic contaminants in European water samples","volume":"153","author":"Schulze","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2022.119972_bib63","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1021\/es5002105","article-title":"Identifying small molecules via high resolution mass spectrometry: communicating confidence","volume":"48","author":"Schymanski","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119972_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-069X-8-8","article-title":"Environmental Health Applicability of non-invasively collected matrices for human biomonitoring","volume":"8","author":"Smolders","year":"2009","journal-title":"Environ. Health"},{"key":"10.1016\/j.envpol.2022.119972_bib65","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/10937404.2016.1175981","article-title":"Sources, fates, toxicity, and risks of trifluoroacetic acid and its salts: relevance to substances regulated under the Montreal and Kyoto Protocols","volume":"19","author":"Solomon","year":"2016","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.envpol.2022.119972_bib66","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.scitotenv.2007.01.095","article-title":"Efficiency of conventional drinking-water-treatment processes in removal of pharmaceuticals and other organic compounds","volume":"377","author":"Stackelberg","year":"2007","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119972_bib67","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.wasman.2019.06.010","article-title":"Identification of groundwater pollution sources in a landfill site using artificial sweeteners, multivariate analysis and transport modeling","volume":"95","author":"Stefania","year":"2019","journal-title":"Waste Manag."},{"key":"10.1016\/j.envpol.2022.119972_bib68","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2478\/v10102-009-0010-6","article-title":"Toxicological risk of melamine and cyanuric acid in food and feed","volume":"2","author":"Such\u00fd","year":"2009","journal-title":"Interdiscipl. Toxicol."},{"key":"10.1016\/j.envpol.2022.119972_bib69","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00414-015-1222-2","article-title":"Detection of the ethanol consumption markers ethyl glucuronide and ethyl sulfate in urine samples from inmates of two German prisons","volume":"130","author":"Thierauf-Emberger","year":"2016","journal-title":"Int. J. Leg. Med."},{"key":"10.1016\/j.envpol.2022.119972_bib70","series-title":"REACH: Improvement of Guidance and Methods for the Identification and Assessment of PM\/PMT Substances","year":"2019"},{"key":"10.1016\/j.envpol.2022.119972_bib71","first-page":"138","article-title":"Saccharin genotoxicity and carcinogenicity: a review","volume":"37","author":"U\u00e7ar","year":"2015","journal-title":"Adv. Food Sci."},{"key":"10.1016\/j.envpol.2022.119972_bib72","series-title":"SC-9\/12: Listing of Perfluorooctanoic Acid (PFOA), its Salts and PFOA-Related Compounds","first-page":"1","year":"2019"},{"key":"10.1016\/j.envpol.2022.119972_bib73","first-page":"1","year":"2009","journal-title":"SC-4\/17: Listing of perfluorooctane sulfonic acid, its salts and perfluorooctane sulfonyl fluoride, Stockholm Convention on Persistent Organic Pollutants"},{"key":"10.1016\/j.envpol.2022.119972_bib74","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3390\/toxics9100245","article-title":"Urinary polycyclic aromatic hydrocarbon metabolites are associated with biomarkers of chronic endocrine stress, oxidative stress, and inflammation in adolescents: FLEHS-4 (2016\u20132020)","volume":"9","author":"Verheyen","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2022.119972_bib75","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10311-009-0253-7","article-title":"Occurrence of pharmaceuticals and hormones in drinking water treated from surface waters","volume":"9","author":"Vulliet","year":"2011","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.envpol.2022.119972_bib76","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1177\/0960327111420744","article-title":"Toxicity of cyanuric acid to broilers on hepatic and renal health with and without melamine","volume":"31","author":"Wang","year":"2012","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.envpol.2022.119972_bib77","doi-asserted-by":"crossref","first-page":"10163","DOI":"10.1021\/es401525n","article-title":"First report of a Chinese PFOS alternative overlooked for 30 years: its toxicity, persistence, and presence in the environment","volume":"47","author":"Wang","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119972_bib78","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.scitotenv.2018.04.279","article-title":"Using hair, nail and urine samples for human exposure assessment of legacy and emerging per- and polyfluoroalkyl substances","volume":"636","author":"Wang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.119972_bib80","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1093\/jee\/toz014","article-title":"Sublethal effects of the insecticide pyrifluquinazon on the European honey bee (Hymenoptera: apidae)","volume":"112","author":"Wilson","year":"2019","journal-title":"J. Econ. Entomol."},{"key":"10.1016\/j.envpol.2022.119972_bib81","series-title":"Safety Evaluation of Certain Food Additives and Contaminants","article-title":"Sodium dichloroisocyanurate","year":"2004"},{"key":"10.1016\/j.envpol.2022.119972_bib82","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.envint.2017.06.007","article-title":"Per- and polyfluoroalkyl substances in human serum and urine samples from a residentially exposed community","volume":"106","author":"Worley","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2022.119972_bib83","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00253-012-4414-4","article-title":"Paracetamol in the environment and its degradation by microorganisms","volume":"96","author":"Wu","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.envpol.2022.119972_bib84","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1360-0443.2005.01245.x","article-title":"Ethyl sulphate: a direct ethanol metabolite reflecting recent alcohol consumption","volume":"101","author":"Wurst","year":"2006","journal-title":"Addiction"},{"key":"10.1016\/j.envpol.2022.119972_bib85","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s11356-019-06689-4","article-title":"Distribution characteristics of trifluoroacetic acid in the environments surrounding fluorochemical production plants in Jinan, China","volume":"27","author":"Xie","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2022.119972_bib86","doi-asserted-by":"crossref","first-page":"8140","DOI":"10.1021\/es800631n","article-title":"Perfluorinated compounds and total and extractable organic fluorine in human blood samples from China","volume":"42","author":"Yeung","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2022.119972_bib87","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/jssc.201601094","article-title":"Simultaneous determination of pyrifluquinazon and its main metabolite in fruits and vegetables by using QuEChERS\u2013HPLC\u2013MS\/MS","volume":"40","author":"You","year":"2016","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.envpol.2022.119972_bib88","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.chroma.2008.06.041","article-title":"Simultaneous trace determination of nine organic UV-absorbing compounds (UV filters) in environmental samples","volume":"1202","author":"Zenker","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.envpol.2022.119972_bib89","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.chemosphere.2014.09.033","article-title":"A 17-fold increase of trifluoroacetic acid in landscape waters of Beijing, China during the last decade","volume":"129","author":"Zhai","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2022.119972_bib90","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1007\/s11356-014-3725-7","article-title":"PFOS and PFOA in paired urine and blood from general adults and pregnant women: assessment of urinary elimination","volume":"22","author":"Zhang","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2022.119972_bib91","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.taap.2010.10.001","article-title":"The UV-absorber benzophenone-4 alters transcripts of genes involved in hormonal pathways in zebrafish (Danio rerio) eleuthero-embryos and adult males","volume":"250","author":"Zucchi","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749122011861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749122011861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:41:20Z","timestamp":1778510480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749122011861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":94,"alternative-id":["S0269749122011861"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2022.119972","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive investigation of persistent and mobile chemicals and per- and polyfluoroalkyl substances in urine of flemish adolescents using a suspect screening approach","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2022.119972","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119972"}}